scholarly journals Relationship Between Salivary Nitric Oxide Concentration and Dental Caries in Children: A Systematic Review and Meta-Analysis

2020 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Nadia Elyassi ◽  
Ali Malekzadeh Shafaroudi ◽  
Pegah Nasiri ◽  
Mahmood Moosazadeh ◽  
Azam Nahvi
Keyword(s):  
Nitric Oxide ◽  
Nitrous Oxide ◽  
Dental Caries ◽  
Meta Analysis ◽  
Control Group ◽  
Analysis Study ◽  
Oxide Concentration ◽  
The Mean ◽  
The Relationship ◽  
Nitrous Oxide Concentration

Context: Conflicting results have been reported in the literature concerning the relationship between salivary nitrous oxide concentration and dental caries in children. Metaanalysis studies aim to combine different studies and reduce the difference between the parameters by increasing the number of studies involved in the analysis process. Objectives: Accordingly, this meta-analysis study aimed at determining the relationship between salivary nitrous oxide concentration and dental caries in children. Methods: Databases were searched using the keywords “nitric oxide”, “salivary”, “Caries”, “DMFT Index”, “children”, “early childhood caries” and OR, AND and NOT operators. Quality assessment was then performed based on the Newcastle-Ottawa scale (NOS) checklist. The standardized mean difference (SMD) of DMFT, dmft, and salivary nitric oxide (NO) concentration was estimated. Results: Seven studies made a comparison between the mean salivary NO concentration in children with dental caries and that in the control group. In four studies, the mean salivary NO concentration in children with dental caries was lower, as compared to that in the control group. This difference was significant in all four studies. Also, the mean standardized difference of the salivary NO index was also estimated to be -0.11 (CI 95%: -1.77, 1.55). Conclusions: This meta-analysis study demonstrated that salivary NO concentration was not significantly related to dental caries. Moreover, since salivary NO concentration is affected by various factors, it is not sufficient to determine the likelihood of the incidence of caries.

scholarly journals Comparison of decayed, missing, filled teeth index between thalassemia major patients and control group in Iran: a systematic review and meta-analysis

BDJ Open ◽  
2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Mahmood Moosazadeh ◽  
Nadia Elyassi Gorji ◽  
Pegah Nasiri ◽  
Ali Malekzadeh Shafaroudi
Keyword(s):  
Dental Caries ◽  
Meta Analysis ◽  
Scientific Evidence ◽  
Thalassemia Major ◽  
Control Group ◽  
Dmft Index ◽  
The Mean ◽  
And Control ◽  
The Relationship ◽  
Quality Checklist

Abstract Introduction Scientific evidence of the association between Decayed, Missing, and Filled Teeth (DMFT) and thalassemia are conflicting and difficult to establish conclusions. Therefore, this study aimed to determine the relationship between dental caries (using the DMFT index) and thalassemia major using meta-analysis. Methods Databases were searched using such keywords as “Thalassemia,” “Caries,” “decay,” “DMFT,” “Iran,” and OR operators, AND, and NOT. After the elimination of duplicate documentation, the articles which met the inclusion criteria were selected. Quality assessment was performed based on the Newcastle-Ottawa Quality Checklist. Thereafter, the standardized mean difference of the DMFT index was estimated. Results In eight studies, the mean DMFT was compared between patients with thalassemia major and the control group. In six studies, the mean of this index was higher in patients with thalassemia major than in the control group and in all six of the studies, the differences were statistically significant. The mean standardized difference of DMFT, D, M, and F were reported as 1.36 (0.41, 2.30), 2.63 (0.42, 4.84), 1.65 (−0.14, 3.45), and 0.02 (−1.67, 1.72), respectively. Conclusion The results of this meta-analysis indicated that DMFT index was more inappropriate in patients with thalassemia, as compared to the control group which represents the higher incidence of dental caries among patients with thalassemia compared to the control group.

