Gut mycobiota alterations in patients with COVID-19 and H1N1 infections and their associations with clinical features

AbstractThe relationship between gut microbes and COVID-19 or H1N1 infections is not fully understood. Here, we compared the gut mycobiota of 67 COVID-19 patients, 35 H1N1-infected patients and 48 healthy controls (HCs) using internal transcribed spacer (ITS) 3-ITS4 sequencing and analysed their associations with clinical features and the bacterial microbiota. Compared to HCs, the fungal burden was higher. Fungal mycobiota dysbiosis in both COVID-19 and H1N1-infected patients was mainly characterized by the depletion of fungi such as Aspergillus and Penicillium, but several fungi, including Candida glabrata, were enriched in H1N1-infected patients. The gut mycobiota profiles in COVID-19 patients with mild and severe symptoms were similar. Hospitalization had no apparent additional effects. In COVID-19 patients, Mucoromycota was positively correlated with Fusicatenibacter, Aspergillus niger was positively correlated with diarrhoea, and Penicillium citrinum was negatively correlated with C-reactive protein (CRP). In H1N1-infected patients, Aspergillus penicilloides was positively correlated with Lachnospiraceae members, Aspergillus was positively correlated with CRP, and Mucoromycota was negatively correlated with procalcitonin. Therefore, gut mycobiota dysbiosis occurs in both COVID-19 patients and H1N1-infected patients and does not improve until the patients are discharged and no longer require medical attention.

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EVALUATION OF THE RELATIONSHIP OF LEVELS OF C-REACTIVE PROTEIN AND HOMOCYSTEIN IN PATIENTS WITH ABDOMINAL OBESITY AND PATHOLOGICAL CHANGES IN THE LIVER DEFINED BY BIOPROGNOSTIC TEST STEATOSCREEN.

10.26226/morressier.59a6b341d462b80290b53e58 ◽

2017 ◽

Author(s):

Ekaterina Chernetcova

Keyword(s):

Abdominal Obesity ◽

Pathological Changes ◽

C Reactive Protein ◽

Reactive Protein ◽

Relationship Of ◽

The Relationship

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The Relationship between Vitamin D and Coronary Artery Ectasia in Subjects with a Normal C-Reactive Protein Level

Korean Circulation Journal ◽

10.4070/kcj.2016.0198 ◽

2017 ◽

Vol 47 (2) ◽

pp. 231 ◽

Cited By ~ 2

Author(s):

Goksel Cagirci ◽

Selcuk Kucukseymen ◽

Isa Oner Yuksel ◽

Nermin Bayar ◽

Erkan Koklu ◽

...

Keyword(s):

Vitamin D ◽

Coronary Artery ◽

Protein Level ◽

Coronary Artery Ectasia ◽

C Reactive Protein ◽

Reactive Protein ◽

The Relationship

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Serum C reactive protein levels and genetic variation in the CRP gene are not associated with the prevalence, incidence or progression of osteoarthritis independent of body mass index

Annals of the Rheumatic Diseases ◽

10.1136/ard.2009.125260 ◽

2010 ◽

Vol 69 (11) ◽

pp. 1976-1982 ◽

Cited By ~ 46

Author(s):

Hanneke J M Kerkhof ◽

Sita M A Bierma-Zeinstra ◽

Martha C Castano-Betancourt ◽

Moniek P de Maat ◽

Albert Hofman ◽

...

Keyword(s):

Systematic Review ◽

Body Mass Index ◽

Genetic Variation ◽

Body Mass ◽

Analysis Of Covariance ◽

C Reactive Protein ◽

Knee Oa ◽

Reactive Protein ◽

Serum Crp ◽

The Relationship

ObjectiveTo study the relationship between serum C reactive protein (CRP) levels, genetic variation in the CRP gene and the prevalence, incidence and progression of radiographic osteoarthritis (ROA) in the Rotterdam Study-I (RS-I). A systematic review of studies assessing the relationship between osteoarthritis (OA) and CRP levels was also performed.MethodsThe association between CRP levels and genetic variation in the CRP gene and ROA was examined in 861 patients with hand OA, 718 with knee OA, 349 with hip OA and 2806 controls in the RS-I using one-way analysis of covariance and logistic regression, respectively. PubMed was searched for articles published between January 1992 and August 2009 assessing the relationship between CRP levels and OA.ResultsIn RS-I the prevalence of knee OA, but not hip OA or hand OA, was associated with 14% higher serum CRP levels compared with controls (p=0.001). This association disappeared after adjustment for age and especially body mass index (BMI) (p=0.33). Genetic variation of the CRP gene was not consistently associated with the prevalence, incidence or progression of OA within RS-I. The systematic review included 18 studies (including RS-I) on serum CRP levels and the prevalence, incidence or progression of OA. Consistently higher crude CRP levels were found in cases of prevalent knee OA compared with controls. No association was observed between serum CRP levels and the prevalence of knee OA following adjustment for BMI (n=3 studies, meta-analysis p value=0.61).ConclusionThere is no evidence of association between serum CRP levels or genetic variation in the CRP gene with the prevalence, incidence or progression of OA independent of BMI.

