scholarly journals Adaptive Landscape Shaped by Core Endogenous Network Coordinates Complex Early Progenitor Fate Commitments in Embryonic Pancreas

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Junqiang Wang ◽  
Ruoshi Yuan ◽  
Xiaomei Zhu ◽  
Ping Ao
2019 ◽  
Vol 11 (9) ◽  
pp. 2578
Author(s):  
Jumeniyaz Seydehmet ◽  
Guang-Hui Lv ◽  
Abdugheni Abliz

Irrational use and management of water and land are associated with poor hydro-geological conditions causing water logging and salinization problems, possibly leading to farmland abandonment and economic loss. This poses a great challenge to the sustainability of oasis’ and requires desalinization through reasonable landscape design by multiple crossing studies so we collected traditional knowledge by field interviews and literature schemes, except for the modern desalinization approaches by literature, and we found that the salinization problem has been solved by traditional land reclamation, traditional drainage, natural drainage and flood irrigation, locally. It is worth mentioning that the traditional reclamation in salinized areas requires flood water, sand dunes and a salinized pit area; the sand dunes are used to elevate the pit surface, and water is used to leach salt from the soil. Natural drainage (the depth and width are 4–10 m and 50–100 m, respectively) caused by flash flooding has significant benefits to some salinized villages in the range of 3000–5000 m and ancient groundwater drainage systems, such as Karez are supporting the oasis with drainage water for centuries. In addition landscape characteristics, salinization and hydro-geological conditions of the oasis were studied from Landsat image, DEM, literature and field photos. Then based on the gathered information above, a desalinization model was developed to decrease the groundwater table and salt leaching in the water logging landscape. Then according to landscape characteristics, different desalinization approaches were recommended for different landscapes. To address environmental uncertainties, an adaptive landscape management and refinement approach was developed, and acceptance of the model was validated by stakeholder opinion. The results provide guidelines for sustainable desalinization design and highlight the importance of combining traditional knowledge and modern ecological principles in sustainable landscape design.


2021 ◽  
Author(s):  
Anik Dutta ◽  
Fanny E. Hartmann ◽  
Carolina Sardinha Francisco ◽  
Bruce A. McDonald ◽  
Daniel Croll

AbstractThe adaptive potential of pathogens in novel or heterogeneous environments underpins the risk of disease epidemics. Antagonistic pleiotropy or differential resource allocation among life-history traits can constrain pathogen adaptation. However, we lack understanding of how the genetic architecture of individual traits can generate trade-offs. Here, we report a large-scale study based on 145 global strains of the fungal wheat pathogen Zymoseptoria tritici from four continents. We measured 50 life-history traits, including virulence and reproduction on 12 different wheat hosts and growth responses to several abiotic stressors. To elucidate the genetic basis of adaptation, we used genome-wide association mapping coupled with genetic correlation analyses. We show that most traits are governed by polygenic architectures and are highly heritable suggesting that adaptation proceeds mainly through allele frequency shifts at many loci. We identified negative genetic correlations among traits related to host colonization and survival in stressful environments. Such genetic constraints indicate that pleiotropic effects could limit the pathogen’s ability to cause host damage. In contrast, adaptation to abiotic stress factors was likely facilitated by synergistic pleiotropy. Our study illustrates how comprehensive mapping of life-history trait architectures across diverse environments allows to predict evolutionary trajectories of pathogens confronted with environmental perturbations.


2018 ◽  
Vol 49 (1) ◽  
pp. 379-408 ◽  
Author(s):  
Roger B.J. Benson

Dinosaurs were large-bodied land animals of the Mesozoic that gave rise to birds. They played a fundamental role in structuring Jurassic–Cretaceous ecosystems and had physiology, growth, and reproductive biology unlike those of extant animals. These features have made them targets of theoretical macroecology. Dinosaurs achieved substantial structural diversity, and their fossil record documents the evolutionary assembly of the avian body plan. Phylogeny-based research has allowed new insights into dinosaur macroevolution, including the adaptive landscape of their body size evolution, patterns of species diversification, and the origins of birds and bird-like traits. Nevertheless, much remains unknown due to incompleteness of the fossil record at both local and global scales. This presents major challenges at the frontier of paleobiological research regarding tests of macroecological hypotheses and the effects of dinosaur biology, ecology, and life history on their macroevolution.


