Changes in corneal endothelial cell density after initial Ex-PRESS drainage device implantation and its relating factors over 3 years

AbstractThis population-based cross-sectional study was performed to determine the mean corneal endothelial cell density (ECD), coefficient of variation (CV), and hexagonality (HEX), and their associations with myopia in Japanese adults living in Chikusei city. Of 7109 participants with available data, 5713 (2331 male and 3382 female) participants were eligible for analysis. After assessing the relationship between participant characteristics and spherical equivalent refraction (SER), the association of SER with the abnormal value of ECD (< 2000 cells/mm), CV (≥ 0.40), and HEX (≤ 50%) were determined using the logistic regression models adjusting for potential confounders (age, intraocular pressure, keratometric power, height, and antihypertensive drug use). In male participants, there was no statistically significant relationships between SER and endothelial parameters. In female participants, compared to emmetropia, SER ≤ − 6 D had significantly higher odds ratio (OR) of having the abnormal value of CV (OR = 2.07, 95% confidence interval [CI] 1.39–3.10) and HEX (OR = 2.04, 95% CI 1.29–3.23), adjusted for potential confounders, indicating that the high myopia was associated with the abnormal values of CV and HEX. Further adjustment for contact lenses wear partly attenuated these associations. Association between the SER and ECD was not detected.

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27-gauge trocar-assisted sutureless intraocular lens fixation

BMC Ophthalmology ◽

10.1186/s12886-020-01758-6 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Tatsuya Jujo ◽

Jiro Kogo ◽

Hiroki Sasaki ◽

Reio Sekine ◽

Keiji Sato ◽

...

Keyword(s):

Visual Acuity ◽

Endothelial Cell ◽

Cell Density ◽

Intraocular Lens ◽

Vitreous Hemorrhage ◽

Corneal Endothelial Cell ◽

Endothelial Cell Density ◽

Corneal Endothelial Cell Density ◽

The Mean ◽

Iol Fixation

Abstract Backgrounds However there have been numerous investigations of intrascleral intraocular lens (IOL) fixation techniques, there is room for improvement in terms of simplifying complicated techniques and reducing the high levels of skill required. This study aimed to report a novel technique for sutureless intrascleral fixation of the IOL using retinal forceps with a 27-gauge trocar. Methods Nineteen eyes of 18 patients underwent intrascleral fixation of the IOL from July 2018 to September 2019 were enrolled in this study. A 27-gauge trocar formed 3-mm scleral tunnels positioned at 4 and 10 o’clock, 2 mm from the corneal limbus. We used a 3-piece IOL haptic grasped by a 27-gauge retinal forceps and pulled from the 27-gauge trocar. The IOL was fixed by making a flange. Main outcome measures were visual acuity, corneal endothelial cell density, IOL tilt, decentration, predicted error of refraction and complications. Results The 19 eyes were followed up for 1 month. The mean pre- and postoperative logMAR uncorrected visual acuity (UCVA) was 1.06 ± 0.63 and 0.40 ± 0.26, respectively (p < 0.01), while the mean pre- and postoperative logMAR best corrected visual acuity (BCVA) was 0.27 ± 0.51 and 0.06 ± 0.15, respectively (p = 0.09). The mean corneal endothelial cell density was 2406 ± 625 to 2004 ± 759 cells/mm2 at 1 month (p = 0.13). The mean IOL tilt was 3.52 ± 3.00°, and the mean IOL decentration was 0.39 ± 0.39 mm. There was no correlation among IOL tilt, decentration and BCVA (p > 0.05). The mean prediction error of the target refraction was − 0.03 ± 0.93 D. The complications were vitreous hemorrhage (3 eyes), hyphema (1 eye), IOP elevation (1 eye), iris capture of the IOL (1 eye) and hypotony (2 eyes). No IOL dislocation occurred. Conclusions IOL intrascleral fixation with a flange achieved good IOL fixation and visual outcome in the scleral tunnels created with the 27-gauge trocar.

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Age-Stratified Analysis of Diabetes and Pseudophakia Effects on Corneal Endothelial Cell Density

Cornea ◽

10.1097/ico.0000000000001107 ◽

2017 ◽

Vol 36 (3) ◽

pp. 367-371 ◽

Cited By ~ 3

Author(s):

Yicheng Chen ◽

Sean W. Tsao ◽

Moonseong Heo ◽

Patrick K. Gore ◽

Mitchell D. McCarthy ◽

...

Keyword(s):

Endothelial Cell ◽

Cell Density ◽

Corneal Endothelial Cell ◽

Endothelial Cell Density ◽

Corneal Endothelial Cell Density ◽

Stratified Analysis

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The Effect of Glaucoma Filtering Surgery on Corneal Endothelial Cell Density

Ophthalmic Surgery Lasers and Imaging Retina ◽

10.3928/1542-8877-19910501-04 ◽

1991 ◽

Vol 22 (5) ◽

pp. 251-255

Author(s):

David L Smith ◽

Gregory L Skuta ◽

Kim A Lindenmuth ◽

David C Musch ◽

Terry J Bergstrom

Keyword(s):

Endothelial Cell ◽

Cell Density ◽

Corneal Endothelial Cell ◽

Endothelial Cell Density ◽

Filtering Surgery ◽

Corneal Endothelial Cell Density

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The Effects of Nonfixated Lower Lens Haptics of Binkhorst Lenses on Corneal Endothelial Cell Density

