scholarly journals Relationship between biodosimetric parameters and treatment volumes in three types of prostate radiotherapy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Zsuzsa S. Kocsis ◽  
Tibor Major ◽  
Csilla Pesznyák ◽  
Dalma Mihály ◽  
Gábor Stelczer ◽  
...  
Keyword(s):  
Biological Effect ◽  
External Beam Radiotherapy ◽  
Time Range ◽  
Prostate Radiotherapy ◽  
Dose Rates ◽  
Long Time ◽  
Biological Dose ◽  
Relationship Of ◽  
The Relationship

AbstractBrachytherapy (BT) and external beam radiotherapy (EBRT) apply different dose rates, overall treatment times, energies and fractionation. However, the overall impact of these variables on the biological dose of blood is neglected. As the size of the irradiated volume influences the biological effect as well, we studied chromosome aberrations (CAs) as biodosimetric parameters, and explored the relationship of isodose surface volumes (ISVs: V1%, V1Gy, V10%, V10Gy, V100%, V150%) and CAs of both irradiation modalities. We performed extended dicentrics assay of lymphocytes from 102 prostate radiotherapy patients three-monthly for a year. Aberration frequency was the highest after EBRT treatment. It increased after the therapy and did not decrease significantly during the first follow-up year. We showed that various types of CAs 9 months after LDR BT, 3 months after HDR BT and in a long time-range (even up to 1 year) after EBRT positively correlated with ISVs. Regression analysis confirmed these relationships in the case of HDR BT and EBRT. The observed differences in the time points and aberration types are discussed. The ISVs irradiated by EBRT showed stronger correlation and regression relationships with CAs than the ISVs of brachytherapy.

scholarly journals Relationship Between Biodosimetric Parameters and Treatment Volumes in Three Types of Prostate Radiotherapy

2021 ◽  
Author(s):  
Zsuzsa S. Kocsis ◽  
Tibor Major ◽  
Csilla Pesznyák ◽  
Dalma Mihály ◽  
Gábor Stelczer ◽  
...  
Keyword(s):  
Biological Effect ◽  
External Beam Radiotherapy ◽  
Time Range ◽  
Prostate Radiotherapy ◽  
Dose Rates ◽  
Long Time ◽  
One Year ◽  
Relationship Of ◽  
The Relationship

Abstract Brachytherapy (BT) and external beam radiotherapy (EBRT) apply different dose rates, overall treatment times, energies, fractionation. However, the overall impact of these variables is neglected on the biological dose of blood. As the size of the irradiated volume also influences the biological effect, we studied chromosome aberrations (CAs) as biodosimetric parameters, and explored the relationship of isodose surface volumes (ISVs: V1%, V1Gy, V10%, V10Gy, V50Gy, V100%, V150%) and CAs in case of both irradiation modalities. We performed extended dicentrics assay of lymphocytes from 102 prostate radiotherapy patients three-monthly for a year. Aberration frequency was the highest after EBRT treatment. It increased after the therapy and did not decrease significantly during the first follow-up year. We showed that various types of CAs nine months after LDR BT, three months after HDR BT in a long time-range (even till one year) after EBRT positively correlated with ISVs. Regression analysis confirmed these relationships in case of HDR BT and EBRT. The observed differences in the time points and aberration types are discussed.The ISVs irradiated by EBRT showed stronger correlation and regression relationships with CAs than the ISVs of brachytherapy in spite of the fractionation.

A Decade of Disparities in Diabetes Technology Use and HbA1c in Pediatric Type 1 Diabetes: A Trans-Atlantic Comparison

2020 ◽  
Author(s):  
Ananta Addala ◽  
Marie Auzanneau ◽  
Kellee Miller ◽  
Werner Maier ◽  
Nicole Foster ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Technology Use ◽  
Hemoglobin A1c ◽  
Diabetes Technology ◽  
Design And Methods ◽  
Relationship Of ◽  
The Relationship ◽  
Pediatric Type 1 Diabetes

