scholarly journals Evaluation of physiological risk factors, oxidant-antioxidant imbalance, proteolytic and genetic variations of matrix metalloproteinase-9 in patients with pressure ulcer

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Khlifi Latifa ◽  
Sahli Sondess ◽  
Graiet Hajer ◽  
Ben-Hadj-Mohamed Manel ◽  
Khelil Souhir ◽  
...  
Keyword(s):  
Risk Factors ◽  
Matrix Metalloproteinase ◽  
Pressure Ulcer ◽  
Genetic Variations ◽  
Matrix Metalloproteinase 9 ◽  
Physiological Risk ◽  
Metalloproteinase 9

scholarly journals The cross-talk between matrix metalloproteinase-9, RANKL/OPG system and cardiovascular risk factors in ovariectomized rat model of postmenopausal osteoporosis

PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0258254
Author(s):  
Maha Sabry ◽  
Seham Mostafa ◽  
Samaa Kamar ◽  
Laila Rashed ◽  
Suzanne Estaphan
Keyword(s):  
Risk Factors ◽  
Matrix Metalloproteinase ◽  
Inflammatory Markers ◽  
Matrix Metalloproteinase 9 ◽  
Female Rats ◽  
Tnf Alpha ◽  
Cvd Risk ◽  
Turnover Markers ◽  
Metalloproteinase 9 ◽  
Control Sham

Epidemiology and pathogenesis of cardiovascular diseases (CVD) and osteoporosis are strikingly overlapping. This study presents matrix metalloproteinase-9 (MMP-9), as a simple molecular link more consistently associated with the pathophysiology of both osteoporosis and CVD risk factors. 40 adult female rats were randomly distributed into 4 groups [control sham-operated, untreated osteoporosis, carvedilol-treated osteoporosis and alendronate-treated osteoporosis]. After 8 weeks, blood samples were collected to estimate Lipid profile (Total cholesterol, HDL, Triglycerides), inflammatory markers (IL-6, TNF alpha, CRP and NO), and Bone turnover markers (BTM) (Alkaline phosphatase, osteocalcin and pyridinoline). The tibias were dissected to estimate MMP-9 and NF-kB gene expression, OPG, RANKL levels and for histological examination. Induction of osteoporosis resulted in a significant elevation in BTM, inflammatory markers and dyslipidemia. MMP-9 was significantly elevated and positively correlated with BTM, inflammation and dyslipidemia markers. Carvedilol and alendronate exerted a bone preservative role and attenuated dyslipidaemia and inflammation in accordance with their respective effect on MMP-9.

Matrix metalloproteinase-9 genetic variations affect MMP-9 levels in obese children

2011 ◽  
Vol 36 (1) ◽  
pp. 69-75 ◽  
Author(s):  
V A Belo ◽  
D C Souza-Costa ◽  
M R Luizon ◽  
C M M Lanna ◽  
P C Carneiro ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Genetic Variations ◽  
Matrix Metalloproteinase 9 ◽  
Obese Children ◽  
Metalloproteinase 9

scholarly journals Relations of Plasma Matrix Metalloproteinase-9 to Clinical Cardiovascular Risk Factors and Echocardiographic Left Ventricular Measures

Circulation ◽  
2004 ◽  
Vol 109 (23) ◽  
pp. 2850-2856 ◽  
Author(s):  
Johan Sundström ◽  
Jane C. Evans ◽  
Emelia J. Benjamin ◽  
Daniel Levy ◽  
Martin G. Larson ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Matrix Metalloproteinase ◽  
Cardiovascular Risk Factors ◽  
Left Ventricular ◽  
Matrix Metalloproteinase 9 ◽  
Metalloproteinase 9

scholarly journals THE CORRELATION OF MATRIX METALLOPROTEINASE-9 WITH STROKE AND PREVALENCE, RISK FACTORS, AND KNOWLEDGE OF STROKE AMONG PALESTINIANS

2020 ◽  
pp. 33-39
Author(s):  
ROZAN ATTILI ◽  
HATEM A HEJAZ
Keyword(s):  
Risk Factors ◽  
Matrix Metalloproteinase ◽  
Research Study ◽  
Matrix Metalloproteinase 9 ◽  
Stroke Patients ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Associated Risk Factors ◽  
Palestinian Population ◽  
Metalloproteinase 9

Objectives: The research study aims to estimate the prevalence of the stroke, to evaluate the stroke associated risk factors, and to determine the factors and symptoms associated with the knowledge of the stroke among the Palestinian population. Furthermore, to find the association between matrix metalloproteinase-9 (MMP-9) levels and the stroke, the concentration of MMP-9 in the serum of stroke patients was measured. Methods: The research study includes a cross-sectional survey that was conducted. The serum MMP-9 levels were also measured in 11 stroke patients using an ELISA reader. Statistical analysis was performed by GraphPad Prism version 8. Sociodemographic characteristics of stroke patients associated with stroke among the Palestinian population were also obtained and analyzed. Results: The higher incidence of the stroke was in the patient’s ages between 51 and 60 years old, with 30 patients (46%) of the total stroke patients. The majority of the stroke patients 40 (60.6%) were having enough income. Most of the stroke patients (29, 43.9%) were none educated. The majority of the stroke patients 48 (72.2%) had a family member/s who has been diagnosed with a stroke. Most of the stroke patients 60 (90.9%) have sudden numbness, weakness in the face, arms, and legs. All the samples analyzed showed a marked increase in MMP-9 concentration. Conclusions: The prevalence of stroke and the high risk of stroke were high among adults aged ≥51 years in Palestine. Hypertension was the highest risk factor for stroke. The serum MMP-9 could be an important prognostic factor for the stroke.

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