Ophthalmic Surgery Lasers and Imaging Retina ◽

10.3928/1542-8877-19860501-06 ◽

1986 ◽

Vol 17 (5) ◽

pp. 286-289

Author(s):

Brad W Richards ◽

Winn L Richards ◽

Randall J Olson ◽

Scott C Richards

Keyword(s):

Endothelial Cell ◽

Cell Density ◽

Corneal Endothelial Cell ◽

Endothelial Cell Density ◽

Corneal Endothelial Cell Density

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Corneal endothelial cell density loss following glaucoma surgery alone or in combination with cataract surgery: a systematic review protocol

BMJ Open ◽

10.1136/bmjopen-2021-050992 ◽

2021 ◽

Vol 11 (9) ◽

pp. e050992

Author(s):

Clarissa E H Fang ◽

Peng Tee Khaw ◽

Rashmi G Mathew ◽

Christin Henein

Keyword(s):

Endothelial Cell ◽

Cataract Surgery ◽

Cell Density ◽

Systematic Reviews ◽

Glaucoma Surgery ◽

Corneal Endothelial Cell ◽

Endothelial Cell Density ◽

Controlled Trials ◽

Surgical Trauma ◽

Corneal Endothelial Cell Density

ObjectiveWe aim to systematically assess and compare corneal endothelial cell density (ECD) loss in patients with glaucoma following glaucoma surgery and cataract surgery.IntroductionCorneal ECD loss may occur due to intraoperative surgical trauma in glaucoma surgery or postoperatively with chronic endothelial cell trauma or irritation. Corneal oedema and decompensation after aqueous shunt glaucoma surgery has been reported but the long-term ECD loss is still unknown.Inclusion criteriaTrabeculectomy, glaucoma filtration surgery or microinvasive glaucoma surgery in adults with ocular hypertension, primary and secondary open angle glaucoma, normal tension glaucoma and angle-closure glaucoma. Participants with pre-existing corneal disease will be excluded. Glaucoma laser treatments and peripheral iridotomy will be excluded. The outcomes include preoperative and postoperative corneal ECD, percentage change of corneal ECD and adverse events.MethodsWe will conduct an electronic database search for randomised controlled trials, prospective non-randomised studies, observational studies in MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), ClinicalTrials.gov and The International Prospective Register of Systematic Reviews (PROSPERO). Eligibility criteria will include quantitative articles published after and including the year 2000, written in English and containing data on ECD loss. Two independent reviewers will screen titles and abstracts and extract data from full texts, reporting outcomes according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Data extraction of key characteristics will be completed using customised forms. Methodological quality will be assessed using the Joanna Briggs Institute critical appraisal forms.Ethics and disseminationEthics approval is not required for this review, as it will only include published data. Findings will be published in a peer-reviewed journal and disseminated across ophthalmic networks.PROSPERO registration numberPROSPERO CRD42020192303.

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Change in corneal endothelial cell density after phacoemulsification in patients with type II diabetes mellitus

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.35.5.596 ◽

2019 ◽

Vol 35 (5) ◽

Author(s):

Muhammad Khalid ◽

Muhammad Kashif Hanif ◽

Qamar Ul Islam ◽

Muhammad Asim Mehboob

Keyword(s):

Endothelial Cell ◽

Cell Density ◽

Type Ii Diabetes Mellitus ◽

Corneal Endothelial Cell ◽

Endothelial Cell Density ◽

Diabetic Patients ◽

Type Ii ◽

Significant Difference ◽

Corneal Endothelial Cell Density ◽

Study Population

Objective: To compare the mean change in Corneal Endothelial cell Density (CED), from baseline (pre-operative value), two months after phacoemulsification cataract surgery between type II diabetic patients and non-diabetic patients. Methods: This prospective stratified controlled study was conducted at PNS Shifa Hospital, Karachi. 80 eyes of 72 type II diabetic patients and 80 eyes of 77 non diabetic controls, having Nuclear Opalescence (NO) grades 2 and 3 on slit lamp examination underwent phacoemulsification surgery. CED was measured in cells/mm2, of concerned eye of each subject preoperatively and 2 months post operatively using specular microscope. The difference in mean CED change between the two groups after surgery was analyzed. Results: Mean age of study population was 61.41± 6.76 years. Out of study population, 92 (57.5%) were males and 68 (42.5%) were females. There was a statistically significant difference between both groups in terms of mean post-operative CED, mean change in CED and mean frequency change in CED (p <0.05). There was no statistically significant difference between both groups in age, gender, laterality of eyes and mean pre-operative CED, (p >0.05). Difference of pre-operative CED from post-operative CED in each group was statistically significant. Conclusion: There is a significant difference between diabetic population and normal population in terms of corneal endothelial loss after uneventful phacoemulsification cataract surgery. doi: https://doi.org/10.12669/pjms.35.5.596 How to cite this:Khalid M, Hanif MK, Qamar ul Islam, Mehboob MA. Change in corneal endothelial cell density after phacoemulsification in patients with type II diabetes mellitus. Pak J Med Sci. 2019;35(5):---------. doi: https://doi.org/10.12669/pjms.35.5.596 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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