IgE-mediated allergic rhinitis and conjunctivitis caused by Calocedrus decurrens (incense cedar)

Allergy ◽  
2003 ◽  
Vol 58 (11) ◽  
pp. 1201-1202 ◽  
Author(s):  
G Cavagni ◽  
C Caffarelli ◽  
A Spattini ◽  
G Riva
Keyword(s):  
Allergic Rhinitis ◽  
Calocedrus Decurrens ◽  
Ige Mediated

scholarly journals Sake Lees Fermented with Lactic Acid Bacteria Prevents Allergic Rhinitis-Like Symptoms and IgE-Mediated Basophil Degranulation

2011 ◽  
Vol 75 (1) ◽  
pp. 140-144 ◽  
Author(s):  
Seiji KAWAMOTO ◽  
Mitsuoki KANEOKE ◽  
Kayo OHKOUCHI ◽  
Yuichi AMANO ◽  
Yuki TAKAOKA ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Ige Mediated

Allergic Rhinitis, Conjunctivitis, and Sinusitis

2018 ◽  
Author(s):  
Robert Naclerio
Keyword(s):  
Allergic Rhinitis ◽  
Inflammatory Response ◽  
Key Words ◽  
Outdoor Exposure ◽  
Immunologic Response ◽  
Dust Mites ◽  
Ige Mediated ◽  
Good For ◽  
Perennial Allergens

Allergic rhinitis is an IgE-mediated inflammatory response in the nose to foreign substances known as allergens. It can be classified as seasonal or perennial, depending on the allergens triggering the reaction. This characterization is good for identifying allergen triggers but is limited because it is based on the duration of outdoor exposure (e.g., grass pollinates for 2 months in Chicago and nearly 11 months in Texas). Also, some perennial allergens, such as dust mites, have seasons. The Allergic Rhinitis in Asthma (ARIA) classification was developed to focus on therapy. It assumes that exposure to perennial and to seasonal allergen leads to the same immunologic response. ARIA places patients into the categories of mild intermittent, mild persistent, moderate/severe intermittent, and moderate/severe persistent to recommend treatment and emphasizes the link between allergic rhinitis and asthma. This review contains 5 figures, 9 tables, and 56 references. Key Words: Sinusitis, infection, allergy, antibiotic, decongestant, antihistamine  

Mast cell stabilizers

1992 ◽  
Vol 107 (6_part_2) ◽  
pp. 841-844 ◽  
Author(s):  
Hueston C. King
Keyword(s):  
Allergic Rhinitis ◽  
Mast Cell ◽  
Cell Membrane ◽  
Nasal Mucosa ◽  
Nasal Polyps ◽  
Nasal Congestion ◽  
Correct Diagnosis ◽  
Vasomotor Rhinitis ◽  
Ige Mediated ◽  
Exercise Induced

The precise mode of action of the well-studied cromolyn sodium and the newer nedocromil sodium has not been completely elucidated. Because the drugs do not pass the cell membrane and enter the cell, they are virtually not metabolized, do not exert a systemic action, and therefore are associated with only minimal systemic toxicity. To be effective either drug must be applied topically and directly to the nasal mucosa. Proper contact with the nasal mucosa is essential for efficacy; in patients with nasal congestion and secretions, vasoconstrictors or saline lavages are indicated before cromolyn or nedocromil use. Both products are highly effective in patients who have IgE-mediated allergic rhinitis but must be administered prophylactically before exposure to an allergen to prevent development of the allergic event. Neither drug is effective in vasomotor rhinitis, exercise-induced rhinitis, or in the management of nasal polyps. Correct diagnosis is essential before therapy.

scholarly journals Plasma EVs Display Antigen-Presenting Characteristics in Patients With Allergic Rhinitis and Promote Differentiation of Th2 Cells

2021 ◽  
Vol 12 ◽  
Author(s):  
Shu-Bin Fang ◽  
Zhi-Rou Zhou ◽  
Ya-Qi Peng ◽  
Xiao-Qing Liu ◽  
Bi-Xin He ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Allergic Rhinitis ◽  
T Cell ◽  
Th2 Cells ◽  
T Cell Proliferation ◽  
Healthy Control ◽  
Ige Mediated ◽  
Der P 1 ◽  
Antigen Presenting ◽  
Intercellular Communications

