scholarly journals Advances in healthcare wearable devices

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Sheikh M. A. Iqbal ◽  
Imadeldin Mahgoub ◽  
E Du ◽  
Mary Ann Leavitt ◽  
Waseem Asghar
Keyword(s):  
Drug Delivery ◽  
Cardiovascular Diseases ◽  
Drug Delivery System ◽  
Healthcare System ◽  
Delivery System ◽  
Wearable Devices ◽  
Future Perspectives ◽  
Muscle Disorders ◽  
Personalized Healthcare ◽  
Different Types

AbstractWearable devices have found numerous applications in healthcare ranging from physiological diseases, such as cardiovascular diseases, hypertension and muscle disorders to neurocognitive disorders, such as Parkinson’s disease, Alzheimer’s disease and other psychological diseases. Different types of wearables are used for this purpose, for example, skin-based wearables including tattoo-based wearables, textile-based wearables, and biofluidic-based wearables. Recently, wearables have also shown encouraging improvements as a drug delivery system; therefore, enhancing its utility towards personalized healthcare. These wearables contain inherent challenges, which need to be addressed before their commercialization as a fully personalized healthcare system. This paper reviews different types of wearable devices currently being used in the healthcare field. It also highlights their efficacy in monitoring different diseases and applications of healthcare wearable devices (HWDs) for diagnostic and treatment purposes. Additionally, current challenges and limitations of these wearables in the field of healthcare along with their future perspectives are also reviewed.

SOMES: A REVIEW ON COMPOSITION, FORMULATION METHODS AND EVALUATIONS OF DIFFERENT TYPES OF “SOMES” DRUG DELIVERY SYSTEM

2020 ◽  
pp. 7-18
Author(s):  
KUSUMA PRIYA M. D. ◽  
VINOD KUMAR ◽  
DAMINI V. K. ◽  
ESWAR K. ◽  
KADIRI RAJESH REDDY ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Surface Chemistry ◽  
Drug Delivery System ◽  
Delivery System ◽  
Different Types ◽  
Potent Drug ◽  
Evaluation Parameters ◽  
Selection Of

Many drugs are available in the market for several diseases, disorder or even for a condition, but it is difficult to select a suitable carrier to attain maximum bioavailability and potential for a potent drug. Attaining a controlled and sustained release of a drug is purely focused on the selection of a carrier (natural, synthetic and hybrid) like nanosomes. Nanosomes have become a prominent tool in the field of pharmacy. Nanosomes are small uniform structures which deliver the drug to the specific targeted site, which mainly depends upon the presence of ligands, shape, size and surface chemistry. Nanosomes are available in various types which include Niosomes, Liposomes, Electrosomes, Aquasomes, Transfersomes, Phytosomes, Enzymosomes, Ethosomes, Invasome and Sphingosomes. In general, all these nanosomes are quite similar in nature with minute differences in their vesicular characteristics and composition. This review traces various ‘somes’ composition and their role in the formulation, applications, advantages, disadvantages, common formulation procedures and evaluation parameters.

scholarly journals Tumor Microenvironment-Stimuli Responsive Nanoparticles for Anticancer Therapy

2020 ◽  
Vol 7 ◽  
Author(s):  
Reju George Thomas ◽  
Suchithra Poilil Surendran ◽  
Yong Yeon Jeong
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
The Body ◽  
Stimuli Responsive ◽  
Redox Enzyme ◽  
Nano Drug Delivery ◽  
Different Types ◽  
Internal Ph ◽  
Stimuli Response

Cancer is a disease that affects a large number of people all over the world. For treating cancer, nano-drug delivery system has been introduced recently with objective of increasing therapeutic efficiency of chemotherapeutic drug. The main characteristics of this system are the encapsulation of the insoluble chemotherapeutic cargo, increasing the period of circulation in the body, as well as the delivery of the drug at that specific site. Currently, the nano-drug delivery system based on the stimuli response is becoming more popular because of the extra features for controlling the drug release based on the internal atmosphere of cancer. This review provides a summary of different types of internal (pH, redox, enzyme, ROS, hypoxia) stimuli-responsive nanoparticle drug delivery systems as well as perspective for upcoming times.

Niosomes: The Current and Future perspectives in Drug Delivery System

2021 ◽  
pp. 3961-3966
Author(s):  
Bhupendra Singh ◽  
Pooja Sharma ◽  
Sujit Bose ◽  
Jyoti Thakur ◽  
Geetanjali Saini ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dosage Form ◽  
Ionic Surfactants ◽  
Future Perspectives ◽  
Conventional Drug ◽  
Dosing Frequency ◽  
Novel Drug Delivery System ◽  
Novel Drug

There are many problems with the conventional dosage form of various drugs and one of them is dosing frequency in which patients have to take the drug again and again throughout the day which is very difficult mainly for the elder patient. So, to overcome this problem the approach of a novel drug delivery system (NDDS) is used to replace the conventional drug delivery system. NDDS mainly deals with sustained release of drugs which is effective to reduce the dosing frequency. Niosome is one of the best approaches of a novel drug delivery system, in which the drug in solution form is enclosed in vesicle which is made up of non-ionic surfactants. In the case of liposome which is another part of NDDS vesicles is made up of phospholipids. Niosome formulation is a powerful tool to resolve the issue of insolubility and the low bioavailability of drugs. This paper overviews the various methods of preparation of Niosome along with its pharmaceutical applications.

scholarly journals Combined release of antiseptic and antibiotic drugs from visible light polymerized biodegradable nanocomposite hydrogels for periodontitis treatment

