ACUTE ADMINISTRATION OF A BACE INHIBITOR IN HEALTHY HUMANS RESULTS IN A SIGNIFICANT REDUCTION OF Aβ OLIGOMERS IN CEREBROSPINAL FLUID

2017 ◽  
Vol 13 (7) ◽  
pp. P574
Author(s):  
Juliya Kalinina ◽  
Kyeongmi Cheon ◽  
Julie Stone ◽  
Matthew Kennedy ◽  
Mark Forman ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Acute Administration ◽  
Aβ Oligomers ◽  
Healthy Humans ◽  
Bace Inhibitor

scholarly journals Profiling of Cerebrospinal Fluid Lipids and Their Relationship with Plasma Lipids in Healthy Humans

Metabolites ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 268
Author(s):  
Kosuke Saito ◽  
Kotaro Hattori ◽  
Shinsuke Hidese ◽  
Daimei Sasayama ◽  
Tomoko Miyakawa ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Total Protein ◽  
Plasma Lipids ◽  
Plasma Lipid ◽  
Lipid Profiles ◽  
Brain Diseases ◽  
Lipid Homeostasis ◽  
Total Protein Content ◽  
Lipid Profiling ◽  
Healthy Humans

Lipidomics provides an overview of lipid profiles in biological systems. Although blood is commonly used for lipid profiling, cerebrospinal fluid (CSF) is more suitable for exploring lipid homeostasis in brain diseases. However, whether an individual’s background affects the CSF lipid profile remains unclear, and the association between CSF and plasma lipid profiles in heathy individuals has not yet been defined. Herein, lipidomics approaches were employed to analyze CSF and plasma samples obtained from 114 healthy Japanese subjects. Results showed that the global lipid profiles differed significantly between CSF and plasma, with only 13 of 114 lipids found to be significantly correlated between the two matrices. Additionally, the CSF total protein content was the primary factor associated with CSF lipids. In the CSF, the levels of major lipids, namely, phosphatidylcholines, sphingomyelins, and cholesterolesters, correlated with CSF total protein levels. These findings indicate that CSF lipidomics can be applied to explore changes in lipid homeostasis in patients with brain diseases.

CARDIOVASCULAR EFFECTS OF THE INSECTICIDE ENDRIN

1964 ◽  
Vol 42 (1) ◽  
pp. 41-51 ◽  
Author(s):  
T. E. Emerson Jr. ◽  
C. M. Brake ◽  
L. B. Hinshaw
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Venous Pressure ◽  
Fluid Pressure ◽  
Cardiovascular Effects ◽  
Acute Administration ◽  
Blood Ph ◽  
The Central Nervous System ◽  
Cerebral Venous Pressure

Little is known of the cardiovascular effects of endrin insecticide. Experiments to investigate these phenomena were carried out on dogs with a variety of preparations. Results show that acute administration of endrin produces bradycardia, hypertension, copious salivation, hyperexcitability, tonic–cionic convulsions, increased body temperature, leukocytosis, hemoconcentration, and decreased blood pH. Cerebral venous pressure and cerebrospinal fluid pressure elevations are also prominent features of endrin poisoning. Although most of these effects appear to be caused by endrin acting directly on the central nervous system some may result secondarily from altered cerebral hemodynamics.

scholarly journals Cerebrospinal Fluid Corticotropin-Releasing Hormone in Healthy Humans: Effects of Yohimbine and Naloxone1

2000 ◽  
Vol 85 (11) ◽  
pp. 4138-4145
Author(s):  
Meena Vythilingam ◽  
George M. Anderson ◽  
Michael J. Owens ◽  
Thomas M. Halaszynski ◽  
J. Douglas Bremner ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Healthy Humans

scholarly journals Acute changes in Cerebrospinal Fluid 5-HIAA following Oral Paroxetine Challenge in Healthy Humans

2003 ◽  
Vol 28 (2) ◽  
pp. 339-347 ◽  
Author(s):  
Linda L Carpenter ◽  
George M Anderson ◽  
Jason M Siniscalchi ◽  
Phillip B Chappell ◽  
Lawrence H Price
Keyword(s):  
Cerebrospinal Fluid ◽  
Healthy Humans ◽  
Acute Changes

P3-282: Single oral doses of the novel bace inhibitor bi 1181181 significantly reduce concentrations of cerebrospinal fluid amyloid-beta peptides in healthy subjects

2015 ◽  
Vol 11 (7S_Part_16) ◽  
pp. P740-P740 ◽  
Author(s):  
Andreas Borta ◽  
Laurent Nicolas ◽  
Oliver Kleiner ◽  
Klaus-Peter Kammerer ◽  
Jennifer Schaible ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Amyloid Beta ◽  
Healthy Subjects ◽  
The Novel ◽  
Amyloid Beta Peptides ◽  
Beta Peptides ◽  
Bace Inhibitor ◽  
Oral Doses
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