Potential therapeutic applications of the gut microbiome in obesity: from brain function to body detoxification

2020 ◽  
Vol 44 (9) ◽  
pp. 1818-1831 ◽  
Author(s):  
Béatrice S.-Y. Choi ◽  
Laurence Daoust ◽  
Geneviève Pilon ◽  
André Marette ◽  
Angelo Tremblay
2019 ◽  
Vol 5 (2) ◽  
pp. eaau8317 ◽  
Author(s):  
Peng Zheng ◽  
Benhua Zeng ◽  
Meiling Liu ◽  
Jianjun Chen ◽  
Junxi Pan ◽  
...  

Schizophrenia (SCZ) is a devastating mental disorder with poorly defined underlying molecular mechanisms. The gut microbiome can modulate brain function and behaviors through the microbiota-gut-brain axis. Here, we found that unmedicated and medicated patients with SCZ had a decreased microbiome α-diversity index and marked disturbances of gut microbial composition versus healthy controls (HCs). Several unique bacterial taxa (e.g., Veillonellaceae and Lachnospiraceae) were associated with SCZ severity. A specific microbial panel (Aerococcaceae, Bifidobacteriaceae, Brucellaceae, Pasteurellaceae, and Rikenellaceae) enabled discriminating patients with SCZ from HCs with 0.769 area under the curve. Compared to HCs, germ-free mice receiving SCZ microbiome fecal transplants had lower glutamate and higher glutamine and GABA in the hippocampus and displayed SCZ-relevant behaviors similar to other mouse models of SCZ involving glutamatergic hypofunction. Together, our findings suggest that the SCZ microbiome itself can alter neurochemistry and neurologic function in ways that may be relevant to SCZ pathology.


2021 ◽  
Author(s):  
Basista Rabina Sharma ◽  
Ravindra P. Veeranna

Research so far indicates that gut microbiome and diet interactions influence obesity, diabetes, host immunity, and brain function. The ability of athletes to perform to optimum for a more extended time, as well as the ability to resist, withstand, recover from, and have immunity to fatigue, injury depends on the genetic factor, age, sex, training history, psychological factors, mode, intensity and frequency of training and their interactions with the external dietary components. However, recent evidence indicates that the gut microbiome may also potentially influence the development of endurance in response to the type and composition of the external diet, including several food supplements. Thus, the gut microbiome has become another target in the athlete’s pursuit of optimal performance. This chapter discusses the effect of exercise on the gut microbiome, the interplay between dietary components and supplements on the gut microbiome, and its impact on endurance performance.


2018 ◽  
Vol 76 (7) ◽  
pp. 481-496 ◽  
Author(s):  
M Hasan Mohajeri ◽  
Giorgio La Fata ◽  
Robert E Steinert ◽  
Peter Weber

2019 ◽  
Vol 10 (2) ◽  
pp. 514-528 ◽  
Author(s):  
César G. Fraga ◽  
Kevin D. Croft ◽  
David O. Kennedy ◽  
Francisco A. Tomás-Barberán

Consuming polyphenols is associated with benefits to cardiometabolic health and brain function, which are driven by their complex interrelationship with the gut microbiome, their bioactive metabolites, and other phytochemicals.


Genes ◽  
2018 ◽  
Vol 9 (7) ◽  
pp. 351 ◽  
Author(s):  
Hui Lee ◽  
Haosheng Shen ◽  
In Hwang ◽  
Hua Ling ◽  
Wen Yew ◽  
...  

Microbial communities and their collective genomes form the gut microbiome, of which bacteria are the major contributor. Through their secreted metabolites, bacteria interact with the host, influencing human health and physiology. Perturbation of the microbiota and metabolome has been associated with various diseases and metabolic conditions. As knowledge on fundamental host-microbiome interactions and genetic engineering tools becomes readily available, targeted manipulation of the gut microbiome for therapeutic applications gains favourable attention. Manipulation of the gut microbiome can be achieved by altering the microbiota population and composition, or by modifying the functional metabolic activity of the microbiome to promote health and restore the microbiome balance. In this article, we review current works that demonstrate various strategies employed to manipulate the gut microbiome in situ to various degrees of precision.


2020 ◽  
Vol 29 (11) ◽  
pp. 1463-1474
Author(s):  
Bryna Rackerby ◽  
Hyun Jung Kim ◽  
David C. Dallas ◽  
Si Hong Park

AbstractThe gut microbiome is the complex microbial ecosystem found in the gastrointestinal tract of humans and animals. It plays a vital role in host development, physiology and metabolism, and has been implicated as a factor in brain function, behavior, mental health, and many disease states. While many factors, including host genetics and environmental factors, contribute to the composition of the gut microbiome, diet plays a large role. Microorganisms differ in their nutrient requirements, and alterations in host dietary composition can have strong impacts on the microbial inhabitants of the gastrointestinal tract. The health implications of these dietary and microbial changes are relevant as various global populations consume diets comprised of different macronutrient ratios, and many diets promote alterations to recommended macronutrient ratios to promote health. This review will outline the ways in which specific macro- and micronutrients impact the gut microbiome and host health.


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