Comparison of decayed, missing, filled teeth index between thalassemia major patients and control group in Iran: a systematic review and meta-analysis

Abstract Introduction Scientific evidence of the association between Decayed, Missing, and Filled Teeth (DMFT) and thalassemia are conflicting and difficult to establish conclusions. Therefore, this study aimed to determine the relationship between dental caries (using the DMFT index) and thalassemia major using meta-analysis. Methods Databases were searched using such keywords as “Thalassemia,” “Caries,” “decay,” “DMFT,” “Iran,” and OR operators, AND, and NOT. After the elimination of duplicate documentation, the articles which met the inclusion criteria were selected. Quality assessment was performed based on the Newcastle-Ottawa Quality Checklist. Thereafter, the standardized mean difference of the DMFT index was estimated. Results In eight studies, the mean DMFT was compared between patients with thalassemia major and the control group. In six studies, the mean of this index was higher in patients with thalassemia major than in the control group and in all six of the studies, the differences were statistically significant. The mean standardized difference of DMFT, D, M, and F were reported as 1.36 (0.41, 2.30), 2.63 (0.42, 4.84), 1.65 (−0.14, 3.45), and 0.02 (−1.67, 1.72), respectively. Conclusion The results of this meta-analysis indicated that DMFT index was more inappropriate in patients with thalassemia, as compared to the control group which represents the higher incidence of dental caries among patients with thalassemia compared to the control group.

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Comparison of dental caries (DMFT and DMFS indices) between asthmatic patients and control group in Iran: a meta-analysis

Asthma Research and Practice ◽

10.1186/s40733-021-00068-y ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Nadia Elyassi Gorji ◽

Pegah Nasiri ◽

Ali Malekzadeh Shafaroudi ◽

Mahmood Moosazadeh

Keyword(s):

Dental Caries ◽

Meta Analysis ◽

Control Group ◽

Asthmatic Patients ◽

Health Indices ◽

Analysis Process ◽

Combining Data ◽

And Control ◽

The Relationship ◽

Quality Checklist

Abstract Background The association between caries index, which is diagnosed by Decayed, Missing, and Filled Teeth (DMFT), and asthma has been assessed in several studies, which yielded contradictory results. Meta-analysis is the statistical procedure for combining data from multiple studies and reducing the differences among parameters due to the increased number of studies involved in the analysis process. Therefore, the present study aimed to determine the relationship between dental caries using decayed, missing, filled teeth indices (DMFT, dmft, and DMFS indices) and asthma using meta-analysis. Methods Databases were searched using such keywords as “Asthma,” “Caries,” “DMFT,” “DMFS,” “Iran,” and OR operators, AND, and NOT. After the elimination of duplicate documentation, the articles which met the inclusion criteria were selected. Quality assessment was performed based on the Newcastle-Ottawa Quality Checklist (NOS). After that, standardized mean difference (SMD) of DMFT, dmft, and Decayed, Missing, and Filled Surfaces (DMFS) indices were estimated. Results The number of 10 evidence was extracted out of nine studies in which mean oral health indices were compared between asthmatic patients and the control group. Out of 10 evidences that examined the association of DMFT, dmft, and DMFS with asthma, these indices were higher in asthmatic patients than the control group in seven cases. In three cases, these differences were statistically significant. The SMD of DMFT, dmft, and DMFS indices between asthmatic patients and the control group at the confidence level of 95% were reported as 0.29 (− 0.05, 0.62), 0.48 (− 0.20, 1.17), and − 0.05(− 0.30, 0.21), respectively. Conclusion According to the results, the prevalence of dental caries is higher among patients with asthma than in the control group. Therefore, having asthma could be considered a risk factor for the development of dental caries.