2021 ◽  
Author(s):  
József Bakó ◽  
Ferenc Tóth ◽  
József Gáll ◽  
István Varga ◽  
Anton Sculean ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Periodontal Pocket ◽  
Elution Time ◽  
Nanocomposite Hydrogels ◽  
Buffer Solutions ◽  
Antibiotic Drugs ◽  
Different Types

Abstract The in-situ used combination of different types of drugs revolutionized the area of periodontal therapy. The purpose of this study was to develop biodegradable nanocomposite hydrogel (NCHG) as a pH-sensitive drug delivery system. To reach the local applicability of the NCHG in dental practice routinely used blue-light photopolymerization was chosen for the preparation. The reaction time was 60 seconds, which resulted in stable hydrogel structures. Universal Britton-Robinson buffer solutions were used to investigate only the effect of pH for the release of the periodontal pocket useable drugs in the 4-12 range. The release of metronidazole was faster, it came out from the NCHGs within 12 hours, but the chlorhexidine had shown a longer elution time, which was more than 7 days as far as the antiseptic effect was maintained. The release of chlorhexidine showed strong pH depending. The biocompatibility of the NCHGs was proved by Alamar-blue test, and the effectiveness of drug release in the acidic medium was demonstrated. This fast photopolymerizable NCHG can help to approach an ideal locally useable combined drug delivery system which can be used in the amount required of the medicines and can reduce the side effects with the increased effectiveness by following pH changes.

scholarly journals Solid-State Lipid - Based Lipid Drug Delivery System

2021 ◽  
Vol 001 (01) ◽  
Author(s):  
Mamta Nasit ◽  
Meshva Patel ◽  
Ajay Solanki ◽  
Jayendrakumar Patel
Keyword(s):  
Drug Delivery ◽  
Solid State ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Bioavailability ◽  
Aqueous Solubility ◽  
Water Soluble ◽  
Different Types ◽  
Water Soluble Drugs ◽  
Lipid Excipients

In recent time, about 70% of new molecules discovered or under discovery are lipophilic in nature with low aqueous solubility which makes a great challenge for formulation scientists to making these molecules to be have a sufficient aqueous solubility and oral bioavailability. Lipid-based drug delivery system (LBDDS- wide ranging designation for formulations containing a dissolved or suspended drug in lipid excipients) is one of the appropriate approach which gained significant popularity due to their ability to deliver poorly water-soluble drugs with improved solubility and oral bioavailability. Conventional LBDDS, including lipid emulsions, suspensions etc. suffer from various drawbacks limiting their widespread commercialization and use. Therefore, solid-state LBDDS fabricated from conventional LBDDS using different types of solid carriers via various solidification methods eliminated some of the various limitations of conventional LBDDS with great stability. The present review provide overview on the various types of solid state lipid based drug delivery systems, different types of solid carriers use in formulation of solid state lipid based drug delivery system, various solidification techniques for conversion of liquid lipid system to solid dosage form, advantages and some practical limitations of lipid based drug delivery system.

scholarly journals Review of Internet of Wearable Things and Healthcare based Computational Devices

2021 ◽  
Vol 3 (3) ◽  
pp. 263-275
Author(s):  
Joy Iong-Zong Chen
Keyword(s):  
Drug Delivery ◽  
Health Care ◽  
Cardiovascular Diseases ◽  
Drug Delivery Systems ◽  
Wearable Computing ◽  
Future Perspective ◽  
Computing Systems ◽  
Muscle Disorders ◽  
Different Types

Wearable computing have variety of applications in healthcare ranging from muscle disorders to neurocognitive disorders, Alzheimer’s disease, Parkinson’s disease, and psychological diseases, such as cardiovascular diseases, hypertension and so on. Different types of wearable computing devices are used, for example, bio fluidic-place on wearables, textile-place on wearables, and skin-place on wearables including tattoo place on wearables. In drug delivery systems, the wearable computing systems have shown promising developments, increasing its use in personalized healthcare. Wearable contain experiments, which need to be addressed before their consumerist as a fully customized healthcare system. Distinct types of wearable computing devices currently used in healthcare field are reviewed in this paper. Based on various factors, the paper provides an extensive classification of wearable computing devices. Additionally, limitations, current challenges and future perspective in health care is reviewed.

scholarly journals AN OVERVIEW OF TRANSDERMAL DELIVERY SYSTEM

2017 ◽  
Vol 10 (10) ◽  
pp. 36 ◽  
Author(s):  
Reshmi Jayaprakash ◽  
Jahnara Hameed ◽  
Anupriya Anupriya
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Drug Delivery ◽  
Dosage Form ◽  
Systemic Circulation ◽  
Oral Dosage ◽  
Transdermal Drug Delivery System ◽  
Different Types ◽  
Conventional Dosage

Recently, most widely using conventional dosage form such as tablet, capsules, and injections but due to some case we are preferable to choose transdermal drug delivery system (TDDS) because conventional oral dosage form undergo first pass metabolism. In TDDS, skin is the effective medium for the penetration of drug into systemic circulation. This system required very low dose for the effective result or action. One of the major disadvantages of TDDS is penetration rate is very low through the stratum corneum. Nowadays, different types of skin penetration enhancement techniques are used for increasing the penetration. These types of techniques can be also increase the bioavailability. The patients have more preferable to choose this type of drug delivery system because it has more advantages than conventional dosage form. This article is discuses about the anatomy and physiology of skin and its drug penetration capacity, polymers used in transdermal drug delivery and different types of TDDS.

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