Author(s):  
Anja Brüll ◽  
Timo Matti Wirth ◽  
Frank Lohrberg ◽  
Annet Kempenaar ◽  
Marlies Brinkhuijsen ◽  
...  

AbstractLandscapes can be understood as socialecological systems under constant change. In Europe various territorial dynamics pose persistent challenges to maintaining diverse landscapes both as European heritage and in their capacity to provide vital functions and services. Concurrently, under the competence of cohesion policy, the EU is attempting to improve policy making by better policy coordination and respecting regional specifics. This paper explores the question how a policy dedicated to landscape can help to handle territorial change and support territorial cohesion. It presents results and performances of the ESPON applied research study LP3LP: (1) a common landscape policy for the Three Countries Park, across the Dutch, German and Belgium borders, including a spatial landscape vision, a governance proposal of adaptive landscape management, and thematic strategies dealing with green infrastructure, cultural heritage, complementary biomass and quality production; (2) recommendations at the EU level. In discussing the significance of a landscape approach for EU policy,three dimensions of landscape are linked withimportant aspects of territorial cohesion: ‘landscape as asset’ addressing natural-cultural territorial capital as an indigenous base forsmart, sustainable, and inclusivedevelopment;‘landscape as place’ stressing the relevance of landscape for place-based policies; and ‘landscape as common ground’ highlighting its potential for horizontal, vertical, and territorial integration.


2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Gustavo Jesus Vazquez-Zapien ◽  
Monica Maribel Mata-Miranda ◽  
Virginia Sanchez-Monroy ◽  
Raul Jacobo Delgado-Macuil ◽  
David Guillermo Perez-Ishiwara ◽  
...  

Some of the greatest challenges in stem cells (SCs) biology and regenerative medicine are differentiation control of SCs and ensuring the purity of differentiated cells. In this work, we differentiated mouse pluripotent stem cells (mPSCs) toward pancreatic cells characterizing this differentiation process by molecular and spectroscopic technics. Both mPSCs and Differentiated Pancreatic Cells (DPCs) were subjected to a genetic, phenotypic, and biochemical analysis by real-time quantitative PCR (RT-qPCR), immunocytochemistry, and Fourier Transform Infrared (FTIR) spectroscopy. Cultured mPCSs expressed pluripotent genes and proteins (NanogandSOX2). DPCs expressed endodermal genes (SOX17andPdx1) at day 11, an inductor gene of embryonic pancreas development (Pdx1) at day 17 and pancreas genes and proteins (InsulinandGlucagon) at day 21 of differentiation. Likewise, FTIR spectra of mPSCs and DPCs at different maturation stages (11, 17, and 21 days) were obtained and showed absorption bands related with different types of biomolecules. These FTIR spectra exhibited significant spectral changes agreeing with the differentiation process, particularly in proteins and nucleic acids bands. In conclusion, the obtained DPCs passed through the chronological stages of embryonic pancreas development and FTIR spectra provide a new biophysical parameter based on molecular markers indicating the differentiation process of mPSCs to specialized cells.


1999 ◽  
Vol 35 (10) ◽  
pp. 560-563 ◽  
Author(s):  
Michael I. Rose ◽  
Dale C. Brown ◽  
Neil R. Pellis ◽  
Christopher A. Crisera ◽  
Kari L. Colen ◽  
...  
Keyword(s):  

2021 ◽  
Author(s):  
James Lyons-Weiler

AbstractHuman evolution sits at several important thresholds. In organic evolution, interplay between exogenous environmental and genetic factors rendered new phenotypes at rates limited by genetic variation. The interplay took place on adaptive fitness landscapes determined by correspondence of genetic and environmental relationships. Human evolution involved important emergences that altered the adaptive landscape: language, writing, organized societies, science, and the internet. These endogenous factors ushered in transformative periods leading to more rapidly evolving emergences. I explore the impact of development of emerging biotransformative technologies capable of being applied to effect self-genetic modification and artificial intelligence-augmented cognition on the evolutionary landscape of phenotypes important to cognitive plasticity. Interaction effects will yield unanticipated emergences resulting in hyperrealm adaptive landscapes with more rapid evolutionary processes that feed back upon more fundamental levels while vastly outpacing organic evolution. Emerging technologies exist that are likely to impact the evolution of cognitive plasticity in humans in ways and at rates that will lead to societal upheaval. I show that the theoretical contribution of organic evolution in future human evolution is expected to become comparatively insignificant relative to that made by endogenous environmental factors such as external cognition aids and manipulation of the human genome. The results support the conclusion of a strong recommendation of a moratorium on the adoption of any technology capable of completely altering the course of human evolution.


