Construction of Enzymatic Biodegradable Multilayered Film via Layer-by-Layer Self-Assembly to Control Release of DNA

2004 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
K. Ren ◽  
J. Ji ◽  
J. Shen
Keyword(s):  
Self Assembly ◽  
Control Release ◽  
Layer By Layer ◽  
Multilayered Film

scholarly journals Construction of Chitosan/Alginate Nano-Drug Delivery System for Improving Dextran Sodium Sulfate-Induced Colitis in Mice

Nanomaterials ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1884
Author(s):  
Mengfei Jin ◽  
Shangyong Li ◽  
Yanhong Wu ◽  
Dandan Li ◽  
Yantao Han
Keyword(s):  
Self Assembly ◽  
Average Diameter ◽  
Mucosal Healing ◽  
Plga Nanoparticles ◽  
Narrow Particle Size Distribution ◽  
Layer By Layer ◽  
Systemic Side Effects ◽  
Assembly Technology ◽  
The Fourier Transform ◽  
Polyelectrolyte Film

(1) Background: In the treatment of ulcerative colitis (UC), accurate delivery and release of anti-inflammatory drugs to the site of inflammation can reduce systemic side effects. (2) Methods: We took advantage of this goal to prepare resveratrol-loaded PLGA nanoparticles (RES-PCAC-NPs) by emulsification solvent volatilization. After layer-by-layer self-assembly technology, we deposited chitosan and alginate to form a three-layer polyelectrolyte film. (3) Results: It can transport nanoparticles through the gastric environment to target inflammation sites and slowly release drugs at a specific pH. The resulting RES-PCAC-NPs have an ideal average diameter (~255 nm), a narrow particle size distribution and a positively charged surface charge (~13.5 mV). The Fourier transform infrared spectroscopy showed that resveratrol was successfully encapsulated into PCAC nanoparticles, and the encapsulation efficiency reached 87.26%. In addition, fluorescence imaging showed that RES-PCAC-NPs with positive charges on the surface can effectively target and accumulate in the inflammation site while continuing to penetrate downward to promote mucosal healing. Importantly, oral RES-PCAC-NPs treatment in DSS-induced mice was superior to other results in significantly improved inflammatory markers of UC. (4) Conclusions: Our results strongly prove that RES-PCAC-NPs can target the inflamed colon for maximum efficacy, and this oral pharmaceutical formulation can represent a promising formulation in the treatment of UC.

Graphene-Based Multilayers Constructed from Layer-by-Layer Self-Assembly Techniques

2014 ◽  
Vol 14 (2) ◽  
pp. 1145-1153 ◽  
Author(s):  
Bing Yu ◽  
Xiaomian Liu ◽  
Hailin Cong ◽  
Hua Yuan ◽  
Dong Wang ◽  
...  
Keyword(s):  
Self Assembly ◽  
Layer By Layer

Layer-by-layer self-assembly of PDDA/PWA–Nafion composite membranes for direct methanol fuel cells

2010 ◽  
Vol 46 (9) ◽  
pp. 1434 ◽  
Author(s):  
Meng Yang ◽  
Shanfu Lu ◽  
Jinlin Lu ◽  
San Ping Jiang ◽  
Yan Xiang
Keyword(s):  
Fuel Cells ◽  
Self Assembly ◽  
Direct Methanol Fuel Cells ◽  
Composite Membranes ◽  
Layer By Layer ◽  
Direct Methanol ◽  
Methanol Fuel Cells

scholarly journals Layer-by-Layer Self-Assembly Composite Coatings for Improved Corrosion and Wear Resistance of Mg Alloy for Biomedical Applications

Coatings ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 515
Author(s):  
Tongfang Liu ◽  
Song Rui ◽  
Sheng Li
Keyword(s):  
Wear Resistance ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Composite Coatings ◽  
Covalent Bond ◽  
Mg Alloys ◽  
Mg Alloy ◽  
Layer By Layer ◽  
Corrosion Propagation ◽  
Chemical Linkage

