scholarly journals Diverse protein assembly driven by metal and chelating amino acids with selectivity and tunability

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Minwoo Yang ◽  
Woon Ju Song
Keyword(s):  
Amino Acids ◽  
Self Assembly ◽  
Protein Structures ◽  
Functional Materials ◽  
Building Blocks ◽  
Unnatural Amino Acid ◽  
Metal Coordination ◽  
Specific Chemical ◽  
Natural Building ◽  
Kinetics Of

AbstractProteins are versatile natural building blocks with highly complex and multifunctional architectures, and self-assembled protein structures have been created by the introduction of covalent, noncovalent, or metal-coordination bonding. Here, we report the robust, selective, and reversible metal coordination properties of unnatural chelating amino acids as the sufficient and dominant driving force for diverse protein self-assembly. Bipyridine-alanine is genetically incorporated into a D3 homohexamer. Depending on the position of the unnatural amino acid, 1-directional, crystalline and noncrystalline 2-directional, combinatory, and hierarchical architectures are effectively created upon the addition of metal ions. The length and shape of the structures is tunable by altering conditions related to thermodynamics and kinetics of metal-coordination and subsequent reactions. The crystalline 1-directional and 2-directional biomaterials retain their native enzymatic activities with increased thermal stability, suggesting that introducing chelating ligands provides a specific chemical basis to synthesize diverse protein-based functional materials while retaining their native structures and functions.

Amino Acid Functional Polymers: Biomimetic Polymer Design Enabling Catalysis, Chiral Materials, and Drug Delivery

2016 ◽  
Vol 69 (7) ◽  
pp. 705 ◽  
Author(s):  
Emma R. L. Brisson ◽  
Zeyun Xiao ◽  
Luke A. Connal
Keyword(s):  
Drug Delivery ◽  
Amino Acids ◽  
Amino Acid ◽  
Self Assembly ◽  
Building Blocks ◽  
Functional Polymers ◽  
Responsive Materials ◽  
Biomimetic Polymer ◽  
Tunable Optical Properties ◽  
Natural Building

Amino acids are the natural building blocks for the world around us. Highly functional, these small molecules have unique catalytic properties, chirality, and biocompatibility. Imparting these properties to surfaces and other macromolecules is highly sought after and represents a fast-growing field. Polymers functionalized with amino acids in the side chains have tunable optical properties, pH responsiveness, biocompatibility, structure and self-assembly properties. Herein, we review the synthesis of amino acid functional polymers, discuss manipulation of available strategies to achieve the desired responsive materials, and summarize some exciting applications in catalysis, chiral particles, and drug delivery.

Fmoc-modified amino acids and short peptides: simple bio-inspired building blocks for the fabrication of functional materials

2016 ◽  
Vol 45 (14) ◽  
pp. 3935-3953 ◽  
Author(s):  
Kai Tao ◽  
Aviad Levin ◽  
Lihi Adler-Abramovich ◽  
Ehud Gazit
Keyword(s):  
Amino Acids ◽  
Self Assembly ◽  
Functional Materials ◽  
Building Blocks ◽  
The Self ◽  
Short Peptides

In this review, the studies on the self-assembly of Fmoc-modified biomolecules and their relevant applications in diverse advanced fields are summarized.

scholarly journals Self-assembly of amino acids toward functional biomaterials

2021 ◽  
Vol 12 ◽  
pp. 1140-1150
Author(s):  
Huan Ren ◽  
Lifang Wu ◽  
Lina Tan ◽  
Yanni Bao ◽  
Yuchen Ma ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Self Assembly ◽  
Functional Materials ◽  
Building Blocks ◽  
The Self ◽  
Self Assembled ◽  
Functional Biomaterials ◽  
Proteins And Peptides

Biomolecules, such as proteins and peptides, can be self-assembled. They are widely distributed, easy to obtain, and biocompatible. However, the self-assembly of proteins and peptides has disadvantages, such as difficulty in obtaining high quantities of materials, high cost, polydispersity, and purification limitations. The difficulties in using proteins and peptides as functional materials make it more complicate to arrange assembled nanostructures at both microscopic and macroscopic scales. Amino acids, as the smallest constituent of proteins and the smallest constituent in the bottom-up approach, are the smallest building blocks that can be self-assembled. The self-assembly of single amino acids has the advantages of low synthesis cost, simple modeling, excellent biocompatibility and biodegradability in vivo. In addition, amino acids can be assembled with other components to meet multiple scientific needs. However, using these simple building blocks to design attractive materials remains a challenge due to the simplicity of the amino acids. Most of the review articles about self-assembly focus on large molecules, such as peptides and proteins. The preparation of complicated materials by self-assembly of amino acids has not yet been evaluated. Therefore, it is of great significance to systematically summarize the literature of amino acid self-assembly. This article reviews the recent advances in amino acid self-assembly regarding amino acid self-assembly, functional amino acid self-assembly, amino acid coordination self-assembly, and amino acid regulatory functional molecule self-assembly.

