scholarly journals Diagnosis of common pulmonary diseases in children by X-ray images and deep learning

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Kai-Chi Chen ◽  
Hong-Ren Yu ◽  
Wei-Shiang Chen ◽  
Wei-Che Lin ◽  
Yi-Chen Lee ◽  
...  

Abstract Acute lower respiratory infection is the leading cause of child death in developing countries. Current strategies to reduce this problem include early detection and appropriate treatment. Better diagnostic and therapeutic strategies are still needed in poor countries. Artificial-intelligence chest X-ray scheme has the potential to become a screening tool for lower respiratory infection in child. Artificial-intelligence chest X-ray schemes for children are rare and limited to a single lung disease. We need a powerful system as a diagnostic tool for most common lung diseases in children. To address this, we present a computer-aided diagnostic scheme for the chest X-ray images of several common pulmonary diseases of children, including bronchiolitis/bronchitis, bronchopneumonia/interstitial pneumonitis, lobar pneumonia, and pneumothorax. The study consists of two main approaches: first, we trained a model based on YOLOv3 architecture for cropping the appropriate location of the lung field automatically. Second, we compared three different methods for multi-classification, included the one-versus-one scheme, the one-versus-all scheme and training a classifier model based on convolutional neural network. Our model demonstrated a good distinguishing ability for these common lung problems in children. Among the three methods, the one-versus-one scheme has the best performance. We could detect whether a chest X-ray image is abnormal with 92.47% accuracy and bronchiolitis/bronchitis, bronchopneumonia, lobar pneumonia, pneumothorax, or normal with 71.94%, 72.19%, 85.42%, 85.71%, and 80.00% accuracy, respectively. In conclusion, we provide a computer-aided diagnostic scheme by deep learning for common pulmonary diseases in children. This scheme is mostly useful as a screening for normal versus most of lower respiratory problems in children. It can also help review the chest X-ray images interpreted by clinicians and may remind possible negligence. This system can be a good diagnostic assistance under limited medical resources.

2021 ◽  
Vol 11 (10) ◽  
pp. 993
Author(s):  
Roberta Fusco ◽  
Roberta Grassi ◽  
Vincenza Granata ◽  
Sergio Venanzio Setola ◽  
Francesca Grassi ◽  
...  

Objective: To report an overview and update on Artificial Intelligence (AI) and COVID-19 using chest Computed Tomography (CT) scan and chest X-ray images (CXR). Machine Learning and Deep Learning Approaches for Diagnosis and Treatment were identified. Methods: Several electronic datasets were analyzed. The search covered the years from January 2019 to June 2021. The inclusion criteria were studied evaluating the use of AI methods in COVID-19 disease reporting performance results in terms of accuracy or precision or area under Receiver Operating Characteristic (ROC) curve (AUC). Results: Twenty-two studies met the inclusion criteria: 13 papers were based on AI in CXR and 10 based on AI in CT. The summarized mean value of the accuracy and precision of CXR in COVID-19 disease were 93.7% ± 10.0% of standard deviation (range 68.4–99.9%) and 95.7% ± 7.1% of standard deviation (range 83.0–100.0%), respectively. The summarized mean value of the accuracy and specificity of CT in COVID-19 disease were 89.1% ± 7.3% of standard deviation (range 78.0–99.9%) and 94.5 ± 6.4% of standard deviation (range 86.0–100.0%), respectively. No statistically significant difference in summarized accuracy mean value between CXR and CT was observed using the Chi square test (p value > 0.05). Conclusions: Summarized accuracy of the selected papers is high but there was an important variability; however, less in CT studies compared to CXR studies. Nonetheless, AI approaches could be used in the identification of disease clusters, monitoring of cases, prediction of the future outbreaks, mortality risk, COVID-19 diagnosis, and disease management.


