Effects of a Nutritional Supplement Fortified with Vitamin B-12 on Well Nourished, Free-Living Elderly Subjects

2006 ◽  
Vol 76 (2) ◽  
pp. 95-99 ◽  
Author(s):  
Sandra Hirsch ◽  
Laura Leiva ◽  
Pía de la Maza ◽  
Vivian Gattás ◽  
Gladys Barrera ◽  
...  
Keyword(s):  
Clinical Manifestations ◽  
Serum Vitamin ◽  
The Elderly ◽  
Nutritional Supplement ◽  
Elderly Subjects ◽  
Control Group ◽  
Vitamin B ◽  
Free Living ◽  
Healthy Elderly ◽  
Vitamin B 12

Vitamin B-12 deficiency is prevalent among the elderly population but it is often unrecognized because the clinical manifestations are not present. Objective: To evaluate the effects of a nutritional supplement fortified with vitamin B-12 on well nourished, free-living elderly subjects. Patients and methods: Healthy elderly subjects attending two of four clinics were allocated to receive, over six months’ duration, a nutritional supplement with 3.8 µg of vitamin B-12. Subjects attending the other two clinics served as controls. Serum vitamin B-12 levels were measured at baseline and 6 months after the supplementation was started. Results: After 6 months of consuming the supplement fortified with vitamin B-12, serum B-12 concentration increased from 350.1 ± 166.5 pmol/L to 409.0 ± 166.1 and decreased in the control group from 319.4 ± 129.1 to 290.1 ± 135.7 (ANOVA, p < 0.005). Conclusion: A supplementation with 3.8 µg /day of vitamin B-12 led to significant improvements in the serum concentrations of vitamin B-12 in older persons.

Effect of Age on Plasma Homocysteine Concentrations in Young and Elderly Subjects Considering Serum Vitamin Concentrations and Different Lifestyle Factors

2004 ◽  
Vol 74 (2) ◽  
pp. 129-136 ◽  
Author(s):  
Straßburg ◽  
Krems ◽  
Lührmann ◽  
Hartmann ◽  
Neuhäuser-Berthold
Keyword(s):  
Young Adults ◽  
Linear Regression Analysis ◽  
Serum Vitamin ◽  
Lifestyle Factors ◽  
Elderly Subjects ◽  
Vitamin B ◽  
Serum Concentrations ◽  
Plasma Thcy ◽  
Vitamin B 12 ◽  
Young And Elderly Subjects

Objectives: The aim of this study was to investigate whether an increase in total homocysteine (tHcy) concentration with increasing age is due to diminishing serum concentrations of pyridoxal-5-phosphate (PLP), vitamin B-12, and folate. The possible influence of different lifestyle factors on tHcy concentration was considered. Methods: Plasma tHcy, serum concentrations of pyridoxal-5-phosphate, vitamin B-12, and folate, intake of coffee and tea, alcohol, and methionine, as well as cigarette smoking, were determined in 252 elderly subjects (60–87 years old) of the longitudinal study on nutrition and health status in an aging population in Gießen (GISELA) and 99 young adults (20–34 years old) of the study on health and nutrition of young adults (GEJE). Results: Mean plasma tHcy concentrations were significantly higher in elderly than in young female subjects (9.7 ± 1.9 mumol/L vs. 9.0 ± 1.6 mumol/L, p < 0.05), but there was no difference between elderly and young men (10.6 ± 2.1 mumol/L vs. 10.7 ± 2.6 mumol/L). No differences in tHcy were observed between young and elderly subjects after adjustment for serum concentrations of PLP, vitamin B-12, and folate. Multiple linear regression analysis revealed a significant influence of age only in elderly, but not in younger subjects. Conclusion: Higher tHcy concentrations in the elderly, in comparison to younger women, are due to lower serum concentrations of PLP, vitamin B-12, and folate, whereas within the age group of elderly subjects alone tHcy concentrations increase with age irrespective of serum vitamin concentrations.

