Metachronous advanced neoplasia after submucosal invasive colorectal cancer resection

AbstractLittle is known about the incidence of metachronous advanced neoplasia (AN) following resection of submucosal invasive colorectal cancer (SM-CRC). Here, we aimed to assess the occurrence of metachronous AN following SM-CRC resection. We retrospectively reviewed consecutive patients who underwent SM-CRC resection at an academic medical center between 2005 and 2013. Among 343 patients, 250 (72.9%) underwent surgical resection or endoscopic resection followed by surgical resection and 93 (27.1%) underwent only endoscopic resection. During a median follow-up period of 61.5 months, the overall incidence of metachronous AN was 7.6%, and the cumulative incidence at 5 years was 6.1%. The cumulative incidence was significantly higher in the endoscopic resection group than in surgical resection group, in patients with colonic disease than in those with rectal disease, and in patients with synchronous AN than in those without. Multivariate analysis revealed that synchronous AN was the only significant risk factor for metachronous AN (HR 4.35; 95% CI 1.88–10.1). These findings imply that depending on synchronous AN, a surveillance protocol following SM-CRC resection can be changed for better detection of metachronous AN.

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Endoscopic Resection Versus Surgical Resection for Gastric Neuroendocrine Neoplasms Without Distant Metastasis

10.21203/rs.3.rs-53696/v1 ◽

2020 ◽

Author(s):

Huiying Shi ◽

Hailing Yao ◽

Shuxin Tian ◽

Chen Jiang ◽

Qin Zhang ◽

...

Keyword(s):

Lymph Node ◽

Surgical Resection ◽

Endoscopic Resection ◽

Distant Metastasis ◽

Neuroendocrine Neoplasms ◽

Resection Group ◽

Node Metastasis ◽

Significant Difference ◽

Well Differentiated

Abstract Background: Resection is the main method for treating gastric neuroendocrine neoplasms (g-NENs). However, the threshold for tumor size needs to be removed, and the prognostic difference between the endoscopic and surgical resection groups remains unclear. Methods: In this study, 929 g-NENs patients without distant metastasis were collected and analyzed (857 patients from the SEER database, 72 patients from Wuhan Union Hospital or the First Affiliated Hospital of Shihezi University). Results: Overall, for g-NENs without distant metastasis, the resected group had a better prognosis than the unresected group ( p =0.0019). For tumor >2cm, the resection group had a better prognosis than the unresected group ( p =0.0002), but there was no significant difference in survival between the endoscopic and surgical resection group ( p >0.05). For tumor <1cm or 1-2cm, there was no significant difference in survival between the resected group and the unresected group, and there was no significant difference in survival between the endoscopic resection group and the surgical resection group ( p >0.05). Furthermore, for g-NENs confined to in-situ and T1, or with well-differentiated morphology or w/wo lymph node metastasis without distant metastasis, there was no significant difference in prognosis between the endoscopic resection group and the surgical resection group ( p >0.05). Conclusions: Resection can significantly improve the prognosis of g-NENs patients without distant metastasis, and 2cm can be used as a resection threshold. For g-NENs within the size of endoscopic resection, which localized in situ and T1, or with well-differentiated morphology, or w/wo lymph node metastasis without distant metastasis, endoscopic resection is feasible.

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Additional Surgical Resection After Endoscopic Resection for Patients With High-risk T1 Colorectal Cancer

In Vivo ◽

10.21873/invivo.11596 ◽

2019 ◽

Vol 33 (4) ◽

pp. 1243-1248 ◽

Cited By ~ 2

Author(s):

KENTA IGUCHI ◽

HIROYUKI MUSHIAKE ◽

TORU AOYAMA ◽

HIROKAZU SUWA ◽

NORIO YUKAWA ◽

...

