scholarly journals Artificial neural network based prediction of postthrombolysis intracerebral hemorrhage and death

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Chen-Chih Chung ◽  
Lung Chan ◽  
Oluwaseun Adebayo Bamodu ◽  
Chien-Tai Hong ◽  
Hung-Wen Chiu

AbstractDespite the salient benefits of the intravenous tissue plasminogen activator (tPA), symptomatic intracerebral hemorrhage (sICH) remains a frequent complication and constitutes a major concern when treating acute ischemic stroke (AIS). This study explored the use of artificial neural network (ANN)-based models to predict sICH and 3-month mortality for patients with AIS receiving tPA. We developed ANN models based on evaluation of the predictive value of pre-treatment parameters associated with sICH and mortality in a cohort of 331 patients between 2009 and 2018. The ANN models were generated using eight clinical inputs and two outputs. The generalizability of the model was validated using fivefold cross-validation. The performance of each model was assessed according to the accuracy, precision, sensitivity, specificity, and area under the receiver operating characteristic curve (AUC). After adequate training, the ANN predictive model AUC for sICH was 0.941, with accuracy, sensitivity, and specificity of 91.0%, 85.7%, and 92.5%, respectively. The predictive model AUC for 3-month mortality was 0.976, with accuracy, sensitivity, and specificity of 95.2%, 94.4%, and 95.5%, respectively. The generated ANN-based models exhibited high predictive performance and reliability for predicting sICH and 3-month mortality after thrombolysis; thus, its clinical application to assist decision-making when administering tPA is envisaged.

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Zhonghui Thong ◽  
Jolena Ying Ying Tan ◽  
Eileen Shuzhen Loo ◽  
Yu Wei Phua ◽  
Xavier Liang Shun Chan ◽  
...  

AbstractRegression models are often used to predict age of an individual based on methylation patterns. Artificial neural network (ANN) however was recently shown to be more accurate for age prediction. Additionally, the impact of ethnicity and sex on our previous regression model have not been studied. Furthermore, there is currently no age prediction study investigating the lower limit of input DNA at the bisulfite treatment stage prior to pyrosequencing. Herein, we evaluated both regression and ANN models, and the impact of ethnicity and sex on age prediction for 333 local blood samples using three loci on the pyrosequencing platform. Subsequently, we trained a one locus-based ANN model to reduce the amount of DNA used. We demonstrated that the ANN model has a higher accuracy of age prediction than the regression model. Additionally, we showed that ethnicity did not affect age prediction among local Chinese, Malays and Indians. Although the predicted age of males were marginally overestimated, sex did not impact the accuracy of age prediction. Lastly, we present a one locus, dual CpG model using 25 ng of input DNA that is sufficient for forensic age prediction. In conclusion, the two ANN models validated would be useful for age prediction to provide forensic intelligence leads.


2018 ◽  
Vol 204 ◽  
pp. 02018
Author(s):  
Aisyah Larasati ◽  
Anik Dwiastutik ◽  
Darin Ramadhanti ◽  
Aal Mahardika

This study aims to explore the effect of kurtosis level of the data in the output layer on the accuracy of artificial neural network predictive models. The artificial neural network predictive models are comprised of one node in the output layer and six nodes in the input layer. The number of hidden layer is automatically built by the program. Data are generated using simulation approach. The results show that the kurtosis level of the node in the output layer is significantly affect the accuracy of the artificial neural network predictive model. Platycurtic and leptocurtic data has significantly higher misclassification rates than mesocurtic data. However, the misclassification rates between platycurtic and leptocurtic is not significantly different. Thus, data distribution with kurtosis nearly to zero results in a better ANN predictive model.


2019 ◽  
Vol 116 ◽  
pp. 69-81 ◽  
Author(s):  
Amir Ahmad Hedayat ◽  
Ehsan Ahmadi Afzadi ◽  
Hossein Kalantaripour ◽  
Esmaeil Morshedi ◽  
Amin Iranpour