Nonexercise movement in elderly compared with young people

2007 ◽  
Vol 292 (4) ◽  
pp. E1207-E1212 ◽  
Author(s):  
Ann M. Harris ◽  
Lorraine M. Lanningham-Foster ◽  
Shelly K. McCrady ◽  
James A. Levine
Keyword(s):  
Energy Expenditure ◽  
Lean Body Mass ◽  
Body Mass ◽  
The Elderly ◽  
Energetic Cost ◽  
Elderly Subjects ◽  
Older Individuals ◽  
Free Living ◽  
Healthy Elderly ◽  
Young Subjects

The association between free-living daily activity and aging is unclear because nonexercise movement and its energetic equivalent, nonexercise activity thermogenesis, have not been exhaustively studied in the elderly. We wanted to address the hypothesis that free-living nonexercise movement is lower in older individuals compared with younger controls matched for lean body mass. Ten lean, healthy, sedentary elderly and 10 young subjects matched for lean body mass underwent measurements of nonexercise movement and body posture over 10 days using sensitive, validated technology. In addition, energy expenditure was assessed using doubly labeled water and indirect calorimetry. Total nonexercise movement (acceleration arbitrary units), standing time, and standing acceleration were significantly lower in the elderly subjects; this was specifically because the elderly walked less distance per day despite having a similar number of walking bouts per day compared with the young individuals. The energetic cost of basal metabolic rate, thermic effect of food, total daily energy expenditure, and nonexercise activity thermogenesis were not different between the elderly and young groups. Thus, the energetic cost of walking in the elderly may be greater than in the young. Lean, healthy elderly individuals may have a biological drive to be less active than the young.

scholarly journals An Ancient Boxing Exercise Improves Physical Functions, Balance, and Quality of Life in Healthy Elderly Persons

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Taweesak Janyacharoen ◽  
Thitipa Srisamai ◽  
Kittisak Sawanyawisuth
Keyword(s):  
Quality Of Life ◽  
Daily Practice ◽  
The Elderly ◽  
Controlled Study ◽  
Elderly Subjects ◽  
Control Group ◽  
Elderly Persons ◽  
Healthy Elderly ◽  
Physical Functions

It has been shown that traditional dances can be effective in improving physical functions in the elderly persons. Unlike other traditional dance exercises, the ancient Thai boxing exercise may be suitable for elderly persons in other ethnicities who are interested in boxing. This randomized controlled study aimed to evaluate the effects of the exercise on physical functions in elderly subjects. Healthy elderly subjects were recruited and randomly divided into two groups: the control group and the ancient Thai boxing group. The control group received education about the exercise and a home program of daily practice. The ancient Thai boxing group performed the modified ancient Thai boxing exercise for 12 weeks. There were six outcomes in this study which were recorded at baseline and at the end of study (week 12) including a six-minute walk test (6MWT), five times sit to stand test (FTSST), flexibility by trunk flexometer, time up and go test (TUGT), and Berg balance scale (BBS), as well as a test to determine quality of life (QOL). All outcomes were compared to the baseline, as well as between groups. There were 56 subjects enrolled in the study, 28 in the control group, and 28 in the ancient Thai boxing group, with mean ages of 68.6 and 65.9 years, respectively. The majority of subjects in both groups were women (96.4% and 89.3%). After 12 weeks of study, significant differences were found in terms of all seven outcomes between the two groups. For example, the 6MWT in the control group was 415.8 vs 480.3 m in the ancient boxing group. In conclusion, the 12-week ancient boxing exercise significantly improved physical functions, balance, and QOL in the elderly.

Association between trait anxiety and endothelial function observed in elderly males but not in young males

2006 ◽  
Vol 19 (5) ◽  
pp. 947-954 ◽  
Author(s):  
Kosuke Narita ◽  
Tetsuhito Murata ◽  
Toshihiko Hamada ◽  
Tetsuya Takahashi ◽  
Hirotaka Kosaka ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Trait Anxiety ◽  
Clinical Manifestations ◽  
Young Male ◽  
The Elderly ◽  
Elderly Subjects ◽  
Elderly Male ◽  
Healthy Elderly ◽  
Atherosclerotic Lesions ◽  
Young Subjects

