Clinical implications of exosome-derived noncoding RNAs in liver

2022 ◽  
Author(s):  
Zhe Wen Zhou ◽  
Wei Zheng ◽  
Zheng Xiang ◽  
Cun Si Ye ◽  
Qiao Qiao Yin ◽  
...  
Keyword(s):  
Noncoding Rnas ◽  
Clinical Implications

scholarly journals New Insights Into the Regulatory Roles of Extracellular Vesicles in Tumor Angiogenesis and Their Clinical Implications

2021 ◽  
Vol 9 ◽  
Author(s):  
Maohua Huang ◽  
Yuhe Lei ◽  
Yinqin Zhong ◽  
Chiwing Chung ◽  
Mei Wang ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Tumor Progression ◽  
Cancer Patients ◽  
Extracellular Vesicles ◽  
Tumor Angiogenesis ◽  
Growth And Development ◽  
Noncoding Rnas ◽  
Clinical Implications ◽  
Biological Processes ◽  
Bodily Fluids

Angiogenesis is required for tumor growth and development. Extracellular vesicles (EVs) are important signaling entities that mediate communication between diverse types of cells and regulate various cell biological processes, including angiogenesis. Recently, emerging evidence has suggested that tumor-derived EVs play essential roles in tumor progression by regulating angiogenesis. Thousands of molecules are carried by EVs, and the two major types of biomolecules, noncoding RNAs (ncRNAs) and proteins, are transported between cells and regulate physiological and pathological functions in recipient cells. Understanding the regulation of EVs and their cargoes in tumor angiogenesis has become increasingly important. In this review, we summarize the effects of tumor-derived EVs and their cargoes, especially ncRNAs and proteins, on tumor angiogenesis and their mechanisms, and we highlight the clinical implications of EVs in bodily fluids as biomarkers and as diagnostic, prognostic, and therapeutic targets in cancer patients.

scholarly journals Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Ju-Ha Kim ◽  
Jisung Hwang ◽  
Ji Hoon Jung ◽  
Hyo-Jung Lee ◽  
Dae Young Lee ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Cancer Progression ◽  
Noncoding Rnas ◽  
Treg Cells ◽  
Molecular Networks ◽  
Cellular Immunotherapy ◽  
Clinical Implications ◽  
Immune Disorders ◽  
Dual Roles ◽  
Forkhead Box

AbstractThough Forkhead box P (FOXP) transcription factors comprising of FOXP1, FOXP2, FOXP3 and FOXP4 are involved in the embryonic development, immune disorders and cancer progression, the underlying function of FOXP3 targeting CD4 + CD25+ regulatory T (Treg) cells and the dual roles of FOXP proteins as an oncogene or a tumor suppressor are unclear and controversial in cancers to date. Thus, the present review highlighted research history, dual roles of FOXP proteins as a tumor suppressor or an oncogene, their molecular networks with other proteins and noncoding RNAs, cellular immunotherapy targeting FOXP3, and clinical implications in cancer progression.

scholarly journals Noncoding RNAs and immune checkpoints-clinical implications as cancer therapeutics

FEBS Journal ◽  
2017 ◽  
Vol 284 (13) ◽  
pp. 1952-1966 ◽  
Author(s):  
Maria A. Smolle ◽  
Horatiu N. Calin ◽  
Martin Pichler ◽  
George A. Calin
Keyword(s):  
Noncoding Rnas ◽  
Cancer Therapeutics ◽  
Immune Checkpoints ◽  
Clinical Implications

scholarly journals A Systematic Review of Long Noncoding RNAs in Hepatocellular Carcinoma: Molecular Mechanism and Clinical Implications

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Xiaoge Hu ◽  
Jiahong Jiang ◽  
Qiuran Xu ◽  
Chao Ni ◽  
Liu Yang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Systematic Review ◽  
Mortality Rate ◽  
Molecular Mechanisms ◽  
Potential Role ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Clinical Implications ◽  
Current Review ◽  
Complex Process

Hepatocellular carcinoma (HCC) has the second highest mortality rate worldwide among all cancers. Previous studies have revealed the significant involvement of long noncoding RNAs (lncRNAs) in numerous human cancers including HCC. Both oncogenic and tumor repressive lncRNAs have been identified and implicated in the complex process of hepatocarcinogenesis. They can be further explored as prospective diagnostic, prognostic, and therapeutic markers for HCC. An in-depth understanding of lncRNAs’ mechanism in HCC is therefore required to fully explore their potential role. In the current review, we will concentrate on the underlying function, molecular mechanisms, and potential clinical implications of lncRNA in HCC.

Effects of Selected Rhinologic Disorders on the Perception of Nasal Resonance in Children

1984 ◽  
Vol 15 (1) ◽  
pp. 44-50 ◽  
Author(s):  
Michael P. Rastatter ◽  
Melvin Hyman
Keyword(s):  
Allergic Rhinitis ◽  
Clinical Implications ◽  
Normal Children ◽  
Nasal Resonance

A group of sophisticated listeners judged the nasal resonance characteristics of normal children versus children evidencing selected rhinologic disorders under three speaking conditions. Results showed that perceptions of denasality are influenced by both speakers and speaking tasks. That is, children with allergic rhinitis and edemic adenoids were perceived as being denasal when they produced VCV utterances and recited sentences. However, their resonance characteristics were deemed normal for vowel productions. Interestingly, children with severely deviated septums were judged to have normal nasal resonance under all speaking conditions. Clinical implications are discussed.

Sign in / Sign up

Export Citation Format

Share Document