Author(s):  
Mugahed A. Al-antari ◽  
Cam-Hao Hua ◽  
Sungyoung Lee

Abstract Background and Objective: The novel coronavirus 2019 (COVID-19) is a harmful lung disease that rapidly attacks people worldwide. At the end of 2019, COVID-19 was discovered as mysterious lung disease in Wuhan, Hubei province of China. World health organization (WHO) declared the coronavirus outbreak a pandemic in the second week of March 2020. Simultaneous deep learning detection and classification of COVID-19 from the entire digital X-ray images is the key to efficiently assist patients and physicians for a fast and accurate diagnosis.Methods: In this paper, a deep learning computer-aided diagnosis (CAD) based on the YOLO predictor is proposed to simultaneously detect and diagnose COVID-19 among the other eight lung diseases: Atelectasis, Infiltration, Pneumothorax, Mass, Effusion, Pneumonia, Cardiomegaly, and Nodule. The proposed CAD system is assessed via five-fold tests for multi-class prediction problem using two different databases of chest X-ray images: COVID-19 and ChestX-ray8. The proposed CAD system is trained using an annotated training set of 50,490 chest X-ray images.Results: The suspicious regions of COVID-19 from the entire X-ray images are simultaneously detected and classified end-to-end via the proposed CAD predictor achieving overall detection and classification accuracies of 96.31% and 97.40%, respectively. The most testing images of COVID-19 and other lunge diseases are correctly predicted achieving intersection over union (IoU) with their GTs greater than 90%. Applying deep learning regularizers of data balancing and augmentation improve the diagnostic performance by 6.64% and 12.17% in terms of overall accuracy and F1-score, respectively. Meanwhile, the proposed CAD system presents its feasibility to diagnose the individual chest X-ray image within 0.009 second. Thus, the presented CAD system could predict 108 frames/second (FPS) at the real-time of prediction.Conclusion: The proposed deep learning CAD system shows its capability and reliability to achieve promising COVID-19 diagnostic performance among all other lung diseases. The proposed deep learning model seems reliable to assist health care systems, patients, and physicians in their practical validations.


2021 ◽  
Author(s):  
Soumava Dey ◽  
Gunther Correia Bacellar ◽  
Mallikarjuna Basappa Chandrappa ◽  
Raj Kulkarni

The rise of the coronavirus disease 2019 (COVID-19) pandemic has made it necessary to improve existing medical screening and clinical management of this disease. While COVID-19 patients are known to exhibit a variety of symptoms, the major symptoms include fever, cough, and fatigue. Since these symptoms also appear in pneumonia patients, this creates complications in COVID-19 detection especially during the flu season. Early studies identified abnormalities in chest X-ray images of COVID-19 infected patients that could be beneficial for disease diagnosis. Therefore, chest X-ray image-based disease classification has emerged as an alternative to aid medical diagnosis. However, manual detection of COVID-19 from a set of chest X-ray images comprising both COVID-19 and pneumonia cases is cumbersome and prone to human error. Thus, artificial intelligence techniques powered by deep learning algorithms, which learn from radiography images and predict presence of COVID-19 have potential to enhance current diagnosis process. Towards this purpose, here we implemented a set of deep learning pre-trained models such as ResNet, VGG, Inception and EfficientNet in conjunction with developing a computer vision AI system based on our own convolutional neural network (CNN) model: Deep Learning in Healthcare (DLH)-COVID. All these CNN models cater to image classification exercise. We used publicly available resources of 6,432 images and further strengthened our model by tuning hyperparameters to provide better generalization during the model validation phase. Our final DLH-COVID model yielded the highest accuracy of 96% in detection of COVID-19 from chest X-ray images when compared to images of both pneumonia-affected and healthy individuals. Given the practicality of acquiring chest X-ray images by patients, we also developed a web application (link: https://toad.li/xray) based on our model to directly enable users to upload chest X-ray images and detect the presence of COVID-19 within a few seconds. Taken together, here we introduce a state-of-the-art artificial intelligence-based system for efficient COVID-19 detection and a user-friendly application that has the capacity to become a rapid COVID-19 diagnosis method in the near future.


Life ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1281
Author(s):  
Anca Loredana Udriștoiu ◽  
Alice Elena Ghenea ◽  
Ștefan Udriștoiu ◽  
Manuela Neaga ◽  
Ovidiu Mircea Zlatian ◽  
...  

