The influence of the mental trauma on the behavior and lipid metabolism in female rats

2007 ◽  
Author(s):  
S. G. Tsikunov ◽  
A. G. Pshenichnaya ◽  
A. G. Kusov ◽  
N. N. Klyueva
Keyword(s):  
Lipid Metabolism ◽  
Female Rats ◽  
Mental Trauma

scholarly journals Letrozole Accelerates Metabolic Remodeling through Activation of Glycolysis in Cardiomyocytes: A Role beyond Hormone Regulation

2022 ◽  
Vol 23 (1) ◽  
pp. 547
Author(s):  
Jun H. Heo ◽  
Sang R. Lee ◽  
Seong Lae Jo ◽  
Hyun Yang ◽  
Hye Won Lee ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lipid Metabolism ◽  
Cancer Patients ◽  
Cardiovascular Effects ◽  
Female Rats ◽  
Acid Oxidation ◽  
Hormone Regulation ◽  
Breast Cancer Patients ◽  
Metabolic Remodeling

Estrogen receptor-positive (ER+) breast cancer patients are recommended hormone therapy as a primary adjuvant treatment after surgery. Aromatase inhibitors (AIs) are widely administered to ER+ breast cancer patients as estrogen blockers; however, their safety remains controversial. The use of letrozole, an AI, has been reported to cause adverse cardiovascular effects. We aimed to elucidate the effects of letrozole on the cardiovascular system. Female rats exposed to letrozole for four weeks showed metabolic changes, i.e., decreased fatty acid oxidation, increased glycolysis, and hypertrophy in the left ventricle. Although lipid oxidation yields more ATP than carbohydrate metabolism, the latter predominates in the heart under pathological conditions. Reduced lipid metabolism is attributed to reduced β-oxidation due to low circulating estrogen levels. In letrozole-treated rats, glycolysis levels were found to be increased in the heart. Furthermore, the levels of glycolytic enzymes were increased (in a high glucose medium) and the glycolytic rate was increased in vitro (H9c2 cells); the same was not true in the case of estrogen treatment. Reduced lipid metabolism and increased glycolysis can lower energy supply to the heart, resulting in predisposition to heart failure. These data suggest that a letrozole-induced cardiac metabolic remodeling, i.e., a shift from β-oxidation to glycolysis, may induce cardiac structural remodeling.

SEX DIFFERENCES OF CARBOHYDRATE AND LIPID METABOLISM IMPAIRMENT IN RATS WITH TYPE 2 DIABETES MELLITUS

2018 ◽  
Vol 64 (2) ◽  
pp. 39-45 ◽  
Author(s):  
Nataliia Gorbenko ◽  
Oleksii Borikov ◽  
Olha Ivanova ◽  
K. V. Taran ◽  
T. S. Litvinova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Body Weight ◽  
Lipid Metabolism ◽  
Female Rats ◽  
Glucose And Lipid Metabolism ◽  
Carbohydrate And Lipid Metabolism ◽  
Lipid Metabolism Disorders

A sex difference of carbohydrate and lipid metabolism disorders in rats with type 2 diabetes has been studied. It was established that type 2 diabetes leads to a more pronounced deterioration in carbohydrate toleranceand insulin sensitivity in males compared to female rats, but the sex doesn’t affect basal glycemia and fructosamine levels. It was found that the increase of body weight and visceral fat in rats with type 2 diabetes is moremanifested in females than in males. It has been determined that hypertriglyceridemia is higher in diabeticmales compared to diabetic females, and the level of common lipids in the liver, both intact females and femaleswith type 2 diabetes, is lower than that of the males. The obtained results indicate a more expressive impairment of glucose and lipid metabolism in males compared to females with type 2 diabetes

Combinatory effects of phytoestrogens and exercise on body fat mass and lipid metabolism in ovariectomized female rats

