Neuropsychological Effects of Cybercycling for Older Adults: One-Year Follow-Up

Physical performance tests are associated with different adverse outcomes in older people. Theobjective of this study was to test the association between handgrip strength and gait speed with incidentdisability in community-dwelling, well-functioning, Mexican older adults (age ≥70 years). Incident disability wasdefined as the onset of any difficulty in basic or instrumental activities of daily living. Of a total of 133participants, 52.6% (n=70) experienced incident disability during one year of follow-up. Significant associationsof handgrip strength (odds ratio [OR] 0.96, 95% confidence interval [95%CI] 0.93-0.99) and gait speed (OR0.27, 95%CI 0.07-0.99) with incident disability were reported. The inclusion of covariates in the models reducedthe statistical significance of the associations without substantially modifying the magnitude of them. Handgripstrength and gait speed are independently associated with incident disability in Mexican older adults.

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One-Year Follow-Up of Healthy Older Adults with Electroencephalographic Risk for Neurocognitive Disorder After Neurofeedback Training

Journal of Alzheimer s Disease ◽

10.3233/jad-215538 ◽

2021 ◽

pp. 1-15

Author(s):

Graciela C. Alatorre-Cruz ◽

Thalía Fernández ◽

Susana A. Castro-Chavira ◽

Mauricio González-López ◽

Sergio M. Sánchez-Moguel ◽

...

Keyword(s):

Older Adults ◽

Theta Activity ◽

Control Group ◽

Global Changes ◽

Healthy Population ◽

Healthy Older Adults ◽

Cognitive Improvement ◽

One Year ◽

Experimental Group

Background: In healthy older adults, excess theta activity is an electroencephalographic (EEG) predictor of cognitive impairment. In a previous study, neurofeedback (NFB) treatment reinforcing reductions theta activity resulted in EEG reorganization and cognitive improvement. Objective: To explore the clinical applicability of this NFB treatment, the present study performed a 1-year follow-up to determine its lasting effects. Methods: Twenty seniors with excessive theta activity in their EEG were randomly assigned to the experimental or control group. The experimental group received an auditory reward when the theta absolute power (AP) was reduced. The control group received the reward randomly. Results: Both groups showed a significant decrease in theta activity at the training electrode. However, the EEG results showed that only the experimental group underwent global changes after treatment. These changes consisted of delta and theta decreases and beta increases. Although no changes were found in any group during the period between the posttreatment evaluation and follow-up, more pronounced theta decreases and beta increases were observed in the experimental group when the follow-up and pretreatment measures were compared. Executive functions showed a tendency to improve two months after treatment which became significant one year later. Conclusion: These results suggest that the EEG and behavioral benefits of this NFB treatment persist for at least one year, which adds up to the available evidence contributing to identifying factors that increase its efficacy level. The relevance of this study lies in its prophylactic features of addressing a clinically healthy population with EEG risk of cognitive decline.

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Anticholinergics and Benzodiazepines on Cognitive Impairment among Elderly with Alzheimer’s Disease: a One year Follow-Up Study

10.21203/rs.2.17956/v1 ◽

2019 ◽

Author(s):

Rewadee Jenraumjit ◽

Surarong Chinwong ◽

Dujrudee Chinwong ◽

Tipaporn Kanjanarach ◽

Thanat Kshetradat ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Older Adults ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Psychological Symptoms ◽

Esterase Inhibitors ◽

One Year ◽

State Examination ◽

Harmful Effects

Abstract Objective Age-associated decline in central cholinergic activity makes older adults susceptible to harmful effects of anticholinergics (ACs). Evidence exists of an association between effects of AC medications on cognition. This retrospective cohort study examines how ACs affect cognition among older adults with Alzheimer’s disease (AD) who received acetylcholine esterase inhibitors (AChEIs) over the course of 12 months. Results A total of 133 (80% women, mean age 78.38 years, SD 7.4) were recruited. No difference in sex, age and comorbid diseases was observed between participants who took ACs, Benzodiazepines (BZDs) and AChEIs. The most common prescribed ACs was quetiapine, being used for behavioral and psychological symptoms (BPSD). Multilevel analysis showed that the change of mental state examination scores were significantly predicted in the group using ACs (t (169), -2.52, p = .020) but not with the groups using BZD (t (162), 0.84, p = .440). Evidence showed that older adults with Alzheimer’s disease and exposed to ACs exhibited lower global cognitive scores than those without AC exposure. Using ACs could be a trade-off between controlling BPSD and aggravating cognitive impairment. Highlighting the awareness of the potential anticholinergic effect is important and may be the best policy.

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One-Year Follow-up of Non-institutionalized Dependent Older Adults: Mortality, Hospitalization, and Mobility

Canadian Journal on Aging / La Revue canadienne du vieillissement ◽

10.1017/s0714980812000244 ◽

2012 ◽

Vol 31 (3) ◽

pp. 357-361 ◽

Cited By ~ 3

Author(s):

Marcos Aparecido Sarria Cabrera ◽

Mara Solange Gomes Dellaroza ◽

Celita Salmaso Trelha ◽

Celso Henrique Cecilio ◽

Sara Ellias de Souza

Keyword(s):

