scholarly journals Mapping of novel loci involved in lung and colon tumor susceptibility by the use of genetically selected mouse strains

2021 ◽  
Author(s):  
Andrea Borrego ◽  
José Ricardo Jensen ◽  
Wafa Hanna Koury Cabrera ◽  
Solange Massa ◽  
Orlando Garcia Ribeiro ◽  
...  
Keyword(s):  
Inbred Mouse ◽  
Differential Susceptibility ◽  
Genomic Variation ◽  
Mouse Strains ◽  
Tumor Susceptibility ◽  
Genome Wide ◽  
Chemically Induced ◽  
Tumor Types ◽  
The Relationship ◽  
Dna Genotyping

AbstractTwo non-inbred mouse lines, phenotypically selected for maximal (AIRmin) and minimal (AIRmax) acute inflammatory response, show differential susceptibility/resistance to the development of several chemically-induced tumor types. An intercross pedigree of these mice was generated and treated with the chemical carcinogen dimethylhydrazine, which induces lung and intestinal tumors. Genome wide high-density genotyping with the Restriction Site-Associated DNA genotyping (2B-RAD) technique was used to map genetic loci modulating individual genetic susceptibility to both lung and intestinal cancer. Our results evidence new common quantitative trait loci (QTL) for those phenotypes and provide an improved understanding of the relationship between genomic variation and individual genetic predisposition to tumorigenesis in different organs.

scholarly journals The relationship between nephron number, kidney size and body weight in two inbred mouse strains

Organogenesis ◽  
2010 ◽  
Vol 6 (3) ◽  
pp. 189-194 ◽  
Author(s):  
Inga J. Murawski ◽  
Rita W. Maina ◽  
Indra R. Gupta
Keyword(s):  
Body Weight ◽  
Inbred Mouse ◽  
Mouse Strains ◽  
Inbred Mouse Strains ◽  
Nephron Number ◽  
Kidney Size ◽  
The Relationship

scholarly journals Dysregulated Inflammatory Response to Candida albicans in a C5-Deficient Mouse Strain

2004 ◽  
Vol 72 (10) ◽  
pp. 5868-5876 ◽  
Author(s):  
Alaka Mullick ◽  
Miria Elias ◽  
Serge Picard ◽  
Lucie Bourget ◽  
Orce Jovcevski ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Inflammatory Response ◽  
Mouse Strain ◽  
Host Response ◽  
Inbred Mouse ◽  
Differential Susceptibility ◽  
Mouse Strains ◽  
Causative Role ◽  
Loss Of Function ◽  
Necrosis Factor Alpha

ABSTRACT Experimental infection of inbred mouse strains with Candida albicans provides a good model system to identify host genetic determinants that regulate onset of, response to, and ultimate outcome of disseminated candidiasis. The A/J mouse strain is exquisitely sensitive to infection with C. albicans, while the C57BL/6J strain is relatively resistant, as measured by survival following intravenous injection of Candida blastospores. This differential susceptibility is caused by an A/J-specific loss-of-function mutation in the C5 component of the complement pathway. C5 plays several critical roles in host response to infection, including target lysis and phagocyte recruitment. Therefore, to determine which of its functions were required for host resistance to candidiasis, a detailed comparative analysis of pathophysiology and host response to acute C. albicans infection was conducted in A/J and C57BL/6J mice. C5-sufficient C57BL/6J mice were found to succumb late in infection due to severe kidney pathology, typified by fungal replication and robust neutrophil-based inflammatory response associated with extensive tissue damage. In contrast, A/J mice were moribund within 24 h postinfection but displayed little if any kidney damage despite an inability to mobilize granulocytes and a high fungal load in the kidney. Rather, C5 deficiency in A/J mice was associated with higher levels of circulating cytokines tumor necrosis factor alpha, interleukin-6, monocyte chemotactic protein 1 (MCP-1), MCP-5, and eotaxin in response to C. albicans. Transfer of the C5-defective allele from A/J onto a C57BL/6J genetic background in recombinant congenic strain BcA17 recapitulated the phenotypic aspects of the susceptibility of A/J mice to C. albicans, confirming the causative role of C5 deficiency in the dysregulated cytokine response.

scholarly journals NUTRITION OF THE HOST AND NATURAL RESISTANCE TO INFECTION

1949 ◽  
Vol 89 (5) ◽  
pp. 529-539 ◽  
Author(s):  
Howard A. Schneider
Keyword(s):  
Inbred Mouse ◽  
Natural Resistance ◽  
Single Infection ◽  
Mouse Strains ◽  
Time Interval ◽  
Special Cases ◽  
Resistance To Infection ◽  
Relationship Of ◽  
First Time ◽  
The Relationship

The double strain inoculation (DSI) method of testing for natural resistance to infection has been examined in the instance of mouse salmonellosis. The DSI method has been found capable of detecting differences in natural resistance due to genetic as well as nutritional causes. A difference in response to Salmonella infection was found for the first time between the two "susceptible" inbred mouse strains, BSVR and BSVS. Whereas BSVS mice for the most part survived an intraperitoneal injection of 103 "avirulent" S. typhimurium, BSVR mice all succumbed. The relationship of the DSI test to the usual single infection test has been discussed and it is suggested that such single infection tests are special cases of the DSI test, since they involve a heterogeneous bacterial population which can be considered as a mixture of cultures of differing virulence and in which, by a single injection, the usual time interval between the two injections of the DSI method has been reduced to 0.

scholarly journals The Relationship between PROP and Ethanol Preferences: An Evaluation of 4 Inbred Mouse Strains

2007 ◽  
Vol 32 (9) ◽  
pp. 847-853 ◽  
Author(s):  
T. L. White ◽  
L. V. Dishaw ◽  
P. R. Sheehe ◽  
S. L. Youngentob
Keyword(s):  
Inbred Mouse ◽  
Mouse Strains ◽  
Inbred Mouse Strains ◽  
The Relationship
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