Insight into the Critical Role of Surface Hydrophilicity for Dendrite-Free Zinc Metal Anodes

This article analyses the growing participation of UK Christians in climate initiatives over the last five years. In many cases, climate science is cited as a necessary consideration for the fulfilment of already-existing Christian commitments. This represents a significant shift in the ways UK Christians understand the role of dialogue between theology and the sciences; previous science and theology dialogue has usually been treated as an area of expert concern, primarily offering insight into apologetics or specific ethical problems. By contrast, the dialogue between climate science and theology has seen the emergence of non-technical leadership amid the expectation that climate science plays a critical role in re-examining the meaning of Christian life, both for individuals and as communities.

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Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs

10.1101/442459 ◽

2018 ◽

Cited By ~ 2

Author(s):

David M. Kern ◽

SeCheol Oh ◽

Richard K. Hite ◽

Stephen G. Brohawn

Keyword(s):

Lipid Bilayers ◽

Critical Role ◽

Anion Channel ◽

Lipid Binding ◽

Channel Structure ◽

Anion Channels ◽

Cryo Electron Microscopy ◽

Lipid Nanodiscs ◽

Insight Into

AbstractHypoosmotic conditions activate volume-regulated anion channels in vertebrate cells. These channels are formed by leucine-rich repeat-containing protein 8 (LRRC8) family members and contain LRRC8A in homo- or hetero-hexameric assemblies. Here we present single-particle cryo-electron microscopy structures of LRRC8A in complex with the inhibitor DCPIB reconstituted in lipid nanodiscs. DCPIB plugs the channel like a cork in a bottle - binding in the extracellular selectivity filter and sterically occluding ion conduction. Constricted and expanded structures reveal coupled dilation of cytoplasmic LRRs and the channel pore, suggesting a mechanism for channel gating by internal stimuli. Conformational and symmetry differences between LRRC8A structures determined in detergent micelles and lipid bilayers related to reorganization of intersubunit lipid binding sites demonstrate a critical role for the membrane in determining channel structure. These results provide insight into LRRC8 gating and inhibition and the role of lipids in the structure of an ionic-strength sensing ion channel.

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A Metal-Organic Framework Host for Highly Reversible Dendrite-free Zinc Metal Anodes

Joule ◽

10.1016/j.joule.2019.02.012 ◽

2019 ◽

Vol 3 (5) ◽

pp. 1289-1300 ◽

Cited By ~ 120

Author(s):

Zhuo Wang ◽

Jianhang Huang ◽

Zhaowei Guo ◽

Xiaoli Dong ◽

Yao Liu ◽

...

Keyword(s):

Metal Organic Framework ◽

Zinc Metal ◽

Free Zinc ◽

Metal Organic ◽

Metal Anodes ◽

Organic Framework

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The Cognitive Component of Elite High Jumpers’ Preperformance Routines

The Sport Psychologist ◽

10.1123/tsp.2019-0093 ◽

2020 ◽

Vol 34 (2) ◽

pp. 99-110

Author(s):

Thomas Gretton ◽

Lindsey Blom ◽

Dorice Hankemeier ◽

Lawrence Judge

Keyword(s):

Thematic Analysis ◽

Critical Role ◽

Valuable Insight ◽

Psychological Skills ◽

Cognitive Content ◽

Successful Performance ◽

Cognitive Component ◽

Inductive Thematic Analysis ◽

Insight Into

Preperformance routines are microlevel performance processes utilized by athletes to facilitate the attainment of an optimal state and enhance the chance for successful performance. Despite continued examination of these routines, only a small proportion of research has been directed toward the cognitive component of these routines. This study explored the cognitive component of elite high jumpers’ preperformance routines, and specifically the consistency of the cognitive content (i.e., psychological skills and strategies). Data were acquired over an 8-week high-jump season and subjected to inductive thematic analysis. Results revealed the consistent implementation of the cognitive content (e.g., visualization) but an inconsistent design of this content (i.e., the content of the visualization). Furthermore, results underline the critical role of high-jump coaches and an athlete’s need to be adaptable and competent in utilizing various types of preperformance routine. This study offers valuable insight into the complexities and inconsistencies of the cognitive component of high jumpers’ preperformance routines.