Older Adults ◽

Nous Avons ◽

Personnes Âgées ◽

Étude Prospective ◽

Soins De Santé ◽

De Se ◽

One Year ◽

Pour Cent

RÉSUMÉLes aînés dépendants qui ne sont pas institutionnalisées présentent une forte morbidité et mortalité, exigent des soins de leurs familles et consomment de ressources primaires de soins de santé. Pour élargir les connaissances en ce qui concerne ce groupe, nous avons effectué une étude prospective d’un an, basée sur la population de cohorte de 130 personnes âgées dépendantes et non-institutionnalisées (60 ans et plus). Cette étude a été stratifiée en fonction du degré de la mobilité: la marche indépendante (groupe A), l’utilisation des aides pour la marche (groupe B), et alité ou confiné au fauteuil roulant (groupe C). Les résultats analysés étaient les suivants: la mort, l’hospitalisation, et l’incapacité de se déplacer. La mortalité totale était au pourcentage de 8.5 (p = 0,05). Le taux global d’hospitalisation était au pourcentage de 34,6, les principales causes étant l’AVC et la pneumonie. La mortalité totale était de 8,5 pour cent (p = 0,05). Le taux global d’hospitalisation était de 34,6 pour cent, les principales causes étant l’AVC et la pneumonie. À la fin d’un an, la proportion de sujets classés comme capables de marcher d’une façon indépendante a baissé (57% contre 43%, p = 0,03). Nous pourrions déduire qu’il y avait un taux élevé de mortalité et d’hospitalisation dans ce groupe de personnes âgées dépendantes, et une proportion croissante de gens handicapés après un an.

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One-Year Follow-Up of Medication Management Capacity in Highly Functioning Older Adults

The Journals of Gerontology Series A ◽

10.1093/gerona/55.10.m550 ◽

2000 ◽

Vol 55 (10) ◽

pp. M550-M553 ◽

Cited By ~ 27

Author(s):

H. K. Edelberg ◽

E. Shallenberger ◽

J. M. Hausdorff ◽

J. Y. Wei

Keyword(s):

Older Adults ◽

Medication Management ◽

Management Capacity ◽

One Year ◽

Medication Management Capacity

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Differences in cause and 12-month follow-up outcome of parkinsonian symptoms in depressed older adults treated with antipsychotics: a case series

BMC Psychiatry ◽

10.1186/s12888-021-03298-9 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Anastasios Politis ◽

Nikolaos Kokras ◽

Michael Souvatzoglou ◽

Kostas Siarkos ◽

Panagiotis Toulas ◽

...

Keyword(s):

Older Adults ◽

Single Photon ◽

Photon Emission ◽

Case Series ◽

Post Discharge ◽

Drug Induced ◽

Depth Study ◽

Prognostic Implications ◽

One Year

Abstract Background Parkinsonian symptoms are common adverse effects of antipsychotics. Older adults are particularly vulnerable to drug-induced parkinsonism. Nonetheless, parkinsonian symptoms in seniors treated with antipsychotics cannot be straightforwardly attributed to antipsychotic medication. A comprehensive diagnostic workup is necessary in many cases in order to shed light on the cause of such symptoms in this patient population. Case series Eight cases of hospitalized depressed older adults with parkinsonian symptoms, who were treated for at least one year with antipsychotics, are reported. Based on neurological consultation, structural brain imaging and Ioflupane (I-123) dopamine transporter (DAT) single photon emission computerized tomography (SPECT), Parkinson’s disease was diagnosed in one case, idiopathic tremor in another, vascular parkinsonism in another one, while in another individual parkinsonian symptoms persisted at 12-month post-discharge follow-up even though his/her symptoms were classified as drug-induced on discharge. In four patients, parkinsonian symptoms were definitely drug-induced and no movement disturbances were reported at follow-up. Conclusions Differences in the cause and outcome of parkinsonian symptoms in seniors treated with antipsychotics merit systematic and in-depth study considering the therapeutic and prognostic implications of an accurate detection of the cause of such symptoms. Familiarizing clinical psychiatrists with these differences could pave the way towards approaching seniors with severe, atypical and/or persistent parkinsonian symptoms in a more individualized diagnostic and therapeutic manner, and towards more cautious prescribing of antipsychotics in this age group.

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Anticholinergics and Benzodiazepines on Cognitive Impairment among Elderly with Alzheimer’s Disease: a One year Follow-Up Study

10.21203/rs.2.17956/v2 ◽

2019 ◽

Author(s):

Rewadee Jenraumjit ◽

Surarong Chinwong ◽

Dujrudee Chinwong ◽

Tipaporn Kanjanarach ◽

Thanat Kshetradat ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Older Adults ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Psychological Symptoms ◽

Esterase Inhibitors ◽

One Year ◽

State Examination ◽

Harmful Effects

Abstract Objective Age-associated decline in central cholinergic activity makes older adults susceptible to harmful effects of anticholinergics (ACs). Evidence exists of an association between effects of AC medications on cognition. This retrospective cohort study examines how ACs affect cognition among older adults with Alzheimer’s disease (AD) who received acetylcholine esterase inhibitors (AChEIs) over the course of 12 months. Results A total of 133 (80% women, mean age 78.38 years, SD 7.4) were recruited. No difference in sex, age and comorbid diseases was observed between participants who took ACs, Benzodiazepines (BZDs) and AChEIs. The most common prescribed ACs was quetiapine, being used for behavioral and psychological symptoms (BPSD). Multilevel analysis showed that the change of mental state examination scores were significantly predicted in the group using ACs ( t (169), -2.52, p = .020) but not with the groups using BZD ( t (162), 0.84, p = .440). Evidence showed that older adults with Alzheimer’s disease and exposed to ACs exhibited lower global cognitive scores than those without AC exposure. Using ACs could be a trade-off between controlling BPSD and aggravating cognitive impairment. Highlighting the awareness of the potential anticholinergic effect is important and may be the best policy.

Download Full-text