Interaction of Isoflurane and Nitrous Oxide Combinations Similar for Median Electroencephalographic Frequency and Clinical Anesthesia

1996 ◽  
Vol 84 (4) ◽  
pp. 782-788. ◽  
Author(s):  
Heiko Ropcke ◽  
Helmut Schwilden
Keyword(s):  
Nitrous Oxide ◽  
Minimum Alveolar Concentration ◽  
Dose Range ◽  
Volatile Anesthetic ◽  
Oxide Concentration ◽  
Anesthetic Requirement ◽  
Clinical Anesthesia ◽  
Sparing Effect ◽  
The Relationship ◽  
Nitrous Oxide Concentration

Background The volatile anesthetic sparing effect of nitrous oxide in clinical studies is less than might be expected from the additivity of minimum alveolar concentration values. Other studies identify nonadditive interactions between isoflurane and nitrous oxide. The aim of this study was to quantify the interaction of isoflurane and nitrous oxide at a constant median electroencephalographic frequency. Methods Twenty-five patients were studied during laparotomies. Nitrous oxide was randomly administered in concentrations of 0, 20, 40, 60, and 75 vol%, to ten patients for each nitrous oxide concentration. Isoflurane vaporizer settings were chosen so that the median electroencephalographic frequency was held between 2 and 3 Hz. The relationship between nitrous oxide concentrations and required isoflurane concentrations was examined with the method of isoboles. Results Nitrous oxide linearly decreased the isoflurane requirement. Addition of every 10 vol% of nitrous oxide decreases the isoflurane requirement by approximately 0.04 vol%. The total anesthetic requirement of isoflurane and nitrous oxide, expressed in terms of previously reported minimum alveolar concentration values, increased significantly with increasing nitrous oxide concentrations. Conclusions The interaction of isoflurane and nitrous oxide in the dose range 0-75 vol% on median electroencephalographic frequency is compatible with additivity. The potency of nitrous oxide as a substitute for isoflurane is less than on a minimum alveolar concentration basis. Maintaining median electroencephalographic frequency more appropriately reflects the clinical usage of isoflurane and nitrous oxide than does maintaining minimum alveolar concentration.

scholarly journals The Relationship between Endothelial Nitric Oxide Synthase with Dyslipidemia in Coronary Heart Disease

2020 ◽  
Vol 8 (A) ◽  
pp. 537-542
Author(s):  
Eryati Darwin ◽  
Eka Fithra Elfi ◽  
Eva Decroli ◽  
Dwitya Elvira
Keyword(s):  
Nitric Oxide ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Medical Condition ◽  
Density Lipoprotein ◽  
Lipid Profiles ◽  
Control Group ◽  
Protective Function ◽  
The Mean ◽  
The Relationship

BACKGROUND: Dyslipidemia is a medical condition that refers to an abnormal of blood lipids level, most common is hyperlipidemia. Elevation of blood lipid such as cholesterol, triglycerides, low-density lipoprotein (LDL) cholesterol, or a low high-density lipoprotein (HDL) cholesterol level induces disturbance of endothelial function. Endothelial dysfunction in dyslipidemia is in large part due to a reduced bioavailability of nitric oxide (NO) which is synthesized by endothelial NO synthase (eNOS) which will trigger the development of atherosclerosis, and increases the risk of coronary heart disease (CHD). AIM: This study aims to determine the relationship of lipid profiles of dyslipidemia with eNOS levels in CHD patients. MATERIALS AND METHODS: This study design was a cross-sectional study. The sample in this study was 26 patients which diagnosed as CHD of outpatients in the department of cardiology of a regional general hospital and fulfilled the inclusion and exclusion criteria. Fifteen healthy individuals who come for the general check-up were included as a control group. Blood samples were collected for measurements of eNOS levels and lipid profiles that carried out according to laboratory standards. Statistical analyses were conducted using analysis of variance and Shapiro–Wilk test. RESULTS: The results of this study showed that eNOS levels in the group of CHD patients (24.174 ± 7.136 ng/ml) were significantly lower (p < 0.05) than those in the control group (72.092 ± 30.065 ng/ml). The mean of triglycerides and HDL levels has a weak correlation with the level of eNOS (p > 0.05). The mean of LDL level has moderately positive correlation with eNOS, while cholesterol has a moderate negative correlation with the level of eNOS (p > 0.05). CONCLUSION: This study concluded that high cholesterol levels and low HDL levels in dyslipidemia condition were correlated with eNOS, which has a protective function in CHD.