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Relationship Between Salivary Nitric Oxide Concentration and Dental Caries in Children: A Systematic Review and Meta-Analysis

Iranian Journal of Pediatrics ◽

10.5812/ijp.107050 ◽

2020 ◽

Vol In Press (In Press) ◽

Author(s):

Nadia Elyassi ◽

Ali Malekzadeh Shafaroudi ◽

Pegah Nasiri ◽

Mahmood Moosazadeh ◽

Azam Nahvi

Keyword(s):

Nitric Oxide ◽

Nitrous Oxide ◽

Dental Caries ◽

Meta Analysis ◽

Control Group ◽

Analysis Study ◽

Oxide Concentration ◽

The Mean ◽

The Relationship ◽

Nitrous Oxide Concentration

Context: Conflicting results have been reported in the literature concerning the relationship between salivary nitrous oxide concentration and dental caries in children. Metaanalysis studies aim to combine different studies and reduce the difference between the parameters by increasing the number of studies involved in the analysis process. Objectives: Accordingly, this meta-analysis study aimed at determining the relationship between salivary nitrous oxide concentration and dental caries in children. Methods: Databases were searched using the keywords “nitric oxide”, “salivary”, “Caries”, “DMFT Index”, “children”, “early childhood caries” and OR, AND and NOT operators. Quality assessment was then performed based on the Newcastle-Ottawa scale (NOS) checklist. The standardized mean difference (SMD) of DMFT, dmft, and salivary nitric oxide (NO) concentration was estimated. Results: Seven studies made a comparison between the mean salivary NO concentration in children with dental caries and that in the control group. In four studies, the mean salivary NO concentration in children with dental caries was lower, as compared to that in the control group. This difference was significant in all four studies. Also, the mean standardized difference of the salivary NO index was also estimated to be -0.11 (CI 95%: -1.77, 1.55). Conclusions: This meta-analysis study demonstrated that salivary NO concentration was not significantly related to dental caries. Moreover, since salivary NO concentration is affected by various factors, it is not sufficient to determine the likelihood of the incidence of caries.

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Comparison of Dental Caries Prevalence in Patients with Cleft Lip and/or Palate and Their Sibling Controls

The Cleft Palate-Craniofacial Journal ◽

10.1597/08-003.1 ◽

2009 ◽

Vol 46 (5) ◽

pp. 529-531 ◽

Cited By ~ 22

Author(s):

Mahmoud Al-Dajani

Keyword(s):

Dental Caries ◽

Cleft Lip ◽

Cleft Lip And Palate ◽

Maxillofacial Surgery ◽

Permanent Teeth ◽

Control Group ◽

Oral And Maxillofacial Surgery ◽

Caries Prevalence ◽

Dmft Index ◽

And Control

Objective: To evaluate the prevalence of dental caries in patients with cleft lip and/or palate and their cleft-free sibling controls. Methods: The two subject groups (patient and control) comprised 106 participants. The former group consisted of 53 patients with cleft lip and/or palate, aged 12 to 29 years, who visited the Oral and Maxillofacial Surgery Hospital at Damascus University of Syria. The control group consisted of the patients’ siblings who had no clefts, and they were sex matched to the patient group. Dental caries were examined clinically and were reported using the decayed, missing, and filled permanent teeth (DMFT) index. The DMFT scores were compared between the two groups. Results: The author found an overall association of dental caries with the presence of cleft lip and/or palate (odds ratio = 2.52; 95% confidence interval = 1.389–4.574; p < .05). The DMFT index scores were proportionally higher in patients with cleft lip and/or palate compared with the control group (p < .001). Conclusion: Subjects with cleft lip and palate are susceptible to dental caries independently of socioeconomic status.

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Right ventricular free-wall longitudinal speckle tracking strain as a prognostic criterion of adverse outcomes in patients with pulmonary hypertension: a systematic review and meta-analysis

Russian Journal of Cardiology ◽

10.15829/1560-4071-2021-4417 ◽

2021 ◽

Vol 26 (4) ◽

pp. 4417

Author(s):

E. Z. Golukhova ◽

I. V. Slivneva ◽

M. L. Mamalyga ◽

D. I. Marapov ◽

M. N. Alekhin ◽

...

