Mannoside Glycolipid Conjugates Display Anti-inflammatory Activity by Inhibition of Toll-like Receptor-4 Mediated Cell Activation

2015 ◽  
Vol 10 (12) ◽  
pp. 2697-2705 ◽  
Author(s):  
Vincent Flacher ◽  
Patrick Neuberg ◽  
Floriane Point ◽  
François Daubeuf ◽  
Quentin Muller ◽  
...  
Keyword(s):  
Cell Activation ◽  
Inflammatory Activity ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Anti Inflammatory

scholarly journals Anti-Inflammatory Activity of Odina wodier Roxb, an Indian Folk Remedy, through Inhibition of Toll-Like Receptor 4 Signaling Pathway

PLoS ONE ◽  
2014 ◽  
Vol 9 (8) ◽  
pp. e104939 ◽  
Author(s):  
Durbadal Ojha ◽  
Hemanta Mukherjee ◽  
Supriya Mondal ◽  
Aditya Jena ◽  
Ved Prakash Dwivedi ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Inflammatory Activity ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Folk Remedy ◽  
Anti Inflammatory

scholarly journals Isolation of an endotoxin-MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations

2004 ◽  
Vol 101 (12) ◽  
pp. 4186-4191 ◽  
Author(s):  
T. L. Gioannini ◽  
A. Teghanemt ◽  
D. Zhang ◽  
N. P. Coussens ◽  
W. Dockstader ◽  
...  
Keyword(s):  
Cell Activation ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Dependent Cell

3,6-Dihydroxyflavone: A Potent Inhibitor with Anti-Inflammatory Activity Targeting Toll-like Receptor 2

2018 ◽  
Vol 40 (1) ◽  
pp. 51-55
Author(s):  
Pavithra K. Balasubramanian ◽  
Jieun Kim ◽  
Kkabi Son ◽  
Prasannavenkatesh Durai ◽  
Yangmee Kim
Keyword(s):  
Potent Inhibitor ◽  
Inflammatory Activity ◽  
Toll Like Receptor ◽  
Toll Like Receptor 2 ◽  
Anti Inflammatory

Oxymatrine inhibits lipopolysaccharide-induced inflammation by down-regulating Toll-like receptor 4/nuclear factor-kappa B in macrophages

2015 ◽  
Vol 93 (4) ◽  
pp. 253-260 ◽  
Author(s):  
Yu Zhang ◽  
Ruhong Yan ◽  
Yae Hu
Keyword(s):  
Nitric Oxide ◽  
Interleukin 1 ◽  
Chinese Herb ◽  
Mrna Levels ◽  
Nuclear Factor ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Anti Inflammatory

Oxymatrine (OMT) is the quinolizidine alkaloid extracted from the Chinese herb Sophora flavescens Ait. that has many pharmacological effects and is used for the treatment of some inflammatory diseases. In this study, RAW264.7 cells and THP-1 differentiated macrophages were pretreated with various concentrations of OMT at 2 h prior to treatment with lipopolysaccharide (LPS) (1.0 μg/mL) for different durations. We detected the anti-inflammatory effect of OMT in LPS-stimulated macrophages and investigated the molecular mechanism. We showed that OMT pretreatment significantly inhibited the LPS-induced secretion of nitric oxide (NO), interleukin-1 beta (IL-1β), and tumor necrosis factor-alpha (TNF-α) in supernatant, attenuated the mRNA levels of inducible nitric oxide synthase (iNOS), IL-1β, TNF-α, and Toll-like receptor 4 (TLR4), increased TLR4 and phosphorylation of inhibitor of kappa B-alpha (p-IBα) in cytosol, and decreased the nuclear level of nuclear factor-κB (NF-κB) p65 in macrophages. In conclusion, OMT exerts anti-inflammatory properties in LPS-stimulated macrophages by down-regulating the TLR4/NF-κB pathway.

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