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Cryo-EM structure of 90S small ribosomal subunit precursors in transition states

Science ◽

10.1126/science.aba9690 ◽

2020 ◽

Vol 369 (6510) ◽

pp. 1477-1481 ◽

Cited By ~ 3

Author(s):

Yifei Du ◽

Weidong An ◽

Xing Zhu ◽

Qi Sun ◽

Jia Qi ◽

...

Keyword(s):

Structural Changes ◽

Critical Role ◽

Ribosomal Subunit ◽

Rna Degradation ◽

Ribosomal Subunits ◽

Cryo Electron Microscopy ◽

Nuclear Exosome ◽

Assembly Intermediate ◽

Insight Into

The 90S preribosome is a large, early assembly intermediate of small ribosomal subunits that undergoes structural changes to give a pre-40S ribosome. Here, we gained insight into this transition by determining cryo–electron microscopy structures of Saccharomyces cerevisiae intermediates in the path from the 90S to the pre-40S. The full transition is blocked by deletion of RNA helicase Dhr1. A series of structural snapshots revealed that the excised 5′ external transcribed spacer (5′ ETS) is degraded within 90S, driving stepwise disassembly of assembly factors and ribosome maturation. The nuclear exosome, an RNA degradation machine, docks on the 90S through helicase Mtr4 and is primed to digest the 3′ end of the 5′ ETS. The structures resolved between 3.2- and 8.6-angstrom resolution reveal key intermediates and the critical role of 5′ ETS degradation in 90S progression.

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Local modes

Canadian Journal of Chemistry ◽

10.1139/v02-188 ◽

2002 ◽

Vol 80 (12) ◽

pp. 1635-1642 ◽

Cited By ~ 68

Author(s):

Bryan R Henry ◽

Henrik G Kjaergaard

Keyword(s):

Atmospheric Chemistry ◽

Molecular Conformation ◽

Critical Role ◽

Historical Background ◽

Local Mode ◽

Local Modes ◽

Band Profile ◽

Methyl Rotation ◽

Insight Into

The historical background for the development of the local mode approach is reviewed, including the critical role of the radiation field. The harmonically coupled anharmonic oscillator model is described. Local modes have been used in the interpretation of XH stretching overtone spectra. These spectra can be used as sensitive probes of molecular properties such as bond length and molecular conformation. Examples of these spectral features are discussed. An intensity theory has been developed that permits the accurate calculation of relative and absolute overtone intensities. In molecules with low barriers to methyl rotation, torsional states contribute to the XH stretching band profile. A successful theoretical approach is presented that accounts for these effects and provides insight into the vibrational dynamics. The application of calculated local mode overtone spectra to atmospheric chemistry is discussed.Key words: local mode, overtone, vibrational intensity.

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High-Molecular-Weight, High-Unsaturation Copolymers of Isobutylene and Conjugated Dienes. I. Synthesis

Rubber Chemistry and Technology ◽

10.5254/1.3534996 ◽

1976 ◽

Vol 49 (4) ◽

pp. 960-966 ◽

Cited By ~ 21

Author(s):

W. A. Thaler ◽

D. J. Buckley

Keyword(s):

Molecular Weight ◽

High Molecular Weight ◽

Cationic Polymerization ◽

Critical Role ◽

Conjugated Dienes ◽

Solution Properties ◽

Insight Into

Abstract This investigation has provided insight into the critical role of solution properties on the course of cationic polymerization and has led to a technique for reconciling the opposing demands for synthesis of isoolefin-diene copolymers both free from gel and high in molecular weight. By this technique, the synthesis of a broad range of intermediate-unsaturation elastomers of quality has been realized.

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The Role of HDAC6 in Autophagy and NLRP3 Inflammasome

Frontiers in Immunology ◽

10.3389/fimmu.2021.763831 ◽

2021 ◽

Vol 12 ◽

Author(s):

Panpan Chang ◽

Hao Li ◽

Hui Hu ◽

Yongqing Li ◽

Tianbing Wang

Keyword(s):