Keyword(s):

Right Ventricular ◽

Predictive Value ◽

Speckle Tracking ◽

Meta Analysis ◽

Composite Endpoint ◽

Adverse Outcomes ◽

Control Group ◽

Right Ventricular Free Wall ◽

The Mean ◽

And Control

The absence of consensus regarding the reference values of right ventricular free wall longitudinal strain (RVFWLS) and its predictive value prompted us to conduct a systematic review and meta-analysis of publications on the predictive role of this parameter in patients with pulmonary hypertension (PH).Aim. To study the independent predictive value of RVFWLS in PH patients using 2D/3D speckle tracking echocardiography.Material and methods. Firstly, 317 publications (PubMed) and 857 Google Scholar results were selected. Of the initially identified search results, 12 articles were analyzed. The papers were cohort designed.Results. The total number of patients with PH was 1281. The mean age of patients was 54,7±6,8 years. Four studies compared the RVFWLS with a control group (n=251). The mean RVFWLS were -17,0±2,4% and -24,7±2,2% in the experimental and control groups, respectively. A meta-analysis of the difference between the mean RVFWLS values in experimental and control group patients showed its total increase in PH subjects of 8,06% (95% CI: 5,18-10,94%; p<0,00001).The total number of deaths was 268 (all-cause — 180, composite endpoint — 88). According to the meta-analysis, with an increase of 1% in RVFWLS, there is an increase in mean all-cause mortality risk by 14% (p<0,00001), as well as mean risk of adverse outcomes or PH-related events (composite endpoint) by 14% (p<0,0001).Conclusion. These results highlight the high independent predictive value of RVFWLS as a predictor of adverse outcomes or events associated with a right ventricular dysfunction progression in PH patients.

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The Relationship Between Intraabdominal Hypertension and Preeclampsia

Gynecology Obstetrics and Reproductive Medicine ◽

10.21613/gorm.2016.628 ◽

2016 ◽

pp. 5

Author(s):

Mesut A. Ünsal ◽

Ülkü İnce ◽

Sevil Cengiz ◽

S. Caner Karahan ◽

Turhan Aran

Keyword(s):

Statistical Significance ◽

Intraabdominal Pressure ◽

Control Group ◽

Abdominal Pressure ◽

Study Group ◽

Abdominal Hypertension ◽

Intraabdominal Hypertension ◽

The Mean ◽

And Control ◽

The Relationship

OBJECTIVE: We aimed to measure abdominal pressure and placental levels of malondialdehyde in patients with preeclampsia and investigate the relationship between intraabdominal pressure and clinical features of preeclampsia. STUDY DESIGN: Study was conducted at a tertiary referral clinic. Study group consisted of patients with preeclampsia and control group consisted of normotensive pregnant women. Both placental malondialdehyde and intraabdominal pressure levels were studied in all patients. Intraabdominal pressure was assessed indirectly via a Foley bladder catheter both antepartum and postpartum period. Statistical comparisons among groups were made using the Mann-Whitney U test, independent T test and Chi-square test. Statistical significance was set as p<0.05. RESULTS: Study and control group consisted of 35 pregnant patients. The mean patients’ age, gravidity, parity, weight and BMI were not different between study and control groups. In the study group, Caesarean, preterm delivery and abdominal hypertension rate were significantly higher whereas the mean neonatal birth weight was lower. The mean antepartum and postpartum intraabdominal pressure levels were significantly higher in study group. The mean intraabdominal pressure was highest in patients with oliguria (19.8±1.8 cmH2O). Abdominal hypertension was detected in 30 (86%) patients in study group and in 3 (9%) patients in control group. The mean placental malondialdehyde level was significantly higher in patients with intraabdominal hypertension. CONCLUSION: Abdominal hypertension rate is very high in patients with preeclampsia. Abdominal hypertension may have an additional role in preeclampsia.

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Ambulatory Blood Pressure Monitoring (ABPM) in Children with Thalassemia Major (TM).

