Voxel-based morphometric brain comparison between healthy subjects and major depressive disorder patients in Japanese with the s/s genotype of 5-HTTLPR

IntroductionAccelerated aging is associated with major depressive disorder (MDD) and studies of yoga and meditation based lifestyle intervention (YMLI) on biomarkers of cellular aging are lacking.Aim and objectivesTo investigate the peripheral blood biomarkers of cellular aging in MDD patients after short term YMLI. Biomarkers include DNA damage, oxidative stress (OS), telomere attrition, and nutrition sensing assessed respectively by 8-hydroxy 2’- deoxyguanosine (8-OHdG); reactive oxygen species (ROS) and total antioxidant capacity (TAC); telomere length and telomerase activity; and sirtuin-1.MethodsWe consecutively enrolled 33 MDD patients and 40 healthy subjects; 30 MDD patients were followed up with 12- week YMLI. Biomarkers of cellular aging in peripheral blood were measured with assay kits. All patients were evaluated by examining the correlation between cellular aging markers and Montgomery–Asberg Depression Rating Scale (MADRS) scores.ResultsThe levels of DNA damage, OS, and telomere attrition in MDD patients were significantly higher than healthy subjects (all P = 0.005). The MADRS scores had a significantly positive association with 8-OHdG and ROS levels and negative association with TAC, telomerase and sirtuin-1 levels (all P < 0.01).ConclusionsPeripheral blood biomarker levels in our results suggest significant cellular aging in MDD patients compared to healthy subjects. There was strong correlation between the changes in biomarkers of cellular aging and clinical improvement in MDD. Our study is the first to show significant increase in sirtuin-1 levels in MDD patients after yoga and meditation. Therefore, biomarkers of cellular aging might be indicators of MDD severity and clinical remission after YMLI.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Significantly lower nerve growth factor levels in patients with major depressive disorder than in healthy subjects: a meta-analysis and systematic review

Neuropsychiatric Disease and Treatment ◽

10.2147/ndt.s81432 ◽

2015 ◽

pp. 925 ◽

Cited By ~ 4

Author(s):

Ping-Tao Tseng ◽

Pao-Yen Lin ◽

Kun-Yu Tu ◽

Yu-Shian Cheng ◽

Ching-Kuan Wu ◽

...

Keyword(s):

Systematic Review ◽

Major Depressive Disorder ◽

Nerve Growth Factor ◽

Growth Factor ◽

Depressive Disorder ◽

Healthy Subjects ◽

Meta Analysis ◽

Major Depressive ◽

Nerve Growth

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Identification of major depressive disorder disease-related genes and functional pathways based on system dynamic changes of network connectivity

10.21203/rs.2.16893/v2 ◽

2020 ◽

Author(s):

Ruijie Geng ◽

Xiao Huang

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Pathway Analysis ◽

Healthy Subjects ◽

Kegg Pathway ◽

Network Connectivity ◽

Differentially Expressed ◽

Therapeutic Drug ◽

Major Depressive ◽

Kegg Pathway Analysis

Abstract Objective: Major depressive disorder (MDD) is a leading psychiatric disorder that involves complex abnormal biological functions and neural networks. This study aimed to compare the changes in the network connectivity of different brain tissues under different pathological conditions, analyzed the biological pathways and genes that are significantly related to disease progression, and further predicted the potential therapeutic drug targets.Methods: Expression of differentially expressed genes (DEGs) were analyzed with postmortem cingulate cortex (ACC) and prefrontal cortex (PFC) mRNA expression profile datasets downloaded from the Gene Expression Omnibus (GEO) database, including 76 MDD patients and 76 healthy subjects in ACC and 63 MDD patients and 63 healthy subjects in PFC. The co-expression network construction was based on system network analysis. The function of the genes was annotated by Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. Human Protein Reference Database (HPRD, http://www.hprd.org/) was used for gene interaction relationship mapping.Results: We filtered 586 DEGs in ACC and 616 DEGs in PFC for further analysis. By constructing the Co-expression network, we found that the gene connectivity was significantly reduced under disease conditions (P=0.04 in PFC and P=1.227e-09 in ACC). Crosstalk analysis showed that CD19, PTDSS2 and NDST2 were significantly differentially expressed in ACC and PFC of MDD patients. Among them, CD19 and PTDSS2 have been targeted by several drugs in the Drugbank database. KEGG pathway analysis demonstrated that the function of CD19 and PTDSS2 were enriched with the pathway of Glycerophospholipid metabolism and T cell receptor signaling pathway. Conclusion: Co-expression network and tissue comparing analysis can identify signaling pathways and cross talk genes related to MDD, which may provide novel insight for understanding the molecular mechanisms of MDD.

