Proteomic Analysis of Recurrent Joint Inflammation in Juvenile Idiopathic Arthritis

Juvenile idiopathic arthritis (JIA) is the most common form of chronic synovial joint inflammation in children. It potentially leads to disability and psychosocial outcomes for children and their families. In the absence of appropriate treatment, this can lead to joint destruction and disability. Thus, early diagnosis and aggressive treatment are essential. With the presentation of new biologic DMARDs, based on understanding the disease pathophysiology and molecular pathogenesis, the course of the disease and its outcome have been changed profoundly. In this chapter, the early diagnosis, appropriate treatment, and outcomes approaches are described. These include the latest diagnosis and management options.

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Physical Findings Associated With Active Temporomandibular Joint Inflammation in Children With Juvenile Idiopathic Arthritis

Journal of Oral and Maxillofacial Surgery ◽

10.1016/j.joms.2013.04.009 ◽

2013 ◽

Vol 71 (10) ◽

pp. 1683-1687 ◽

Cited By ~ 27

Author(s):

Shelly Abramowicz ◽

Harlyn K. Susarla ◽

Susan Kim ◽

Leonard B. Kaban

Keyword(s):

Juvenile Idiopathic Arthritis ◽

Temporomandibular Joint ◽

Joint Inflammation ◽

Physical Findings ◽

Temporomandibular Joint Inflammation

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Joint inflammation assessed by physical examination and MRI of the knee in juvenile idiopathic arthritis: low predictive value for synovitis

Pediatric Rheumatology ◽

10.1186/1546-0096-12-s1-p2 ◽

2014 ◽

Vol 12 (S1) ◽

Cited By ~ 1

Author(s):

Charlotte M Nusman ◽

Robert Hemke ◽

Dieneke Schonenberg ◽

Koert Dolman ◽

Marion van Rossum ◽

...

Keyword(s):

Juvenile Idiopathic Arthritis ◽

Physical Examination ◽

Predictive Value ◽

Joint Inflammation

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Epidemiology and demographics of juvenile idiopathic arthritis in Africa and Middle East

Pediatric Rheumatology ◽

10.1186/s12969-021-00650-x ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Sulaiman M. Al-Mayouf ◽

Muna Al Mutairi ◽

Kenza Bouayed ◽

Sara Habjoka ◽

Djohra Hadef ◽

...

Keyword(s):

Juvenile Idiopathic Arthritis ◽

Middle East ◽

Treatment Guidelines ◽

Local Treatment ◽

Epidemiological Data ◽

Joint Inflammation ◽

Global Estimate ◽

Medical Need ◽

Prevalent Subtype ◽

Children And Young Adults

AbstractJuvenile Idiopathic Arthritis (JIA) is a group of chronic heterogenous disorders that manifests as joint inflammation in patients aged <16 years. Globally, approximately 3 million children and young adults are suffering from JIA with prevalence rates consistently higher in girls. The region of Africa and Middle East constitute a diverse group of ethnicities, socioeconomic conditions, and climates which influence the prevalence of JIA. There are only a few studies published on epidemiology of JIA in the region. There is an evident paucity of adequate and latest data from the region. This review summarizes the available data on the prevalence of JIA and its subtypes in Africa and Middle East and discusses unmet needs for patients in this region. A total of 8 journal publications were identified concerning epidemiology and 42 articles describing JIA subtypes from Africa and Middle East were included. The prevalence of JIA in Africa and Middle East was observed to be towards the lower range of the global estimate. We observed that the most prevalent subtype in the region was oligoarticular arthritis. The incidence of uveitis and anti-nuclear antibody (ANA) positivity were found to be lower as compared to the incidence from other regions. There is a huge unmet medical need in the region for reliable epidemiological data, disease awareness, having regional and local treatment guidelines and timely diagnosis. Paucity of the pediatric rheumatologists and economic disparities also contribute to the challenges regarding the management of JIA.

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Synovial Fluid Neutrophils in Oligoarticular Juvenile Idiopathic Arthritis Have an Altered Phenotype and Impaired Effector Functions

10.21203/rs.3.rs-200749/v1 ◽

2021 ◽

Author(s):

Sabine Arve-Butler ◽

Tobias Schmidt ◽

Anki Mossberg ◽

Elisabet Berthold ◽

Birgitta Gullstrand ◽

...