Nlrp3 Inflammasome ◽

Inflammatory Diseases ◽

Critical Role ◽

Histone Deacetylase 6 ◽

Physiological Processes ◽

Class Iib ◽

Underlying Mechanisms ◽

Nlrp3 Inflammasomes ◽

Insight Into

Autophagy fights against harmful stimuli and degrades cytosolic macromolecules, organelles, and intracellular pathogens. Autophagy dysfunction is associated with many diseases, including infectious and inflammatory diseases. Recent studies have identified the critical role of the NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) inflammasomes activation in the innate immune system, which mediates the secretion of proinflammatory cytokines IL-1β/IL-18 and cleaves Gasdermin D to induce pyroptosis in response to pathogenic and sterile stimuli. Accumulating evidence has highlighted the crosstalk between autophagy and NLRP3 inflammasome in multifaceted ways to influence host defense and inflammation. However, the underlying mechanisms require further clarification. Histone deacetylase 6 (HDAC6) is a class IIb deacetylase among the 18 mammalian HDACs, which mainly localizes in the cytoplasm. It is involved in two functional deacetylase domains and a ubiquitin-binding zinc finger domain (ZnF-BUZ). Due to its unique structure, HDAC6 regulates various physiological processes, including autophagy and NLRP3 inflammasome, and may play a role in the crosstalk between them. In this review, we provide insight into the mechanisms by which HDAC6 regulates autophagy and NLRP3 inflammasome and we explored the possibility and challenges of HDAC6 in the crosstalk between autophagy and NLRP3 inflammasome. Finally, we discuss HDAC6 inhibitors as a potential therapeutic approach targeting either autophagy or NLRP3 inflammasome as an anti-inflammatory strategy, although further clarification is required regarding their crosstalk.

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The Role of CARD9 Deficiency in Neutrophils

Mediators of Inflammation ◽

10.1155/2021/6643603 ◽

2021 ◽

Vol 2021 ◽

pp. 1-5

Author(s):

Ruanmei Sheng ◽

Xiaoming Zhong ◽

Zhiwen Yang ◽

Xuemin Wang

Keyword(s):

Critical Role ◽

Myeloid Cell ◽

Immune Defense ◽

Innate Immune ◽

Innate Immune Defense ◽

The Central Nervous System ◽

Clinical Advances ◽

Insight Into ◽

Increased Susceptibility

Neutrophils play a critical role in innate immune defense and directly contribute to infectious and autoimmune ailments. Great efforts are underway to better understand the nature of neutrophilic inflammation. Of note, CARD9, a myeloid cell-specific signaling protein that mainly expresses in macrophages and dendritic cells, is also present in neutrophils, emerging as a critical mediator for intercellular communication. CARD9–deficiency neutrophils display an increased susceptibility to fungal infection that primarily localize to the central nervous system, subcutaneous, and skin tissue. Additionally, CARD9–deficiency neutrophils are associated with some autoimmune diseases and even provide protection against a few bacteria. Here, the review summarizes recent preclinical and clinical advances that have provided a novel insight into the pathogenesis of CARD9 deficiency in neutrophils.

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Assertion, Negotiation and Subjugation of Identity: Understanding the Tamil-Malayali Conflict in Munnar

Millennial Asia ◽

10.1177/0976399619853711 ◽

2019 ◽

Vol 10 (2) ◽

pp. 167-182

Author(s):

Shyam Hari P.

Keyword(s):

Social Interaction ◽

Social Identity ◽

Critical Role ◽

Vital Role ◽

Social Identities ◽

Dynamic Nature ◽

Major Objective ◽

Heterogeneous Societies ◽

Insight Into

Social identities play a critical role in the various phases of conflict. Existing literature often examines the role of social identity of groups in inducing conflict in heterogeneous societies. This article puts forward the view that the role of identity is not limited in terms of inducing conflict, but it also plays a vital role in influencing the dynamics of conflict. Based on this conceptual framework, the article outlines the conflict dynamics observable in the Kannan Devan Hills village in Kerala, where several factors, over the course of time in the last century, have led to the perception of conflict between the Tamils and the Malayalis. As a major objective, the article identifies the issues and processes of social interaction between the two groups that necessarily influence the nature of the conflict. The article identifies that the conflict between the two communities, though mostly latent, can be seen through three important aspects: assertion, negotiation and subjugation of identities. Through assertion of identity, the conflict is perceived over ethnic lines, whereas the process of negotiation and subjugation of identity constantly undermines the ethnic nature of conflict to specific grievances, thus giving insight into the dynamic nature of the conflict.

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