A Dynamic Route to Structure and Function: Recent Advances in Imine-Based Organic Nanostructured Materials

2013 ◽  
Vol 66 (1) ◽  
pp. 9 ◽  
Author(s):  
Yi Liu ◽  
Zhan-Ting Li
Keyword(s):  
Self Assembly ◽  
Reaction System ◽  
Functional Materials ◽  
Building Blocks ◽  
The Self ◽  
Interlocked Molecules ◽  
Functional Aspects ◽  
Imine Bond ◽  
And Function ◽  
Dynamic Route

The chemistry of imine bond formation from simple aldehyde and amine precursors is among the most powerful dynamic covalent chemistries employed for the construction of discrete molecular objects and extended molecular frameworks. The reversible nature of the C=N bond confers error-checking and proof-reading capabilities in the self-assembly process within a multi-component reaction system. This review highlights recent progress in the self-assembly of complex organic molecular architectures that are enabled by dynamic imine chemistry, including molecular containers with defined geometry and size, mechanically interlocked molecules, and extended frameworks and polymers, from building blocks with preprogrammed steric and electronic information. The functional aspects associated with the nanometer-scale features not only place these dynamically constructed nanostructures at the frontier of materials sciences, but also bring unprecedented opportunities for the discovery of new functional materials.

scholarly journals Straightforward Preparation of Supramolecular Janus Nanorods by Hydrogen Bonding of End-Functionalized Polymers

2020 ◽  
Author(s):  
Shuaiyuan Han ◽  
Sandrine Pensec ◽  
Cédric Lorthioir ◽  
Jacques Jestin ◽  
Jean-Michel Guigner ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Self Assembly ◽  
Functional Materials ◽  
Phase Segregation ◽  
Building Blocks ◽  
Functionalized Polymers ◽  
Nanometer Range ◽  
One Dimensional ◽  
Oil In Water ◽  
First Time

Janus cylinders are one-dimensional colloids that have two faces with different compositions and functionalities and are useful as building blocks for advanced functional materials. Such anisotropic objects are difficult to prepare with nanometric dimensions. Here we describe a robust and versatile strategy to form micrometer long Janus nanorods with diameters in the 10-nanometer range, by self-assembly in water of end-functionalized polymers. For the first time, the Janus topology is not a result of the phase segregation of incompatible polymer arms, but is driven by the interactions between unsymmetrical and complementary hydrogen bonded stickers. It is therefore independent of the actual polymers used and works even for compatible polymers. To illustrate their applicative potential, we show that these Janus nanorods can efficiently stabilize oil-in-water emulsions.

scholarly journals The Assembly of Porphyrin Systems in Well-Defined Nanostructures: An Update

Molecules ◽  
2019 ◽  
Vol 24 (23) ◽  
pp. 4307 ◽  
Author(s):  
Gabriele Magna ◽  
Donato Monti ◽  
Corrado Di Natale ◽  
Roberto Paolesse ◽  
Manuela Stefanelli
Keyword(s):  
Self Assembly ◽  
Energy Transport ◽  
Functional Materials ◽  
Building Blocks ◽  
Spatial Arrangement ◽  
Transport Processes ◽  
Internal Electric Field ◽  
Porphyrin Derivatives ◽  
Molecular Building Blocks ◽  
The Individual

The interest in assembling porphyrin derivatives is widespread and is accounted by the impressive impact of these suprastructures of controlled size and shapes in many applications from nanomedicine and sensors to photocatalysis and optoelectronics. The massive use of porphyrin dyes as molecular building blocks of functional materials at different length scales relies on the interdependent pair properties, consisting of their chemical stability/synthetic versatility and their quite unique physicochemical properties. Remarkably, the driven spatial arrangement of these platforms in well-defined suprastructures can synergically amplify the already excellent properties of the individual monomers, improving conjugation and enlarging the intensity of the absorption range of visible light, or forming an internal electric field exploitable in light-harvesting and charge-and energy-transport processes. The countless potentialities offered by these systems means that self-assembly concepts and tools are constantly explored, as confirmed by the significant number of published articles related to porphyrin assemblies in the 2015–2019 period, which is the focus of this review.