2021 ◽  
Author(s):  
DEVIN NIELSEN ◽  
TYLER LOTT ◽  
SOM DUTTA ◽  
JUHYEONG LEE

In this study, three artificial neural network (ANN) models are developed with back propagation (BP) optimization algorithms to predict various lightning damage modes in carbon/epoxy laminates. The proposed ANN models use three input variables associated with lightning waveform parameters (i.e., the peak current amplitude, rising time, and decaying time) to predict fiber damage, matrix damage, and through-thickness damage in the composites. The data used for training and testing the networks was actual lightning damage data collected from peer-reviewed published literature. Various BP training algorithms and network architecture configurations (i.e., data splitting, the number of neurons in a hidden layer, and the number of hidden layers) have been tested to improve the performance of the neural networks. Among the various BP algorithms considered, the Bayesian regularization back propagation (BRBP) showed the overall best performance in lightning damage prediction. When using the BRBP algorithm, as expected, the greater the fraction of the collected data that is allocated to the training dataset, the better the network is trained. In addition, the optimal ANN architecture was found to have a single hidden layer with 20 neurons. The ANN models proposed in this work may prove useful in preliminary assessments of lightning damage and reduce the number of expensive experimental lightning tests.


2019 ◽  
Vol 9 (9) ◽  
pp. 1844 ◽  
Author(s):  
Jesús Ferrero Bermejo ◽  
Juan F. Gómez Fernández ◽  
Fernando Olivencia Polo ◽  
Adolfo Crespo Márquez

The generation of energy from renewable sources is subjected to very dynamic changes in environmental parameters and asset operating conditions. This is a very relevant issue to be considered when developing reliability studies, modeling asset degradation and projecting renewable energy production. To that end, Artificial Neural Network (ANN) models have proven to be a very interesting tool, and there are many relevant and interesting contributions using ANN models, with different purposes, but somehow related to real-time estimation of asset reliability and energy generation. This document provides a precise review of the literature related to the use of ANN when predicting behaviors in energy production for the referred renewable energy sources. Special attention is paid to describe the scope of the different case studies, the specific approaches that were used over time, and the main variables that were considered. Among all contributions, this paper highlights those incorporating intelligence to anticipate reliability problems and to develop ad-hoc advanced maintenance policies. The purpose is to offer the readers an overall picture per energy source, estimating the significance that this tool has achieved over the last years, and identifying the potential of these techniques for future dependability analysis.


2020 ◽  
Vol 12 (10) ◽  
pp. 4001
Author(s):  
Sung-Sik Park ◽  
Peter D. Ogunjinmi ◽  
Seung-Wook Woo ◽  
Dong-Eun Lee

Conventionally, liquefaction-induced settlements have been predicted through numerical or analytical methods. In this study, a machine learning approach for predicting the liquefaction-induced settlement at Pohang was investigated. In particular, we examined the potential of an artificial neural network (ANN) algorithm to predict the earthquake-induced settlement at Pohang on the basis of standard penetration test (SPT) data. The performance of two ANN models for settlement prediction was studied and compared in terms of the R2 correlation. Model 1 (input parameters: unit weight, corrected SPT blow count, and cyclic stress ratio (CSR)) showed higher prediction accuracy than model 2 (input parameters: depth of the soil layer, corrected SPT blow count, and the CSR), and the difference in the R2 correlation between the models was about 0.12. Subsequently, an optimal ANN model was used to develop a simple predictive model equation, which was implemented using a matrix formulation. Finally, the liquefaction-induced settlement chart based on the predictive model equation was proposed, and the applicability of the chart was verified by comparing it with the interferometric synthetic aperture radar (InSAR) image.


2019 ◽  
Vol 65 (No. 4) ◽  
pp. 134-143 ◽  
Author(s):  
Tuan Nguyen Thanh ◽  
Tai Dinh Tien ◽  
Hai Long Shen

Korean pine (Pinus koraiensis Sieb. et Zucc.) is one of the highly commercial woody species in Northeast China. In this study, six nonlinear equations and artificial neural network (ANN) models were employed to model and validate height-diameter (H-DBH) relationship in three different stand densities of one Korean pine plantation. Data were collected in 12 plots in a 43-year-old even-aged stand of P. koraiensis in Mengjiagang Forest Farm, China. The data were randomly split into two datasets for model development (9 plots) and for model validation (3 plots). All candidate models showed a good perfomance in explaining H-DBH relationship with error estimation of tree height ranging from 0.61 to 1.52 m. Especially, ANN models could reduce the root mean square error (RMSE) by the highest 40%, compared with Power function for the density level of 600 trees. In general, our results showed that ANN models were superior to other six nonlinear models. The H-DBH relationship appeared to differ between stand density levels, thus it is necessary to establish H-DBH models for specific stand densities to provide more accurate estimation of tree height.


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