Blood ◽

10.1182/blood.v106.11.3839.3839 ◽

2005 ◽

Vol 106 (11) ◽

pp. 3839-3839

Author(s):

Baris Kuskonmaz ◽

Sule Unal ◽

Ali Duzova ◽

Yelda Yilmaz Bilginer ◽

Aysin Bakkaloglu ◽

...

Keyword(s):

Blood Pressure ◽

Renal Dysfunction ◽

Blood Pressure Monitoring ◽

Thalassemia Major ◽

Control Group ◽

Healthy Children ◽

Biochemical Tests ◽

Long Term Follow Up ◽

The Mean ◽

And Control

Abstract In TM chronic anemia, blood transfusions and iron over load result in impairments in many organs. Little is known about the changes in blood pressure (BP) patterns of children with TM. To evaluate ABPM changes and associated laboratory and clinical features in children with TM. ABPM was performed in 20 TM patients with no cardiac or renal dysfunction (12M, 8F; 11.3+/−3.8 years), and 20 healthy children (11M, 9F; 11.6+/−2.4 years). Blood and timed urine samples were collected for hematological and biochemical tests. [Dipping: a fall in the mean systolic (diastolic) BP during nighttime of more than 10% of the mean daytime systolic (diastolic) BP]. Mean daytime (8AM–8PM) and nighttime (midnight to 6AM) systolic (SBP) and diastolic (DBP) blood pressures were comparable. No patient in TM and control group had mean 24-h, day time, nighttime SBP or DBP above 90th percentile. SBP and DBP- loads were always less than 20% in control group. In TM group: SBP-load was more than 20% in 1, and 1 patient during daytime and nighttime, respectively; and DBP- load was more than 20% in 1, and 2 patients during daytime and nighttime, respectively. The percentage of systolic (60% vs 35%; p:0.102) and diastolic (30% vs 20%; p:0.118) non-dippers among TM patients were higher, compared to control group. In TM group: the percentage of systolic (80% vs 40%; p:0.063) and diastolic (50% vs 10%; p:0.044) non-dippers among older (12–16 years) patients were higher, compared to younger (5–11 years) patients. There was no association between non-dipping pattern and hemoglobin, ferritin or albuminuria level. Our preliminary results suggest that BP anomalies in TM occur before the development of cardiac or renal dysfunction. There is an association between non-dipping and the age of the patient. Long-term follow-up will make clear whether abnormalities in ABPM patterns have a predictive value in the development of renal and cardiac dysfunction in TM patients.

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Association of fibroblast growth factor 23 and α-klotho in hemodialysis patients during administration of ferric citrate hydrate: post hoc analysis of ASTRIO study

BMC Nephrology ◽

10.1186/s12882-021-02575-9 ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Kyoko Ito ◽

Keitaro Yokoyama ◽

Masaaki Nakayama ◽

Masafumi Fukagawa ◽

Hideki Hirakata

Keyword(s):

