scholarly journals High-intensity training induces non-stoichiometric changes in the mitochondrial proteome of human skeletal muscle without reorganisation of respiratory chain content

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Cesare Granata ◽  
Nikeisha J. Caruana ◽  
Javier Botella ◽  
Nicholas A. Jamnick ◽  
Kevin Huynh ◽  
...  
Keyword(s):  
Electron Flow ◽  
Mitochondrial Bioenergetics ◽  
Mitochondrial Content ◽  
Mitochondrial Proteome ◽  
High Intensity Training ◽  
Mitochondrial Defects ◽  
Atp Generation ◽  
Intensity Training ◽  
Mitochondrial Adaptations

AbstractMitochondrial defects are implicated in multiple diseases and aging. Exercise training is an accessible, inexpensive therapeutic intervention that can improve mitochondrial bioenergetics and quality of life. By combining multiple omics techniques with biochemical and in silico normalisation, we removed the bias arising from the training-induced increase in mitochondrial content to unearth an intricate and previously undemonstrated network of differentially prioritised mitochondrial adaptations. We show that changes in hundreds of transcripts, proteins, and lipids are not stoichiometrically linked to the overall increase in mitochondrial content. Our findings suggest enhancing electron flow to oxidative phosphorylation (OXPHOS) is more important to improve ATP generation than increasing the abundance of the OXPHOS machinery, and do not support the hypothesis that training-induced supercomplex formation enhances mitochondrial bioenergetics. Our study provides an analytical approach allowing unbiased and in-depth investigations of training-induced mitochondrial adaptations, challenging our current understanding, and calling for careful reinterpretation of previous findings.

scholarly journals Influence Of High-intensity Training On Quality Of Life And Daily Activity Performance In Multiple Sclerosis

2020 ◽  
Vol 52 (7S) ◽  
pp. 138-139
Author(s):  
Sebastian Proschinger ◽  
Jens Bansi ◽  
Annette Rademacher ◽  
Niklas Joisten ◽  
Alexander Schenk ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
High Intensity ◽  
Daily Activity ◽  
High Intensity Training ◽  
Activity Performance ◽  
Intensity Training

Mediterranean diet, moderate-to-high intensity training, and health-related quality of life in adults with metabolic syndrome

2012 ◽  
Vol 20 (4) ◽  
pp. 555-564 ◽  
Author(s):  
L Landaeta-Díaz ◽  
JM Fernández ◽  
M Da Silva-Grigoletto ◽  
D Rosado-Alvarez ◽  
A Gómez-Garduño ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Metabolic Syndrome ◽  
Mediterranean Diet ◽  
High Intensity ◽  
Health Related Quality ◽  
High Intensity Training ◽  
Related Quality ◽  
Health Related ◽  
Intensity Training

scholarly journals Effects of high-intensity training on the quality of life of cancer patients and survivors: a systematic review with meta-analysis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ana Myriam Lavín-Pérez ◽  
Daniel Collado-Mateo ◽  
Xián Mayo ◽  
Gary Liguori ◽  
Liam Humphreys ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Cancer Patients ◽  
High Intensity ◽  
Meta Analysis ◽  
Moderate Intensity ◽  
High Intensity Training ◽  
Global Quality Of Life ◽  
Intensity Training

AbstractCancer and associated medical treatments affect patients' health-related quality of life (HRQoL) by decreasing functional dimensions of physical, social, cognitive, and emotional well-being, while increasing short and late-term symptoms. Exercise, however, is demonstrated to be a useful therapy to improve cancer patients' and survivors’ HRQoL, yet the effectiveness of high-intensity training (HIT) exercise is uncertain. This systematic review and meta-analysis aimed to analyse the effects of HIT on HRQoL dimensions in cancer patients and survivors as well as evaluate the optimal prescription of HIT. The search followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PRISMA) and examined Web of Science and PubMed (Medline) databases. Data were analysed utilizing Review Manager Software. Twenty-two articles were included in the systematic review and 17 in the meta-analysis. Results showed HIT improved global quality of life, physical functioning, role functioning, social functioning, cognitive functioning, fatigue, pain, dyspnea, and insomnia, compared to an inactive control group, yet no differences were found between HIT and low to moderate-intensity exercise interventions. Particular improvements in HRQoL were observed during cancer treatment and with a training duration of more than eight weeks, a frequency of 2 days/week, and a volume of at least 120 min/week, including 15 min or more of HIT. Our findings whilst encouraging, highlight the infancy of the extant evidence base for the role of HIT in the HRQoL of cancer patients and survivors.

scholarly journals Effects of High-Intensity Training on the Quality of Life of Cancer Patients and Survivors: A Systematic Review With Meta-Analysis

2021 ◽  
Author(s):  
Ana Lavín-Pérez ◽  
Daniel Collado-Mateo ◽  
Xián Mayo ◽  
Gary Liguori ◽  
Liam Humphreys ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Cancer Patients ◽  
High Intensity ◽  
Meta Analysis ◽  
Moderate Intensity ◽  
High Intensity Training ◽  
Global Quality Of Life ◽  
Intensity Training