Keyword(s):

Juvenile Idiopathic Arthritis ◽

Synovial Fluid ◽

Oxidative Burst ◽

Joint Inflammation ◽

Mannose Receptor ◽

Inactive Disease ◽

Phagocytic Capacity ◽

Effector Functions ◽

Oligoarticular Juvenile Idiopathic Arthritis ◽

And Function

Abstract BackgroundNeutrophils are the most prevalent immune cells in synovial fluid in inflamed joints of children with oligoarticular juvenile idiopathic arthritis (JIA). Despite this, little is known about neutrophil function at the site of inflammation in JIA and how local neutrophils contribute to disease pathogenesis. This study aimed to characterize phenotype and function of synovial fluid neutrophils in oligoarticular JIA.Methods Neutrophils obtained from paired blood and synovial fluid from patients with active oligoarticular JIA were investigated phenotypically (n=17) and functionally (phagocytosis and oxidative burst, n=13) by flow cytometry. In a subset of patients (n=6), blood samples were also obtained during inactive disease at a follow-up visit. Presence of CD206-expressing neutrophils was investigated in synovial biopsies from four patients by immunofluorescence. ResultsNeutrophils in synovial fluid had an activated phenotype, characterized by increased CD66b and CD11b levels, and most neutrophils had a CD16hi CD62Llow aged phenotype. A large proportion of the synovial fluid neutrophils expressed CD206, a mannose receptor not commonly expressed by neutrophils but by monocytes, macrophages and dendritic cells. CD206 expressing neutrophils were also found in synovial tissue biopsies. The synovial fluid neutrophil phenotype was not dependent on transmigration alone. Functionally, synovial fluid neutrophils had reduced phagocytic capacity and a trend towards impaired oxidative burst compared to blood neutrophils. In addition, the effector functions of the synovial fluid neutrophils correlated negatively with the proportion of CD206+ neutrophils.ConclusionsNeutrophils in the inflamed joint in oligoarticular JIA were altered, both regarding phenotype and function. Neutrophils in the synovial fluid were activated, had an aged phenotype, had gained monocyte-like features and had impaired phagocytic capacity. The impairment in phagocytosis and oxidative burst was associated to the phenotype shift. We speculate that these neutrophil alterations might play a role in the sustained joint inflammation seen in JIA.

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Juvenile Idiopathic Arthritis: A Review of Novel Diagnostic and Monitoring Technologies

Healthcare ◽

10.3390/healthcare9121683 ◽

2021 ◽

Vol 9 (12) ◽

pp. 1683

Author(s):

Amelia J. Garner ◽

Reza Saatchi ◽

Oliver Ward ◽

Daniel P. Hawley

Keyword(s):

Juvenile Idiopathic Arthritis ◽

Functional Disability ◽

Three Dimensional ◽

Joint Damage ◽

Joint Inflammation ◽

Infrared Thermal Imaging ◽

Insidious Onset ◽

Assessment And Monitoring ◽

Monitoring Technologies ◽

Tools And Techniques

Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease of childhood and is characterized by an often insidious onset and a chronic relapsing–remitting course, once diagnosed. With successive flares of joint inflammation, joint damage accrues, often associated with pain and functional disability. The progressive nature and potential for chronic damage and disability caused by JIA emphasizes the critical need for a prompt and accurate diagnosis. This article provides a review of recent studies related to diagnosis, monitoring and management of JIA and outlines recent novel tools and techniques (infrared thermal imaging, three-dimensional imaging, accelerometry, artificial neural networks and fuzzy logic) which have demonstrated potential value in assessment and monitoring of JIA. The emergence of novel techniques to assist clinicians’ assessments for diagnosis and monitoring of JIA has demonstrated promise; however, further research is required to confirm their clinical utility.

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Juvenile Idiopathic Arthritis

Musculoskeletal Imaging Volume 1 ◽

10.1093/med/9780190938161.003.0031 ◽

2019 ◽

pp. 148-151

Author(s):

Kevin B. Hoover

Keyword(s):

Juvenile Idiopathic Arthritis ◽

Chronic Disease ◽

Ionizing Radiation ◽

Imaging Techniques ◽

Joint Inflammation ◽

Radiographic Evaluation ◽

Skeletally Immature ◽

Skeletally Immature Patient

Chapter 31 discusses juvenile idiopathic arthritis (JIA), which is a heterogeneous disease of joint inflammation. Initial radiographic evaluation is useful for excluding other diseases. Radiographs are sensitive to late findings of JIA, but not early changes of JIA. The monitoring of chronic disease, however, relies on modalities that do not result in ionizing radiation and are more sensitive to changes in the skeletally immature patient. MRI and US are both safe imaging techniques, which can detect inflammation in joints that are not well evaluated by radiography and can better classify the disease. US can also be useful for guiding intraarticular injections.

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Transcriptomic and proteomic analysis of iris tissue and aqueous humor in juvenile idiopathic arthritis-associated uveitis

Journal of Autoimmunity ◽

10.1016/j.jaut.2019.03.004 ◽

2019 ◽

Vol 100 ◽

pp. 75-83 ◽

Cited By ~ 7

Author(s):

Lena Wildschütz ◽

Doreen Ackermann ◽

Anika Witten ◽

Maren Kasper ◽

Martin Busch ◽

...