Phosphate Binder ◽

Fibroblast Growth Factor 23 ◽

Control Group ◽

Control Groups ◽

Post Hoc Analysis ◽

The Mean ◽

Iron Based ◽

Post Hoc ◽

And Control ◽

The Relationship

Abstract Background Fibroblast growth factor-23 (FGF23) and α-klotho are associated with anemia in patients with chronic kidney disease. In this post hoc analysis of the ASTRIO study (UMIN000019176), we investigated the relationship between FGF23 and α-klotho during treatment with an iron-based phosphate binder, ferric citrate hydrate (FC), compared with non-iron-based phosphate binders in hemodialysis (HD) patients. We examined the effect of iron absorption by FC on the relationship between FGF23 and α-klotho. There have been few clinical studies evaluating these biomarkers simultaneously in HD patients. Methods The ASTRIO study was a 24-week, randomized, open-label, multicenter trial. HD patients taking non-iron-based phosphate binder(s) were randomized at a 1:1 ratio to continue other binder(s) (control group) or switch to FC (FC group). Serum phosphate (P) and hemoglobin (Hb) were maintained within 3.5–6.0 mg/dL and 10–12 g/dL, respectively. Plasma levels of intact FGF23 (i-FGF23), C-terminal FGF23 (c-FGF23), and α-klotho were measured, as were iron-related parameters. Association analyses of FGF23 and α-klotho were conducted. Results Patients were randomized to FC (n = 48) and control (n = 45) groups. Serum ferritin significantly increased from baseline to end-of-treatment (EOT) in the FC group, compared with the control group (adjusted mean difference [95% confidence interval]: 79.5 [44.7, 114.4] ng/mL; p < 0.001). The mean change from baseline to EOT in c-FGF23 was significantly different between the FC and control groups (mean ± standard deviation (SD): − 0.2 ± 0.8 loge pg/mL vs. 0.2 ± 0.8 loge pg/mL, respectively; p = 0.04). The mean change from baseline to EOT in i-FGF23 and α-klotho were not significantly different between the FC and control groups (mean ± SD: − 0.1 ± 0.8 loge pg/mL vs. 0.1 ± 0.9 loge pg/mL; p = 0.33, and 2.0 ± 91.5 pg/mL vs. − 8.9 ± 145.3; p = 0.58, respectively). However, both forms of FGF23 and α-klotho were not significantly associated with each other in both groups. Conclusions Iron absorbed via FC administration in HD patients did not influence the correlation relationship between plasma levels of FGF23 and α-klotho under the condition of serum P and Hb were maintained. Trial registration ASTRIO study (UMIN000019176, registered at UMIN Clinical Trials Registry on October 1, 2015).

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FIBRINOGEN DAN TRANSCRANIAL DOPPLER DI STROK ISKEMIK AKUT

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY ◽

10.24293/ijcpml.v21i3.741 ◽

2016 ◽

Vol 21 (3) ◽

pp. 280

Author(s):

Hafizah Soraya Dalimunthe ◽

Adi Koesoema Aman ◽

Yuneldi Anwar

Keyword(s):

Ischemic Stroke ◽

Transcranial Doppler ◽

Pearson Correlation ◽

Control Group ◽

Mean Velocity ◽

Diastolic Velocity ◽

Stroke Group ◽

The Mean ◽

And Control ◽

The Relationship

Elevated fibrinogen levels is related to the blood hyperviscosity, that causes low blood velocity. Non-contrast-enhanced transcranial Doppler (TCD) is used to evaluate blood flow from the cerebrovascular system. To know the relationship between fibrinogen levels and examination of TCD in acute ischemic stroke through evaluation. A cross sectional study was admitted from July 2012-Juny 2013. The researchers determined the differences between fibrinogen and TCD in the stroke group and control. The researchers examined the relationship between fibrinogen and TCD examination in the stroke group. The fibrinogenwas measured with Clauss method. The TCD was examined due to middle of the cerebral artery (MCA) and the Internal Carotid one Artery (ICA). The patients were diagnosed as ischemic stroke from head CT-scan. Statistical analyses employed the Independent T test, Anova test and Pearson correlation. The researchers had 24 patients and 24 controls that the Fibrinogen levels in stroke group is 549.16±104.84 mg/mL and in the control group is 385.64±16.80 mg/mL. The researchers examined MCA in the stroke as well as the control and found the mean velocity 43.12±21.03and 56.97±6.22 (p=0.05), the peak velocity 74.17±32.58 and 94.55±14.11 (p=0.05) end diastolic velocity 23.27±12.66 and 35.30±7.34 (p=0.00). In ICA, the stroke group and control and found the mean velocity 31.40±8.86 and 43.07±8.06 (p=0.00), thepeak velocity 54.99±11.50 and 75.04±16.04 (p=0.00) end diastolic velocity 18.23±7.67 and 25.64±5.24 (p=0.00). The correlation between fibrinogen and TCD in the stroke group was not significant on MCA and ICA, P>0.05. It can be concluded that the differences between fibrinogen levels and TCD in the stroke group and control are significant. But there is no correlation between the fibrinogen and TCD in the stroke group.

