Urine metabolomics in neonates with late-onset sepsis in a case-control study

Sepsis neonatorum merupakan salah satu penyakit yang masih menjadi masalah utama pada neonatus saat ini, karena banyaknya faktor risiko yang belum dapat dicegah.Salah satu faktor risiko tersebut adalah berat badan lahir rendah atau lebih. Tujuan penelitian ini adalah menentukan hubungan sepsis neonatorum dengan berat badan lahir pada bayi di RSUP Dr. M. Djamil Padang. Jenis penelitian ini adalah analitik retrospektif dengan metode case control study. Populasi adalah seluruh neonatus yang mengalami sepsis neonatorum (kasus) dan yang tidak mengalami sepsis neonatorum (kontrol) yang diambil dari data rekam medik RSUP.Dr. M. Djamil Padang periode Januari 2014 sampai Juli 2016. Subjek penelitian adalah populasi dengan data rekam medik yang lengkap. Hasil penelitian diolah dengan uji Chi-square. Jumlah subjek penelitian adalah 162 orang yang terdiri dari 81 kasus dan 81 kontrol. Dari 81 neonatus yang mengalami sepsis neonatorum, 43 diantaranya mengalami sepsis dengan late onset sepsis, 38 dengan early onset sepsis, 25 dengan Berat Badan Lahir Rendah (BBLR) dan 56 tidak BBLR. Setelah dilakukan uji hubungan antara sepsis neonatorum dengan berat badan lahir menggunakan uji Chi-square didapatkan nilai p=0,601, OR=1,276, CI= 0,643-2,530. Simpulan studi ini ialah tidak terdapat hubungan yang bermakna antara sepsis neonatorum dengan berat badan lahir bayi. BBLR memiliki risiko yang lebih besar untuk mengalami sepsis daripada yang tidak BBLR.

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Hubungan Sepsis Neonatorum dengan Berat Badan Lahir pada Bayi di RSUP Dr. M. Djamil Padang

Jurnal Kesehatan Andalas ◽

10.25077/jka.v7i3.894 ◽

2018 ◽

Vol 7 (3) ◽

pp. 405

Author(s):

Putri Rahmawati ◽

Mayetti Mayetti ◽

Sukri Rahman

Keyword(s):

Early Onset ◽

Case Control Study ◽

Late Onset ◽

Case Control ◽

Chi Square ◽

Late Onset Sepsis ◽

Early Onset Sepsis ◽

Control Study

Sepsis neonatorum merupakan salah satu penyakit yang masih menjadi masalah utama pada neonatus saat ini, karena banyaknya faktor risiko yang belum dapat dicegah.Salah satu faktor risiko tersebut adalah berat badan lahir rendah atau lebih. Tujuan penelitian ini adalah menentukan hubungan sepsis neonatorum dengan berat badan lahir pada bayi di RSUP Dr. M. Djamil Padang. Jenis penelitian ini adalah analitik retrospektif dengan metode case control study. Populasi adalah seluruh neonatus yang mengalami sepsis neonatorum (kasus) dan yang tidak mengalami sepsis neonatorum (kontrol) yang diambil dari data rekam medik RSUP.Dr. M. Djamil Padang periode Januari 2014 sampai Juli 2016. Subjek penelitian adalah populasi dengan data rekam medik yang lengkap. Hasil penelitian diolah dengan uji Chi-square. Jumlah subjek penelitian adalah 162 orang yang terdiri dari 81 kasus dan 81 kontrol. Dari 81 neonatus yang mengalami sepsis neonatorum, 43 diantaranya mengalami sepsis dengan late onset sepsis, 38 dengan early onset sepsis, 25 dengan Berat Badan Lahir Rendah (BBLR) dan 56 tidak BBLR. Setelah dilakukan uji hubungan antara sepsis neonatorum dengan berat badan lahir menggunakan uji Chi-square didapatkan nilai p=0,601, OR=1,276, CI= 0,643-2,530. Simpulan studi ini ialah tidak terdapat hubungan yang bermakna antara sepsis neonatorum dengan berat badan lahir bayi. BBLR memiliki risiko yang lebih besar untuk mengalami sepsis daripada yang tidak BBLR.

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Performance of Pediatric Systemic Inflammatory Response Syndrome and Organ Dysfunction Criteria in Late-Onset Sepsis in a Quaternary Neonatal Intensive Care Unit: A Case-Control Study

The Journal of Pediatrics ◽

10.1016/j.jpeds.2019.12.064 ◽

2020 ◽

Vol 219 ◽

pp. 133-139.e1 ◽

Cited By ~ 2

Author(s):

Sarah Coggins ◽

Mary Catherine Harris ◽

Robert Grundmeier ◽

Elizabeth Kalb ◽

Ursula Nawab ◽

...

