scholarly journals Acute changes in Cerebrospinal Fluid 5-HIAA following Oral Paroxetine Challenge in Healthy Humans

2003 ◽  
Vol 28 (2) ◽  
pp. 339-347 ◽  
Author(s):  
Linda L Carpenter ◽  
George M Anderson ◽  
Jason M Siniscalchi ◽  
Phillip B Chappell ◽  
Lawrence H Price
Keyword(s):  
Cerebrospinal Fluid ◽  
Healthy Humans ◽  
Acute Changes

scholarly journals Profiling of Cerebrospinal Fluid Lipids and Their Relationship with Plasma Lipids in Healthy Humans

Metabolites ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 268
Author(s):  
Kosuke Saito ◽  
Kotaro Hattori ◽  
Shinsuke Hidese ◽  
Daimei Sasayama ◽  
Tomoko Miyakawa ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Total Protein ◽  
Plasma Lipids ◽  
Plasma Lipid ◽  
Lipid Profiles ◽  
Brain Diseases ◽  
Lipid Homeostasis ◽  
Total Protein Content ◽  
Lipid Profiling ◽  
Healthy Humans

Lipidomics provides an overview of lipid profiles in biological systems. Although blood is commonly used for lipid profiling, cerebrospinal fluid (CSF) is more suitable for exploring lipid homeostasis in brain diseases. However, whether an individual’s background affects the CSF lipid profile remains unclear, and the association between CSF and plasma lipid profiles in heathy individuals has not yet been defined. Herein, lipidomics approaches were employed to analyze CSF and plasma samples obtained from 114 healthy Japanese subjects. Results showed that the global lipid profiles differed significantly between CSF and plasma, with only 13 of 114 lipids found to be significantly correlated between the two matrices. Additionally, the CSF total protein content was the primary factor associated with CSF lipids. In the CSF, the levels of major lipids, namely, phosphatidylcholines, sphingomyelins, and cholesterolesters, correlated with CSF total protein levels. These findings indicate that CSF lipidomics can be applied to explore changes in lipid homeostasis in patients with brain diseases.

The effect of chronic and acute changes in plasma composition on vasopressin secretion and cerebrospinal fluid in the rat

1992 ◽  
Vol 127 (2) ◽  
pp. 174-178 ◽  
Author(s):  
Timothy Wells ◽  
Richard J Balment
Keyword(s):  
Cerebrospinal Fluid ◽  
New Zealand ◽  
Plasma Osmolality ◽  
Sodium Concentration ◽  
Fluid Composition ◽  
Plasma Composition ◽  
Plasma Vasopressin ◽  
Vasopressin Secretion ◽  
Acute Changes ◽  
Hypertonic Saline Injection

The effects of chronic and acute changes in plasma composition on the osmolality and sodium concentration of cerebrospinal fluid and plasma vasopressin (AVP) concentration have been examined. Chronic elevation of plasma osmolality in three strains of genetically AVP-deflcient rats (Brattleboro and New Zealand hypertensive and normotensive Brattleboro) was associated with increased cerebrospinal fluid osmolality by comparison with AVP-replete controls (Long Evans and New Zealand genetically hypertensive and normotensive rats). The linear correlation between plasma and cerebrospinal fluid osmolality did not reflect a similar relationship between plasma and cerebrospinal fluid sodium concentration. Hypertensive animals exhibited a threefold higher plasma AVP concentration in association with significantly elevated cerebrospinal fluid osmolality by comparison with normotensive controls. Although ip hypertonic saline injection elicited parallel increases in plasma and cerebrospinal fluid osmolality and sodium concentration in both hypertensive and normotensive rats, only in the normotensives did this result in an increase in plasma AVP concentration. These results indicate that cerebrospinal fluid is subject to modest chronic and acute changes in osmolality and sodium concentration which may contribute to the osmotic control of AVP secretion. The disturbed control of vasopressin secretion in hypertensive rats may in part be related to the abnormal cerebrospinal fluid composition in these animals.

scholarly journals Cerebrospinal Fluid Corticotropin-Releasing Hormone in Healthy Humans: Effects of Yohimbine and Naloxone1

2000 ◽  
Vol 85 (11) ◽  
pp. 4138-4145
Author(s):  
Meena Vythilingam ◽  
George M. Anderson ◽  
Michael J. Owens ◽  
Thomas M. Halaszynski ◽  
J. Douglas Bremner ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Healthy Humans

180. Circadian rhythmicity, variability and correlation of Interleukin-6 in plasma and cerebrospinal fluid of healthy humans

2012 ◽  
Vol 26 ◽  
pp. S50
Author(s):  
A. Agorastos ◽  
R.L. Hauger ◽  
T. Moeller-Bertram ◽  
D. Barkauskas ◽  
P.L. Clopton ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Interleukin 6 ◽  
Circadian Rhythmicity ◽  
Healthy Humans

ACUTE ADMINISTRATION OF A BACE INHIBITOR IN HEALTHY HUMANS RESULTS IN A SIGNIFICANT REDUCTION OF Aβ OLIGOMERS IN CEREBROSPINAL FLUID

2017 ◽  
Vol 13 (7) ◽  
pp. P574
Author(s):  
Juliya Kalinina ◽  
Kyeongmi Cheon ◽  
Julie Stone ◽  
Matthew Kennedy ◽  
Mark Forman ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Acute Administration ◽  
Aβ Oligomers ◽  
Healthy Humans ◽  
Bace Inhibitor

Phenylephrine-induced hypertension acutely decreases genioglossus EMG activity in awake humans

1992 ◽  
Vol 72 (1) ◽  
pp. 110-115 ◽  
Author(s):  
E. Garpestad ◽  
R. C. Basner ◽  
J. Ringler ◽  
J. Lilly ◽  
R. Schwartzstein ◽  
...  
Keyword(s):  
Minute Ventilation ◽  
Upper Airway ◽  
Face Mask ◽  
Systemic Blood Pressure ◽  
Emg Activity ◽  
Healthy Humans ◽  
Baseline Activity ◽  
Acute Changes ◽  
End Tidal ◽  
Airway Tone

To investigate the relationship between systemic blood pressure (BP) and upper airway dilator muscle activity, we recorded genioglossus electromyograms (EMGgg) during pharmacologically induced acute increases in BP in five healthy humans (ages 27–40 yr). EMGgg was measured with perorally placed fine-wire electrodes; phasic EMGgg was expressed as percentage of baseline activity. Subjects were studied supine, awake, and breathing through a face mask with their mouths taped. End-tidal PCO2 was monitored with a mass spectrometer; minute ventilation was measured with a pneumotachograph. Digital BP was monitored continuously with the Penaz method (Finapres, Ohmeda). Mean arterial pressure (MAP) at baseline was 89 +/- 6 (SD) mmHg. Phenylephrine was infused until MAP reached 15–25 mmHg above baseline (107 +/- 7 mmHg). Recording was continued until MAP returned to baseline (90 +/- 7 mmHg). Elevated BP was associated with a significantly decreased phasic EMGgg (P less than 0.005). With return of MAP to baseline, phasic EMGgg returned toward normal (P less than 0.01). Minute ventilation and end-tidal PCO2 did not differ among conditions. Genioglossus activity appears to be influenced by acute changes in systemic BP. We speculate that BP elevations accompanying obstructive apneas during sleep may decrease upper airway tone and facilitate subsequent apneas.

Sign in / Sign up

Export Citation Format

Share Document