CHAPTER 7. The Role of Extracellular Vesicles in the Neuronal System: Application of Extracellular Vesicles in Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis, and Dementia

In the last decade, the microbiome in general and the gut microbiome in particular have been associated not only to brain development and function, but also to the pathophysiology of brain aging and to neurodegenerative disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), depression, or multiple sclerosis (MS) [...]

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Exercise and Alzheimer's Disease, Parkinson's Disease, and Multiple Sclerosis

The Physician and Sportsmedicine ◽

10.1080/00913847.1991.11710211 ◽

1991 ◽

Vol 19 (12) ◽

pp. 85-92 ◽

Cited By ~ 6

Author(s):

Charles M. Poser ◽

Michael Ronthal

Keyword(s):

Multiple Sclerosis ◽

Alzheimer’S Disease ◽

Parkinson’S Disease ◽

Alzheimer's Disease ◽

Parkinson's Disease

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Immune gene network of neurological diseases: Multiple Sclerosis (MS), Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD)

Heliyon ◽

10.1016/j.heliyon.2021.e08518 ◽

2021 ◽

pp. e08518

Author(s):

Shradha Mukherjee

Keyword(s):

Multiple Sclerosis ◽

Alzheimer’S Disease ◽

Parkinson’S Disease ◽

Alzheimer's Disease ◽

Parkinson's Disease ◽

Huntington's Disease ◽

Huntington’S Disease ◽

Gene Network ◽

Neurological Diseases ◽

Immune Gene

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New Insights on the Role of Manganese in Alzheimer’s Disease and Parkinson’s Disease

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph16193546 ◽

2019 ◽

Vol 16 (19) ◽

pp. 3546 ◽

Cited By ~ 10

Author(s):

Airton Cunha Martins ◽

Patricia Morcillo ◽

Omamuyovwi Meashack Ijomone ◽

Vivek Venkataramani ◽

Fiona Edith Harrison ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Parkinson’S Disease ◽

Alzheimer's Disease ◽

Parkinson's Disease ◽

Critical Role ◽

Essential Trace Element ◽

Neuronal Function ◽

Therapy Options ◽

Physiological Processes

Manganese (Mn) is an essential trace element that is naturally found in the environment and is necessary as a cofactor for many enzymes and is important in several physiological processes that support development, growth, and neuronal function. However, overexposure to Mn may induce neurotoxicity and may contribute to the development of Alzheimer’s disease (AD) and Parkinson’s disease (PD). The present review aims to provide new insights into the involvement of Mn in the etiology of AD and PD. Here, we discuss the critical role of Mn in the etiology of these disorders and provide a summary of the proposed mechanisms underlying Mn-induced neurodegeneration. In addition, we review some new therapy options for AD and PD related to Mn overload.

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Neuroprotective Role of Phytochemicals

Molecules ◽

10.3390/molecules23102485 ◽

2018 ◽

Vol 23 (10) ◽

pp. 2485 ◽

Cited By ~ 18

Author(s):

Bharath Velmurugan ◽

Baskaran Rathinasamy ◽

Bharathi Lohanathan ◽

Varadharajan Thiyagarajan ◽

Ching-Feng Weng

Keyword(s):

Alzheimer’S Disease ◽

Parkinson’S Disease ◽

Alzheimer's Disease ◽

Parkinson's Disease ◽

Side Effects ◽

Neurodegenerative Diseases ◽

Evidence Based ◽

Extensive Investigation ◽

Potential Efficacy

Neurodegenerative diseases are normally distinguished as disorders with loss of neurons. Various compounds are being tested to treat neurodegenerative diseases (NDs) but they possess solitary symptomatic advantages with numerous side effects. Accumulative studies have been conducted to validate the benefit of phytochemicals to treat neurodegenerative diseases including Alzheimer’s disease (AD) and Parkinson’s disease (PD). In this present review we explored the potential efficacy of phytochemicals such as epigallocatechin-3-galate, berberin, curcumin, resveratrol, quercetin and limonoids against the most common NDs, including Alzheimer’s disease (AD) and Parkinson’s disease (PD). The beneficial potentials of these phytochemicals have been demonstrated by evidence-based but more extensive investigation needs to be conducted for reducing the progression of AD and PD.

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