scholarly journals Experimental designs for evaluation of genetic variability and selection of ancient grapevine varieties: a simulation study

Heredity ◽  
2009 ◽  
Vol 104 (6) ◽  
pp. 552-562 ◽  
Author(s):  
E Gonçalves ◽  
A St.Aubyn ◽  
A Martins
2014 ◽  
Vol 14 (2) ◽  
pp. 94-101 ◽  
Author(s):  
Sonia Maria Lima Salgado ◽  
Juliana Costa de Rezende ◽  
José Airton Rodrigues Nunes

The purpose of this study was to select Coffea arabica progenies for resistance to M. paranaensis in an infested coffee growing area using Henderson's mixed model methodology. Forty-one genotypes were selected at the Coffee Active Germplasm Bank of Minas Gerais, and evaluated in regard to stem diameter, number of plagiotropic branches, reaction to the nematode, and yield per plant. There was genetic variability among the genotypes studied for all the traits evaluated, and among the populations studied for yield and reaction to the nematode, indicating possibilities for obtaining genetic gains through selection in this population. There was high rate of genotypic association between all the traits studied. Coffee plants of Timor Hybrid UFV408-01 population, and F3 progenies derived from crossing Catuaí Vermelho and Amphillo MR 2161 were the most promising in the area infested by M. paranaensis.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Mar Rodríguez-Girondo ◽  
Niels van den Berg ◽  
Michel H. Hof ◽  
Marian Beekman ◽  
Eline Slagboom

Abstract Background Although human longevity tends to cluster within families, genetic studies on longevity have had limited success in identifying longevity loci. One of the main causes of this limited success is the selection of participants. Studies generally include sporadically long-lived individuals, i.e. individuals with the longevity phenotype but without a genetic predisposition for longevity. The inclusion of these individuals causes phenotype heterogeneity which results in power reduction and bias. A way to avoid sporadically long-lived individuals and reduce sample heterogeneity is to include family history of longevity as selection criterion using a longevity family score. A main challenge when developing family scores are the large differences in family size, because of real differences in sibship sizes or because of missing data. Methods We discussed the statistical properties of two existing longevity family scores: the Family Longevity Selection Score (FLoSS) and the Longevity Relatives Count (LRC) score and we evaluated their performance dealing with differential family size. We proposed a new longevity family score, the mLRC score, an extension of the LRC based on random effects modeling, which is robust for family size and missing values. The performance of the new mLRC as selection tool was evaluated in an intensive simulation study and illustrated in a large real dataset, the Historical Sample of the Netherlands (HSN). Results Empirical scores such as the FLOSS and LRC cannot properly deal with differential family size and missing data. Our simulation study showed that mLRC is not affected by family size and provides more accurate selections of long-lived families. The analysis of 1105 sibships of the Historical Sample of the Netherlands showed that the selection of long-lived individuals based on the mLRC score predicts excess survival in the validation set better than the selection based on the LRC score . Conclusions Model-based score systems such as the mLRC score help to reduce heterogeneity in the selection of long-lived families. The power of future studies into the genetics of longevity can likely be improved and their bias reduced, by selecting long-lived cases using the mLRC.


2021 ◽  
Vol 12 ◽  
Author(s):  
James Crum

Neuroimaging and neuropsychological methods have contributed much toward an understanding of the information processing systems of the human brain in the last few decades, but to what extent do cognitive neuroscientific findings represent and generalize to the inter- and intra-brain dynamics engaged in adapting to naturalistic situations? If it is not marked, and experimental designs lack ecological validity, then this stands to potentially impact the practical applications of a paradigm. In no other domain is this more important to acknowledge than in human clinical neuroimaging research, wherein reduced ecological validity could mean a loss in clinical utility. One way to improve the generalizability and representativeness of findings is to adopt a more “real-world” approach to the development and selection of experimental designs and neuroimaging techniques to investigate the clinically-relevant phenomena of interest. For example, some relatively recent developments to neuroimaging techniques such as functional near-infrared spectroscopy (fNIRS) make it possible to create experimental designs using naturalistic tasks that would otherwise not be possible within the confines of a conventional laboratory. Mental health, cognitive interventions, and the present challenges to investigating the brain during treatment are discussed, as well as how the ecological use of fNIRS might be helpful in bridging the explanatory gaps to understanding the cultivation of mental health.


2020 ◽  
Vol 5 (01) ◽  
pp. 45-49
Author(s):  
Ankit Kumar ◽  
Amit Tomar

The results revealed that parents namely, TSK-10, TSK-27, New Blue-II, Kurara and TSK-109 were found highly genetic diverse for days to 50% tasseling, days to 50% silking, days to 755 dry husk. The parents namely, TSK-109, Kurara, New Blue-II and TSK-10 were found highly genetic diverse for plant height (cm), cob height, number of cobs per plant and number of grains per cob. The parents namely, Kurara, TSK-109, TSK-10, New Blue-II and TSK-27 were found highly genetic diverse for shelling percentage, grain yield per plant, grain yield per cob and 100-grain weight.