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Religious Personality and Smoking among Form Two Students in Rural Schools in Malacca, Malaysia

IIUM Medical Journal Malaysia ◽

10.31436/imjm.v11i2.530 ◽

2020 ◽

Vol 11 (2) ◽

Author(s):

Nor Afiah MZ ◽

Rahmah MA ◽

Salmiah MS ◽

Fazilah I ◽

Shamsul Azhar S

Keyword(s):

Rural Schools ◽

Control Group ◽

Cluster Sampling ◽

The Family ◽

The Mean ◽

And Control ◽

The Relationship ◽

Religious Personality ◽

Control Study ◽

Holy Book

Introduction: There is an increasing trend in smoking among rural adolescents compared to urban adolescents in Malaysia. This study was to determine the relationship between religious personality and smoking among form two students from the rural schools in Malacca. Methods: This was an unmatched case-control study conducted from May 2010 to August 2010 among form two school children from rural area in Malacca. There were 484 cases, and 444 controls selected using randomized cluster sampling. The dependent variable was smoking, and the independent factors were religious personality. Validated and reliability-tested questionnaires were used for data collection. Results: The mean age (year) at which smoking was first tried among the cases was 11.39 + 2.107. There were eleven out of twenty three significant differences between religious personality statements in the cases and control group. Those were: reciting the Quran/Holy book/Scriptures even when busy, making efforts to deepen the understanding of the religion, trying to understand the teachings of the religion in the Holy book/Quran, inviting others to perform solat/prayer/religious service, making sure all the family members are following the teachings according to the religion, referring to the learned people when feeling uncertain about the rulings/teachings of the religion, performing work duties enthusiastically because of the religion/God, making efforts to remember death and afterlife often, making efforts to internalize the ethical conduct of the religion in daily life, setting aside money every year for religious purposes and looking for opportunities to give charity. Conclusion: Religious personality is an important factor which may influence adolescents volved in smoking.

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The Effect of Lavender (Lavandula stoechas L.) on Reducing Labor Pain: A Systematic Review and Meta-Analysis

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2020/4384350 ◽

2020 ◽

Vol 2020 ◽

pp. 1-11

Author(s):

Mohsen Kazeminia ◽

Alireza Abdi ◽

Aliakbar Vaisi-Raygani ◽

Rostam Jalali ◽

Shamarina Shohaimi ◽

...

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Intervention Group ◽

Labor Pain ◽

Cochrane Library ◽

Control Group ◽

Policy Makers ◽

Lavandula Stoechas ◽

The Mean ◽

And Control

Background. Labor pain is one of the most severe pains, which most of women experience. By using novel supportive methods, the labor pain can be reduced, which makes this event pleasant and delightful. Several original studies have been conducted in regard to the effect of lavender on reducing labor pain, whose results are controversial. One of the applications of meta-analysis studies is to respond to these hypotheses and remove controversies; therefore, this study aimed to determine the effect of lavender on labor pain in Iran by using meta-analysis. Methods. In this study, to find published articles electronically from 2006 to 2019, the published articles in national and international databases of SID, MagIran, IranMedex, IranDoc, Google Scholar, Cochrane Library, Embase, ScienceDirect, Scopus, PubMed, and Web of Science (ISI) were used. Heterogenic index between studies was determined by Cochrane test (Q)c and I2. Due to heterogeneity, the random effects model was used to estimate standardize difference of the mean score of lavender test in order to assess the labor pain between intervention and control group. Results. In this meta-analysis and systematic review, finally 13 eligible articles met the inclusion criteria of the study. The sample size from original studies enrolled in the meta-analysis entered in the intervention group was 794 individuals and in the control group was 795 individuals. Mean score for pain in the control group was 7.2 ± 0.42 and in the intervention group was 5.4 ± 0.58 and this difference was statistically significant p ≤ 0.001 . Conclusion. The results of this study showed that lavender can reduce labor pain, which can be considered by health policy makers and gynecologists.

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