Background and objectives: Endothelial function plays a key role in determining the clinical manifestations of atherosclerosis. Recent reports have shown that healthy elderly subjects with higher trait anxiety tend to have heightened risks of atherosclerotic lesions and cardiovascular disease. The present study was intended to examine whether an association exists between trait anxiety and endothelial function in healthy young and elderly subjects.Methods: This study examined 26 young male and 30 elderly male subjects using brachial artery flow-mediated dilation (FMD) – a non-invasive ultrasound method – to evaluate endothelial function by measuring the dilation responses of vascular smooth muscle to the nitric oxide produced by endothelial cells following hyperemia.Results: A significant negative correlation was observed between the State and Trait Anxiety Inventory (STAI)-trait score as a parameter of anxiety and the percentage change of FMD (%FMD) in the elderly subjects, but not in the young subjects. The elderly subjects showed significantly lower %FMD than the young subjects.Conclusion: These results suggest the possibility that trait anxiety is a predisposing risk factor for cardiovascular damage that might, over a long period, induce atherosclerotic lesions.

Nutritional B12 Deficiency in Infants of Vitamin B12-Deficient Mothers

2011 ◽  
Vol 81 (5) ◽  
pp. 328-334 ◽  
Author(s):  
Oya Halicioglu ◽  
Sezin Asik Akman ◽  
Sumer Sutcuoglu ◽  
Berna Atabay ◽  
Meral Turker ◽  
...  
Keyword(s):  
Megaloblastic Anemia ◽  
Maternal Diet ◽  
Clinical Manifestations ◽  
Serum Vitamin ◽  
Failure To Thrive ◽  
Clinical Findings ◽  
Vitamin B ◽  
Animal Products ◽  
Hematological Evaluation ◽  
Nutritional Vitamin

Aim: Nutritional vitamin B12 deficiency in infants may occur because the maternal diet contains inadequate animal products. Clinical presentations of the infants who had nutritional vitamin B12 deficiency were analyzed in this study. Subjects and Methods: Patients with nutritional vitamin B12 deficiency were enrolled in the study between 2003 and 2010. The diagnosis was based on a nutritional history of mothers and infants, clinical findings, hematological evaluation, and low level of serum vitamin B12. Results: Thirty children aged 1 - 21 months constituted the study group. Poverty was the main cause of inadequate consumption of animal products of the mothers. All infants had predominantly breastfed. The most common symptoms were developmental delay, paleness, apathy, lethargy, anorexia, and failure to thrive. Hematological findings were megaloblastic anemia (83.3 %), thrombocytopenia (30 %), and severe anemia (13.3 %). All of the mothers had low serum B12 levels; eight of them had megaloblastic anemia. Conclusion: The unusual clinical manifestations of vitamin B12 deficiency may also be seen apart from neurological and hematological findings. Nutritional vitamin B12 deficiency due to maternal deficiency might be a serious health problem in infants. Therefore, screening and supplementation of pregnant and lactating women to prevent infantile vitamin B12 deficiency should be considered.

scholarly journals Masked vitamin B12 and folate deficiency in the elderly

1985 ◽  
Vol 54 (3) ◽  
pp. 613-619 ◽  
Author(s):  
G. M. Craig ◽  
C. Elliot ◽  
K. R. Hughes
Keyword(s):  
Clinical Investigation ◽  
Binding Capacity ◽  
Serum Vitamin ◽  
The Elderly ◽  
Folate Deficiency ◽  
Significant Negative Correlation ◽  
Serum Folate ◽  
Fe Deficiency ◽  
Vitamin B ◽  
Geriatric Unit

1. A high incidence of vitamin B12 or folate deficiency, or both, may be found in the elderly, particularly those in hospital. This report concerns fifty cases detected in an inner-city-area geriatric unit during the course of routine clinical investigation. The majority had none of the classical haematological signs of vitamin B12 or folate deficiency, and all the patients reported had a mean corpuscular volume (MCV) of less than 100 fl.2. There was a significant negative correlation between the MCV and the erythrocyte folate (P< 0.01), supporting earlier published work using a low serum folate as an index of folate deficiency.3. There was no correlation between the MCV and the serum vitamin B12. Published work differs on this point.4. Serum iron, total Fe-binding capacity and percentage Fe saturation results were available in forty patients in this series. There was a significant positive correlation between the serum Fe and the MCV (P<0.01) and 34% of patients had haematological evidence of Fe deficiency. In the majority, however, there was no evidence that associated Fe deficiency had masked the haematological signs of vitamin B12 or folate deficiency.5. More attention should be paid to the problem of ‘masked’ vitamin B12 and folate deficiency in the elderly. There is a case for routine screening of the elderly for vitamin B12 and folate deficiency irrespective of the MCV.

