scholarly journals Deposition of Ibuprofen Crystals on Hydroxypropyl Cellulose/Polyacrylamide Gel: Experimental and Mathematic Modeling Releasing

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Claudia Alicia Castillo-Miranda ◽  
Ana Beatriz Morales-Cepeda ◽  
Carlos Fernando Castro-Guerrero ◽  
Homero Salas-Papayanopolos ◽  
Hugo Alberto Velasco-Ocejo ◽  
...  
Keyword(s):  
Release Kinetics ◽  
Hydroxypropyl Cellulose ◽  
Fickian Diffusion ◽  
Solution Temperature ◽  
Phenyl Propionic Acid ◽  
Diffusion Media ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Kinetics Of ◽  
Made In

The crystallization of nonsteroidal anti-inflammatory drug [2-(4-isobutyl-phenyl) propionic acid] ibuprofen (IBP) on a hydroxypropyl cellulose (HPC) and polyacrylamide (PAAm) gel was studied as well as the release kinetics of the drug. The IBP was crystallized on the gel surface of HPC/PAAm. It had a prismatic shape and the growth was made in an aqueous medium; the crystallinity grade of the gels HPC/PAAm and HPC/PAAm-IBU increased to 68% and to 58%, respectively. The release of IBP is performed by two means: by a non-Fickian diffusion process and by relaxation of the chains of the gel; without regard to temperature and the diffusion media, this correlates with the lower critical solution temperature (LCST) of the proposed gel. This polymer matrix provides an option for releasing nonsteroidal anti-inflammatory drugs in a temperature range of 35–39°C. Korsmeyer and Peppas mathematical model was simulated for data releases, statistically significant at 95% confidence level.

scholarly journals ETIOPATHOGENESIS OF PEPTIC ULCER: back to the past?

2014 ◽  
Vol 51 (2) ◽  
pp. 155-161 ◽  
Author(s):  
Mariana Barbosa ARAÚJO ◽  
Paulo BORINI ◽  
Romeu Cardoso GUIMARÃES
Keyword(s):  
Peptic Ulcer ◽  
General Population ◽  
Peptic Ulcers ◽  
Data Bases ◽  
Duodenal Ulcers ◽  
The Past ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
H Pylori ◽  
Made In

ObjectivesTo review some aspects of the etiopathogenesis of peptic ulcerous disease especially on the basis of studies on its correlation withHelicobacter pylori (H. pylori).MethodsA search was made in the data bases MEDLINE, LILACS and PubMed, and in Brazilian and foreign books, referring to the incidence and prevalence of infection by H. pylori and of peptic ulcerous disease in various populations of different countries.ResultsIt was observed that the prevalence of H. pyloriinfection is similar in individuals with peptic ulcerous disease and the general population. There are differences between countries with respect to the prevalence of infection and of gastric or duodenal peptic ulcers. In many countries the prevalence of infection by H. pylorishows stability while the prevalence of peptic ulcerous disease is declining. The prevalence of peptic ulcerous disease without H. pylori infection varies between 20% and 56% in occidental countries.DiscussionThe observations might be suggestive of H. pyloribeing only one more factor to be summed together with other aggressive components in the genesis of peptic ulcerous disease. We would therewith be returning to the classic concept that peptic gastric and duodenal ulcers have multifactorial etiology and would result from imbalance between aggressive and defensive factors. The focus of studies should be enriched with the identification of the defensive factors and of other aggressive factors besides the well known H. pylori and non-steroidal anti-inflammatory drugs, since these two aggressors do not exhaust the full causal spectrum.

Delivery of dexamethasone from electrospun PCL–PEO binary fibers and their effects on inflammation regulation

RSC Advances ◽  
2015 ◽  
Vol 5 (43) ◽  
pp. 34166-34172 ◽  
Author(s):  
Yan-Fang Li ◽  
Marina Rubert ◽  
Ying Yu ◽  
Flemming Besenbacher ◽  
Menglin Chen
Keyword(s):  
Gene Expression ◽  
Chemical Composition ◽  
Surface Topography ◽  
Release Kinetics ◽  
Related Gene ◽  
Inflammatory Drug ◽  
Anti Inflammatory ◽  
Kinetics Of

Differences in surface topography, chemical composition, wettability and release kinetics of the anti-inflammatory drug dexamethasone among different PCL–PEO fibers collectively affected the regulation of inflammatory related gene expression.