BackgroundAllergic rhinitis (AR) is characterized by IgE-mediated mucosa response after exposure to allergens. Extracellular vesicles (EVs) are nano-size vesicles containing biological cargos for intercellular communications. However, the role of plasma EVs in pathogenesis of AR remains largely unknown.MethodsPlasma EVs from patients with AR were isolated, quantified, and characterized. The expression of Der p 1 and antigen-presenting molecules on EVs was determined by Western blot, flow cytometry, or ELISA. PKH26- and CFSE (carboxyfluorescein succinimidyl ester)-stained AR-EVs were used to determine the uptake of EVs by CD4+T cells and their effects on CD4+T cell proliferation, respectively.ResultsPlasma EVs in healthy control (HC) and AR patients were similar in the concentration of particles, expression for specific EV markers, and both had structural lipid bilayer. However, the levels of Der p 1 on plasma EVs from both mild and moderate-severe AR patients were significantly higher than that on HC. The levels of antigen-presenting molecules on plasma EVs were similar from three subjects. Moreover, levels of Der p 1 on EVs in plasma, but not nasal secretion, were significantly associated with the symptom score of AR patients and level of plasma IL-13. Additionally, plasma EVs from patients with AR promoted the development of Th2 cells, while no effect was found on CD4+ T-cell proliferation.ConclusionsPlasma EVs derived from patients with AR exhibited antigen-presenting characteristics and promoted differentiation of Th2 cells, thus providing novel understanding of the pathogenesis of AR.

scholarly journals Mechanisms of allergen-specific immunotherapy for allergic rhinitis and food allergies

2020 ◽  
Vol 40 (4) ◽  
Author(s):  
Hiu Yan Lam ◽  
Vinay Tergaonkar ◽  
Kwang Seok Ahn
Keyword(s):  
Allergic Rhinitis ◽  
Specific Immunotherapy ◽  
Food Allergies ◽  
Potential Treatment ◽  
Allergen Specific Immunotherapy ◽  
Detailed Mechanism ◽  
Ige Mediated ◽  
Immunological Changes ◽  
Underlying Mechanisms ◽  
Specific Allergen

Abstract Allergen-specific immunotherapy (AIT) is currently the only potential treatment for allergies including allergic rhinitis (AR) and food allergies (FA) that can modify the underlying course of the diseases. Although AIT has been performed for over a century, the precise and detailed mechanism for AIT is still unclear. Previous clinical trials have reported that successful AIT induces the reinstatement of tolerance against the specific allergen. In this review, we aim to provide an updated summary of the knowledge on the underlying mechanisms of IgE-mediated AR and FA as well as the immunological changes observed after AIT and discuss on how better understanding of these can lead to possible identification of biomarkers and novel strategies for AIT.

Allergic and Nonallergic Rhinitis: Classification and Pathogenesis Part I. Allergic Rhinitis

1989 ◽  
Vol 3 (1) ◽  
pp. 21-47 ◽  
Author(s):  
Robert S. Zeiger
Keyword(s):  
Allergic Rhinitis ◽  
Clinical History ◽  
Laboratory Findings ◽  
Chronic Rhinitis ◽  
Associated Symptoms ◽  
Life Threatening ◽  
Therapeutic Measures ◽  
Ige Mediated ◽  
Routine Procedures

Chronic rhinitis, although not life-threatening, substantially interferes with one's quality of life. Associated symptoms of nasal obstruction, sneezing, rhinorrhea, and anosmia afflict an estimated 40 million Americans. Directed clinical history and physical examination combined with noninvasive and routine procedures permit physicians to diagnose the myriad conditions causing rhinitis. Although the precise etiology of many of these conditions is only partially known, a practical diagnostic classification can be formulated based on clinical and laboratory findings. An understanding of the pathophysiology of allergic rhinitis as well as the other less understood entities provides the clinician with a integral foundation to implement preventative and therapeutic measures. This comprehensive review should provide the reader an opportunity to better understand and appreciate the causes and pathophysiology of chronic rhinitis. Part I of this article concentrates on IgE-mediated reactions, mediators, and drugs involved in allergic rhinitis. Part II focuses on the recent advances gained in understanding the nonallergic (non-IgE) causes of chronic rhinitis.

