scholarly journals Differential integrative omic analysis for mechanism insights and biomarker discovery of abnormal Savda syndrome and its unique Munziq prescription

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Xia Guo ◽  
Iskandar Bakri ◽  
Abulizi Abudula ◽  
Kalbinur Arken ◽  
Mahmut Mijit ◽  
...  
Keyword(s):  
Biomarker Discovery ◽  
Abnormal Savda ◽  
Abnormal Savda Syndrome

scholarly journals Correlative analysis of neoplasm patients with phlegm-stasis () or abnormal savda () syndrome, based on metabonomics

2012 ◽  
Vol 32 (1) ◽  
pp. 119-124 ◽  
Author(s):  
Mamtimin BATUR ◽  
Upur HALMURAT ◽  
Fu-hua HAO ◽  
Aiziz RENA ◽  
Matsidik AYNUR
Keyword(s):  
Correlative Analysis ◽  
Abnormal Savda ◽  
Abnormal Savda Syndrome

scholarly journals Establishment and Comparison of Combining Disease and Syndrome Model of Asthma with “Kidney Yang Deficiency” and “Abnormal Savda”

2013 ◽  
Vol 2013 ◽  
pp. 1-15 ◽  
Author(s):  
Bei Li ◽  
Qing-li Luo ◽  
Mammat Nurahmat ◽  
Hua-liang Jin ◽  
Yi-jie Du ◽  
...  
Keyword(s):  
Airway Remodeling ◽  
Deficiency Syndrome ◽  
High Dose ◽  
Rat Models ◽  
Traditional Uighur Medicine ◽  
Kidney Yang Deficiency ◽  
Abnormal Savda ◽  
Abnormal Savda Syndrome ◽  
Nerve System ◽  
First Time

The study was the first time to establish and compare two rat models of two common syndromes: Kidney Yang Deficiency syndrome (KYDS) in traditional Chinese medicine (TCM) and abnormal savda syndrome (ASS) in traditional Uighur medicine (TUM). Then, we also established and evaluated rat models of combining disease and syndrome models of asthma with KYDS or ASS. Results showed that usage of the high dose of corticosterone (CORT) injection or external factors could successfully establish the KYDS or ASS rat models, and the two models had similar changes in biological characterization, abnormal behaviors, dysfunction of hypothalamic-pituitary-target organ axes (HPTOA), and sympathetic/parasympathetic (S/P) nerve system but varied in different degrees. The rat models of combining disease and syndrome of asthma with KYDS or ASS had either pathological characteristics of asthma such as airway hyperresponsiveness (AHR), airway inflammation, airway remodeling, which were more serious than allergy exposure alone, or the syndrome performance of Kidney Yang Deficiency in TCM and abnormal savda in TUM. These findings provide a biological rationale for further investigation of combining disease and syndrome model of asthma as an effective animal model for exploring asthma based on the theory of traditional medicine.

Abnormal Savda syndrome: Long-term consequences of emotional and physical stress on endocrine and immune activities in an animal model

2012 ◽  
Vol 19 (8) ◽  
pp. 603-609 ◽  
Author(s):  
Adiljan Ablimit ◽  
Harald Kühnel ◽  
Alois Strasser ◽  
Halmurat Upur
Keyword(s):  
Animal Model ◽  
Physical Stress ◽  
Long Term Consequences ◽  
Abnormal Savda ◽  
Abnormal Savda Syndrome

scholarly journals Metabolomic changes in patients with chronic obstructive pulmonary disease with abnormal Savda syndrome

2014 ◽  
Vol 9 (2) ◽  
pp. 425-431 ◽  
Author(s):  
WEI-FANG XU ◽  
HALMURAT UPUR ◽  
YU-HUA WU ◽  
BATUR MAMTIMIN ◽  
JIAN YANG ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Abnormal Savda ◽  
Abnormal Savda Syndrome

scholarly journals Transition of the abnormal Savda syndrome to the hepatic carcinoma shifted unfolded protein response to autophagy was partly reversed by Savda Munziq in a rat model

2020 ◽  
Vol 121 ◽  
pp. 109643
Author(s):  
Yi Hao ◽  
Yue Xiao ◽  
Zhihong Zhang ◽  
Hongli Zhao ◽  
Wenyan Zhou ◽  
...  
Keyword(s):  
Unfolded Protein Response ◽  
Rat Model ◽  
Hepatic Carcinoma ◽  
Unfolded Protein ◽  
Abnormal Savda ◽  
Abnormal Savda Syndrome ◽  
Protein Response

scholarly journals Plasma proteins as potential targets of abnormal Savda syndrome in asthma patients treated with unique Uighur prescription

2017 ◽  
Vol 14 (1) ◽  
pp. 267-275 ◽  
Author(s):  
Canhua Zhang ◽  
Abulizi Abudula ◽  
Maliyegu Awuti ◽  
Huiwu Wang ◽  
Xiaimuxikamaier Aihemaiti ◽  
...  
Keyword(s):  
Plasma Proteins ◽  
Asthma Patients ◽  
Abnormal Savda ◽  
Abnormal Savda Syndrome

scholarly journals Effect of Abnormal Savda Munziq, a Traditional Uighur Herbal Medicine, on Pulmonary Function and Aquaporins of COPD Rat Model with Abnormal Savda Syndrome

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Gao Zhen ◽  
Halmurat Upur ◽  
Wang Jing ◽  
Jing Jing ◽  
Li Zheng ◽  
...  
Keyword(s):  
Protein Expression ◽  
Pulmonary Function ◽  
Rat Model ◽  
Mrna Level ◽  
Male Rats ◽  
Chronic Obstructive ◽  
Mrna Levels ◽  
Abnormal Savda ◽  
Abnormal Savda Syndrome ◽  
Abnormal Savda Munziq

Objective. To investigate the effect of abnormal savda munziq (ASM) on the pulmonary function and expression of lung-specific aquaporins in the rat model of chronic obstructive pulmonary disease with abnormal savda syndrome (ASSCOPD). Methods. Eighty male rats were randomized into ASSCOPD, COPD, and control groups. ASSCOPD was further categorized into ASM and non-ASM groups. COPD model was established by combining fumigation with airway instillation of elastase; ASSCOPD model was developed based on COPD by induction with dry cold diet, cold dry environment, and plantar electric stimulation. ASM was administered twice daily. The pulmonary function was evaluated based on respiration. The mRNA and protein levels of AQPs were estimated by real-time PCR and Western blot, respectively. Results. MV, TV, the mRNA level of AQP5, and the protein expression of AQP1, AQP4, and AQP5 were increased in ASMCOPD compared to ASSCOPD. Conclusion. The pulmonary function was impaired in ASSCOPD group; the expression of AQP1, AQP4, and AQP5 was decreased at protein and mRNA levels in ASSCOPD group. ASM can improve the pulmonary function in ASSCOPD for MV and TV. ASM could elevate the protein expression of AQP1, AQP4, and AQP5 and the mRNA level of AQP5 in lung tissue.

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