Mg alloys are promising biomedical metal due to their natural degradability, good processability, and favorable mechanical properties. However, the poor corrosion resistance limits their further clinical applications. In this study, the combined strategies of surface chemical treatment and layer-by-layer self-assembly were used to prepare composite coatings on Mg alloys to improve the biocorrosion resistance. Specially, alkalized AZ91 Mg alloy generated chemical linkage with silane via Si–O–Mg covalent bond at the interface. Subsequently, Si–OH group from silane formed a crosslinked silane layer by Si–O–Si network. Further chemical assembly with graphene oxide (GO), lengthened the diffusion pathway of corrosive medium. The chemically assembled composite coatings could firmly bond to Mg alloy substrate, which persistently and effectively acted as compact barriers against corrosion propagation. Improved biocorrosion resistance of AZ91 Mg alloy with self-assembly composite coatings of silane/GO was subsequently confirmed by immersion tests. Besides, the Mg alloy exhibited good wear resistance due to outside layer of GO with a lubricant effect. Cell viability of higher than 75% had also been found for the alloy with self-assembly composite coatings, which showed good cytocompatibility.

scholarly journals Direct Patterning and Spontaneous Self-Assembly of Graphene Oxide via Electrohydrodynamic Jet Printing for Energy Storage and Sensing

Micromachines ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 13 ◽  
Author(s):  
Bin Zhang ◽  
Jaehyun Lee ◽  
Mincheol Kim ◽  
Naeeung Lee ◽  
Hyungdong Lee ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Energy Storage ◽  
Self Assembly ◽  
High Performance ◽  
Three Dimensional ◽  
Chemical Properties ◽  
Layer By Layer ◽  
Energy Storage Devices ◽  
Laminar Structure ◽  
Jet Printing

The macroscopic assembly of two-dimensional materials into a laminar structure has received considerable attention because it improves both the mechanical and chemical properties of the original materials. However, conventional manufacturing methods have certain limitations in that they require a high temperature process, use toxic solvents, and are considerably time consuming. Here, we present a new system for the self-assembly of layer-by-layer (LBL) graphene oxide (GO) via an electrohydrodynamic (EHD) jet printing technique. During printing, the orientation of GO flakes can be controlled by the velocity distribution of liquid jet and electric field-induced alignment spontaneously. Closely-packed GO patterns with an ordered laminar structure can be rapidly realized using an interfacial assembly process on the substrates. The surface roughness and electrical conductivity of the LBL structure were significantly improved compared with conventional dispensing methods. We further applied this technique to fabricate a reduced graphene oxide (r-GO)-based supercapacitor and a three-dimensional (3D) metallic grid hybrid ammonia sensor. We present the EHD-assisted assembly of laminar r-GO structures as a new platform for preparing high-performance energy storage devices and sensors.

Multilayer composite beads constructed via layer-by-layer self-assembly for lysozyme controlled release

RSC Advances ◽  
2014 ◽  
Vol 4 (46) ◽  
pp. 24369-24376 ◽  
Author(s):  
Jiemin Zhao ◽  
Xiaoping Wang ◽  
Yanshen Kuang ◽  
Yufeng Zhang ◽  
Xiaowen Shi ◽  
...  
Keyword(s):  
Controlled Release ◽  
Self Assembly ◽  
Cross Linking ◽  
Layer By Layer ◽  
Multilayer Composite ◽  
Composite Beads ◽  
Assembly Technique ◽  
Positively Charged

Alginate (ALG)–lysozyme (LZ) beads were fabricated by a cross-linking process. Negatively charged ALG and positively charged LZ were alternately deposited on the positively charged ALG–LZ beads via a layer-by-layer (LBL) self-assembly technique.

Microcapsules for controlled release fabricated via layer-by-layer self-assembly of polyelectrolytes

2008 ◽  
Vol 3 (2) ◽  
pp. 133-145 ◽  
Author(s):  
Chaoyang Wang ◽  
Shiqu Ye ◽  
Qilong Sun ◽  
Chengyi He ◽  
Weihua Ye ◽  
...  
Keyword(s):  
Controlled Release ◽  
Self Assembly ◽  
Layer By Layer
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