Facile self-assembly of porphyrin-embedded polymeric vesicles for theranostic applications

Smart polymeric vesicles with both tertiary amine and epoxy functional groups were fabricated for the first time via a reversible addition–fragmentation chain transfer dispersion polymerization approach.

Download Full-text

Aqueous Self-Assembly of Block Copolymers to Form Manganese Oxide-Based Polymeric Vesicles for Tumor Microenvironment-Activated Drug Delivery

Nano-Micro Letters ◽

10.1007/s40820-020-00447-9 ◽

2020 ◽

Vol 12 (1) ◽

Cited By ~ 1

Author(s):

Yalei Miao ◽

Yudian Qiu ◽

Mengna Zhang ◽

Ke Yan ◽

Panke Zhang ◽

...

Keyword(s):

Drug Delivery ◽

Tumor Microenvironment ◽

Block Copolymers ◽

Manganese Oxide ◽

Self Assembly ◽

Polymeric Vesicles

Download Full-text

Polymersome Poration and Rupture Mediated by Plasmonic Nanoparticles in Response to Single-Pulse Irradiation

Polymers ◽

10.3390/polym12102381 ◽

2020 ◽

Vol 12 (10) ◽

pp. 2381

Author(s):

Gina M. DiSalvo ◽

Abby R. Robinson ◽

Mohamed S. Aly ◽

Eric R. Hoglund ◽

Sean M. O’Malley ◽

...

Keyword(s):

Self Assembly ◽

Diblock Copolymers ◽

Single Pulse ◽

Plasmonic Nanoparticles ◽

Pulse Irradiation ◽

Triggered Release ◽

Hydrophobic Membrane ◽

Polymeric Vesicles ◽

Vesicle Rupture ◽

Amphiphilic Diblock Copolymers

The self-assembly of amphiphilic diblock copolymers into polymeric vesicles, commonly known as polymersomes, results in a versatile system for a variety of applications including drug delivery and microreactors. In this study, we show that the incorporation of hydrophobic plasmonic nanoparticles within the polymersome membrane facilitates light-stimulated release of vesicle encapsulants. This work seeks to achieve tunable, triggered release with non-invasive, spatiotemporal control using single-pulse irradiation. Gold nanoparticles (AuNPs) are incorporated as photosensitizers into the hydrophobic membrane of micron-scale polymersomes and the cargo release profile is controlled by varying the pulse energy and nanoparticle concentration. We have demonstrated the ability to achieve immediate vesicle rupture as well as vesicle poration resulting in temporal cargo diffusion. Additionally, changing the pulse duration, from femtosecond to nanosecond, provides mechanistic insight into the photothermal and photomechanical contributors that govern membrane disruption in this polymer–nanoparticle hybrid system.

Download Full-text

Synchronous Synthesis of Polymeric Vesicles with Controllable Size and Low‐Polydispersity by Polymerization‐Induced Self‐Assembly

Chinese Journal of Chemistry ◽

10.1002/cjoc.202100665 ◽

2021 ◽

Author(s):

Ren‐Man Zhu ◽

Cheng‐Lin Yang ◽

Zi‐Xuan Chang ◽

Cai‐Yuan Pan ◽

Wen‐Jian Zhang ◽

...

Keyword(s):

Self Assembly ◽

Polymeric Vesicles ◽

Controllable Size

Download Full-text

Controllable Vesicular Size and Shape in Polymerization-Induced Self-assembly Aided by Aromatic Interactions

10.21203/rs.3.rs-90575/v1 ◽

2020 ◽

Author(s):

Xiao-Fei Xu ◽

Ren-Man Zhu ◽

Cai-Yuan Pan ◽

Ye-Zi You ◽

Wen-Jian Zhang ◽

...