(1) Background: The new SARS-COV-2 pandemic overwhelmed intensive care units, clinicians, and radiologists, so the development of methods to forecast the diagnosis’ severity became a necessity and a helpful tool. (2) Methods: In this paper, we proposed an artificial intelligence-based multimodal approach to forecast the future diagnosis’ severity of patients with laboratory-confirmed cases of SARS-CoV-2 infection. At hospital admission, we collected 46 clinical and biological variables with chest X-ray scans from 475 COVID-19 positively tested patients. An ensemble of machine learning algorithms (AI-Score) was developed to predict the future severity score as mild, moderate, and severe for COVID-19-infected patients. Additionally, a deep learning module (CXR-Score) was developed to automatically classify the chest X-ray images and integrate them into AI-Score. (3) Results: The AI-Score predicted the COVID-19 diagnosis’ severity on the testing/control dataset (95 patients) with an average accuracy of 98.59%, average specificity of 98.97%, and average sensitivity of 97.93%. The CXR-Score module graded the severity of chest X-ray images with an average accuracy of 99.08% on the testing/control dataset (95 chest X-ray images). (4) Conclusions: Our study demonstrated that the deep learning methods based on the integration of clinical and biological data with chest X-ray images accurately predicted the COVID-19 severity score of positive-tested patients.


2020 ◽  
Author(s):  
kishore Medhi ◽  
Md. Jamil ◽  
Iftekhar Hussain

COVID-19 infection has created a panic across the globe in recent times. Early detection of COVID-19 infection can save many lives in the pre-vailing situation. This virus affects the respiratory system of a person and creates white patchy shadows in the lungs. Deep learning is one of the most effective Artificial Intelligence techniques to analyse chest X-ray images for efficient and reliable COVID-19 screening. In this paper, we have proposed a Deep Convolutional Neural Network method for fast and dependable identification of COVID-19 infection cases from the patient chest X-ray images. To validate the performance of the proposed system, chest X-ray images of more than 150 confirmed COVID-19 patients from the Kaggle data repository are used in the experimentation. The results show that the proposed system identifies the cases with an accuracy of 93%.


10.2196/18089 ◽  
2020 ◽  
Vol 8 (8) ◽  
pp. e18089
Author(s):  
Ryoungwoo Jang ◽  
Namkug Kim ◽  
Miso Jang ◽  
Kyung Hwa Lee ◽  
Sang Min Lee ◽  
...  

Background Computer-aided diagnosis on chest x-ray images using deep learning is a widely studied modality in medicine. Many studies are based on public datasets, such as the National Institutes of Health (NIH) dataset and the Stanford CheXpert dataset. However, these datasets are preprocessed by classical natural language processing, which may cause a certain extent of label errors. Objective This study aimed to investigate the robustness of deep convolutional neural networks (CNNs) for binary classification of posteroanterior chest x-ray through random incorrect labeling. Methods We trained and validated the CNN architecture with different noise levels of labels in 3 datasets, namely, Asan Medical Center-Seoul National University Bundang Hospital (AMC-SNUBH), NIH, and CheXpert, and tested the models with each test set. Diseases of each chest x-ray in our dataset were confirmed by a thoracic radiologist using computed tomography (CT). Receiver operating characteristic (ROC) and area under the curve (AUC) were evaluated in each test. Randomly chosen chest x-rays of public datasets were evaluated by 3 physicians and 1 thoracic radiologist. Results In comparison with the public datasets of NIH and CheXpert, where AUCs did not significantly drop to 16%, the AUC of the AMC-SNUBH dataset significantly decreased from 2% label noise. Evaluation of the public datasets by 3 physicians and 1 thoracic radiologist showed an accuracy of 65%-80%. Conclusions The deep learning–based computer-aided diagnosis model is sensitive to label noise, and computer-aided diagnosis with inaccurate labels is not credible. Furthermore, open datasets such as NIH and CheXpert need to be distilled before being used for deep learning–based computer-aided diagnosis.