<b>Objective:</b> As diabetes technology use in youth increases worldwide, inequalities in access may exacerbate disparities in hemoglobin A1c (HbA1c). We hypothesized an increasing gap in diabetes technology use by socioeconomic status (SES) would be associated with increased HbA1c disparities. <p> </p> <p><b>Research Design and Methods: </b>Participants aged <18 years with diabetes duration ≥1 year in the Type 1 Diabetes Exchange (T1DX, US, n=16,457) and Diabetes Prospective Follow-up (DPV, Germany, n=39,836) registries were categorized into lowest (Q1) to highest (Q5) SES quintiles. Multiple regression analyses compared the relationship of SES quintiles with diabetes technology use and HbA1c from 2010-2012 and 2016-2018. </p> <p> </p> <p><b>Results: </b>HbA1c was higher in participants with lower SES (in 2010-2012 & 2016-2018, respectively: 8.0% & 7.8% in Q1 and 7.6% & 7.5% in Q5 for DPV; and 9.0% & 9.3% in Q1 and 7.8% & 8.0% in Q5 for T1DX). For DPV, the association between SES and HbA1c did not change between the two time periods, whereas for T1DX, disparities in HbA1c by SES increased significantly (p<0.001). After adjusting for technology use, results for DPV did not change whereas the increase in T1DX was no longer significant.</p> <p> </p> <p><b>Conclusions: </b>Although causal conclusions cannot be drawn, diabetes technology use is lowest and HbA1c is highest in those of the lowest SES quintile in the T1DX and this difference for HbA1c broadened in the last decade. Associations of SES with technology use and HbA1c were weaker in the DPV registry. </p>

scholarly journals Investigation of the Correlation between Postherpetic Itch and Neuropathic Pain over Time

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Rie Ishikawa ◽  
Masako Iseki ◽  
Rie Koga ◽  
Eiichi Inada
Keyword(s):  
Neuropathic Pain ◽  
Herpes Zoster ◽  
Pain Intensity ◽  
Visual Analog Scale ◽  
Analog Scale ◽  
Paindetect Questionnaire ◽  
Relationship Of ◽  
The Relationship ◽  
Over Time

Postherpetic itch (PHI), or herpes zoster itch, is an intractable and poorly understood disease. We targeted 94 herpes zoster patients to investigate their pain and itch intensities at three separate stages of the condition (acute, subacute, and chronic). We used painDETECT questionnaire (PDQ) scores to investigate the correlation between PHI and neuropathic pain. Seventy-six patients were able to complete follow-up surveys. The prevalence of PHI was 47/76 (62%), 28/76 (37%), and 34/76 (45%) at the acute, subacute, and chronic stages, respectively. PHI manifestation times and patterns varied. We investigated the relationship of PHI with neuropathic pain using the visual analog scale (VAS), which is a measure of pain intensity, and the PDQ, which is a questionnaire used to evaluate the elements of neuropathic pain. The VAS and PDQ scores did not differ significantly between PHI-positive and PHI-negative patients. A large neuropathic component was not found for herpes zoster itch, suggesting that neuropathic pain treatments may not able to adequately control the itch. Accordingly, we suggest that a more PHI-focused therapy is required to address this condition.

A Research on the Morphology and Composition of Flocs (Part 1: Floc Breaage Disregarded)

2013 ◽  
Vol 726-731 ◽  
pp. 1566-1572 ◽  
Author(s):  
Shi Qiang Ding ◽  
Qing Na Li ◽  
Xin Rong Pang ◽  
Ji Run Xu
Keyword(s):  
Dimensional Space ◽  
Three Dimensional ◽  
New Classification ◽  
Suspension Viscosity ◽  
Primary Particles ◽  
Long Time ◽  
Relationship Of ◽  
The Relationship ◽  
Three Dimensional Space ◽  
Floc Breakage

The characteristics of flocs aggregated in flocculation have been paid more and more attention for a long time. In this paper, a new classification and analyses method dealing with the flocs is developed. The flocs formed after flocculation is divided into four kinds, including the left primary particles, linear flocs with all component particles in a line, planar flocs with all component particles on a plane and volumetric flocs with all component particles in a three-dimensional space. By analyzing the formation approaches of different kind of flocs regardless of the floc breakage, the number of every kind of floc is analyzed to be related with the suspension concentration mathematically. After comparing the different items in the models describing the relationship of floc number and concentration, a series of simplified expressions are presented. Lastly, a mathematical equation relating the measurable suspension viscosity with the numbers of different flocs is obtained.

