scholarly journals Forecasting the long-term trend of COVID-19 epidemic using a dynamic model

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Jichao Sun ◽  
Xi Chen ◽  
Ziheng Zhang ◽  
Shengzhang Lai ◽  
Bo Zhao ◽  
...  

AbstractThe current outbreak of coronavirus disease 2019 (COVID-19) has recently been declared as a pandemic and spread over 200 countries and territories. Forecasting the long-term trend of the COVID-19 epidemic can help health authorities determine the transmission characteristics of the virus and take appropriate prevention and control strategies beforehand. Previous studies that solely applied traditional epidemic models or machine learning models were subject to underfitting or overfitting problems. We propose a new model named Dynamic-Susceptible-Exposed-Infective-Quarantined (D-SEIQ), by making appropriate modifications of the Susceptible-Exposed-Infective-Recovered (SEIR) model and integrating machine learning based parameter optimization under epidemiological rational constraints. We used the model to predict the long-term reported cumulative numbers of COVID-19 cases in China from January 27, 2020. We evaluated our model on officially reported confirmed cases from three different regions in China, and the results proved the effectiveness of our model in terms of simulating and predicting the trend of the COVID-19 outbreak. In China-Excluding-Hubei area within 7 days after the first public report, our model successfully and accurately predicted the long trend up to 40 days and the exact date of the outbreak peak. The predicted cumulative number (12,506) by March 10, 2020, was only 3·8% different from the actual number (13,005). The parameters obtained by our model proved the effectiveness of prevention and intervention strategies on epidemic control in China. The prediction results for five other countries suggested the external validity of our model. The integrated approach of epidemic and machine learning models could accurately forecast the long-term trend of the COVID-19 outbreak. The model parameters also provided insights into the analysis of COVID-19 transmission and the effectiveness of interventions in China.

2020 ◽  
Author(s):  
Jichao Sun ◽  
Xi Chen ◽  
Ziheng Zhang ◽  
Shengzhang Lai ◽  
Bo Zhao ◽  
...  

Abstract Background The current outbreak of coronavirus disease 2019 (COVID-19) has recently been declared as a pandemic and spread over 200 countries and territories. Forecasting the long-term trend of the COVID-19 epidemic can help health authorities determine the transmission characteristics of the virus and take appropriate prevention and control strategies beforehand. Previous studies that applied the traditional epidemic models or machine learning models were subject to underfitting or overfitting problems.Methods We propose a new model named Dynamic-Susceptible-Exposed-Infective-Quarantined (D-SEIQ), by making appropriate modifications of the Susceptible-Exposed-Infective-Recovered (SEIR) model and integrating machine learning based parameter optimization under epidemiological rational constraints. We used the model to predict the long-term reported cumulative numbers of COVID-19 cases in China from 27 January, 2020.Results We evaluated our model on officially reported confirmed cases from three different regions in China, and the results proved the effectiveness of our model in terms of simulating and predicting the trend of COVID-19 outbreak. In China-Excluding-Hubei area within 7 days after the first public report, our model successfully and accurately predicted the 40 days long trend and the exact date of turning point. The predicted cumulative number (12,506) by 10, March 2020 was only 3·8% different with the actual number (13,005). The parameters obtained by our model proved the effectiveness of prevention and intervention strategies on epidemic control in China.Conclusions The integrated approach of epidemic and machine learning models could accurately forecast the long-term trend of COVID-19 outbreak. The learned parameters suggested the effectiveness of intervention measures taken in China.


2021 ◽  
Author(s):  
Yongmin Cho ◽  
Rachael A Jonas-Closs ◽  
Lev Y Yampolsky ◽  
Marc W Kirschner ◽  
Leonid Peshkin

We present a novel platform for testing the effect of interventions on life- and health-span of a short-lived semi transparent freshwater organism, sensitive to drugs with complex behavior and physiology - the planktonic crustacean Daphnia magna. Within this platform, dozens of complex behavioural features of both routine motion and response to stimuli are continuously accurately quantified for large homogeneous cohorts via an automated phenotyping pipeline. We build predictive machine learning models calibrated using chronological age and extrapolate onto phenotypic age. We further apply the model to estimate the phenotypic age under pharmacological perturbation. Our platform provides a scalable framework for drug screening and characterization in both life-long and instant assays as illustrated using long term dose response profile of metformin and short term assay of such well-studied substances as caffeine and alcohol.


2020 ◽  
Vol 214 ◽  
pp. 01023
Author(s):  
Linan (Frank) Zhao

Long-term unemployment has significant societal impact and is of particular concerns for policymakers with regard to economic growth and public finances. This paper constructs advanced ensemble machine learning models to predict citizens’ risks of becoming long-term unemployed using data collected from European public authorities for employment service. The proposed model achieves 81.2% accuracy on identifying citizens with high risks of long-term unemployment. This paper also examines how to dissect black-box machine learning models by offering explanations at both a local and global level using SHAP, a state-of-the-art model-agnostic approach to explain factors that contribute to long-term unemployment. Lastly, this paper addresses an under-explored question when applying machine learning in the public domain, that is, the inherent bias in model predictions. The results show that popular models such as gradient boosted trees may produce unfair predictions against senior age groups and immigrants. Overall, this paper sheds light on the recent increasing shift for governments to adopt machine learning models to profile and prioritize employment resources to reduce the detrimental effects of long-term unemployment and improve public welfare.


