CuInS2 quantum dots/poly(l-glutamic acid)–drug conjugates for drug delivery and cell imaging

A highly efficient multifunctional nanoplatform for dual-modal luminescence imaging and pH-responsive drug delivery has been developed on the basis of a facile and novel strategy by covalently binding up-conversion luminescent NaYF4:Yb,Er nanoparticles with down-conversion fluorescent AgInS2–ZnS quantum dots.

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Ultrasmall and photostable nanotheranostic agents based on carbon quantum dots passivated with polyamine-containing organosilane molecules

Nanoscale ◽

10.1039/c7nr05613c ◽

2017 ◽

Vol 9 (40) ◽

pp. 15441-15452 ◽

Cited By ~ 37

Author(s):

Jingjing Yang ◽

Ge Gao ◽

Xiaodong Zhang ◽

Yong-Hao Ma ◽

Hao-Ran Jia ◽

...

Keyword(s):

Drug Delivery ◽

Quantum Dots ◽

Anticancer Drug ◽

Cell Imaging ◽

Carbon Quantum Dots ◽

Facile Synthesis ◽

Anticancer Drug Delivery

Facile synthesis of multifunctional CDs for cell imaging and imaging-guided anticancer drug delivery.

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Fabrication of PEGylated graphitic carbon nitride quantum dots as traceable, pH-sensitive drug delivery systems

New Journal of Chemistry ◽

10.1039/c8nj02542h ◽

2018 ◽

Vol 42 (17) ◽

pp. 14263-14270 ◽

Cited By ~ 15

Author(s):

Jian Dong ◽

Yanli Zhao ◽

Hongyu Chen ◽

Li Liu ◽

Wenxian Zhang ◽

...

Keyword(s):

Drug Delivery ◽

Quantum Dots ◽

Drug Delivery Systems ◽

Carbon Nitride ◽

Cell Imaging ◽

Delivery Systems ◽

Ph Sensitive ◽

Graphitic Carbon ◽

Graphitic Carbon Nitride

Fluorescent PEGylated carbon nitride quantum dots are synthesized and characterized for traceable drug delivery and cell imaging.

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Quantum dots loaded nanogels for low cytotoxicity, pH-sensitive fluorescence, cell imaging and drug delivery

Carbohydrate Polymers ◽

10.1016/j.carbpol.2014.12.016 ◽

2015 ◽

Vol 121 ◽

pp. 477-485 ◽

Cited By ~ 54

Author(s):

Zhenshun Li ◽

Wei Xu ◽

Yuntao Wang ◽

Bakht Ramin Shah ◽

Chunlan Zhang ◽

...

Keyword(s):

Drug Delivery ◽

Quantum Dots ◽

Cell Imaging ◽

Ph Sensitive ◽

Low Cytotoxicity

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Carbon Nanotubes, Quantum Dots and Dendrimers as Potential Nanodevices for Nanotechnology Drug Delivery Systems

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2013.6.3.2 ◽

2013 ◽

Vol 6 (3) ◽

pp. 2113-2124

Author(s):

Prashant Malik ◽

Neha Gulati ◽

Raj Kaur Malik ◽

Upendra Nagaich

Keyword(s):

Carbon Nanotubes ◽

Drug Delivery ◽

Quantum Dots ◽

Self Assembly ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Atomic Scale ◽

Sustained Drug Delivery ◽

Pharmaceutical Nanotechnology ◽

Conventional Device

Nanotechnology deal with the particle size in nanometers. Nanotechnology is ranging from extensions of conventional device physics to completely new approaches based upon molecular self assembly, from developing new materials with dimensions on the nanoscale to direct control of matter on the atomic scale. In nanotechnology mainly three types of nanodevices are described: carbon nanotubes, quantum dots and dendrimers. It is a recent technique used as small size particles to treat many diseases like cancer, gene therapy and used as diagnostics. Nanotechnology used to formulate targeted, controlled and sustained drug delivery systems. Pharmaceutical nanotechnology embraces applications of nanoscience to pharmacy as nanomaterials and as devices like drug delivery, diagnostic, imaging and biosensor materials. Pharmaceutical nanotechnology has provided more fine tuned diagnosis and focused treatment of disease at a molecular level.

