How the immune system shapes atherosclerosis: roles of innate and adaptive immunity

2021 ◽  
Author(s):  
Payel Roy ◽  
Marco Orecchioni ◽  
Klaus Ley
Keyword(s):  
Immune System ◽  
Adaptive Immunity ◽  
Innate And Adaptive Immunity

scholarly journals Aging and Options to Halt Declining Immunity to Virus Infections

2021 ◽  
Vol 12 ◽  
Author(s):  
Miguel Ángel Palacios-Pedrero ◽  
Albert D. M. E. Osterhaus ◽  
Tanja Becker ◽  
Husni Elbahesh ◽  
Guus F. Rimmelzwaan ◽  
...  
Keyword(s):  
Older Adults ◽  
Immune System ◽  
Immune Function ◽  
Adaptive Immunity ◽  
Bacterial Infections ◽  
Viral Infections ◽  
Age Group ◽  
Virus Infections ◽  
Innate And Adaptive Immunity ◽  
Chronic Viral Infections

Immunosenescence is a process associated with aging that leads to dysregulation of cells of innate and adaptive immunity, which may become dysfunctional. Consequently, older adults show increased severity of viral and bacterial infections and impaired responses to vaccinations. A better understanding of the process of immunosenescence will aid the development of novel strategies to boost the immune system in older adults. In this review, we focus on major alterations of the immune system triggered by aging, and address the effect of chronic viral infections, effectiveness of vaccination of older adults and strategies to improve immune function in this vulnerable age group.

scholarly journals Bacteriophages and the immune system of the macroorganism

2019 ◽  
pp. 79-84
Author(s):  
I. A. Ivanovа ◽  
A. A. Trufanova ◽  
A. V. Filippenko ◽  
I. A. Bespalova ◽  
N. D. Omelchenko
Keyword(s):  
Immune System ◽  
Immune Responses ◽  
Adaptive Immunity ◽  
Antibiotic Resistant ◽  
Innate And Adaptive Immunity ◽  
Biological Products ◽  
Treatment And Prevention ◽  
Resistant Strains ◽  
Bacterial Viruses

Due to the emergence of antibiotic-resistant strains of bacteria in recent years, the treatment and prevention of various infections with bacteriophages have again become an important area of research. However, when using phages for this purpose, it is necessary to take into account the immune responses of a macroorganism to their introduction. The data about impact of bacterial viruses on the innate and adaptive immunity system of mammals in available literature are few and contradictory. This issue requires further detailed study, especially in the development of new therapeutic and prophylactic biological products based on bacteriophages.

Introduction to Clinical Immunology: Overview of the Immune Response, Autoimmune Conditions, and Immunosuppressive Therapeutics for Rheumatic Diseases

2016 ◽  
Author(s):  
Steven K. Lundy ◽  
Alison Gizinski ◽  
David A. Fox
Keyword(s):  
Immune Response ◽  
Immune System ◽  
T Cell ◽  
Immune Responses ◽  
Autoimmune Diseases ◽  
Adaptive Immunity ◽  
Cell Populations ◽  
Hematopoietic Stem ◽  
Innate And Adaptive Immunity ◽  
Adaptive Immune

The immune system is a complex network of cells and mediators that must balance the task of protecting the host from invasive threats. From a clinical perspective, many diseases and conditions have an obvious link to improper functioning of the immune system, and insufficient immune responses can lead to uncontrolled acute and chronic infections. The immune system may also be important in tumor surveillance and control, cardiovascular disease, health complications related to obesity, neuromuscular diseases, depression, and dementia. Thus, a working knowledge of the role of immunity in disease processes is becoming increasingly important in almost all aspects of clinical practice. This review provides an overview of the immune response and discusses immune cell populations and major branches of immunity, compartmentalization and specialized immune niches, antigen recognition in innate and adaptive immunity, immune tolerance toward self antigens, inflammation and innate immune responses, adaptive immune responses and helper T (Th) cell subsets, components of the immune response that are important targets of treatment in autoimmune diseases, mechanisms of action of biologics used to treat autoimmune diseases and their approved uses, and mechanisms of other drugs commonly used in the treatment of autoimmune diseases. Figures show the development of erythrocytes, platelets, lymphocytes, and other immune system cells originating from hematopoietic stem cells that first reside in the fetal liver and later migrate to the bone marrow, antigen–major histocompatibility complex recognition by T cell receptor control of T cell survival and activation, and Th cells as central determinants of the adaptive immune response toward different stimuli. Tables list cell populations involved in innate and adaptive immunity, pattern recognition receptors with known ligands, autoantibody-mediated human diseases: examples of pathogenic mechanisms, selected Food and Drug Administration–approved autoimmune disease indications for biologics, and mechanism of action of biologics used to treat autoimmune diseases.   This review contains 3 highly rendered figures, 5 tables, and 64 references.