scholarly journals Comparison of dental caries (DMFT and DMFS indices) between asthmatic patients and control group in Iran: a meta-analysis

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Nadia Elyassi Gorji ◽  
Pegah Nasiri ◽  
Ali Malekzadeh Shafaroudi ◽  
Mahmood Moosazadeh
Keyword(s):  
Dental Caries ◽  
Meta Analysis ◽  
Control Group ◽  
Asthmatic Patients ◽  
Health Indices ◽  
Analysis Process ◽  
Combining Data ◽  
And Control ◽  
The Relationship ◽  
Quality Checklist

Abstract Background The association between caries index, which is diagnosed by Decayed, Missing, and Filled Teeth (DMFT), and asthma has been assessed in several studies, which yielded contradictory results. Meta-analysis is the statistical procedure for combining data from multiple studies and reducing the differences among parameters due to the increased number of studies involved in the analysis process. Therefore, the present study aimed to determine the relationship between dental caries using decayed, missing, filled teeth indices (DMFT, dmft, and DMFS indices) and asthma using meta-analysis. Methods Databases were searched using such keywords as “Asthma,” “Caries,” “DMFT,” “DMFS,” “Iran,” and OR operators, AND, and NOT. After the elimination of duplicate documentation, the articles which met the inclusion criteria were selected. Quality assessment was performed based on the Newcastle-Ottawa Quality Checklist (NOS). After that, standardized mean difference (SMD) of DMFT, dmft, and Decayed, Missing, and Filled Surfaces (DMFS) indices were estimated. Results The number of 10 evidence was extracted out of nine studies in which mean oral health indices were compared between asthmatic patients and the control group. Out of 10 evidences that examined the association of DMFT, dmft, and DMFS with asthma, these indices were higher in asthmatic patients than the control group in seven cases. In three cases, these differences were statistically significant. The SMD of DMFT, dmft, and DMFS indices between asthmatic patients and the control group at the confidence level of 95% were reported as 0.29 (− 0.05, 0.62), 0.48 (− 0.20, 1.17), and − 0.05(− 0.30, 0.21), respectively. Conclusion According to the results, the prevalence of dental caries is higher among patients with asthma than in the control group. Therefore, having asthma could be considered a risk factor for the development of dental caries.

scholarly journals Effect of dietary crude protein modification on ammonia and nitrous oxide concentration on a tie-stall dairy barn floor

2010 ◽  
Vol 93 (7) ◽  
pp. 3158-3165 ◽  
Author(s):  
H. Arriaga ◽  
G. Salcedo ◽  
L. Martínez-Suller ◽  
S. Calsamiglia ◽  
P. Merino
Keyword(s):  
Nitrous Oxide ◽  
Crude Protein ◽  
Protein Modification ◽  
Dietary Crude Protein ◽  
Oxide Concentration ◽  
Nitrous Oxide Concentration

scholarly journals Urine CA-2 as a biomarker for diagnosis urinary stone and prediction of its complications

2020 ◽  
Author(s):  
Yuan-jing Leng ◽  
Hai-bin Zhou ◽  
Jiang-ling Fu ◽  
Wen-juan Wang
Keyword(s):  
Healthy Subjects ◽  
Characteristic Curve ◽  
Urinary Stone ◽  
Urinary Stones ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Healthy Control ◽  
The Mean ◽  
The Difference ◽  
The Relationship