2021 ◽  
Vol 2 (1) ◽  
pp. 57-66
Author(s):  
Adhitio Satyo Bayangkari Karno Satyo ◽  
Dodi Arif ◽  
Indra Sari Kusuma Wardhana ◽  
Eka Sally Moreta

The availability of medical aids in adequate quantities is very much needed to assist the work of the medical staff in dealing with the very large number of Covid patients. Artificial Intelligence (AI) with the Deep Learning (DL) method, especially the Convolution Neural Network (CNN), is able to diagnose Chest X-ray images generated by the Computer Tomography Scanner (C.T. Scan) against certain diseases (Covid). Inception Resnet Version 2 architecture was used in this study to train a dataset of 4000 images, consisting of 4 classifications namely covid, normal, lung opacity and viral pneumonia with 1,000 images each. The results of the study with 50 epoch training obtained very good values for the accuracy of training and validation of 95.5% and 91.8%, respectively. The test with 4000 image dataset obtained 98% accuracy testing, with the precision of each class being Covid (99%), Lung_Opacity (97%), Normal (99%) and Viral pneumonia (99%).


2020 ◽  
Author(s):  
Mugahed A. Al-antari ◽  
Cam-Hao Hua ◽  
Sungyoung Lee ◽  
Jaehun Bang

Abstract Coronavirus disease 2019 (COVID-19) is a novel harmful respiratory disease that has rapidly spread worldwide. At the end of 2019, COVID-19 emerged as a previously unknown respiratory disease in Wuhan, Hubei Province, China. The world health organization (WHO) declared the coronavirus outbreak a pandemic in the second week of March 2020. Simultaneous deep learning detection and classification of COVID-19 based on the full resolution of digital X-ray images is the key to efficiently assisting patients by enabling physicians to reach a fast and accurate diagnosis decision. In this paper, a simultaneous deep learning computer-aided diagnosis (CAD) system based on the YOLO predictor is proposed that can detect and diagnose COVID-19, differentiating it from eight other respiratory diseases: atelectasis, infiltration, pneumothorax, masses, effusion, pneumonia, cardiomegaly, and nodules. The proposed CAD system was assessed via five-fold tests for the multi-class prediction problem using two different databases of chest X-ray images: COVID-19 and ChestX-ray8. The proposed CAD system was trained with an annotated training set of 50,490 chest X-ray images. The regions on the entire X-ray images with lesions suspected of being due to COVID-19 were simultaneously detected and classified end-to-end via the proposed CAD predictor, achieving overall detection and classification accuracies of 96.31% and 97.40%, respectively. Most test images from patients with confirmed COVID-19 and other respiratory diseases were correctly predicted, achieving average intersection over union (IoU) greater than 90%. Applying deep learning regularizers of data balancing and augmentation improved the COVID-19 diagnostic performance by 6.64% and 12.17% in terms of the overall accuracy and the F1-score, respectively. It is feasible to achieve a diagnosis based on individual chest X-ray images with the proposed CAD system within 0.0093 s. Thus, the CAD system presented in this paper can make a prediction at the rate of 108 frames/s (FPS), which is close to real-time. The proposed deep learning CAD system can reliably differentiate COVID-19 from other respiratory diseases. The proposed deep learning model seems to be a reliable tool that can be used to practically assist health care systems, patients, and physicians.


Author(s):  
Widi Hastomo

The availability of medical aids in adequate quantities is very much needed to assist the work of the medical staff in dealing with the very large number of Covid patients. Artificial Intelligence (AI) with the Deep Learning (DL) method, especially the Convolution Neural Network (CNN), is able to diagnose Chest X-ray images generated by the Computer Tomography Scanner (C.T. Scan) against certain diseases (Covid). Resnet Version-152 architecture was used in this study to train a dataset of 10.300 images, consisting of 4 classifications namely covid, normal, lung opacity with 3,000 images each and viral pneumonia 1,000 images. The results of the study with 50 epoch training obtained very good values for the accuracy of training and validation of 95.5% and 91.8%, respectively. The test with 10.300 image dataset obtained 98% accuracy testing, with the precision of each class being Covid (99%), Lung_Opacity (99%), Normal (98%) and Viral pneumonia (98%). 


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