Effect of perennial dust mites allergy on symptom severity of autumn allergic rhinitis in adults

2020 ◽  
Vol 41 (5) ◽  
pp. 363-371
Author(s):  
Qingqing Xu ◽  
Yuan Zhang ◽  
Luo Zhang
Keyword(s):  
Allergic Rhinitis ◽  
Symptom Severity ◽  
Immunoglobulin E ◽  
Pollen Allergy ◽  
Adult Patients ◽  
Dust Mites ◽  
Pollen Allergens ◽  
Ocular Symptoms ◽  
Artemisia Argyi ◽  
Ige Mediated

Background: Multiple immunoglobulin E (IgE) mediated sensitizations and/or allergies often coexist in patients with allergic rhinitis (AR). Several simultaneous allergen exposures in multiple IgE-mediated sensitizations and/or allergies may increase the allergen load and be related to disease severity. No study has verified whether positive allergen serum IgE levels and allergen categories together are associated with AR severity in adults. Objective: To investigate the effects of perennial dust mites (DMs) allergy and multiple serum sIgE-mediated autumn pollen allergy coexistence on symptom severity in adult patients with AR in autumn. Methods: In total, 153 patients with AR and with autumn pollen allergy (Artemisia argyi, ragweed, and hop) with or without DMs allergy were recruited in the autumn pollen season. Symptom severity was assessed by using the Chinese version of the visual analog scale (VAS): four rhinitis symptoms (sneezing, rhinorrhea, nasal pruritus, and nasal congestion) and two ocular symptoms (ocular itching and/or grittiness and/or redness, and ocular tearing) were scored at approximately the same period. We measured allergen serum sIgE levels for the inhaled allergens. The effects of DMs allergy and multiple autumn pollen allergy coexistence on symptom severity were analyzed. Results: Neither the sum of the autumn pollen allergens categories (total number of positive autumn pollen allergens, i.e., Artemisia argyi or ragweed or hop positive: 1; Artemisia argyi and ragweed positive: 2; Artemisia argyi, ragweed, and hop positive: 3) nor serum sIgE levels( total sIgE levels of positive autumn pollen allergens) exerted any influence on the severity of nasal and ocular symptoms (p > 0.05). When the concomitant DMs allergy status was considered, the sum of the positive autumn pollen allergen categories and accumulated positive autumn pollen and DMs serum sIgE levels (total levels of serum sIgE of positive autumn pollen allergens plus the levels of serum sIgE of DMs) had no influence on patients’ symptom severity (p > 0.05). Conclusion: The coexistence of perennial DMs allergy and multiple autumn pollen allergy did not affect the severity of symptoms among adult patients with AR and with autumn pollen allergy in autumn.

Correlation between serum IL-23 and serum total IgE levels in allergic rhinitis patients

2021 ◽  
Vol 30 (3) ◽  
pp. 59-63
Author(s):  
Aya M. EL-Aidy ◽  
Mohammad E. Abd Elbary ◽  
Gehan EL-Shennawy ◽  
Emad A. Morad
Keyword(s):  
Allergic Rhinitis ◽  
Th17 Cells ◽  
Immunoglobulin E ◽  
Total Ige ◽  
Positive Correlation ◽  
Chronic Disorder ◽  
Ige Mediated ◽  
Serum Total Ige ◽  
Novel Target

Background: Allergic rhinitis (AR) is an immunoglobulin E (IgE) mediated inflammatory chronic disorder of the nasal mucosa caused by contact to allergens which affects a significant percentage of population. Th17 cells might be involved in the acute phase of the allergic reaction. Th17 cells are regulated by IL-23, which is a member of the IL-12 cytokine family. IL-23 was suggested to be a pivotal cytokine involved in the pathogenesis of AR and may become a novel target in the treatment of AR. Objective: Here we investigate the role of serum IL-23 and its correlation with serum total IgE level in AR. Methodology: This case control study included the investigation of 48subjects. Blood samples were collected for measuring serum IL-23 and total IgE levels by ELISA. Results: positive correlation was found between IL-23 and total IgE serum level in AR patients. Conclusion: Positive correlation was found between serum IL-23 and serum total IgE levels in allergic rhinitis patients.

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