Serum VEGF levels in women with a benign breast tumor or breast cancer

1999 ◽  
Vol 53 (2) ◽  
pp. 161-166 ◽  
Author(s):  
Petri Salven ◽  
Vesa Perhoniemi ◽  
Heikki Tykkä ◽  
Hanna Mäenpää ◽  
Heikki Joensuu
2009 ◽  
Vol 42 (3) ◽  
pp. 213
Author(s):  
Eugene Shim ◽  
Sei Hyun Ahn ◽  
You-Jeong Hwang ◽  
Yang Cha Lee-Kim

2006 ◽  
Vol 371 (1-2) ◽  
pp. 112-116 ◽  
Author(s):  
Sławomir Ławicki ◽  
Maciej Szmitkowski ◽  
Marek Wojtukiewicz

2015 ◽  
Vol 407 (17) ◽  
pp. 5065-5077 ◽  
Author(s):  
Li Yang ◽  
Xinge Cui ◽  
Ningning Zhang ◽  
Min Li ◽  
Yu Bai ◽  
...  

2020 ◽  
Vol 11 (2) ◽  
pp. 1438-1446
Author(s):  
Abbas M. Ajeed ◽  
Alaa G. Hussein ◽  
Nazar Alwakeel ◽  
Omar F. Abdul-Rasheed

To determine the possible role of the assessment of Ghrelin receptor expression in breast tissues as a tool for the diagnosis of breast cancer and differentiate it from a benign breast tumor. A case-control study was done on 60 female patients with breast cancer and 60 female patients with benign breast tumors (Fibroadenoma) who were recruited from Al Imamain Al-Kadhemain Medical City and Oncology teaching Hospital, Baghdad, Iraq between May 2018 and December 2018. Immunohistochemical staining was done on the breast tissue samples obtained from patients and compared with the control group, which comprised 75 fibrocystic tissue samples obtained from age, BMI and sex-matched females. The degree of Ghrelin Receptor expression was determined immunohistochemically. The expression of Ghrelin receptors in breast malignant tumor tissues was higher than that in benign breast tumor tissues and controls, in addition to that, results obtained from all groups revealed that Ghrelin receptor intensity and its expression proportion were strongly and significantly associated with the type of tissues. The expression of the Ghrelin receptor can be considered as a highly significant immunohistochemical marker for the detection of breast tumors and for the differentiation between both types of tumors; benign and malignant.


1998 ◽  
Vol 128 (11) ◽  
pp. 1920-1926 ◽  
Author(s):  
Kyung-Jin Yeum ◽  
Sei-Hyun Ahn ◽  
Sergio Alberto Rupp de Paiva ◽  
Yang Cha Lee-Kim ◽  
Norman I. Krinsky ◽  
...  

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e22094-e22094
Author(s):  
Peng Shen ◽  
Aijuan Wang ◽  
Wei Ke ◽  
Mengye He ◽  
Lanfang Yu ◽  
...  

e22094 Background: The immune therapy of human cancer is a promising therapeutic approach. Myeloid-derived suppressor cells (MDSCs) have been confirmed as an indispensable component of immune system and associated with tumor induced immune suppression. Thus, MDSCs play an important role in immune therapy. Although a lot of research work has been done, currently there exists limited data about MDSCs status in cancer patients. The aim of this study was to determine whether MDSCs levels in peripheral blood were different in healthy volunteers, benign breast tumor patients and breast cancer patients, and to investigate the relation between MDSCs and several characteristics in breast cancer patients. Methods: Peripheral blood cells (PBC) were collected from 36 normal healthy volunteers, 52 patients with breast cancer and 62 patients with benign breast tumor. Peripheral blood samples of breast cancer patients were obtained before treatment. Circulating MDSCs (identified as Lin-/Lo HLA-DR-CD33+) were measured by flow cytometry. Statistical methods included two sample t tests and one way ANOVA. Results: The percentage of MDSCs was higher in breast cancer than benign breast tumor patients and healthy volunteers (2.017% vs 1.578% vs1.594%; p=0.0002), and the stage III/IV breast cancer patients had more MDSCs accumulation than those in stage I/II (2.92% vs 2.155%; P=0.0806). The levels of MDSCs in peripheral blood showed a significant correlation with HER-2/neu expression in breast cancer patients, but had no correlation with incidence age, ER status, PR status and P53 expression respectively. The percentage of MDSCs was lower in HER-2/neu over expression breast cancer patients than HER-2/neu negative patients (1.715% vs 2.882%, GP=0.0012). Conclusions: MDSCs seemed to have positive correlation with clinical stage and negative correlation with HER-2/neu expression in breast cancer patients . Further research will contribute to the better understanding of the connection between MDSCs and breast cancer, to develop better approaches to breast cancer therapy.


2020 ◽  
Vol 16 ◽  
Author(s):  
Vibhavana Singh ◽  
Rakesh Reddy ◽  
Antarip Sinha ◽  
Venkatesh Marturi ◽  
Shravani Sripathi Panditharadyula ◽  
...  

: Diabetes and breast cancer are pathophysiologically similar and clinically established diseases that co-exist with a wider complex similar molecular signalling and having similar set of risk factors. Insulin plays a pivotal role for invasion and migration of breast cancer cells. Several ethnopharmacological evidences light the concomitant anti-diabetic and anti-cancer activity of medicinal plant and phytochemicals against breast tumor of patients with diabetes. This present article reviewed the findings on medicinal plants and phytochemicals with concomitant anti-diabetic and anti-cancer effects reported in scientific literature to facilitate the development of dual-acting therapies against diabetes and breast cancer. The schematic tabular form of published literatures on medicinal plants (63 plants belongs to 45 families) concluded the dynamics of phytochemicals against diabetes and breast tumor that could be explored further for the discovery of therapies for controlling of breast cancer cell invasion and migration in patient with diabetes.


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