scholarly journals TiO2 and Active Coated Glass Photodegradation of Ibuprofen

Catalysts ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 560
Author(s):  
Samer Khalaf ◽  
Jawad H. Shoqeir ◽  
Filomena Lelario ◽  
Sabino A. Bufo ◽  
Rafik Karaman ◽  
...  
Keyword(s):  
Emerging Contaminants ◽  
Active Surface ◽  
Heterogeneous Photocatalysis ◽  
Ion Cyclotron Resonance ◽  
Aquatic Life ◽  
Coated Glass ◽  
Promising Tool ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Kinetics Of

Commercial non-steroidal anti-inflammatory drugs (NSAIDs) are considered as toxic to the environment since they induce side effects when consumed by humans or aquatic life. Ibuprofen is a member of the NSAID family and is widely used as an anti-inflammatory and painkiller agent. Photolysis is a potentially important method of degradation for several emerging contaminants, and individual compounds can undergo photolysis to various degrees, depending on their chemical structure. The efficiency oftitanium dioxide (TiO2) and photocatalysis was investigated for the removal of ibuprofen from the aquatic environment, and the performance of these different processes was evaluated. In heterogeneous photocatalysis, two experiments were carried out using TiO2 as (i) dispersed powder, and (ii) TiO2 immobilized on the active surface of commercial coated glass. The kinetics of each photoreaction was determined, and the identification of the photoproducts was carried out by liquid chromatography coupled with Fourier-transform ion cyclotron resonance mass spectrometry (LC-FTICR MS). The overall results suggest that the TiO2 active thin layer immobilized on the glass substrate can avoid recovery problems related to the use of TiO2 powder in heterogeneous photocatalysis and may be a promising tool toward protecting the environment from emerging contaminants such as ibuprofen and its derivatives.

Inhibition of Saccharomyces cerevisiae by Slow Release of Propyl Paraben from a Polymer Coating

2001 ◽  
Vol 64 (9) ◽  
pp. 1420-1424 ◽  
Author(s):  
DONGHWAN CHUNG ◽  
MICHAEL L. CHIKINDAS ◽  
KIT L. YAM
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Slow Release ◽  
Release Kinetics ◽  
Fickian Diffusion ◽  
Propyl Paraben ◽  
Microbial Inhibition ◽  
Direct Addition ◽  
A Cell ◽  
Release Condition ◽  
Kinetics Of

The inhibition of Saccharomyces cerevisiae by slow release of propyl paraben from a styrene-acrylatecopolymer coating was examined and compared with the inhibition by direct addition of propyl paraben. Under slow release condition, a slow but continuous microbial inhibition was observed, whereas a cell outgrowth was observed under direct addition condition after a sufficient incubation time. S. cerevisiae cells isolated from the culture under direct addition condition were more tolerant of propyl paraben than cells isolated from the culture under slow release condition. The equilibrium propyl paraben concentrations under both conditions were 150 ppm. The release kinetics of propyl paraben from the coating at 30°C was found to be controlled by Fickian diffusion within the coating. The estimated partition and diffusion coefficients were 4.65 × 10−3 and 2.01 × 10−10 cm2/s, respectively.

scholarly journals Evaluation of in vitro release kinetics of Capsaicin-loaded chitosan nanoparticles using DDSolver

2020 ◽  
Vol 11 (3) ◽  
pp. 4555-4559
Author(s):  
Narissara Kulpreechanan ◽  
Feuangthit Niyamissara Sorasitthiyanukarn
Keyword(s):  
Gastrointestinal Tract ◽  
Sustained Release ◽  
Release Kinetics ◽  
Chitosan Nanoparticles ◽  
Circulatory System ◽  
Fickian Diffusion ◽  
Release Mechanism ◽  
Release Study ◽  
Kinetics Of

The present aim is to evaluate the release profile and its release kinetics of encapsulated capsaicin from chitosan nanoparticles using the software DDSolver. The release study was performed by using a dialysis technique in PBS solutions with different pHs (1.2, 6.8 and 7.4) to mimics the different gastrointestinal tract and circulatory system pH ranges as a releasing medium. The nanoparticles were prepared using o/w emulsification and ionotropic gelation technique under optimal condition obtained from response surface methodology (RSM) design as described in our previous study. These nanoparticles were around 180 nm in average hydrodynamic size and encapsulation efficiency percentage around 70%, respectively. In vitro drug release study suggested that the chitosan nanoparticles can potentially use to controlled and sustained release of capsaicin over at least 96. The kinetic release analysis results by DDSolver software indicated that Weibull model was suggested to be the best dynamic models with highest R2adjusted and model selection criteria (MSC) and lowest Akaike information criterion (AIC), respectively, for capsaicin loaded chitosan nanoparticles. The release mechanism of capsaicin from nanoparticles was found to be Fickian diffusion. The results suggest that the chitosan nanoparticles can be applied for the controlled and sustained release of capsaicin in the gastrointestinal tract and circulatory system.

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