2018 ◽  
Vol 178 ◽  
pp. 73-81 ◽  
Author(s):  
Wenya Zheng ◽  
Jana Rogoschin ◽  
Anja Niehoff ◽  
Kristina Oden ◽  
Sabine E. Kulling ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Body Fat ◽  
Fat Mass ◽  
Female Rats ◽  
Body Fat Mass

Chlorella pyrenoidosa, young barley and fruit peel polyphenols in rat breast cancer model – the effects on plasma lipid metabolism

Biologia ◽  
2015 ◽  
Vol 70 (2) ◽  
Author(s):  
Andrea Kapinová ◽  
Peter Kubatka ◽  
Peter Kružliak ◽  
Michal Mokáň ◽  
Martin Péč ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lipid Metabolism ◽  
Ldl Cholesterol ◽  
Plasma Lipid ◽  
Chlorella Pyrenoidosa ◽  
Female Rats ◽  
Cancer Model ◽  
Fruit Peel ◽  
Vldl Cholesterol ◽  
Breast Cancer Model

AbstractOn the basis of several preclinical and clinical studies, we have assumed that phytochemicals may play an important role in plasma lipid metabolism. The aim of this study was to evaluate the effects of dietary administered Chlorella pyrenoidosa, young barley and fruit peel polyphenols from Flavin7 on plasma lipid metabolism in breast cancer model in female rats. The phytopharmaceuticals were dietary administered at two different concentrations (0.3% and 3%). The administration of drugs lasted for the whole duration of the experiment (14-15 weeks) until autopsy. At the end of the experiments blood was collected from animals and serum lipid parameters were evaluated. Flavin7 in lower dose significantly decreased LDL-cholesterol and in higher dose significantly decreased triacylglycerol and VLDL-cholesterol levels. Chlorella at the higher dose significantly decreased LDL- and VLDL-cholesterol and triacylglycerol levels. Young barley significantly decreased LDL cholesterol (at the higher dose); on the other hand, a tendency of increased serum triacylglycerol and VLDLcholesterol levels was found (in both doses). Our results pointed to significant beneficial effects of fruit peel polyphenols from Flavin7 and C. pyrenoidosa on plasma lipid metabolism in female rats. Further research is needed to elucidate the health benefits of phytochemicals in whole foods.

Lipid Metabolism of Young Female Rats Fed Diets Varying in Fat and Calories

1963 ◽  
Vol 80 (4) ◽  
pp. 397-402 ◽  
Author(s):  
Jacqueline Dupont ◽  
Harvye Lewis
Keyword(s):  
Lipid Metabolism ◽  
Young Female ◽  
Female Rats

Abstract P799: Nicotine Along With Oral Contraceptive Exposure Alters Brain Lipid Metabolism and Exacerbates Ischemic Injury in Female Rats

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Jonathan Siegel ◽  
Francisca Diaz ◽  
Ami P Raval
Keyword(s):  
Fatty Acid ◽  
Lipid Metabolism ◽  
Molecular Mechanisms ◽  
Female Rats ◽  
Pathway Enrichment Analysis ◽  
Female Rat ◽  
Acetyl Coa ◽  
Oxidation Rates ◽  
Activity Measurements ◽  
Metabolic Fingerprint