scholarly journals The Relationship of Left Ventricular Trabeculation to Ventricular Function and Structure Over a 9.5-Year Follow-Up

2014 ◽  
Vol 64 (19) ◽  
pp. 1971-1980 ◽  
Author(s):  
Filip Zemrak ◽  
Mark A. Ahlman ◽  
Gabriella Captur ◽  
Saidi A. Mohiddin ◽  
Nadine Kawel-Boehm ◽  
...  
Keyword(s):  
Ventricular Function ◽  
Left Ventricular ◽  
Relationship Of ◽  
The Relationship

scholarly journals Influence of uric acid on the correlation between waist circumference and triglyceride glucose index: an analysis from CHARLS

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Jia Zheng ◽  
Min Jiang ◽  
Yanxia Xie
Keyword(s):  
Uric Acid ◽  
Waist Circumference ◽  
Mediation Effects ◽  
Panel Model ◽  
Triglyceride Glucose Index ◽  
Study Population ◽  
Relationship Of ◽  
The Relationship ◽  
Longitudinal Relationships

Abstract Background Waist circumference (WC) and uric acid (UA) are significantly related. Still, their temporal sequence and how the sequence works on future risk of triglyceride glucose (TyG) are unknown, especially in the Chinese population. Methods Cross-lagged panel model was used to analyze the reciprocal, longitudinal relationships among a set of interrelated variables. The mediation model was constructed to test the effect of the relationship between WC and UA on TyG. Results A total of 5727 subjects were enrolled in our study population, of which 53.5% were women, and the mean age was 59.0 (standard deviation, 8.62) years. After adjusting for traditional confounding factors, the results showed that a higher level of baseline WC was significantly associated with a higher level of follow-up UA (β = 0.003, P = 0.031) and follow-up TyG (β = 0.003, P < 0.001);. Simultaneously, there was no statistical association between the level of baseline UA and the level of follow-up WC (β = − 0.009, P = 0.951). The mediation effects of UA on WC-TyG were estimated to be 18.1% in adults, and 36.2% in women. Conclusions The current study demonstrated that higher baseline level of WC probably preceded UA’ level in general population. In addition, UA mediated the relationship of WC to TyG, especially in females. And the possible mechanism would require further clarification.

The Relationship of Frequency of Follow-Up Visits to Asthma Outcomes in Patients with Moderate Persistent Asthma

2003 ◽  
Vol 40 (1) ◽  
pp. 49-53 ◽  
Author(s):  
Michael Schatz ◽  
Eva Rodriguez ◽  
Reuben Falkoff ◽  
Robert S. Zeiger
Keyword(s):  
Persistent Asthma ◽  
Asthma Outcomes ◽  
Relationship Of ◽  
The Relationship ◽  
Moderate Persistent Asthma

scholarly journals Prediction of Reproductive Success in Multiparous First Service Dairy Cows by Parameters from In-Line Sensors

Agriculture ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 334
Author(s):  
Ramūnas Antanaitis ◽  
Vida Juozaitienė ◽  
Dovilė Malašauskienė ◽  
Mindaugas Televičius ◽  
Mingaudas Urbutis ◽  
...  
Keyword(s):  
Electrical Conductivity ◽  
Blood Parameters ◽  
Negative Energy ◽  
Hydroxybutyric Acid ◽  
Pregnancy Status ◽  
Group A ◽  
Biochemical Indices ◽  
Relationship Of ◽  
The Relationship

