Effects of low skeletal muscle mass and sarcopenic obesity on albuminuria: a 7-year longitudinal study

Abstract Objectives Obesity is a major risk factor for metabolic syndrome, with its prevalence has increased over the past decade. Major changes in body composition with aging have a significant effect on many clinical outcomes. Sarcopenic obesity consists of both the presence of abnormal adipose tissue with a deficit of muscle mass. Results Of the 241 subjects in this study (average age 35.32 years), 176 (73.03%) were classified as MUO phenotype. Based on this study, the prevalence of sarcopenic obesity was 7.88%. We found that high fat-free mass was more strongly and significantly associated with MUO phenotype. Furthermore, we found that individuals with high fat-free mass and high skeletal muscle mass had a significantly low prevalence of MUO phenotype. A significant positive correlation between metabolic phenotypes and sarcopenic obesity was also observed after all potential covariates were adjusted for. These results of this study suggest that increased adiposity and decreased skeletal muscle mass are associated with unfavorable metabolic traits among overweight and obese Iranian women. SO was also found to be associated with a greater risk of developing MUO phenotype.

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Medical costs of a low skeletal muscle mass are modulated by dietary diversity and physical activity in community-dwelling older Taiwanese: a longitudinal study

International Journal of Behavioral Nutrition and Physical Activity ◽

10.1186/s12966-017-0487-x ◽

2017 ◽

Vol 14 (1) ◽

Cited By ~ 8

Author(s):

Yuan-Ting C. Lo ◽

Mark L. Wahlqvist ◽

Yi-Chen Huang ◽

Shao-Yuan Chuang ◽

Chi-Fen Wang ◽

...

Keyword(s):

Physical Activity ◽

Skeletal Muscle ◽

Longitudinal Study ◽

Muscle Mass ◽

Skeletal Muscle Mass ◽

Dietary Diversity ◽

Medical Costs ◽

Community Dwelling

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Additive effect of low skeletal muscle mass and abdominal obesity on coronary artery calcification

Acta Endocrinologica ◽

10.1530/eje-20-0885 ◽

2021 ◽

Author(s):

Ji Eun Jun ◽

Mira Kang ◽

Sang-Man Jin ◽

Kyunga Kim ◽

You-Cheol Hwang ◽

...

Keyword(s):

Skeletal Muscle ◽

Coronary Artery ◽

Muscle Mass ◽

Abdominal Obesity ◽

Coronary Artery Calcification ◽

Skeletal Muscle Mass ◽

Reference Group ◽

Sarcopenic Obesity ◽

Cvd Risk ◽

Increased Risk

Objective We aimed to investigate the interaction of reduced skeletal muscle mass and abdominal obesity on coronary artery calcification (CAC). Design and methods A total of 19,728 adults free of cardiovascular disease (CVD) who contemporaneously underwent cardiac tomography and bioelectrical impedance analysis were enrolled in a cross-sectional and longitudinal cohort. Skeletal muscle mass index (SMI) was calculated the following formula: SMI (%) = total appendicular muscle mass (kg)/body weight (kg) x 100 according to sex. CAC presence or incidence was defined as CAC score>0, and CAC progression was defined as √CAC score (follow-up) − √CAC score (baseline)>2.5. Pre-sarcopenia was defined as SMI ≤ –1.0 standard deviation of the sex-specific mean of a young reference group. Abdominal obesity was defined as waist circumference ≥90cm for men and ≥85cm for women. All individuals were further classified into four groups: normal, abdominal obesity alone, pre-sarcopenia alone, and pre-sarcopenic obesity. Results Individuals with pre-sarcopenic obesity showed the highest adjusted odds ratio (AOR) for CAC presence (AOR 2.16, 95% confidence interval [CI]: 1.98–2.36, P<0.001) as well as total CAC incidence and progression (adjusted hazard ratio 1.54, 95% CI: 1.37–1.75, P<0.001), compared with normal individuals. Pre-sarcopenic obesity significantly increased CAC incidence and progression compared to either pre-sarcopenia or abdominal obesity alone. Conclusion Pre-sarcopenia and abdominal obesity together were significantly associated with a higher CAC presence and increased risk of CAC incidence and progression, independent of traditional CVD risk factors.

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MON-LB700: Impact of Low Skeletal Muscle Mass, Muscle Quality and Sarcopenic Obesity on Patients Awaiting Liver Transplantation

Clinical Nutrition ◽

10.1016/s0261-5614(19)32155-7 ◽

2019 ◽

Vol 38 ◽

pp. S320

Author(s):

C.M. Peteiro Miranda ◽

J.J. Ortez Toro ◽

B. Sanz Martín ◽

S. Roman Gimeno ◽

J.A. Gimeno Orna ◽

...

Keyword(s):

Skeletal Muscle ◽

Liver Transplantation ◽

Muscle Mass ◽

Skeletal Muscle Mass ◽

Muscle Quality ◽

Sarcopenic Obesity

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Association between −308 G/A TNF-αPolymorphism and Appendicular Skeletal Muscle Mass Index as a Marker of Sarcopenia in Normal Weight Obese Syndrome

Disease Markers ◽

10.1155/2013/983424 ◽

2013 ◽

Vol 35 ◽

pp. 615-623 ◽

Cited By ~ 23

Author(s):

L. Di Renzo ◽

F. Sarlo ◽

L. Petramala ◽

L. Iacopino ◽

G. Monteleone ◽

...

Keyword(s):

Skeletal Muscle ◽

Body Composition ◽

Muscle Mass ◽

Lean Mass ◽

Skeletal Muscle Mass ◽

Normal Weight ◽

Sarcopenic Obesity ◽

Appendicular Skeletal Muscle ◽

Skeletal Muscle Mass Index ◽

Appendicular Skeletal Muscle Mass

Background and Aim. Normal weight obese (NWO) syndrome is characterized by normal body mass index (BMI), but high amount of fat mass and reduced lean mass. We evaluated allelic frequency of the G/A −308 TNF-αpolymorphism and prevalence of sarcopenia in NWO.Methods. We enrolled 120 Italian healthy women, distinguished into 3 groups: normal weight (NW); NWO, and preobese-obese (PreOB/OB) and evaluated anthropometric parameters, body composition by dual X-ray absorptiometry, blood tests, and genotyping of G/A −308 TNF-αpolymorphism.Results. We found a positive association between sarcopenic obesity and −308 TNF-αpolymorphism. All obese women were sarcopenic and were no carrier of mutation (G/G). Among all G/G, NWO showed significant differences in lean mass and total body lean mass (TBLean) with respect to NW and PreOB/OB (P<0.001). Regarding appendicular skeletal muscle mass index values, 4.21% of NW were sarcopenic (50% G/G and 50% G/A); the same percentage was observed in NWO subjects (100% G/G). Moreover, 2.10% of PreOB/OB were sarcopenic and all were G/G.Conclusion. Our study suggests that TNF-αpolymorphism contributes to sarcopenic obesity susceptibility, in association with body composition. This is the first study that shows the importance of TNF-αpolymorphism to determine TBLean variation in NWO syndrome.

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