Factors associated with skeletal muscle mass, sarcopenia, and sarcopenic obesity in older adults: a multi-continent study

We sought to identify the frequencies of presarcopenia, sarcopenia, and sarcopenic obesity in patients with nonalcoholic fatty liver disease (NAFLD) and to cross-sectionally determine the nutritional and dietary factors associated with loss of skeletal muscle mass in such patients. Dietary and body component changes produced by a diet intervention were longitudinally investigated. Forty-six NAFLD patients (24 males and 22 females) were enrolled. A second diet treatment was performed at 6 months after entry in 19 of the enrolled patients (6 males and 13 females). Body compositions and dietary nutrients at six months later were compared with those at entry. Three of the 24 (13%) males and four of the 22 (18%) females fulfilled the criteria for presarcopenia and one (5%) female NAFLD patient was in the criteria for sarcopenia at baseline. None of the patients were in the criteria for sarcopenic obesity. The factors associated with skeletal muscle index in the males were body mass index (BMI), insulin-like growth factor-1, total energy intake, and lipid intake, but only BMI and bone mineral density in females at baseline. The diet intervention decreased the skeletal muscle mass in the 6 males by decreasing the total energy intake via lower protein and lipid intakes and improved their liver dysfunction. In the 13 females, a decrease in total energy intake via lower carbohydrate and lipid intake did not change the skeletal muscle mass. These results suggest that loss of skeletal muscle mass is frequently observed in nonobese NAFLD patients and that the frequency of sarcopenic obesity seems to be rare in NAFLD patients. The nutritional and dietary factors that regulate loss of skeletal muscle mass were distinct between our male and female NAFLD patients. Thus, the skeletal muscle mass of such patients as well as their body weight and liver function should be monitored during diet interventions.

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Factors Associated with the Serum Myostatin Level in Patients Undergoing Peritoneal Dialysis: Potential Effects of Skeletal Muscle Mass and Vitamin D Receptor Activator Use

Calcified Tissue International ◽

10.1007/s00223-016-0118-6 ◽

2016 ◽

Vol 99 (1) ◽

pp. 13-22 ◽

Cited By ~ 8

Author(s):

Shunsuke Yamada ◽

Kazuhiko Tsuruya ◽

Hisako Yoshida ◽

Masanori Tokumoto ◽

Kenji Ueki ◽

...

Keyword(s):

Skeletal Muscle ◽

Vitamin D ◽

Peritoneal Dialysis ◽

Muscle Mass ◽

Vitamin D Receptor ◽

Skeletal Muscle Mass ◽

Factors Associated ◽

Receptor Activator

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Cutoff values for appendicular skeletal muscle mass and strength in relation to fear of falling among Brazilian older adults: cross-sectional study

Sao Paulo Medical Journal ◽

10.1590/1516-3180.2017.0049030517 ◽

2017 ◽

Vol 135 (5) ◽

pp. 434-443 ◽

Cited By ~ 5

Author(s):

Ricardo Aurélio Carvalho Sampaio ◽

Priscila Yukari Sewo Sampaio ◽

Luz Albany Arcila Castaño ◽

João Francisco Barbieri ◽

Hélio José Coelho Júnior ◽

...

Keyword(s):

Older Adults ◽

Skeletal Muscle ◽

Muscle Mass ◽

Skeletal Muscle Mass ◽

Fear Of Falling ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Appendicular Skeletal Muscle ◽

Appendicular Skeletal Muscle Mass

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Appendicular skeletal muscle mass to truncal fat mass ratio as a new index for osteosarcopenic obesity syndrome in older adults: emphasizing the role of central obesity

10.21203/rs.2.22583/v1 ◽

2020 ◽

Author(s):

Lazuardhi Dwipa ◽

Rini Widiastuti ◽

Alif Bagus Rakhimullah ◽

Marcellinus Maharsidi ◽

Yuni Susanti Pratiwi ◽

...

Keyword(s):

Older Adults ◽

Skeletal Muscle ◽

Body Composition ◽

Muscle Mass ◽

Fat Mass ◽

Central Obesity ◽

Skeletal Muscle Mass ◽

Positive Correlation ◽

Appendicular Skeletal Muscle ◽

Appendicular Skeletal Muscle Mass

Abstract Background The relationship between obesity and low bone mineral density (BMD) in older adults is still unclear. Most of the previous study did not account the factor of sarcopenia which is the progressive loss of skeletal muscle mass due to aging, and distribution of fat in obesity. Thus, this study was aimed to explore the correlation between appendicular skeletal muscle mass (ASMM), total fat mass (FM), and truncal fat mass (TrFM) as well as indexes (ASMM/FM and ASMM/TrFM ratio) with BMD in older adults.Methods This was an analytic cross-sectional study. Dual x-ray absorptiometry (DXA) and bioelectric impedance analysis (BIA) were used to assess BMD and body composition, respectively. Appendicular Skeletal Muscle Mass (ASMM) were used in the analysis to reflect sarcopenia, Fat Mass (FM) and Trunkal Fat Mass (TrFM) were used to reflect general and central obesity, respectively. All data were obtained from medical records of Geriatric Clinic of Hasan Sadikin General Hospital Bandung Indonesia from January 2014 to December 2018. The correlation between body compositions variable with BMD were analyzed using Spearman’s test. We also conducted a comparison analysis of body composition variables between low and normal BMD using Mann-Whitney test. Results A total of 112 subjects were enrolled in the study. ASMM and TrFM were positive (rs=0.517, p<0.001) and negative (rS=-0.22, p=0.02) correlated with BMD, respectively. FM were not correlated with BMD, rS=-0.113 (p=0.234). As indexes, ASMM/FM and ASMM/TrFM had positive correlation with BMD, rS=0.277 (p<0.001), and rS=0.391 (p<0.001), respectively. The ASMM, TrFM, and ASMM/TrFM ratio between normal and low BMD also significantly different (p<0.001), meanwhile FM were not (p=0.204).Conclusion ASMM and TrFM have a positive and negative correlation with BMD, respectively. ASMM/TrFM ratio as new sarcopenia-central obesity index has a positive correlation with BMD.

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