2021 ◽  
Author(s):  
Meritxell Rovira ◽  
Goutham Atla ◽  
Miguel Angel Maestro ◽  
Vane Grau ◽  
Javier García-Hurtado ◽  
...  

SUMMARYUnderstanding genomic regulatory mechanisms of pancreas differentiation is relevant to the pathophysiology of diabetes mellitus, and to the development of replacement therapies. Numerous transcription factors promote β cell differentiation, although less is known about negative regulators. Earlier epigenomic studies suggested that the transcriptional repressor REST could be a suppressor of endocrine gene programs in the embryonic pancreas. However, pancreaticRestknock-out mice failed to show increased numbers of endocrine cells, suggesting that REST is not a major regulator of endocrine differentiation. Using a different conditional allele that enables profound REST inactivation, we now observe a marked increase in the formation of pancreatic endocrine cells. REST inhibition also promoted endocrinogenesis in zebrafish and mouse early postnatal ducts, and induced β-cell specific genes in human adult duct-derived organoids. Finally, we define REST genomic programs that suppress pancreatic endocrine differentiation. These results establish a crucial role of REST as a negative regulator of pancreatic endocrine differentiation.


2022 ◽  
Vol 354 (11-12) ◽  
pp. 123-128
Author(s):  
E. V. Kuzina

Relevance. The preservation, reproduction and rational use of agricultural soil fertility is the main condition for the stable development of the agro-industrial complex. Mechanical tillage systems, the use of mineral and microbiological fertilizers are one of the main links in adaptive landscape farming systems. In the conditions of a sharp decrease in the rates of fertilizer application, an increase in the imbalance of elements of mineral nutrition of plants observed in recent years in agroecosystems, the function of improving the regimes of chernozems, preserving their fertility is designed to perform resource-saving technologies of soil cultivation in combination with effective methods of using agrochemicals that combine environmental and economic feasibility.Methods. The experiments were laid in 2017–2019 on chernozem heavy loamy soils typical for most farms in the Ulyanovsk region. The object of the study is spring wheat, the variety Ulyanovskaya 100. The subject of the study is the methods of tillage, doses of mineral fertilizers, the biological product "BisolbiFit". The following technological methods of using the biological product were studied: seed treatment before sowing, non-root treatment of vegetating plants and a combination of these methods. The experiment was carried out on three backgrounds: N0P0K0 (control); 2) N30P30K30; 3) N60P60K60.Results. It was found that the best nitrification ability was possessed by variants with fine combback and comb-back with soil-deepening treatment, in which the weighted average content of nitrate nitrogen was 3.29–3.33 mg/100 g, which is 35–36%; 26–28%; 43–44% more than with fine, conventional non-dump and dump treatment respectively. Plowing improved the conditions of phosphorus and potassium nutrition of plants by 25–37% and 6–14% compared to other treatments. When N30P30K30 and N60 P60 K60 were applied to the soil, the content of nitrate nitrogen increased by 46 and 91%, phosphorus — by 0–14% and potassium — by 6 and 21% compared to the nonfertilized background. More effective in terms of the effect on the productivity of spring wheat were comb-shaped treatments, where the average yield was 2.89–2.94 t/ha, which exceeded the usual plowing by 0.19–0.24 t/ha. The greatest increase in yield was obtained when combining the methodsseed treatment + spraying of vegetative plants with the biological preparation "BisolbiFit". On an unfertilized background, the increase in grain yield was -0.71, on the background of N30P30K30 — 1.04, on the background of N60P60K60 — 1.56 t/ha.


Sign in / Sign up

Export Citation Format

Share Document