The Serum Vitamin B12 in the Elderly

1966 ◽  
Vol 8 (4) ◽  
pp. 220-225 ◽  
Author(s):  
A.A. Dawson ◽  
D. Donald
Keyword(s):  
Serum Vitamin ◽  
The Elderly ◽  
Vitamin B

The influence of dynamic visual environments on postural sway in the elderly

1999 ◽  
Vol 9 (3) ◽  
pp. 197-205
Author(s):  
L.L. Borger ◽  
S.L. Whitney ◽  
M.S. Redfern ◽  
J.M. Furman
Keyword(s):  
Visual Information ◽  
Postural Sway ◽  
Center Of Pressure ◽  
Age Groups ◽  
The Elderly ◽  
Visual Scene ◽  
Elderly Subjects ◽  
Mean Velocity ◽  
Healthy Elderly ◽  
Young Subjects

Postural sway during stance has been found to be sensitive to moving visual scenes in young adults, children, and those with vestibular disease. The effect of visual environments on balance in elderly individuals is relatively unknown. The purpose of this study was to compare postural sway responses of healthy elderly to those of young subjects when both groups were exposed to a moving visual scene. Peak to peak, root mean squared, and mean velocity of the center of pressure were analyzed under conditions combining four moving scene amplitudes ( 2 . 5 ∘ , 5 ∘ , 7 . 5 ∘ , 10 ∘ ) and two frequencies of scene movement (0.1 Hz, 0.25 Hz). Each visual condition was tested with a fixed floor and sway referenced platform. Results showed that elderly subjects swayed more than younger subjects when experiencing a moving visual scene under all conditions. The elderly were affected more than the young by sway referencing the platform. The differences between the two age groups were greater at increased amplitudes of scene movement. These results suggest that elderly are more influenced by dynamic visual information for balance than the young, particularly when cues from the ankles are altered.

scholarly journals OPTIMIZATION OF DSME THROUGH INCREASED KNOWLEDGE OF PREVENTION OF COMPLICATIONS AND DIABETES EMERGENCIES IN WONOREJO VILLAGE

2021 ◽  
Vol 3 (1) ◽  
pp. 29
Author(s):  
Ari Pebru Nurlaily ◽  
Meri Oktariani ◽  
Anestasia Pangestu Mei Tyas
Keyword(s):  
Access To Health Care ◽  
Diabetes Complications ◽  
Clinical Manifestations ◽  
The Elderly ◽  
Health Care Facilities ◽  
Basic Knowledge ◽  
Foot Care ◽  
Healthy Elderly ◽  
Access To Health ◽  
Prevention Of Diabetes

Background: Many elderly convey blood sugar often up and down due to lack of attention to their diet. The condition became urgent because the elderly had previously died from complications accompanied by diabetic ulcers. In the posyandu area of wonorejo healthy elderly, DM disease is one of the diseases that are quite widely suffered by its citizens. Objective: The DSME education program for cadres and the elderly at Posyandu Wonorejo aims to increase knowledge and prevent diabetes complications. Method: This DSME program was conducted in four sessions, namely, session 1 discussing basic knowledge about DM (definition, etiology, classification, etiology, clinical manifestations, diagnosis, prevention, treatment, complications), session 2 discussing DM management including nutrition/diet arrangements, and physical activities/exercises that can be done, session 3 discussing foot care and stress management; and session 4 discusses the prevention of chronic and acute complications, and the patient's access to health care facilities. Results: There was an increase in knowledge and prevention of diabetes complications up to 93,75% after this activity was conducted.. Conclusion: The program is optimally implemented.

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