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Emotional processing and executive functions in major depressive disorder: dorsal prefrontal activity correlates with performance in the intra–extra dimensional set shift

Acta Neuropsychiatrica ◽

10.1111/j.1601-5215.2010.00494.x ◽

2010 ◽

Vol 22 (6) ◽

pp. 269-279 ◽

Cited By ~ 11

Author(s):

Alexander Heinzel ◽

Georg Northoff ◽

Heinz Boeker ◽

Peter Boesiger ◽

Simone Grimm

Keyword(s):

Major Depressive Disorder ◽

Prefrontal Cortex ◽

Depressive Disorder ◽

Executive Functions ◽

Healthy Subjects ◽

Emotional Processing ◽

Cognitive Impairments ◽

Healthy Controls ◽

Major Depressive ◽

The Right

Heinzel A, Northoff G, Boeker H, Boesiger P, Grimm S. Emotional processing and executive functions in major depressive disorder: dorsal prefrontal activity correlates with performance in the intra–extra dimensional set shift.Objective:Major depressive disorder (MDD) is characterised by predominately negatively valenced emotional symptoms that are often accompanied by cognitive impairments. We posited that cognitive impairments in MDD are related to altered emotional processing in prefrontal cortex.Methods:We compared 20 medication-free patients with MDD and 29 matched healthy controls. Both groups performed an emotional task during functional magnetic resonance imaging (fMRI). Furthermore, they completed the intra–extra dimensional set shift (IED) test probing for cognitive impairments. Then we correlated the results of the IED with the changes in fMRI BOLD signal in MDD patients and healthy subjects.Results:The subcategory of the IED applying extradimensional shift (EDS) showed a divergent performance of the MDD group committing significantly more errors than the control group. Correlating the EDS errors with fMRI signal changes, the healthy subjects showed a positive correlation with the right ventrolateral prefrontal cortex and the right orbitofrontal cortex. MDD subjects, in contrast, showed a positive correlation in right dorsolateral prefrontal cortex (DLPFC) and a negative correlation in the left dorsomedial prefrontal cortex (DMPFC).Conclusion:We hypothesise that the differential correlation in healthy controls and MDD patients may reflect the use of different strategies in their performance. The impaired executive functions, as reflected by altered processing in right DLPFC and left DMPFC, may implicitly influence emotional processing in patients suffering from MDD.

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Noradrenergic function in generalized anxiety disorder, major depressive disorder, and healthy subjects

Biological Psychiatry ◽

10.1016/0006-3223(89)90158-3 ◽

1989 ◽

Vol 25 (2) ◽

pp. 141-152 ◽

Cited By ~ 79

Author(s):

Serge Sevy ◽

Georges N. Papadimitriou ◽

Daisy W. Surmont ◽

Serge Goldman ◽

Julien Mendiewicz

Keyword(s):

Major Depressive Disorder ◽

Anxiety Disorder ◽

Depressive Disorder ◽

Generalized Anxiety Disorder ◽

Healthy Subjects ◽

Generalized Anxiety ◽

Major Depressive ◽

Noradrenergic Function

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Lower availability of midbrain serotonin transporter between healthy subjects with and without a family history of major depressive disorder – a preliminary two-ligand SPECT study

European Psychiatry ◽

10.1016/j.eurpsy.2013.11.004 ◽

2014 ◽

Vol 29 (7) ◽

pp. 414-418 ◽

Cited By ~ 14

Author(s):

P.C. Hsieh ◽

K.C. Chen ◽

T.L. Yeh ◽

I.H. Lee ◽

P.S. Chen ◽

...

Keyword(s):

Major Depressive Disorder ◽

Family History ◽

Depressive Disorder ◽

Serotonin Transporter ◽

Healthy Subjects ◽

Healthy Controls ◽

Major Depressive ◽

Dopaminergic Dysfunction ◽

History Of ◽

Family History Of Depression

AbstractPurposeSerotonin transporter (SERT) and dopamine transporter (DAT) levels differ in patients with major depressive disorder (MDD) who are in a depressed state in comparison with healthy controls. In addition, a family history of depression is a potent risk factor for developing depression, and inherited vulnerability to serotonergic and dopaminergic dysfunction is suspected in this. The aim of this study was to examine the availabilities of midbrain SERT and striatal DAT in healthy subjects with and without a first-degree family history of MDD.MethodsEight healthy subjects with first-degree relatives with MDD and 16 sex- and age-matched healthy controls were recruited. The availabilities of SERT and DAT were approximated using SPECT, employing [123I] 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM) and [99mTc] TRODAT-1 as the ligands, respectively. There are missing data for one participant with a first-degree family history of MDD from the ADAM study, due to a lack of the radio-ligand at the time of experiment.ResultsSERT availability in the midbrain was significantly lower in subjects with a first-degree family history of MDD than in healthy subjects. However, DAT availability was no different between two groups.ConclusionsThe results with regard to the midbrain SERT level suggest the heritability of MDD.

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