Keyword(s):

Self Assembly ◽

Biological Properties ◽

Vesicle Fusion ◽

Membrane Tension ◽

Tubular Structures ◽

Size And Shape ◽

Aromatic Interactions ◽

Polymeric Vesicles ◽

Solvophobic Interactions ◽

Structural Regulation

Abstract The size and shape of polymeric vesicles have great impact on their physicochemical and biological properties. Polymerization-induced self-assembly (PISA) is an efficient method to fabricate vesicles. In most PISA-cases, the formation of vesicles is driven by the solvophobic interactions which are lack of versatility on finely structural regulation. Herein, controlling vesicular size and shape is realized in PISA aided by aromatic interactions. Aromatic interactions between the membrane-forming blocks contribute to the augments of membrane tension which lead to the formation of smaller vesicles (as small as 70 nm), but overly enhanced aromatic interactions result in vesicle fusion rather than size decreasing. When the membrane tension is dominated by aromatic interactions and meanwhile high enough to overcome the energetic barriers of fusion, the aromatic interactions drive vesicle fusion in a directional manner to form tubular structures. The precise regulation of vesicular size and shape in PISA would pave the way to fabricate vesicles for a series of size/shape-dependent applications.

Download Full-text

Impact of Citrate and Lipid-Functionalized Magnetic Nanoparticles in Dehydropeptide Supramolecular Magnetogels: Properties, Design and Drug Release

Nanomaterials ◽

10.3390/nano11010016 ◽

2020 ◽

Vol 11 (1) ◽

pp. 16

Author(s):

Sérgio R. S. Veloso ◽

Joana F. G. Silva ◽

Loic Hilliou ◽

Cacilda Moura ◽

Paulo J. G. Coutinho ◽

...

Keyword(s):

Magnetic Nanoparticles ◽

Drug Release ◽

Self Assembly ◽

Efficiency Improvement ◽

Gel Properties ◽

Drug Encapsulation ◽

Heating Efficiency ◽

Coated Nanoparticles ◽

Functionalized Magnetic Nanoparticles ◽

Theranostic Applications

Currently, the nanoparticle functionalization effect on supramolecular peptide-based hydrogels remains undescribed, but is expected to affect the hydrogels’ self-assembly and final magnetic gel properties. Herein, two different functionalized nanoparticles: citrate-stabilized (14.4 ± 2.6 nm) and lipid-coated (8.9 ± 2.1 nm) magnetic nanoparticles, were used for the formation of dehydropeptide-based supramolecular magnetogels consisting of the ultra-short hydrogelator Cbz-L-Met-Z-ΔPhe-OH, with an assessment of their effect over gel properties. The lipid-coated nanoparticles were distributed along the hydrogel fibers, while citrate-stabilized nanoparticles were aggregated upon gelation, which resulted into a heating efficiency improvement and decrease, respectively. Further, the lipid-coated nanoparticles did not affect drug encapsulation and displayed improved drug release reproducibility compared to citrate-stabilized nanoparticles, despite the latter attaining a stronger AMF-trigger. This report points out that adsorption of nanoparticles to hydrogel fibers, which display domains that improve or do not affect drug encapsulation, can be explored as a means to optimize the development of supramolecular magnetogels to advance theranostic applications.

Download Full-text

In vitro and in vivo polysaccharides assembly: ultrastructural and cytochemical study of growing plant cell wall components.

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100083035 ◽

1978 ◽

Vol 36 (2) ◽

pp. 434-435

Author(s):

D. Reis ◽

B. Vian ◽

J. C. Roland

Keyword(s):

Cell Wall ◽

Self Assembly ◽

Plant Cell Wall ◽

Higher Plants ◽

Three Dimensional ◽

Cytochemical Study ◽

Wall Components

Wall morphogenesis in higher plants is a problem still open to controversy. Until now the possibility of a transmembrane control and the involvement of microtubules were mostly envisaged. Self-assembly processes have been observed in the case of walls of Chlamydomonas and bacteria. Spontaneous gelling interactions between xanthan and galactomannan from Ceratonia have been analyzed very recently. The present work provides indications that some processes of spontaneous aggregation could occur in higher plants during the formation and expansion of cell wall.Observations were performed on hypocotyl of mung bean (Phaseolus aureus) for which growth characteristics and wall composition have been previously defined.In situ, the walls of actively growing cells (primary walls) show an ordered three-dimensional organization (fig. 1). The wall is typically polylamellate with multifibrillar layers alternately transverse and longitudinal. Between these layers intermediate strata exist in which the orientation of microfibrils progressively rotates. Thus a progressive change in the morphogenetic activity occurs.

Download Full-text