scholarly journals Contribution of Myostatin gene polymorphisms to normal variation in lean mass, fat mass and peak BMD in Chinese male offspring

2012 ◽  
Vol 33 (5) ◽  
pp. 660-667 ◽  
Author(s):  
Hua Yue ◽  
Jin-wei He ◽  
Hao Zhang ◽  
Chun Wang ◽  
Wei-wei Hu ◽  
...  
Keyword(s):  
Fat Mass ◽  
Lean Mass ◽  
Gene Polymorphisms ◽  
Male Offspring ◽  
Normal Variation ◽  
Myostatin Gene ◽  
Chinese Male ◽  
Peak Bmd

Contribution of the Myostatin gene polymorphisms to normal variation in lean mass and fat mass in Chinese male offspring nuclear families

Bone ◽  
2010 ◽  
Vol 47 ◽  
pp. S364
Author(s):  
Hua Yue ◽  
Jin-Wei He ◽  
Zhen-Lin Zhang ◽  
Hao Zhang ◽  
Chun Wang ◽  
...  
Keyword(s):  
Fat Mass ◽  
Lean Mass ◽  
Gene Polymorphisms ◽  
Male Offspring ◽  
Normal Variation ◽  
Myostatin Gene ◽  
Nuclear Families ◽  
Chinese Male

scholarly journals LGR4 Gene Polymorphisms Are Associated With Bone and Obesity Phenotypes in Chinese Female Nuclear Families

2021 ◽  
Vol 12 ◽  
Author(s):  
Su-qin Shi ◽  
Shan-shan Li ◽  
Xiao-ya Zhang ◽  
Zhe Wei ◽  
Wen-zhen Fu ◽  
...  
Keyword(s):  
Lumbar Spine ◽  
Femoral Neck ◽  
Fat Mass ◽  
Lean Mass ◽  
Gene Polymorphisms ◽  
Mineral Density ◽  
Nuclear Families ◽  
Total Hip ◽  
Female Children ◽  
Peak Bmd

ObjectiveThe current study was conducted to determine whether peak bone mineral density (BMD) and obesity phenotypes are associated with certain LGR4 gene polymorphisms found in Chinese nuclear families with female children.MethodsA total of 22 single nucleotide polymorphisms (SNPs) located in and around the LGR4 gene were identified in 1,300 subjects who were members of 390 Chinese nuclear families with female children. Then, BMD readings of the femoral neck, total hip, and lumbar spine as well as measurements of the total lean mass (TLM), total fat mass (TFM), and trunk fat mass were obtained via dual-energy X-ray absorptiometry. The quantitative transmission disequilibrium test was used to analyze the associations between specific SNPs and LGR4 haplotypes and peak BMD as well as between LGR4 haplotypes and TLM, percent lean mass, TFM, percent fat mass, trunk fat mass, and body mass index (BMI).ResultsHere, rs7936621 was significantly associated with the BMD values for the total hip and lumbar spine, while rs10835171 and rs6484295 were associated with the trunk fat mass and BMI, respectively. Regarding the haplotypes, we found significant associations between GAA in block 2 and trunk fat mass and BMI, between AGCGT in block 3 and total hip BMD, between TGCTCC in block 5 and femoral neck BMD, and between TACTTC in block 5 and both lumbar spine and femoral neck BMD (all P-values < 0.05).ConclusionGenetic variations of the LGR4 gene are related to peak BMD, BMI, and trunk fat mass.

scholarly journals No association between LRP5 gene polymorphisms and bone and obesity phenotypes in Chinese male-offspring nuclear families

2010 ◽  
Vol 31 (11) ◽  
pp. 1464-1469 ◽  
Author(s):  
Jin-bo Yu ◽  
Yao-hua Ke ◽  
Jin-wei He ◽  
Hao Zhang ◽  
Wei-wei Hu ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Male Offspring ◽  
Nuclear Families ◽  
Chinese Male

Tests of linkage and/or association of the LEPR gene polymorphisms with obesity phenotypes in Caucasian nuclear families

2004 ◽  
Vol 17 (2) ◽  
pp. 101-106 ◽  
Author(s):  
Yong-Jun Liu ◽  
Sonia M.S. Rocha-Sanchez ◽  
Peng-Yuan Liu ◽  
Ji-Rong Long ◽  
Yan Lu ◽  
...  
Keyword(s):  
Fat Mass ◽  
Lean Mass ◽  
Gene Polymorphisms ◽  
Leptin Receptor ◽  
Data Sets ◽  
Nucleotide Polymorphisms ◽  
Nuclear Families ◽  
Lepr Gene ◽  
General Populations ◽  
Significant Linkage