Abstract PURPOSECarbonic anhydrase-2 (CA-2) plays a role in mineralization and calcification in organism. Strong evidence suggests that CA-2 is associated with urolithiasis. However, the relationship between CA-2 and urinary stone remains unclear. The study aimed to assess the association of urine CA-2 (uCA-2) level and the potential risk of urinary stone.METHODSFrom March 2017 to November 2019, a prospective cohort study was conducted on patients with urinary stones and healthy subjects to determine the pretreatment uCA-2 level detection by Enzyme linked immunosorbent assay (ELISA). The difference of uCA-2 level between patients with urinary stones and healthy subjects was compared. Then comparison between stone patients with complications and without complications was carried out as well as correlation analysis to detect factors associated with biomarker expression.RESULTS118 patients with urinary stones were into urinary stones group and 42 healthy subjects were into healthy control group. The mean pretreatment uCA-2 level was significantly higher in patients with urinary stones group than healthy controls group (P=0.028). Furthermore, The uCA-2 level was positive correlation with urinary stones complications (R=0.379, P=0.000), especially pain complications (R=0.524, P=0.000) and hematuria complications (R=0.374, P=0.000). Receiver operating characteristic curve (ROC) analysis that a uCA-2 level threshold of 10.94 ng/mL had 83.67% sensitivity and 68.12% specificity for predicting urinary stones complications. CONCLUSIONSExcessive uCA-2 excretion is a major risk factor for urinary stone. Our findings suggested that uCA-2 may be used as an unappreciated biomarker for the diagnosis urinary stone in patients and to predict its complications.

scholarly journals The Effectiveness of Microneedling Therapy on The Severity of Acne Scars According to Goodman and Baron: A Systematic review and meta-analysis

2022 ◽  
pp. 48
Author(s):  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Control Group ◽  
Skin Damage ◽  
Acne Scar ◽  
Acne Scars ◽  
Significant Difference ◽  
Acne Scarring ◽  
The Mean ◽  
Z Value

Background: The emergence of acne scars due to skin damage in the acne healing process and causes psychological effects. The management of acne scars can be done in several methods. Microneedling is a very simple, safe, effective, and minimally invasive therapeutic technique compared to other therapeutic modalities in acne scars. The resulting wound is micro-sized, and promotes the growth of growth factors and collagen production. We aimed to assess the effectiveness of using microneedling as an acne scar treatment option. A systematic review and meta-analysis were qualitatively and quantitatively conducted from RCTs, assessing the effectiveness of microneedling in reducing the severity of acne scars according to Goodman and Baron in the treatment of acne scars. Methods: Medline Pubmed, PMC, Scopus, Google Scholar, and JDC library, eligible search. Ten studies (n=514) were analyzed qualitatively with 2 studies (n=53 subjects) and quantitatively analyzed by 2 studies (n=90 subjects). Both analyzes were included in the meta-analysis. The mean age of the participants was 40.5 years. The application of microneedling intervention as monotherapy or a combination in patients with acne scarring was followed for at least 16 weeks, the results obtained were the mean reduction in the degree of acne scarring after microneedling. Result: The combination of microneedling treatment obtained a qualitative decrease in the degree of acne scars according to Goodman and Baron with a Z value (-4.299) and P=<0.001 lower than the control (PRP) with a significant difference. The quantitative decrease in the degree of acne scars according to Goodman and Baron obtained a Z value (-4.681) and P=<0.001 lower than the control (PRP) with a significant difference. Quantitative reduction in the degree of acne scars according to Goodman and Baron on single therapy between treatment and control with a value of Z (-3.536) and P=<0.001 lower than control (fractional CO2) with a significant difference. The results of the degree of acne scars in the group treated with microneedling alone or in combination were lower than the control group. The mean before and after therapy compared to the control there was a significant difference. Conclusion. The results of a systematic review, concluded that the group treated with microneedling had a decrease in the degree of acne scarring according to Goodman and Baron with P=<0.001 compared to before treatment. The decrease was shown in the difference in Z values, which was significantly greater than the control given other therapies. Microneedling therapy can be an alternative therapy option for acne scar patients who are unresponsive to previous therapy or in conditions where there are contraindications to other therapies.

scholarly journals An Investigation of the Relationship between Involvement Sites in Vitiligo Patients and Autoimmune Diseases and Hematological Parameters

2019 ◽  
Vol 4 (10) ◽  
Author(s):  
Ebru KARAGUN
Keyword(s):  
Hematological Parameters ◽  
Fasting Blood Glucose ◽  
Unknown Etiology ◽  
Control Group ◽  
Endocrine Disorders ◽  
Positive Correlation ◽  
Lymphocyte Ratio ◽  
History Of ◽  
The Mean ◽  
The Relationship