scholarly journals Sexual dimorphism in immune function: The role of sex steroid hormones

2018 ◽  
Vol 51 ◽  
pp. 02007
Author(s):  
Anna Mihailova ◽  
Indrikis Krams
Keyword(s):  
Immune System ◽  
Sexual Dimorphism ◽  
Infectious Diseases ◽  
Immune Function ◽  
Steroid Hormones ◽  
Adaptive Immunity ◽  
Gonadal Hormones ◽  
Sex Steroid ◽  
Innate And Adaptive Immunity

There is evidence of the relation of sex steroid hormones and sexual dimorphism in immune system response to infectious diseases. The aim of this review was to identify the role of sex hormones in immune function and sexual dimorphism of immune reactions. Gonadal hormones together with the immune system play an important role in process of immune responses to the disease [1]. Estrogens, progesterone and testosterone have different impacts on immune cells and different gonadal hormones are of high importance for responses of innate and adaptive immunity [1, 2]. Estrogens mainly enhance immune function while testosterone has a suppressive role. Higher progesterone during pregnancy leads to autoimmune disease remission and an elevated susceptibility toward certain infectious diseases [2, 3, 4]. The intensity and prevalence of viral infections are typically higher in males, whereas disease outcome could be worse for females [5]. Sexual dimorphism of immune function is based on different concentrations of sex hormones in males and females and on a specific mediating role of these hormones in immune function and response along with differences in innate and adaptive immunity.

scholarly journals CD38 and CD157 as Receptors of the Immune System: A Bridge Between Innate and Adaptive Immunity

2006 ◽  
Vol 12 (11-12) ◽  
pp. 334-341 ◽  
Author(s):  
Fabio Malavasi ◽  
Silvia Deaglio ◽  
Enza Ferrero ◽  
Ada Funaro ◽  
Jaime Sancho ◽  
...  
Keyword(s):  
Immune System ◽  
Adaptive Immunity ◽  
Innate And Adaptive Immunity ◽  
System A

scholarly journals Immunity against Fungal Infections

2016 ◽  
Vol 8 ◽  
pp. III.S38707 ◽  
Author(s):  
Shuai Jiang
Keyword(s):  
Immune Response ◽  
Immune System ◽  
Adaptive Immunity ◽  
Fungal Pathogens ◽  
Fungal Infections ◽  
New Agents ◽  
Innate And Adaptive Immunity ◽  
Patients With Cancer ◽  
Molecular Patterns ◽  
Major Target

Fungal diseases are major causes of morbidity and mortality among the immunocompromised, including HIV-infected individuals and patients with cancer. Individuals without a weakened immune system can also suffer from these infections. Not surprisingly, fungi are a major target for the immune system, rendered visible to it by expression of pathogen-associated molecular patterns/signatures. We now appreciate the roles of both innate and adaptive immunity in eliminating fungal infections, and how a disproportionate or inadequate immune response can diminish the host's capacity to eliminate fungi. This review focuses on our current understanding of the roles of innate and adaptive immunity in clearing common and emergent fungal pathogens. A clearer understanding of how the host's immune response tackles fungal infection may provide useful clues as to how we might develop new agents to treat those diseases in the future.

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