Keyword(s):

Juvenile Idiopathic Arthritis ◽

Aqueous Humor ◽

Proteomic Analysis

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Preliminary Definitions for Sacroiliac Joint Pathologies in the OMERACT Juvenile Idiopathic Arthritis Magnetic Resonance Imaging Score (OMERACT JAMRIS-SIJ)

The Journal of Rheumatology ◽

10.3899/jrheum.181115 ◽

2019 ◽

Vol 46 (9) ◽

pp. 1192-1197 ◽

Cited By ~ 5

Author(s):

Tarimobo M. Otobo ◽

Philip G. Conaghan ◽

Walter P. Maksymowych ◽

Desiree van der Heijde ◽

Pamela Weiss ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Juvenile Idiopathic Arthritis ◽

Magnetic Resonance ◽

Joint Inflammation ◽

Joint Space ◽

Structural Elements ◽

Resonance Imaging ◽

Structural Joint ◽

Ongoing Development ◽

Magnetic Resonance Imaging Mri

Objective.To develop definitions for the assessment of magnetic resonance imaging (MRI) pathologies of the sacroiliac joints (SIJ) in juvenile idiopathic arthritis.Methods.An Outcome Measures in Rheumatology (OMERACT) consensus-driven methodology consisting of iterative surveys and focus group meetings within an international group of rheumatologists and radiologists.Results.Two domains, inflammation and structural, were identified. Definitions for bone marrow edema, joint space inflammation, capsulitis, and enthesitis were derived for joint inflammation; sclerosis, erosion, fatty lesion, and ankylosis were defined for assessing structural joint changes.Conclusion.Preliminary consensus-driven definitions for inflammation and structural elements have been derived, underpinning the ongoing development of the OMERACT Juvenile Arthritis MRI SIJ scoring system (OMERACT JAMRIS-SIJ).

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AB0019 GENETIC POLYMORPHISM OF THE INFLAMMATORY MARKER SAA1 RS12218 (-13 T/C) IS ASSOCIATED WITH AN APTITUDE TO CLINICAL PHENOTYPES OF JUVENILE IDIOPATHIC ARTHRITIS

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-eular.4119 ◽

2020 ◽

Vol 79 (Suppl 1) ◽

pp. 1312.3-1313

Author(s):

E. Fedorov ◽

S. Salugina ◽

M. Krylov ◽

I. Guseva ◽

E. Samarkina

Keyword(s):

Juvenile Idiopathic Arthritis ◽

Inflammatory Diseases ◽

Inflammatory Marker ◽

Joint Inflammation ◽

Unknown Etiology ◽

Control Group ◽

Number Of Patients ◽

Increased Risk ◽

Allele Specific ◽

Diagnosis And Classification

Background:Juvenile idiopathic arthritis (JIA) is one of the most widely-spread immuno-inflammatory diseases of an unknown etiology, the leading manifestation of which is chronic joint inflammation, occuring in children under the age of 16. The disease is a complex of chronic arthropathies with various phenotypic manifestations.Objectives:To verify the hypothesis about the role of SAA1 rs12218 T / C gene polymorphism in the aptitude to various clinical JIA phenotypes.Methods:The study included 132 children, of whom 66 were diagnosed with JIA and 66 were healthy unrelated volunteers (the college students) as a control group, comparable by gender and age. The group of patients with JIA consisted of 44 girls and 22 boys, with an average age of 11.7 ± 4.2 years and an average disease duration of 4.8 ± 3.8 years. The diagnosis and classification of JIA was established according to ILAR-2004 criteria. The JIA group included 30 (45%) patients with oligoarthritis (oJIA), of which 20 patients (67%) were positive for the HLA-B27 antigen (JIA-B27 +) and 10 (33%) patients with anterior uveitis (uJIA); 20 (30%) patients were assigned to the group with the polyarticular variant (pJIA), while all of them were seronegative for the rheumatoid factor; 16 (24%) patients were diagnosed with JIA with a systemic onset (sJIA). The frequencies of the T / C polymorphism of the SAA1 gene were assessed using an allele-specific polymerase chain reaction in a real time mode (RT-PCR).Results:In the group of patients diagnosed with oJIA and (JIA-B27 +), the frequency of the C allele was significantly higher compared to the control (53.3% and 57.5% versus 37.1%, p = 0.035 and 0.022, respectively). No significant differences were detected in the frequencies of the mutant C allele between sJIA and pJIA and the control group. The logistics analysis of the frequency distribution of the alleles of the SAA1 gene demonstrated an increased risk of the C allele in formation of an aptitude to the oJIA variant (OR 1.94, 95% CI 1.00-3.76, p = 0.035). In the oJIA-B27 (+) group, the risk of an aptitude was also increased compared to the control (OR 2.29, 95% CI 1.05-5.04, p = 0.022).Conclusion:The data obtained confirm for the first time the involvement of the rs12218 polymorphism of the SAA1 gene in an aptitude to the oligoarthritis JIA clinical phenotype. The presented results require further replication researches using an enlarged number of patients from different population groups.Disclosure of Interests:None declared

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