Large payloads of gold nanoparticles into the polyamine network core of stimuli-responsive PEGylated nanogels for selective and noninvasive cancer photothermal therapy

Nanoscale ◽  
2010 ◽  
Vol 2 (5) ◽  
pp. 739 ◽  
Author(s):  
Takahito Nakamura ◽  
Atsushi Tamura ◽  
Hiroki Murotani ◽  
Motoi Oishi ◽  
Yuta Jinji ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Photothermal Therapy ◽  
Stimuli Responsive

scholarly journals Magnetic tri-bead microrobot assisted near-infrared triggered combined photothermal and chemotherapy of cancer cells

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xiaoxia Song ◽  
Zhi Chen ◽  
Xue Zhang ◽  
Junfeng Xiong ◽  
Teng Jiang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Stimuli Responsive ◽  
Lung Cancer Cell ◽  
Precise Movement ◽  
Photothermal Property

AbstractMagnetic micro/nanorobots attracted much attention in biomedical fields because of their precise movement, manipulation, and targeting abilities. However, there is a lack of research on intelligent micro/nanorobots with stimuli-responsive drug delivery mechanisms for cancer therapy. To address this issue, we developed a type of strong covalently bound tri-bead drug delivery microrobots with NIR photothermal response azobenzene molecules attached to their carboxylic surface groups. The tri-bead microrobots are magnetic and showed good cytocompatibility even when their concentration is up to 200 µg/mL. In vitro photothermal experiments demonstrated fast NIR-responsive photothermal property; the microrobots were heated to 50 °C in 4 min, which triggered a significant increase in drug release. Motion control of the microrobots inside a microchannel demonstrated the feasibility of targeted therapy on tumor cells. Finally, experiments with lung cancer cells demonstrated the effectiveness of targeted chemo-photothermal therapy and were validated by cell viability assays. These results indicated that tri-bead microrobots have excellent potential for targeted chemo-photothermal therapy for lung cancer cell treatment.

Multifunctional magnetic-gold nanoparticles for efficient combined targeted drug delivery and interstitial photothermal therapy

2019 ◽  
Vol 554 ◽  
pp. 256-263 ◽  
Author(s):  
Nihal S. Elbialy ◽  
Mohamed M. Fathy ◽  
Reem AL-Wafi ◽  
Reem Darwesh ◽  
Umama A. Abdel-dayem ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Targeted Drug Delivery ◽  
Photothermal Therapy ◽  
Targeted Drug

Thermoswitchable Janus Gold Nanoparticles with Stimuli-Responsive Hydrophilic Polymer Brushes

Langmuir ◽  
2016 ◽  
Vol 32 (17) ◽  
pp. 4297-4304 ◽  
Author(s):  
Xiaoqin Niu ◽  
Fen Ran ◽  
Limei Chen ◽  
Gabriella Jia-En Lu ◽  
Peiguang Hu ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Polymer Brushes ◽  
Hydrophilic Polymer ◽  
Stimuli Responsive

Three-dimensional dynamics of temperature fields in phantoms and biotissue under IR laser photothermal therapy using gold nanoparticles and ICG dye

2010 ◽  
Author(s):  
Georgy G. Akchurin ◽  
Akchurin G. Garif ◽  
Irina L. Maksimova ◽  
Alexander A. Skaptsov ◽  
Georgy S. Terentyuk ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Photothermal Therapy ◽  
Three Dimensional ◽  
Temperature Fields ◽  
Ir Laser ◽  
Laser Photothermal Therapy

scholarly journals Specific Cell Targeting with Nanobody Conjugated Branched Gold Nanoparticles for Photothermal Therapy

ACS Nano ◽  
2011 ◽  
Vol 5 (6) ◽  
pp. 4319-4328 ◽  
Author(s):  
Bieke Van de Broek ◽  
Nick Devoogdt ◽  
Antoine D’Hollander ◽  
Hannah-Laura Gijs ◽  
Karolien Jans ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Photothermal Therapy ◽  
Specific Cell ◽  
Cell Targeting

Pd-Cu nanoalloy for dual stimuli-responsive chemo-photothermal therapy against pathogenic biofilm bacteria

2021 ◽  
Author(s):  
Zefeng Wang ◽  
Yanling Peng ◽  
Yan Zhou ◽  
Shengnan Zhang ◽  
Jianxi Tan ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Stimuli Responsive ◽  
Biofilm Bacteria

Delivery of miR-320a-3p by gold nanoparticles combined with photothermal therapy for directly targeting Sp1 in lung cancer

2021 ◽  
Author(s):  
Jiefei Peng ◽  
Ranran Wang ◽  
Wanru Sun ◽  
Minhua Huang ◽  
Rong Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Overall Survival ◽  
Gold Nanoparticles ◽  
Mortality Rate ◽  
Photothermal Therapy ◽  
Therapeutic Targets ◽  
Novel Therapeutic

Lung cancer is the second most common tumor and has the highest mortality rate. Both novel therapeutic targets and approaches are needed to improve the overall survival of patients with...

Enzyme-conjugated gold nanoparticles for combined enzyme and photothermal therapy of colon cancer cells

2019 ◽  
Vol 572 ◽  
pp. 333-344 ◽  
Author(s):  
Mostafa Akbarzadeh Khiavi ◽  
Azam Safary ◽  
Ayuob Aghanejad ◽  
Jaleh Barar ◽  
Seyed Hossein Rasta ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Photothermal Therapy ◽  
Colon Cancer Cells

scholarly journals Optimization of Nonspherical Gold Nanoparticles for Photothermal Therapy

2019 ◽  
Vol 9 (20) ◽  
pp. 4300
Author(s):  
Paerhatijiang Tuersun ◽  
Xiayiding Yakupu ◽  
Xiang’e Han ◽  
Yingzeng Yin
Keyword(s):  
Gold Nanoparticles ◽  
Refractive Index ◽  
Photothermal Therapy ◽  
Therapeutic Agents ◽  
Tissue Type ◽  
Excitation Wavelength ◽  
Objective Functions ◽  
Design Tolerance ◽  
T Matrix ◽  
Selection Of

Previous investigations devoted to the optimization of nonspherical gold nanoparticles for photothermal therapy (PTT) encountered two issues, namely, the appropriate selection of objective functions and the processing of particle random orientations. In this study, these issues were resolved, and accurate optimization results were obtained for the three typical nonspherical gold nanoparticles (nanospheroid, nanocylinder, and nanorod) by using the T-matrix method. The dependence of the optimization results on the excitation wavelength and the refractive index of tissue was investigated. Regardless of the excitation wavelength and tissue type, gold nanospheroids were found to be the most effective therapeutic agents for PTT. The light absorption ability of optimized nanoparticles could be enhanced by using a laser with a longer wavelength. Finally, the design tolerance for the different sizes of nanoparticles was provided.

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