2019 ◽  
Vol 97 (7) ◽  
pp. 2769-2779 ◽  
Author(s):  
Michelle M Judge ◽  
Thierry Pabiou ◽  
Jessica Murphy ◽  
Stephen B Conroy ◽  
P J Hegarty ◽  
...  

Abstract The ability to alter the morphology of cattle towards greater yields of higher value primal cuts has the potential to increase the value of animals at slaughter. Using weight records of 14 primal cuts from 31,827 cattle, the objective of the present study was to quantify the extent of genetic variability in these primal cuts; also of interest was the degree of genetic variability in the primal cuts adjusted to a common carcass weight. Variance components were estimated for each primal cut using animal linear mixed models. The coefficient of genetic variation in the different primal cuts ranged from 0.05 (bavette) to 0.10 (eye of round) with a mean coefficient of genetic variation of 0.07. When phenotypically adjusted to a common carcass weight, the coefficient of genetic variation of the primal cuts was lesser ranging from 0.02 to 0.07 with a mean of 0.04. The heritability of the 14 primal cuts ranged from 0.14 (bavette) to 0.75 (topside) with a mean heritability across all cuts of 0.48; the heritability estimates reduced, and ranged from 0.12 (bavette) to 0.56 (topside), when differences in carcass weight were accounted for in the statistical model. Genetic correlations between each primal cut and carcass weight were all ≥0.77; genetic correlations between each primal cut and carcass conformation score were, on average, 0.59 but when adjusted to a common carcass weight, the correlations weakened to, on average, 0.27. The genetic correlations among all 14 primal cut weights was, on average, strong (mean correlation of 0.72 with all correlations being ≥0.37); when adjusted to a common carcass weight, the mean of the genetic correlations among all primal cuts was 0.10. The ability of estimated breeding values for a selection of primal cuts to stratify animals phenotypically on the respective cut weight was demonstrated; the weight of the rump, striploin, and fillet of animals estimated to be in the top 25% genetically for the respective cut, were 10 to 24%, 12 to 24%, and 7 to 17% heavier than the weight of cuts from animals predicted to be in the worst 25% genetically for that cut. Significant exploitable genetic variability in primal carcass cuts was clearly evident even when adjusted to a common carcass weight. The high heritability of many of the primal cuts infers that large datasets are not actually required to achieve high accuracy of selection once the structure of the data and the number of progeny per sire is adequate.


2019 ◽  
Vol 81 (2) ◽  
pp. 87-104
Author(s):  
Sabrin Sultana ◽  
Firoz Mahmud ◽  
Md Abdur Rahim

Sesame (Sesamum indicum L.) is one of the oldest oilseed crops and important for high nutritional quality as well as medicinal value. Fifty diverse sesame genotypes were evaluated to study genetic variability. The results revealed that the genotypes were a significant variation in most of the studied characters. In all cases, the phenotypic variances were much higher than genotypic variances suggests a higher level of the environmental effect on the expression of these characters. The highest genotypic coefficient of variations (GCV) was observed in seed yield per plant while the highest heritability was exhibited by hundred seed weight followed by days to 80% maturity, pods per plant, number of branches per plant and seed yield per plant. The genotypic correlation with seed yield per plant showed a significantly strong positive with days to 50% flowering, plant height and number of pods per plant at both the genotypic and phenotypic level. The path coefficient analysis showed that pods per plant and seeds per pod were the most important contributing traits to seed yield. The 50 sesame genotypes were grouped into five clusters. The highest inter-cluster distance was observed between the cluster III and V while the lowest inter-cluster distance was observed between the cluster III and IV. Among 50 sesame genotypes G7, G36, G38 and G46 might be suggested for future hybridization program for the improvement of sesame yield.


1975 ◽  
Vol 12 (S1) ◽  
pp. 9-16
Author(s):  
W. G. Cochran

A selection of Bartlett's work as an operating statistician in his first position as statistician 1934–38 at the I.C.I. agricultural research station at Jealott's Hill, Berks., is described. This illustrates some of the methods he used for the efficient detection of treatment effects and for an appraisal of the suitability of the experimental designs that were being used.


Author(s):  
M. Samuel Jeberson ◽  
K. S. Shashidhar ◽  
Amit Kumar Singh

Analysis of genetic variability, heritability, correlation, path analysis, principal component and cluster analysis was carried for 25 blackgram genotypes grown in the foothills of Manipur. The results showed that phenotypic coefficients of variability recorded were higher than the genotypic coefficients of variability, irrespective of traits, demonstrating the effect of environment thereon. The present study revealed that the heritability (bs) estimates were maximum (>50%) for the traits such as days taken to attain the 50% flowering, number of clusters/plant, number of pods/plant and 100 seed weight. The correlation and path analysis proved the selection of the yield attributes in blackgram based on the characters, viz., number of pods/plant and number of cluster/plants. The first three principal components, having the Eigen values more than 1, contributed 84.52% towards variability among the 25 genotypes screened for quantitative traits. Based on the average linkage, 25 genotypes were grouped into five (5) clusters.


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