The aim of the current study was to evaluate the relationship of different parameters from an automatic milking system (AMS) with the pregnancy status of multiparous cows at first service and to assess the accuracy of such a follow-up with regard to blood parameters. Before the insemination of cows, blood samples for measuring biochemical indices were taken from the coccygeal vessels and the concentrations of blood serum albumin (ALB), cortisol, non-esterified fatty acids (NEFA) and the activities of aspartate aminotransferase (AST) and gamma glutamyltransferase (GGT) were determined. From oestrus day to seven days after oestrus, the following parameters were registered: milk yield (MY), electric milk conductivity, lactate dehydrogenase (LDH) and β-hydroxybutyric acid (BHB). The pregnancy status was evaluated using ultrasound “Easy scan” 30–35 days after insemination. Cows were grouped by reproductive status: PG− (non-pregnant; n = 48) and PG+ (pregnant; n = 44). The BHB level in PG− cows was 1.2 times higher (p < 0.005). The electrical conductivity of milk was statistically significantly higher in all quarters of PG− cows (1.07 times) than of PG+ cows (p < 0.05). The arithmetic mean of blood GGT was 1.61 times higher in PG− cows and the NEFA value 1.23 times higher (p < 0.05) compared with the PG+ group. The liver function was affected, the average ALB of PG− cows was 1.19 times lower (p < 0.05) and the AST activity was 1.16 times lower (p < 0.05) compared with PG+ cows. The non-pregnant group had a negative energy balance demonstrated by high in-line milk BHB and high blood NEFA concentrations. We found a greater number of cows with cortisol >0.0.75 mg/dL in the non-pregnant group. A higher milk electrical conductivity in the non-pregnant cows pointed towards a greater risk of mastitis while higher GGT activities together with lower albumin concentrations indicated that the cows were more affected by oxidative stress.

The relationship of severe health disorders with bone loss, grip strength, and mobility in postmenopausal women – a 15-year follow-up study

2015 ◽  
Vol 38 (14) ◽  
pp. 1407-1414
Author(s):  
Juha Suuronen ◽  
Samu Sjöblom ◽  
Risto Honkanen ◽  
Heli Koivumaa-Honkanen ◽  
Heikki Kröger ◽  
...  
Keyword(s):  
Bone Loss ◽  
Grip Strength ◽  
Postmenopausal Women ◽  
Follow Up Study ◽  
Health Disorders ◽  
Relationship Of ◽  
The Relationship

Frequency of post-traumatic osteoarthritis in dogs after repair of a humeral condylar fracture

2003 ◽  
Vol 16 (01) ◽  
pp. 01-05 ◽  
Author(s):  
M. F. Besancon ◽  
M. G. Conzemius ◽  
K. G. Miles ◽  
A. S. Kapatkin ◽  
W. T. N. Culp ◽  
...  
Keyword(s):  
Fracture Repair ◽  
Fracture Reduction ◽  
Vertical Force ◽  
Condylar Fracture ◽  
Limb Function ◽  
Anatomic Reduction ◽  
Post Traumatic ◽  
Relationship Of ◽  
The Relationship

SummaryThe frequency of post-traumatic osteoarthritis (PTO) in the dog after repair of a humeral condylar fracture (HCF) and the relationship of fracture reduction to outcome is unknown. The objectives of this study were to determine the frequency of PTO in dogs after HCF repair and to determine the relationship between fracture reduction, limb function and follow-up osteoarthrosis (OA) score. All dogs were evaluated by physical and radiographic examinations and dogs with unilateral fracture repair were also examined by force platform gait analysis. Initial and follow-up radiographs were scored for reduction and evidence of osteoarthrosis using previously published grading scales. This study evaluated 15 fractures in 13 dogs with a mean follow-up time of 43 months. Osteoarthrosis developed or progressed radiographically in all elbows. Peak vertical force (PVF) was significantly reduced (p <0.01) in the affected limb, however vertical impulse (VI) did not differ (p = 0.12) when compared to the opposite normal limb. Pain-free range of motion was reduced in flexion (p <0.01), but not in extension (p = 0.98) when compared to the normal limb. Fracture reduction score did not correlate with follow-up OA score (p = 0.07), PVF (p = 0.40), VI (p = 0.72), flexion (p =0.50), or extension (p = 0.62). Due to the high incidence of PTO, owners should be warned of the possibility of declining limb function over time despite near anatomic reduction.

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