Keyword(s):

Colorectal Cancer ◽

High Risk ◽

Surgical Resection ◽

Endoscopic Resection ◽

T1 Colorectal Cancer

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Resection of a Nonampullary Adenoma with the New Gastroduodenal Full-Thickness Resection Device

Journal of Digestive Endoscopy ◽

10.1055/s-0040-1713834 ◽

2020 ◽

Vol 11 (03) ◽

pp. 242-244

Author(s):

Maximilian Gericke ◽

Matthias Mende ◽

Dirk Hartmann ◽

Siegbert Faiss

Keyword(s):

Gastrointestinal Tract ◽

Surgical Resection ◽

Endoscopic Resection ◽

Significant Risk ◽

R0 Resection ◽

High Morbidity ◽

Full Thickness ◽

Endoscopic Full Thickness Resection ◽

Upper Gastrointestinal ◽

Subepithelial Tumors

Abstract Introduction Surgical resection of adenomas or subepithelial tumors in the duodenum has a high morbidity compared with endoscopic resection which also has a significant risk of complication. Endoscopic full-thickness resection has shown its feasibility and safety in the colorectum and in the upper gastrointestinal tract. Patient and Methods We present the new gastroduodenal full-thickness resection device (FTRD) for full-thickness resection in a patient with a recurrent nonlifting adenoma in the nonampullary duodenum. Results The procedure was successful with R0 resection without major complications. A control gastroscopy showed no recurrence of the adenoma. Conclusion The gastroduodenal FTRD seems to be a promising new technique for resecting nonlifting adenomas in the nonampullary duodenum.

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Surgical resection after endoscopic resection in patients with T1 colorectal cancer: a meta-analysis

International Journal of Colorectal Disease ◽

10.1007/s00384-020-03752-2 ◽

2020 ◽

Author(s):

Yuan Tian ◽

Long Rong ◽

Yongchen Ma

Keyword(s):

Colorectal Cancer ◽

Surgical Resection ◽

Endoscopic Resection ◽

Meta Analysis ◽

T1 Colorectal Cancer

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Sa1506 Long-Term Outcome After Endoscopic Resection of Superficial Submucosal Colorectal Cancer Compared to Surgical Resection

Gastrointestinal Endoscopy ◽

10.1016/j.gie.2014.05.125 ◽

2014 ◽

Vol 79 (5) ◽

pp. AB238

Author(s):

Jeong-Sik Byeon ◽

Ji-Beom Kim ◽

Ho-Su Lee ◽

Hyo Jeong Lee ◽

Jae Seung Soh ◽

...

Keyword(s):

Colorectal Cancer ◽

Surgical Resection ◽

Endoscopic Resection ◽

Term Outcome ◽

Long Term Outcome ◽

Submucosal Colorectal Cancer

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Long-term Recurrence-free Survival After Standard Endoscopic Resection Versus Surgical Resection of Submucosal Invasive Colorectal Cancer: A Population-based Study

Clinical Gastroenterology and Hepatology ◽

10.1016/j.cgh.2016.08.041 ◽

2017 ◽

Vol 15 (3) ◽

pp. 403-411.e1 ◽

Cited By ~ 24

Author(s):

Tim D.G. Belderbos ◽

Felice N. van Erning ◽

Ignace H.J.T. de Hingh ◽

Martijn G.H. van Oijen ◽

Valery E.P.P. Lemmens ◽

...

Keyword(s):

Colorectal Cancer ◽

Surgical Resection ◽

Endoscopic Resection ◽

Population Based ◽

Recurrence Free Survival ◽

Population Based Study ◽

Free Survival

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The prognostic role of KRAS and BRAF in patients undergoing surgical resection of colorectal cancer liver metastasis: a systematic review and meta-analysis

Annals of Oncology ◽

10.1093/annonc/mdw335.08 ◽

2016 ◽

Vol 27 ◽

pp. iv41

Author(s):

F. Passiglia ◽

A. Galvano ◽

S. Rizzo ◽

A. Listì ◽

N. Barraco ◽

...

Keyword(s):

Colorectal Cancer ◽

Systematic Review ◽

Liver Metastasis ◽

Surgical Resection ◽

Meta Analysis ◽

Prognostic Role ◽

Colorectal Cancer Liver Metastasis

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460. Point-of-Care, In-Home SARS-CoV-2 IgG Antibody Testing to Assess Seroprevalence in At-Risk Health Care Workers

Open Forum Infectious Diseases ◽

10.1093/ofid/ofaa439.653 ◽

2020 ◽

Vol 7 (Supplement_1) ◽

pp. S297-S297

Author(s):

Eric G Meissner ◽

Christine Litwin ◽

Tricia Crocker ◽

Elizabeth Mack ◽

Lauren Card

Keyword(s):

