scholarly journals Multidimensional imaging of liver injury repair in mice reveals fundamental role of the ductular reaction

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Kenji Kamimoto ◽  
Yasuhiro Nakano ◽  
Kota Kaneko ◽  
Atsushi Miyajima ◽  
Tohru Itoh
Keyword(s):  
Liver Injury ◽  
Ductular Reaction ◽  
Injury Repair ◽  
Multidimensional Imaging

scholarly journals Differential expression of Lutheran/BCAM regulates biliary tissue remodeling in ductular reaction during liver regeneration

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Yasushi Miura ◽  
Satoshi Matsui ◽  
Naoko Miyata ◽  
Kenichi Harada ◽  
Yamato Kikkawa ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Injury ◽  
Critical Role ◽  
Disease Models ◽  
Distinct Mode ◽  
Ductular Reaction ◽  
Deficient Mice ◽  
Injured Liver

Under chronic or severe liver injury, liver progenitor cells (LPCs) of biliary origin are known to expand and contribute to the regeneration of hepatocytes and cholangiocytes. This regeneration process is called ductular reaction (DR), which is accompanied by dynamic remodeling of biliary tissue. Although the DR shows apparently distinct mode of biliary extension depending on the type of liver injury, the key regulatory mechanism remains poorly understood. Here, we show that Lutheran (Lu)/Basal cell adhesion molecule (BCAM) regulates the morphogenesis of DR depending on liver disease models. Lu+ and Lu- biliary cells isolated from injured liver exhibit opposite phenotypes in cell motility and duct formation capacities in vitro. By overexpression of Lu, Lu- biliary cells acquire the phenotype of Lu+ biliary cells. Lu-deficient mice showed severe defects in DR. Our findings reveal a critical role of Lu in the control of phenotypic heterogeneity of DR in distinct liver disease models.

P104 ROLE OF TUMOR NECROSIS FACTOR-a DURING THE DUCTULAR REACTION IN MOUSE MODELS OF LIVER INJURY

2014 ◽  
Vol 60 (1) ◽  
pp. S101
Author(s):  
J. Best ◽  
S. Verhulst ◽  
N. Van Hul ◽  
W.-K. Syn ◽  
F. Heindryckx ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Liver Injury ◽  
Mouse Models ◽  
Tumor Necrosis ◽  
Ductular Reaction ◽  
Necrosis Factor

The role of microbiota in concanavalin A-mediated liver injury

2018 ◽  
Vol 56 (01) ◽  
pp. E2-E89
Author(s):  
B Schiller ◽  
C Wegscheid ◽  
L Berkhout ◽  
A Zarzycka ◽  
U Steinhoff ◽  
...  
Keyword(s):  
Liver Injury ◽  
Concanavalin A

scholarly journals Reply to: “COVID-19-associated liver injury (COVALI): role of hepatologists”

2021 ◽  
Author(s):  
Dongxiao Li ◽  
Xiangming Ding ◽  
Dean Tian ◽  
Limin Xia
Keyword(s):  
Liver Injury

scholarly journals Liver Injury and the Macrophage Issue: Molecular and Mechanistic Facts and Their Clinical Relevance

2021 ◽  
Vol 22 (14) ◽  
pp. 7249
Author(s):  
Siyer Roohani ◽  
Frank Tacke
Keyword(s):  
Bone Marrow ◽  
Liver Injury ◽  
Current Knowledge ◽  
Hepatocellular Cancer ◽  
Complete Recovery ◽  
Hepatic Macrophages ◽  
Liver Injuries ◽  
Microbial Products ◽  
Injured Liver

The liver is an essential immunological organ due to its gatekeeper position to bypassing antigens from the intestinal blood flow and microbial products from the intestinal commensals. The tissue-resident liver macrophages, termed Kupffer cells, represent key phagocytes that closely interact with local parenchymal, interstitial and other immunological cells in the liver to maintain homeostasis and tolerance against harmless antigens. Upon liver injury, the pool of hepatic macrophages expands dramatically by infiltrating bone marrow-/monocyte-derived macrophages. The interplay of the injured microenvironment and altered macrophage pool skews the subsequent course of liver injuries. It may range from complete recovery to chronic inflammation, fibrosis, cirrhosis and eventually hepatocellular cancer. This review summarizes current knowledge on the classification and role of hepatic macrophages in the healthy and injured liver.

scholarly journals An Unexpected Role of Cholesterol Sulfotransferase and its Regulation in Sensitizing Mice to Acetaminophen-Induced Liver Injury

2019 ◽  
Vol 95 (6) ◽  
pp. 597-605 ◽  
Author(s):  
Yunqi An ◽  
Pengcheng Wang ◽  
Pengfei Xu ◽  
Hung-Chun Tung ◽  
Yang Xie ◽  
...  
Keyword(s):  
Liver Injury
Sign in / Sign up

Export Citation Format

Share Document