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Comparison of Clinical Features Between Patients with Positive and Negative Appendectomy

10.21203/rs.3.rs-117309/v1 ◽

2020 ◽

Author(s):

Guner Cakmak ◽

Baris Mantoglu ◽

Emre Gonullu ◽

Kayhan Ozdemir ◽

Burak Kamburoglu

Keyword(s):

Acute Appendicitis ◽

Clinical Features ◽

Total Bilirubin ◽

Negative Appendectomy ◽

C Reactive Protein ◽

Future Studies ◽

Female Patients ◽

Reactive Protein ◽

Male Patients ◽

The Mean

Abstract Background: The objective of this study was to retrospectively compare clinical features and prognostic values between the patients who were referred to the general surgery clinic of our hospital with the presumed diagnosis of acute appendicitis and underwent positive or negative appendectomy.Methods: Patients were divided into two groups as positive (PA) (n:362) and negative appendectomy (NA) (n:284) and the data obtained were compared between these two groups.Laboratory investigations were performed in all patients, and white blood cell (WBC), mean platelet volume (MPV), neutrophils count (NEU), neutrophils (%) (NEU%), C-reactive protein (CRP) and total bilirubin (TBIL) values were studied.Results: The mean MPV value was found as 7.88 fl in PA groups and 8.09 fl in NA group, and the mean MPV value was not statistically significantly difference in PA group, compared to NA groups (p=0.012). Laboratory parameters were also compared between genders. Accordingly, the mean MPV value was statistically significantly higher in female patients compared to male patients in PA group (p = 0.04). The mean TBIL value was 0.97 mg/dl in PA group and 0.69 mg/dl in NA group, and the mean TBIL value was statistically significantly higher in PA group (p< 0.001). Finally, TBIL value was statistically significantly lower in female patients compared to male patients in NA and PA group (p < 0.05).Conclusions: According to the results of our study, MPV and T. BIL values differ in PA and NA groups depending on gender. Therefore, these values may not be used as specific biomarkers in predicting positive acute appendicitis. We believe that these results will contribute to the literature and will be guiding for future studies.

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Correlation of High Sensitive C Reactive Protein Levels as Inflammation Marker with Red Blood Cell Distribution Width Value in Regular Hemodialysis Patients at H. Adam Malik General Hospital

International Journal of Research and Review ◽

10.52403/ijrr.20210703 ◽

2021 ◽

Vol 8 (7) ◽

pp. 14-27

Author(s):

Anwar Sholeh ◽

Alwi Thamrin Nasution ◽

Radar Radius Tarigan

Keyword(s):

General Hospital ◽

Pearson Correlation ◽

Cell Distribution ◽

C Reactive Protein ◽

Distribution Width ◽

Reactive Protein ◽

Pearson Correlation Analysis ◽

The Relationship ◽

Red Blood Cell Distribution ◽

Regular Hemodialysis

Background: Chronic kidney disease (CKD) is characterized by structural and functional disorder of the kidney with irreversible and gradual characteristics with one of the modalities of renal replacement therapy such as hemodialysis (HD). The role of inflammation in HD patients by uremic toxin and dialysis can be assessed by the marker of High Sensitive C Reactive Protein (HsCRP). Several studies have examined the relationship between HsCRP and red cell distribution width (RDW) in regular HD patients which leads to increase patient morbidity and mortality, but until now, there has been no study in Indonesia regarding the correlation between HsCRP and RDW in regular HD patients. This study aims to determine the correlation HsCRP as a marker of inflammation and RDW values in regular HD patients. Methods: This is a cross-sectional study in Regular HD patients at Dialysis Unit-H. Adam Malik General Hospital. A total of 20 subjects were included. Bivariate and multivariate analysis was conducted to analyze the relationship of HsCRP, ureum, creatinin, hemoglobin, and eGFR to RDW. Results: There were 20 Regular HD patients analyzed. The proportion of patients with increased RDW was 80%. In pearson correlation test, there is a strong correlation between HsCRP and RDW (r= 0.667, p<0.001). Discussion: Majority of regular HD patients at H. Adam Malik General Hospital were assessed with increased RDW. Pearson correlation analysis revealed HsCRP was significantly associated with RDW. Conclusion: Increased RDW was found in 80% of regular HD patients at H. Adam malik General Hospital. From pearson correlation analysis, we found HsCRP was significantly associated with RDW. Keywords: inflammation, high sensitive c reactive protein, red blood cell distribution width, regular hemodialysis.