Health Care ◽

At Risk ◽

Health Care Workers ◽

Medical Center ◽

Point Of Care ◽

Academic Medical Center ◽

Significant Risk ◽

Documented Infection ◽

Inconclusive Result ◽

Care Workers

Abstract Background Health care workers are at significant risk for infection with the novel coronavirus SARS-CoV-2. Methods We utilized a point-of-care, lateral flow SARS-CoV-2 IgG immunoassay (RayBiotech) to conduct a seroprevalence study in a cohort of at-risk health care workers (n=339) and normal-risk controls (n=100) employed at an academic medical center. To minimize exposure risk while conducting the study, consents were performed electronically, tests were mailed and then self-administered at home using finger stick blood, and subjects uploaded a picture of the test result while answering an electronic questionnaire. We also validated the assay using de-identified serum samples from patients with PCR-proven SARS-CoV-2 infection. Results Between April 14th and May 6th 2020, 439 subjects were enrolled. Subjects were 68% female, 93% white, and most were physicians (38%) and nurses (27%). In addition, 37% had at least 1 respiratory symptom in the prior month, 34% had cared for a patient with known SARS-CoV-2 infection, 57% and 23% were worried about exposure at work or in the community, respectively, and 5 reported prior documented SARS-CoV-2 infection. On initial testing, 3 subjects had a positive IgG test, 336 had a negative test, and 87 had an inconclusive result. Of those with an inconclusive result who conducted a repeat test (85%), 96% had a negative result. All 3 positive IgG tests were in subjects reporting prior documented infection. Laboratory validation showed that of those with PCR-proven infection more than 13 days prior, 23/30 were IgG positive (76% sensitivity), whereas 1/26 with a negative prior PCR test were seropositive (95% specificity). Repeat longitudinal serologic testing every 30 days for up to 4 times is currently in progress. Conclusion We conducted a contact-free study in the setting of a pandemic to assess SARS-CoV-2 seroprevalence in an at-risk group of health care workers. The only subjects found to be IgG positive were those with prior documented infection, even though a substantial proportion of subjects reported significant potential occupational or community exposure and symptoms that were potentially compatible with SARS-COV-2 infection. Disclosures All Authors: No reported disclosures

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Tumor Tissue MIR92a and Plasma MIRs21 and 29a as Predictive Biomarkers Associated with Clinicopathological Features and Surgical Resection in a Prospective Study on Colorectal Cancer Patients

Journal of Clinical Medicine ◽

10.3390/jcm9082509 ◽

2020 ◽

Vol 9 (8) ◽

pp. 2509

Author(s):

Masahiro Fukada ◽

Nobuhisa Matsuhashi ◽

Takao Takahashi ◽

Nobuhiko Sugito ◽

Kazuki Heishima ◽

...

Keyword(s):

Colorectal Cancer ◽

Prospective Study ◽

Surgical Resection ◽

Tumor Tissue ◽

Lymphatic Invasion ◽

Clinicopathological Features ◽

Stage Iii ◽

Sample Type ◽

Significant Difference ◽

A Prospective Study

Cancer-related microRNAs (miRNAs) are emerging as non-invasive biomarkers for colorectal cancer (CRC). This study aimed to analyze the correlation between the levels of tissue and plasma miRNAs and clinicopathological characteristics and surgical resection. This study was a prospective study of CRC patients who underwent surgery. Forty-four sample pairs of tissue and plasma were analyzed. The miRNA levels were evaluated by RT-qPCR. The level of tumor tissue MIR92a showed a significant difference in CRC with lymph node metastasis, stage ≥ III, and high lymphatic invasion. In preoperative plasma, there were significant differences in CRC with stage ≥ III (MIR29a) and perineural invasion (MIR21). In multivariate analysis of lymphatic invasion, the levels of both preoperative plasma MIR29a and tumor tissue MIR92a showed significant differences. Furthermore, in cases with higher plasma miRNA level, the levels of plasma MIRs21 and 29a were significantly decreased after the operation. In this study, there were significant differences in miRNAs levels with respect to the sample type, clinicopathological features, and surgical resection. The levels of tumor tissue MIR92a and preoperative plasma MIR29a may have the potential as a biomarker for prognosis. The plasma MIRs21 and 29a level has the potential to be a predictive biomarker for treatment efficacy.

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