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Cancer Nanotechnology-An Excursion on Drug Delivery Systems

Anti-Cancer Agents in Medicinal Chemistry ◽

10.2174/1871520618666180720164015 ◽

2019 ◽

Vol 18 (15) ◽

pp. 2078-2092 ◽

Cited By ~ 2

Author(s):

Mala Sharma ◽

Chitranshu Pandey ◽

Neha Sharma ◽

Mohammad A. Kamal ◽

Usman Sayeed ◽

...

Keyword(s):

Drug Delivery ◽

Targeted Delivery ◽

Drug Delivery Systems ◽

Cancer Chemoprevention ◽

Delivery Systems ◽

Nanostructured Lipid Carrier ◽

Nanodrug Delivery ◽

Drug Conjugates ◽

Drug Nanoparticles ◽

Cancer Nanotechnology

Background: Nanotechnology pictures a breakthrough in the domain of cancer therapy owing to its novel properties and functions. This technology is quite amendable as it allows the scientists to engineer drug nanoparticles of dimensions 10nm – 500nm permitting them to pass via leaky vasculature of tumorigenic microenvironment with higher specificity, reduced cytotoxicity and effective release without any after effects. The central part of the review zooms onto the role of nanoparticles and their targeted delivery for the cure of cancer. Methods: The novel and various versatile nanoparticle platforms viz. polymeric (drug-conjugates, micelles, dendrimers), Lipid-based (liposomes, solid nanoparticle, nanostructured lipid carrier, lipid-polymer hybrid), and stimuli-sensitive (thermoresponsive, ultrasound, pH-responsive, hydrogel) etc. have been designed for a persistent, précised nanodrug delivery and the co-delivery of collegial drug conjugates leading to the formation of safer release of myriad of drugs for cancer chemoprevention. Results: The review concerns about tracing and detailing the drug delivery systems of cancer nanotechnology. Conclusion: Nanotechnology is bestowed with the design, depiction, fabrication, and application of nanostructures, and devices with their controlled delivery together with the imaging of the selected target site and drug release at the specific site of action.

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Design, Synthesis and Studies on Novel Polymeric Prodrugs of Erlotinib for Colon Drug Delivery

Anti-Cancer Agents in Medicinal Chemistry ◽

10.2174/1871520620666200811124013 ◽

2020 ◽

Vol 20 ◽

Author(s):

Sahil Kumar ◽

Bandna Sharma ◽

Tilak R. Bhardwaj ◽

Rajesh K. Singh

Keyword(s):

Drug Delivery ◽

Colon Cancer ◽

Drug Release ◽

Anticancer Agents ◽

Release Kinetics ◽

In Vitro Release ◽

Specific Treatment ◽

Drug Conjugates ◽

Polymer Drug Conjugates

Aims: In the present study, polymer-drug conjugates were synthesized based on azo-bond cleavage drug delivery approach for targeting erlotinib as anticancer drug specifically to the colon for the proficient treatment of colon cancer. Background: Colon cancer (CC) is the third commonly detected tumor worldwide and it make up about 10 % of all cases of cancers. Most of the chemotherapeutic drugs available for treating colon cancer are not only toxic to cancerous cells but also to the normal healthy cells. Among the various approaches to get rid of the adverse effects of anticancer agents, prodrugs are one of the most imperative approaches. Objective: The objective of the study is to chemically modify the erlotinib drug through azo-bond linkage and suitable spacer which will be finally linked to polymeric backbone to give desired polymer linked prodrug. The azo reductase enzyme present in colon is supposed to cleave the azo-bond specifically and augment the drug release at the colon. Methods: The synthesized conjugates were characterized by IR and 1H-NMR spectroscopy. The cleavage of aromatic azobond resulted in a potential colon-specific liberation of drug from conjugate studied in rat fecal contents. In vitro release profiles of polyphosphazene-linked conjugates of erlotinib have been studied at pH 1.2, pH 6.8 and pH 7.4. The stability study was designed to exhibit that free drug was released proficiently and unmodified from polyphosphazene-erlotinib conjugates having aromatic azo-bond in artificial colon conditions. Results: The synthesized conjugates were demonstrated to be stable in simulated upper gastro-intestinal tract conditions. The drug release kinetics shows that all the polymer-drug conjugates of erlotinib follow zero-order release kinetics which indicates that the drug release from the polymeric backbone is independent of its concentration. Kinetic study of conjugates with slope (n) shows the anomalous type of release with an exponent (n) > 0.89 indicating a super case II type of release. Conclusion: These studies indicate that polyphosphazene linked drug conjugates of erlotinib could be the promising candidates for the site-specific treatment of colon cancer with least detrimental side-effects.

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