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Replication and reproducibility issues in the relationship between C-reactive protein and depression: A systematic review and focused meta-analysis

Brain Behavior and Immunity ◽

10.1016/j.bbi.2018.06.016 ◽

2018 ◽

Vol 73 ◽

pp. 85-114 ◽

Cited By ~ 31

Author(s):

Sarah R. Horn ◽

Madison M. Long ◽

Benjamin W. Nelson ◽

Nicholas B. Allen ◽

Philip A. Fisher ◽

...

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

C Reactive Protein ◽

Reactive Protein ◽

The Relationship

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The Relationship between C-Reactive Protein and Mortality in Adults with Diabetes: Influences of Demographic Characteristics, Lifestyle Behaviors, and Medications

Nutrition Metabolism and Cardiovascular Diseases ◽

10.1016/j.numecd.2021.09.022 ◽

2021 ◽

Author(s):

Olaitan Akinboboye ◽

Joni S. Williams ◽

Emma Garacci ◽

Leonard E. Egede

Keyword(s):

Demographic Characteristics ◽

Lifestyle Behaviors ◽

C Reactive Protein ◽

Reactive Protein ◽

The Relationship

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A prospective follow-up study of the relationship between high-sensitivity C-reactive protein and primary liver cancer

BMC Cancer ◽

10.1186/s12885-020-07665-9 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Sarah Tan Siyin ◽

Tong Liu ◽

Wenqiang Li ◽

Nan Yao ◽

Guoshuai Xu ◽

...

Keyword(s):

Liver Cancer ◽

Regression Models ◽

Primary Liver Cancer ◽

High Sensitivity ◽

C Reactive Protein ◽

Reactive Protein ◽

Hs Crp ◽

The Relationship ◽

New Onset

Abstract Background Competing risk method has not been used in a large-scale prospective study to investigate whether increased levels of high-sensitivity C-reactive protein (hs-CRP) elevate the risk of primary liver cancer (PLC). Our study aims to prospectively investigate the relationship between hs-CRP and new-onset PLC. Methods and results Ninety-five thousand seven hundred fifty-nine participants without the diagnosis of PLC, and who had their demographic characteristics and biochemical parameters recorded, were analyzed from the Kailuan Cohort study. Cox proportional hazards regression models and competing risk regression models were used to evaluate the hazard ratios (HRs) and 95% confidence intervals (95% CIs) of PLC. During a median follow-up of 11.07 years, 357 incidental PLC cases were identified over a total of 1,035,039 person-years. The multivariable HRs (95%CI) for the association of hs-CRP of 1–3 mg/L group and hs-CRP>3 mg/L with PLC were 1.07(0.82 ~ 1.38), 1.51(1.15 ~ 1.98) in a Cox proportional hazard regression analysis adjusted for other potential confounders. In the cause-specific hazard model, the multivariable HRs (95%CI) for the association of hs-CRP of 1–3 mg/L group and hs-CRP>3 mg/L with PLC were 1.06(0.81 ~ 1.40), 1.50(1.14 ~ 1.99). Similar results were also observed in the sub-distribution hazard function model with corresponding multivariate HRs (95%CI) of 1.05(0.80 ~ 1.40), 1.49(1.13 ~ 1.98) in hs-CRP of 1–3 mg/L group and hs-CRP>3 mg/L group, respectively. Conclusions This prospective study found a significant association of higher levels of hs-CRP with new-onset PLC. The main clinical implications would be an increased awareness of hs-CRP and its correlation to the risk of PLC. This study should be a steppingstone to further research on chronic inflammation and PLC. Trial registration Registration number:ChiCTR–TNRC–11001489.

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