Aim-Objectives: Vitiligo is an acquired idiopathic disease which progresses with melanocyte destruction and is clinically characterized by depigmented lesions of unknown etiology. Vitiligo may be coexistence with a autoimmune and endocrine disorders. This study examined the sT3, fT4, TSH, Anti-TPO, Anti-Tg, Vitamin B12 and fasting blood glucose (FBG) values, and thrombocyte-to-lymphocyte ratio(TLR), neutrophil-to-lymphocyte ratio(NLR), the mean platelet volume(MPV) the correlation of depigmented lesions with the extent of body involvement sites(IS). Materials and Method: The study enrolled 67 patients aged 0‒65 who were diagnosed with non-segmental generalized vitiligo and in whom an increase in lesions had been observed in the last six months. The IS of the lesions in the patients were evaluated as IS ˂10%(1st group), 10%‒20% (2nd group), 20% - 30%(3rd group), 30% - 40%(4th group), 40% ‒50 %(5th group), and ˃50%(6th group). The control group consisted of patients who had presented to the outpatient clinic having had no history of vitiligo detected in themselves nor in their families. Results: No significant correlation was found between IS and sT3, fT4, TSH, Anti-TPO, Anti-Tg, Vit. B12, PBG or MPV. A moderately positive correlation was found between IS and duration (p <0.05) and a mildly positive correlation between IS and NLR and TLR (p <0.05). Conclusion: This study show that every patient diagnosed with vitiligo, independent of the IS, should undergo examination for autoimmune disease. A mild positive correlation between VTA and NLO-TLO was found to be an indicator of increased inflammation in vitiligo patients as the extent of lesions increased.

The relationship between teacher efficacy and students' academic achievement: A meta-analysis

2018 ◽  
Vol 46 (4) ◽  
pp. 529-540 ◽  
Author(s):  
Kyung Ryung Kim ◽  
Eun Hee Seo
Keyword(s):  
Academic Achievement ◽  
Teacher Efficacy ◽  
Classroom Management ◽  
Meta Analysis ◽  
Teaching Experience ◽  
Student Academic Achievement ◽  
Years Of Teaching Experience ◽  
Efficacy Measures ◽  
The Mean ◽  
The Relationship

We conducted a meta-analysis by synthesizing the results of 16 studies involving 4,130 teachers to explore whether or not the relationship between teacher efficacy and students' academic achievement was influenced by the scale used to measure teacher efficacy, and/or by the subfactors of teacher efficacy, length of teaching experience, location of the school, or the students' educational level. The results showed that the mean relationship between teacher efficacy and students' academic achievement was significant but the effect size was small. The results also indicated that the relationship was influenced by some teacher efficacy measures and subfactors, and by length of teaching experience. In studies in which the measure used was Gibson and Dembo's scale, in regard to classroom management, and in the case of teachers with fewer than 11 years of teaching experience, the relationship between teacher efficacy and student academic achievement was nonsignificant.

Antithyroid Effect of Chlorpropamide?

1983 ◽  
Vol 2 (1) ◽  
pp. 149-153 ◽  
Author(s):  
J. Feely ◽  
S. McLaren ◽  
A.M.M. Shepherd ◽  
D. Maclean ◽  
I.H. Stevenson ◽  
...  
Keyword(s):  
Matched Control ◽  
Control Group ◽  
Diabetic Patients ◽  
Matched Control Group ◽  
Serum Thyroxine ◽  
Chronic Therapy ◽  
The Mean ◽  
Clinically Significant ◽  
The Relationship ◽  
Plasma Chlorpropamide

1 The relationship between plasma chlorpropamide concentration and thyroid function was examined in 87 maturity onset diabetic patients receiving chronic therapy. 2 Although plasma chlorpropamide concentration was weakly negatively correlated with serum thyroxine (r= 0.33, P< 0.01) the mean serum thyroxine and thyrotrophin (TSH) were not different from that of a matched control group of diabetics treated with diet alone. 3 Serum thyroxine was negatively correlated with the duration of diabetes in both groups. 4 These results suggest that chlorpropamide does not have a clinically significant antithyroid effect.

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