Abstract Cancer and associated medical treatments affect patients' health-related quality of life (HRQoL) by decreasing functional dimensions of physical, social, cognitive, and emotional well-being, while increasing short and late-term symptoms. Exercise, however, is demonstrated to be a useful therapy to improve cancer patients and survivors’ HRQoL, yet the effectiveness of high-intensity training (HIT) exercise is uncertain. This systematic-review and meta-analysis aimed to analyse the effects of HIT on HRQoL dimensions in cancer patients and survivors as well as evaluate the optimal prescription of HIT. The search followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PRISMA) and examined Web of Science and PubMed (Medline) databases. Data was analysed utilizing Review Manager Software. Twenty-two articles were included in the systematic review and seventeen in the meta-analysis. Results showed HIT improved global quality of life, physical functioning, role functioning, social functioning, cognitive functioning, fatigue, pain, dyspnoea, and insomnia, compared to an inactive control group. Whereas no differences were found in contrast to low to moderate-intensity exercise compared to inactive controls. Particular improvements in HRQoL were observed during the cancer treatment and with the following prescription: a training duration of more than eight weeks, a frequency of 2 days/week, a volume of at least 120 minutes/week including 15 minutes or more of HIT. Our findings whilst encouraging, highlight the infancy of the extant evidence base for the role of HIT in the HRQoL of cancer patients and survivors.

scholarly journals Multi-omics reveal intricate network of mitochondrial adaptations to training in human skeletal muscle

2021 ◽  
Author(s):  
Cesare Granata ◽  
Nikeisha J. Caruana ◽  
Javier Botella ◽  
Nicholas A. Jamnick ◽  
Kevin Huynh ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Human Skeletal Muscle ◽  
Electron Flow ◽  
Tca Cycle ◽  
Functional Protein ◽  
Therapeutic Benefits ◽  
Skeletal Muscle Mitochondria ◽  
Atp Generation ◽  
Response To Exercise ◽  
Mitochondrial Adaptations

AbstractDefects in mitochondria have been implicated in multiple diseases and aging; therefore, interventions able to counteract these changes can improve quality of life. Exercise training is a readily accessible and inexpensive therapeutic intervention; however, the complexity of training-induced mitochondrial adaptations in skeletal muscle remains poorly understood. Here, we describe an intricate and previously undemonstrated network of differentially prioritised training-induced adaptations in human skeletal muscle mitochondria. We show that changes in hundreds of transcripts, proteins, and lipids are not stoichiometrically linked to the increase in mitochondrial content. Moreover, we demonstrate a prioritisation of specific mitochondrial functional protein networks at different stages of the training intervention, including an initial deprioritisation of oxidative phosphorylation (OXPHOS) and a prioritisation of TCA cycle and fatty acid β-oxidation linked mitochondrial respiration. This indicates that enhancing electron flow to OXPHOS may be more important to improve ATP generation in skeletal muscle than increasing the abundance of the OXPHOS machinery. Our research unearths the elaborate and multi-layered nature of the adaptive response to exercise and provides a valuable resource that can be mined to maximise the therapeutic benefits of exercise.

scholarly journals Depression in Physicians: An Overlooked Issue in Mental Health

2020 ◽  
Vol 10 (1) ◽  
pp. 39-42
Author(s):  
Tamanna Bahar ◽  
Shaila Rahman
Keyword(s):  
Mental Health ◽  
Common Mental Disorder ◽  
Meta Analysis ◽  
Self Esteem ◽  
Health Issues ◽  
High Intensity Training ◽  
Prevalence Of Depression ◽  
Suicidal Attempts ◽  
Intensity Training

Depression is a common mental disorder that presents with depressed mood, loss of interest, feelings of guilt or low self-esteem. It affects an estimated one in 15 adults (6.7%) in any given year. One in six people (16.6%) will experience depression at some point in their lifetime. It can strike at any time; but usually it first appears during the late teens to mid-20s. Women usually experience depression more than men. Depression is one of the most common mental health issues among physicians worldwide due to high-intensity training and work overload. Recent systematic reviews and meta-analysis indicated that the prevalence of depression among physicians worldwide was around 28.8% which is quite higher than in the rest of the general population. Depressed physician makes more medical error than others. The burden of depression could lead to a low quality of life, ultimately suicidal attempts. So identifying risk factors for depression must be addressed and solved properly with utmost priority. This article reviews the prevalence of depression in physicians based on recently published literature related to this arena. J Enam Med Col 2020; 10(1): 39-42

scholarly journals A Novel 3-RRR Spherical Parallel Instrument for Daily Living Emulation (SPINDLE) for Functional Rehabilitation of Patients with Stroke

2021 ◽  
Vol 18 (3) ◽  
pp. 172988142110123
Author(s):  
Peidong He ◽  
Nikhil Tej Kantu ◽  
Boxin Xu ◽  
Chinmay Prakash Swami ◽  
Ghazala T Saleem ◽  
...  
Keyword(s):  
Daily Living ◽  
Robotic Rehabilitation ◽  
Stroke Patients ◽  
Robotic Training ◽  
Functional Rehabilitation ◽  
High Intensity Training ◽  
Home Training ◽  
Impaired Motor Function ◽  
Intensity Training

Various robotic rehabilitation devices have been developed for acute stroke patients to ease therapist’s efforts and provide high-intensity training, which resulted in improved strength and functional recovery of patients; however, these improvements did not always transfer to the performance of activities of daily living (ADLs). This is because previous robotic training focuses on the proximal joints or training with exoskeleton-type devices, which do not reflect how humans interact with the environment. To improve the training effect of ADLs, a new robotic training paradigm is suggested with a parallel manipulator that mimics rotational ADL tasks. This study presents training of the proximal and distal joints simultaneously while performing manipulation tasks in a device named spherical parallel instrument for daily living emulation (SPINDLE). Six representative ADLs were chosen to show that both proximal and distal joints are trained when performing tasks with SPINDLE, as compared to the natural ADLs. These results show that SPINDLE can train individuals with movements similar to the ADLs while interacting with the manipulator. We envision using this compact tabletop device as a home-training device to increase the performance of ADLs by restoring the impaired motor function of stroke patients, leading to improved quality of life.

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