scholarly journals Comparative analysis of lysyl oxidase (like) family members in pulmonary fibrosis

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Verena Aumiller ◽  
Benjamin Strobel ◽  
Merrit Romeike ◽  
Michael Schuler ◽  
Birgit E. Stierstorfer ◽  
...  
Respiration ◽  
2012 ◽  
Vol 84 (6) ◽  
pp. 509-517 ◽  
Author(s):  
Shifeng Li ◽  
Xiaoxiao Yang ◽  
Wande Li ◽  
Jingjie Li ◽  
Xingwen Su ◽  
...  

2020 ◽  
Vol 21 (24) ◽  
pp. 9751
Author(s):  
Hung-Yu Lin ◽  
Chia-Jung Li ◽  
Ya-Ling Yang ◽  
Ying-Hsien Huang ◽  
Ya-Tze Hsiau ◽  
...  

The lysyl oxidase (LOX) family members are secreted copper-dependent amine oxidases, comprised of five paralogues: LOX and LOX-like l-4 (LOXL1-4), which are characterized by catalytic activity contributing to the remodeling of the cross-linking of the structural extracellular matrix (ECM). ECM remodeling plays a key role in the angiogenesis surrounding tumors, whereby a corrupt tumor microenvironment (TME) takes shape. Primary liver cancer includes hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), ranked as the seventh most common cancer globally, with limited therapeutic options for advanced stages. In recent years, a growing body of evidence has revealed the key roles of LOX family members in the pathogenesis of liver cancer and the shaping of TME, indicating their notable potential as therapeutic targets. We herein review the clinical value and novel biological roles of LOX family members in tumor progression and the TME of liver cancers. In addition, we highlight recent insights into their mechanisms and their potential involvement in the development of target therapy for liver cancer.


2016 ◽  
Vol 12 (2) ◽  
pp. 499-507 ◽  
Author(s):  
Jinfeng Wang ◽  
Yong Zhu ◽  
Jiuting Tan ◽  
Xiaoxiao Meng ◽  
Hui Xie ◽  
...  

Lysyl oxidase (LOX) is a copper-dependent amine oxidase that plays a critical role in pulmonary fibrosis.


2015 ◽  
Vol 32 (1) ◽  
pp. 13-20 ◽  
Author(s):  
Junio Cota ◽  
Thamy L.R. Corrêa ◽  
André R.L. Damásio ◽  
José A. Diogo ◽  
Zaira B. Hoffmam ◽  
...  

Author(s):  
Patricia Prieto Padín

<p>El presente estudio pretende identificar (a simple golpe de vista, al tomar cuerpo de cuadro comparativo) las similitudes y las diferencias que la excedencia por cuidado de hijos y familiares presentan en los ordenamientos español e irlandés. Para ello, y después de hacer mención a la evolución normativa de estas figuras conciliatorias en ambos países se procede a analizar las categorías fundamentales que integran su estatuto común, compartido o diferenciado, así como los elementos que carecen de correspondencia, conforme aconsejan los maestros en el análisis comparado del Derecho.</p><p>This study aims to identify (at first sight, because of it takes the shape of a comparison chart) the similarities and differences the leave to care for children and family members have in Spanish and Irish’s legal systems. In this sense, and after refering to the regulatory evolution of this conciliatory figures in both countries, the study proceed to analyze the fundamental categories that make up its common statute, shared or differentiated, as well as the elements lacking of correspondence, according advise masters in the comparative analysis of the law.</p>


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