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Systemic Inflammatory Response Syndrome ◽

Inflammatory Response ◽

Neonatal Intensive Care ◽

Case Control Study ◽

Late Onset ◽

Case Control ◽

Late Onset Sepsis ◽

Control Study

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Role of Vitamin-D Deficiency in Term Neonates with Late-Onset Sepsis: A Case–Control Study

Journal of Tropical Pediatrics ◽

10.1093/tropej/fmz021 ◽

2019 ◽

Vol 65 (6) ◽

pp. 609-616 ◽

Cited By ~ 1

Author(s):

Amit Agrawal ◽

Aekta Gupta ◽

Jyotsna Shrivastava

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Case Control Study ◽

Late Onset ◽

Tertiary Care ◽

Case Control ◽

Term Neonates ◽

Late Onset Sepsis ◽

Vitamin D Levels ◽

Control Study

Abstract Objective To find the relationship between vitamin-D levels and late-onset sepsis (LOS) in term neonates. Methods This case–control study was conducted in neonatal intensive care unit of a tertiary care teaching institution in central India. Full-term neonates with culture-proven LOS were taken as cases. Maternal and neonatal demography, clinical examination and investigations were recorded. Correlation of vitamin-D deficiency (<20 ng/ml) with LOS was assessed. Results Total 225 term neonates including 175 cases and 50 controls were included. Maternal and neonatal demographic profile was comparable. The mean vitamin-D level in cases (12.28 ± 6.11 ng/ml) was significantly lower than that in controls (14.88 ± 7.2 ng/ml) (p = 0.002). Total 151 (86.29%) neonates out of 175 cases and 37 (74%) out of 50 controls had the vitamin-D deficiency (p = 0.00003). On multiple regression analysis, neonatal sepsis (p = 0.00003) was found to be significantly associated with vitamin-D deficiency. Conclusion This study shows that vitamin-D deficiency in term neonates may predispose them to LOS.

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166 FECAL VOLATILE METABOLOMICS PREDICT LATE-ONSET SEPSIS IN PRETERM INFANTS: A MULTI-CENTER CASE-CONTROL STUDY

Gastroenterology ◽

10.1016/s0016-5085(21)00843-x ◽

2021 ◽

Vol 160 (6) ◽

pp. S-40

Author(s):

Nina Frerichs ◽

Hendrik Niemarkt ◽

Willem de Boode ◽

Veerle Cossey ◽

Christiaan Hulzebos ◽

...

Keyword(s):

Preterm Infants ◽

Case Control Study ◽

Late Onset ◽

Case Control ◽

Late Onset Sepsis ◽

Control Study

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Faculty Opinions recommendation of Bowel disturbances are the most important risk factors for late onset fecal incontinence: a population-based case-control study in women.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.4909957.4840055 ◽

2010 ◽

Author(s):

Klaus Bielefeldt

Keyword(s):

Risk Factors ◽

Fecal Incontinence ◽

Case Control Study ◽

Late Onset ◽

Population Based ◽

Case Control ◽

Control Study

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Lower Vitamin D Level as a Risk Factor for Late Onset Neonatal Sepsis: An Observational Case–Control Study

American Journal of Perinatology ◽

10.1055/s-0041-1740074 ◽

2021 ◽

Author(s):

Shaimaa Reda Abdelmaksoud ◽

Mostafa Abdel-Azim Mostafa ◽

Rana Atef khashaba ◽

Effat Assar

Keyword(s):

Vitamin D ◽

Case Control Study ◽

Late Onset ◽

Case Control ◽

Sepsis Group ◽

Term Neonates ◽

Maternal Vitamin ◽

Vitamin D Levels ◽

25 Oh Vitamin D ◽

Control Study

Objective The aim of the study is to investigate the relation of neonatal and maternal vitamin D and late-onset sepsis (LOS) Study Design One-hundred twenty term neonates along with their mothers were enrolled in this case–control study. Sixty neonates who were admitted in the neonatal intensive care unit by LOS and had not been previously admitted for last 48 hours and did not receive antibiotics or vitamin D were enrolled as cases (sepsis) group. On the other hand, 60 healthy term neonates were referred as control group. Maternal and neonatal serum 25-OH vitamin D levels were assessed in both the cohorts. Results Maternal and neonatal 25-OH vitamin D levels in cases (17.2 and 16.1 ng/mL, respectively) were significantly lower than in controls (22.7 and 21 ng/mL, respectively) p = 0.001. In the study group, the neonatal 25-OH vitamin D was negatively correlated with C-reactive protein and length of hospital stay (r = −0.616 and −0.596, respectively) p <0.001 for both. With a cut-off value of 12.9 ng/mL, the specificity and positive predictive value of neonatal vitamin D were 83.3 and 74.4%, respectively. The odds ratio was 1.088 (95% CI = 1.034–1.144)) for LOS in vitamin D-deficient neonates. Conclusion Neonates with higher vitamin D level are at lower risk of LOS than those with vitamin D deficiency. Maternal vitamin D correlates with neonatal vitamin D. These data suggest that maternal vitamin supplementation during pregnancy may lower the risk of LOS. Key Points

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