10.29007/mbb7 ◽  
2020 ◽  
Author(s):  
Maher Selim ◽  
Ryan Zhou ◽  
Wenying Feng ◽  
Omar Alam

Many statistical and machine learning models for prediction make use of historical data as an input and produce single or small numbers of output values. To forecast over many timesteps, it is necessary to run the program recursively. This leads to a compounding of errors, which has adverse effects on accuracy for long forecast periods. In this paper, we show this can be mitigated through the addition of generating features which can have an “anchoring” effect on recurrent forecasts, limiting the amount of compounded error in the long term. This is studied experimentally on a benchmark energy dataset using two machine learning models LSTM and XGBoost. Prediction accuracy over differing forecast lengths is compared using the forecasting MAPE. It is found that for LSTM model the accuracy of short term energy forecasting by using a past energy consumption value as a feature is higher than the accuracy when not using past values as a feature. The opposite behavior takes place for the long term energy forecasting. For the XGBoost model, the accuracy for both short and long term energy forecasting is higher when not using past values as a feature.


2021 ◽  
Author(s):  
Cenk Temizel ◽  
Celal Hakan Canbaz ◽  
Karthik Balaji ◽  
Ahsen Ozesen ◽  
Kirill Yanidis ◽  
...  

Abstract Machine learning models have worked as a robust tool in forecasting and optimization processes for wells in conventional, data-rich reservoirs. In unconventional reservoirs however, given the large ranges of uncertainty, purely data-driven, machine learning models have not yet proven to be repeatable and scalable. In such cases, integrating physics-based reservoir simulation methods along with machine learning techniques can be used as a solution to alleviate these limitations. The objective of this study is to provide an overview along with examples of implementing this integrated approach for the purpose of forecasting Estimated Ultimate Recovery (EUR) in shale reservoirs. This study is solely based on synthetic data. To generate data for one section of a reservoir, a full-physics reservoir simulator has been used. Simulated data from this section is used to train a machine learning model, which provides EUR as the output. Production from another section of the field with a different range of reservoir properties is then forecasted using a physics-based model. Using the earlier trained model, production forecasting for this section of the reservoir is then carried out to illustrate the integrated approach to EUR forecasting for a section of the reservoir that is not data rich. The integrated approach, or hybrid modeling, production forecasting for different sections of the reservoir that were data-starved, are illustrated. Using the physics-based model, the uncertainty in EUR predictions made by the machine learning model has been reduced and a more accurate forecasting has been attained. This method is primarily applicable in reservoirs, such as unconventionals, where one section of the field that has been developed has a substantial amount of data, whereas, the other section of the field will be data starved. The hybrid model was consistently able to forecast EUR at an acceptable level of accuracy, thereby, highlighting the benefits of this type of an integrated approach. This study advances the application of repeatable and scalable hybrid models in unconventional reservoirs and highlights its benefits as compared to using either physics-based or machine-learning based models separately.


Author(s):  
Xueru Zhang ◽  
Mohammad Mahdi Khalili ◽  
Mingyan Liu

Machine learning models developed from real-world data can inherit potential, preexisting bias in the dataset. When these models are used to inform decisions involving human beings, fairness concerns inevitably arise. Imposing certain fairness constraints in the training of models can be effective only if appropriate criteria are applied. However, a fairness criterion can be defined/assessed only when the interaction between the decisions and the underlying population is well understood. We introduce two feedback models describing how people react when receiving machine-aided decisions and illustrate that some commonly used fairness criteria can end with undesirable consequences while reinforcing discrimination.


2020 ◽  
Author(s):  
Jichao Sun ◽  
Xi Chen ◽  
Ziheng Zhang ◽  
Shengzhang Lai ◽  
Bo Zhao ◽  
...  

Abstract The current outbreak of coronavirus disease 2019 (COVID-19) has recently been declared as a pandemic and spread over 200 countries and territories. Forecasting the long-term trend of the COVID-19 epidemic can help health authorities determine the transmission characteristics of the virus and take appropriate prevention and control strategies beforehand. This protocol introduced a new model named Dynamic-Susceptible-Exposed-Infective-Quarantined (D-SEIQ), by making appropriate modifications of the Susceptible-Exposed-Infective-Recovered (SEIR) model and integrating machine learning based parameter optimization under epidemiological rational constraints. The model could be applied to forecast the long-term trend of the current COVID-19 epidemic. The parameters obtained by the model could help assess the effectiveness of prevention and intervention strategies on epidemic control in different countries.


EconoQuantum ◽  
2020 ◽  
Vol 18 (1) ◽  
pp. 21-43
Author(s):  
Abraham Ramírez García ◽  
◽  
Ana Lorena Jiménez Preciado ◽  

Objective: To estimate the size and the dynamics of the coro-navirus (covid-19) pandemic in Advanced, Emerging, and Developing Economies, and to determine its implications for economic growth.Methodology: A susceptible Infected Recovered (sir) mod-el is implemented, we calculate the size of the pandemic through numerical integration and phase diagrams for covid-19 trajectory; finally, we use ensemble models (ran-dom forest) to forecast economic growth.Results: We confirm that there are differences in pandemic spread and size among countries; likewise, the trajectories show a long-term spiral cycle. Economic recovery is expect-ed to be slow and gradual for most of the economies.Limitations: All countries differ in covid-19 test applica-tions, which could lead to inaccurate total confirmed cases and an imprecise estimate of the pandemic’s spread and size. In addition, there is a lack of leading indicators in some countries, generating a higher mse of some machine learning models. Originality: To implement economic-epidemiological mod-els to analyze the evolution and virus’ spreading through-out time.Conclusions: It is found the pandemic’s final size to be be-tween 74-77%. Likewise, it is demonstrated that covid-19 is endemic, with a constant prevalence of 9 years on av-erage. The spread of the pandemic has caused countries to self-induce in an unprecedented recession with a slow recovery.


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