Genetic variations in the leptin receptor (LEPR) gene have been conceived to affect body weight in general populations. In this study, using the tests implemented in the statistical package QTDT, we evaluated association and/or linkage of the LEPR gene with obesity phenotypes in a large sample comprising 1,873 subjects from 405 Caucasian nuclear families. Obesity phenotypes tested include body mass index (BMI), fat mass, percentage fat mass (PFM), and lean mass, with the latter three measured by dual-energy X-ray absorptiometry (DXA). Three single nucleotide polymorphisms (SNPs), namely Lys109Arg (A/G), Lys656Asn (G/C), Pro1019Pro (G/A), in the LEPR gene were analyzed. Significant linkage disequilibrium (0.394 ≤ | D′| ≤ 0.688, P < 0.001) was observed between pairs of the three SNPs. No significant population stratification was found for any SNP/phenotype. In single-locus analyses, evidence of association was observed for Lys656Asn with lean mass ( P = 0.002) and fat mass ( P = 0.015). The contribution of this polymorphism to the phenotypic variation of lean mass and fat mass was 2.63% and 1.15%, respectively. Subjects carrying allele G at the Lys656Asn site had, on average, 3.16% higher lean mass and 2.71% higher fat mass than those without it. In the analyses for haplotypes defined by the three SNPs, significant associations were detected between haplotype GCA ( P = 0.005) and lean mass. In addition, marginally significant evidence of association was observed for this haplotype with fat mass ( P = 0.012). No statistically significant linkage was found, largely due to the limited power of the linkage approach to detect small genetic effects in our data sets. Our results suggest that the LEPR gene polymorphisms contribute to variation in obesity phenotypes.

Association between myostatin gene polymorphisms and peak BMD variation in Chinese nuclear families

2007 ◽  
Vol 19 (1) ◽  
pp. 39-47 ◽  
Author(s):  
Z.-L. Zhang ◽  
J.-W. He ◽  
Y.-J. Qin ◽  
Y.-Q. Hu ◽  
M. Li ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Myostatin Gene ◽  
Nuclear Families ◽  
Peak Bmd

scholarly journals Examining Bone, Muscle and Fat in Middle-Aged Long-Term Endurance Runners: A Cross-Sectional Study

2020 ◽  
Vol 9 (2) ◽  
pp. 522
Author(s):  
Ulrike H. Mitchell ◽  
Bruce Bailey ◽  
Patrick J. Owen
Keyword(s):  
Exercise Training ◽  
Aerobic Exercise ◽  
Fat Mass ◽  
Lean Mass ◽  
Aerobic Exercise Training ◽  
Middle Aged ◽  
Cross Sectional ◽  
Endurance Runners ◽  
Total Body

Aerobic exercise training has many known cardiovascular benefits that may promote healthy aging. It is not known if long-term aerobic exercise training is also associated with structural benefits (e.g., lower fat mass, higher areal bone mineral density (BMD) and greater muscle mass). We evaluated these parameters in middle-aged long-term endurance runners compared to sex-, age-, height-, and weight-matched non-running controls. Total and regional lean and fat mass and areal BMD were assessed by dual-energy X-ray absorptiometry. Sagittal magnetic resonance images captured the cross-sectional area and thickness of the lumbar multifidus. Runners (n = 10; all male) had a mean (standard deviation; SD) age of 49 (4) years, height of 178.9 (4.9) cm, weight of 67.8 (5.8) kg, body mass index (BMI) of 21.4 (1.4) kg/m2 and had been running 82.6 (27.9) km/week for 23 (13) years. Controls (n = 9) had a mean (SD) age of 51 (5) years, height of 176.0 (5.1) cm, weight of 72.8 (7.1) kg, and BMI of 23.7 (2.1) kg/m2. BMI was greater in controls (p = 0.010). When compared to controls on average, runners had a 10 percentage-point greater total body lean mass than controls (p = 0.001) and 14% greater trunk lean mass (p = 0.010), as well as less total body (8.6 kg; p < 0.001), arm (58%; p = 0.002), leg (52%; p < 0.001), trunk (73%; p < 0.001), android (91%; p < 0.001), and gynoid fat mass (64%; p < 0.001). No differences were observed between groups for BMD outcomes or multifidus size. These results underscore the benefits of endurance running to body composition that carry over to middle-age.

scholarly journals Body composition in childhood: effects of normal growth and disease

2003 ◽  
Vol 62 (2) ◽  
pp. 521-528 ◽  
Author(s):  
J. C. K. Wells
Keyword(s):  
Body Composition ◽  
Childhood Obesity ◽  
Fat Mass ◽  
Lean Mass ◽  
Normal Weight ◽  
Fat Free Mass ◽  
General Interest ◽  
Childhood And Adolescence ◽  
Adult Disease ◽  
Increased Risk

Body composition in children is of increasing interest within the contexts of childhood obesity, clinical management of patients and nutritional programming as a pathway to adult disease. Energy imbalance appears to be common in many disease states; however, body composition is not routinely measured in patients. Traditionally, clinical interest has focused on growth or nutritional status, whereas more recent studies have quantified fat mass and lean mass. The human body changes in proportions and chemical composition during childhood and adolescence. Most of the weight gain comprises lean mass rather than fat. In general, interest has focused on percentage fat, and less attention has been paid to the way in which lean mass varies within and between individuals. In the general population secular trends in BMI have been widely reported, indicating increasing levels of childhood obesity, which have been linked to reduced physical activity. However, lower activity levels may potentially lead not only to increased fatness, but also to reduced lean mass. This issue merits further investigation. Diseases have multiple effects on body composition and may influence fat-free mass and/or fat mass. In some diseases both components change in the same direction, whereas in other diseases, the changes are contradictory and may be concealed by relatively normal weight. Improved techniques are required for clinical evaluations. Both higher fatness and reduced lean mass may represent pathways to an increased risk of adult disease.

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