Self-assembly of water-soluble silver nanoclusters: superstructure formation and morphological evolution

Nanoscale ◽  
2017 ◽  
Vol 9 (48) ◽  
pp. 19191-19200 ◽  
Author(s):  
Jinglin Shen ◽  
Zhi Wang ◽  
Di Sun ◽  
Guokui Liu ◽  
Shiling Yuan ◽  
...  
Keyword(s):  
Self Assembly ◽  
Morphological Evolution ◽  
Functional Materials ◽  
Building Blocks ◽  
Water Soluble ◽  
Silver Nanoclusters ◽  
Efficient Approach ◽  
Non Covalent Interactions ◽  
Covalent Interactions

Supramolecular self-assembly, based on non-covalent interactions, has been employed as an efficient approach to obtain various functional materials from nanometer-sized building blocks, in particular, [Ag6(mna)6]6−, mna = mercaptonicotinate (Ag6-NC).

scholarly journals Unveiling the Key Templates in the Self-Assembly of Gigantic Molybdenum Blue Wheels

2018 ◽  
Author(s):  
Weimin Xuan ◽  
Robert Pow ◽  
Qi Zheng, ◽  
Nancy Watfa ◽  
De-Liang Long ◽  
...  
Keyword(s):  
Self Assembly ◽  
Electrostatic Interactions ◽  
Structural Evolution ◽  
Functional Materials ◽  
Building Blocks ◽  
Underlying Mechanism ◽  
The Self ◽  
Supramolecular Systems ◽  
Structure Directing Agent ◽  
Molybdenum Blue

Template synthesis is a powerful and useful approach to build a variety of functional materials and complicated supramolecular systems. Systematic study on how templates structurally evolve from basic building blocks and then affect the templated self-assembly is critical to understand the underlying mechanism and gain more guidance for designed assembly but remains challenging. Here we describe the templated self-assembly of a series of gigantic Mo Blue (MB) clusters 1-4 using L-ornithine as structure-directing agent. L-ornithine is essential for the formation of such kind of template⊂host assemblies by providing directional forces of hydrogen bonding and electrostatic interactions. Based on the structural relationship between encapsulated templates of {Mo8} (1), {Mo17} (2) and {Mo36} (4), a plausible pathway of the structural evolution of templates is proposed, thus giving more insight on the templated self-assembly of Mo Blue clusters.

scholarly journals Protein structure from the essential amino acids to the 3D structure

2019 ◽  
Vol 9 (1) ◽  
Keyword(s):  
Amino Acids ◽  
Protein Structure ◽  
Significant Contribution ◽  
Polypeptide Chain ◽  
Protein Structures ◽  
3D Structure ◽  
Building Blocks ◽  
Essential Amino Acids ◽  
Different Types ◽  
Quaternary Structures

Protein structure is a hot topic, not only to the specialist, but with others like the physicists. So this review is targeting those who are not biologists and have to deal with the protein in their research. In this review we travel with the protein structures from the amino acids and its classifications, and how the polypeptide chain is formed from these building blocks up to the final 3D structure. We introduced the secondary structure species like helices with its different types and how it is formed; also the beta sheet formation and types are explained briefly. Finally the tertiary and quaternary structures are presented. The approaches of molecular modeling as well as other important computational methods present significant contribution to studying proteins.

scholarly journals Simultaneous analyte indicator binding assay (SBA) for the monitoring of reversible host-guest complexation kinetics

2021 ◽  
Author(s):  
Zsombor Miskolczy ◽  
Mónika Megyesi ◽  
Stephan Sinn ◽  
Frank Biedermann ◽  
Laszlo Biczok
Keyword(s):  
Self Assembly ◽  
Rational Design ◽  
Binding Assay ◽  
Building Blocks ◽  
The Self ◽  
Kinetics Of ◽  
Complexation Kinetics

Very few information is available for the kinetics of the self-assembly and dissociation of optically silent building blocks despite the importance of such data in the rational design of tailor-made...

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