Background: Smoking-derived nicotine (N) and oral contraceptives (OC) synergistically exacerbate both global and focal ischemic brain damage in females. While the underlying mechanisms remain elusive, our published study showed that OC exacerbate N toxicity via altered mitochondrial electron transport chain function. Because mitochondria play a central role in cellular metabolism, we examined the metabolic fingerprint of adolescent and adult female rat brains exposed to N +/- OC. Methods: Adolescent (6 weeks old) and adult (12 weeks old) Sprague-Dawley female rats were randomly (n = 8/group) exposed to either saline, N (4.5 mg/kg) +/- OC for 16-21 days. Following treatment, brain tissue was harvested for unbias metabolomic analysis (performed by Metabolon Inc.). The metabolomic profile was complemented with western blot analysis and enzyme activity measurements. Results: Pathway enrichment analysis showed significant alterations in lipid metabolism. Adolescent but not adult females treated with N, OC and N+OC compared to saline showed significant increases in carnitine conjugated fatty acid metabolites such as arachidonoylcarnitine (C20:4), docosahexaenoylcarnitine (C22:6) and stearoylcarnitine (C18). These changes in fatty acyl carnitines were accompanied by an increase in a subset of free fatty acids, suggesting elevated fatty acid β-oxidation in the mitochondria to meet energy demand. In support, 3-hydroxybutyrate (BHBA) was significantly lower in OC and N+OC treatment group in adolescent animals, implying a complete shunting of acetyl CoA for energy production via TCA cycle. BHBA is a ketone body that increases in concentration as lipid oxidation rates increase with acetyl CoA accumulation. Reduced BHBA levels may also suggest mitochondrial dysfunction in response to OC and N+OC treatment. Conclusion: The observed changes in the metabolic fingerprint and fatty acid metabolism reflect a general alteration in energy metabolism with nicotine treatment exclusively in young animals and these changes are enhanced by N+OC treatment. Discerning the exact effects of N +/- OC on overall brain metabolism and the molecular mechanisms affecting mitochondrial function at different ages will open a new window for future therapeutic intervention.

scholarly journals EFFECT OF CONTINUOUS EXERCISE ON LIPID METABOLISM OF ADULT OBESE MONOSODIUM GLUTAMATE (MSG) TREATED FEMALE RATS

1999 ◽  
Vol 31 (Supplement) ◽  
pp. S135
Author(s):  
R. C. Couto ◽  
G. E.C. Couto ◽  
M. H.G. Gomes da Silva ◽  
F. A. Mariya ◽  
C. K. Ishizuka ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Monosodium Glutamate ◽  
Female Rats ◽  
Continuous Exercise

scholarly journals Beneficial effects of consumption of acerola, cashew or guava processing by-products on intestinal health and lipid metabolism in dyslipidaemic female Wistar rats

2018 ◽  
Vol 119 (1) ◽  
pp. 30-41 ◽  
Author(s):  
Kamila Sabino Batista ◽  
Adriano Francisco Alves ◽  
Marcos dos Santos Lima ◽  
Laiane Alves da Silva ◽  
Priscilla Paulo Lins ◽  
...  
Keyword(s):  
Body Weight ◽  
Lipid Metabolism ◽  
Wistar Rats ◽  
Female Rats ◽  
Intestinal Health ◽  
Colon Cells ◽  
Positive Effects ◽  
Fruit Processing ◽  
Female Wistar Rats ◽  
By Products

AbstractThis study assessed the effects of diet supplementation with industrial processing by-products of acerola (Malpighia emarginataD.C.), cashew (Anacardium occidentaleL.) and guava (Psidium guajavaL.) fruit on the intestinal health and lipid metabolism of female Wistar rats with diet-induced dyslipidaemia. Female rats were randomly divided into five groups: healthy control, dyslipidaemic control and dyslipidaemic experimental receiving acerola, cashew or guava processing by-products. Fruit processing by-products were administered (400 mg/kg body weight) via orogastric administration for 28 consecutive days. Acerola, cashew and guava by-products caused body weight reduction (3·42, 3·08 and 5·20 %, respectively) in dyslipidaemic female rats. Dyslipidaemic female rats receiving fruit by-products, especially from acerola, presented decreased faecal pH, visceral fat, liver fat and serum lipid levels, as well as increased faecal moisture, faecal fat excretion, faecalBifidobacteriumspp. andLactobacillusspp. counts and amounts of organic acids in faeces. Administration of the tested fruit processing by-products protected colon and liver from tissue damage (e.g. destruction of liver and colon cells and increased fat deposition in hepatocytes) induced by dyslipidaemic diet. Dietary fibres and phenolic compounds in tested fruit by-products may be associated with these positive effects. The industrial fruit processing by-products studied, mainly from acerola, exert functional properties that could enable their use to protect the harmful effects on intestinal health and lipid metabolism caused by dyslipidaemic diet.

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