A small-sized graphene oxide supramolecular assembly for targeted delivery of camptothecin

2014 ◽  
Vol 50 (86) ◽  
pp. 13066-13069 ◽  
Author(s):  
Ying-Ming Zhang ◽  
Yu Cao ◽  
Yang Yang ◽  
Jia-Tong Chen ◽  
Yu Liu
Keyword(s):  
Graphene Oxide ◽  
Targeted Delivery ◽  
Supramolecular Assembly

scholarly journals Graphene Oxide as a Nanocarrier for Controlled Loading and Targeted Delivery of Typhonium giganteum Drugs

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Xiaohua Gu ◽  
Rui Cao ◽  
Fu Li ◽  
Yan Li ◽  
Hongge Jia ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Graphene Oxide ◽  
Targeted Delivery ◽  
Drug Carrier ◽  
Dual Function ◽  
Natural Environments ◽  
Scanning Calorimetry ◽  
Environment Friendly ◽  
A549 Lung ◽  
Scanning Electron

In this study, Typhonium giganteum containing dual-function nanofibers composed of poly(butylene carbonate), polylactic acid, and graphene oxide (PBC/PLA/GO) were successfully fabricated by electrospinning. The results from thermogravimetric analysis (TG), differential scanning calorimetry (DSC), and Fourier-transform infrared spectroscopy (FTIR) indicate that no interactions occurred between PBC and PLA. The nanofiber microstructure upon which graphene oxide was evenly distributed was studied by scanning electron microscopy (SEM) and showed good silk properties. The nanofibers can be used as a drug carrier since loaded Typhonium giganteum fibers possess excellent biocompatibility. Such nanofibers are effective in inhibiting the proliferation of A549 lung cancer cells, and thus they have potential for replacing chemotherapy-based treatments of lung cancer. In addition, the PBC/PLA/GO nanofibers degrade in physiological and natural environments, which is an important feature when engineering tissues and environment-friendly materials.

scholarly journals Injectable Thermo-Sensitive Chitosan Hydrogel Containing CPT-11-Loaded EGFR-Targeted Graphene Oxide and SLP2 shRNA for Localized Drug/Gene Delivery in Glioblastoma Therapy

2020 ◽  
Vol 21 (19) ◽  
pp. 7111 ◽  
Author(s):  
Yu-Jen Lu ◽  
Yu-Hsiang Lan ◽  
Chi-Cheng Chuang ◽  
Wan-Ting Lu ◽  
Li-Yang Chan ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Gene Delivery ◽  
Drug Release ◽  
Delivery System ◽  
Targeted Delivery ◽  
Drug Formulation ◽  
Treatment Modalities ◽  
Gene Delivery System ◽  
Optimal Drug

In this study, we aimed to develop a multifunctional drug/gene delivery system for the treatment of glioblastoma multiforme by combining the ligand-mediated active targeting and the pH-triggered drug release features of graphene oxide (GO). Toward this end, we load irinotecan (CPT-11) to cetuximab (CET)-conjugated GO (GO-CET/CPT11) for pH-responsive drug release after endocytosis by epidermal growth factor receptor (EGFR) over-expressed U87 human glioblastoma cells. The ultimate injectable drug/gene delivery system was designed by co-entrapping stomatin-like protein 2 (SLP2) short hairpin RNA (shRNA) and GO-CET/CPT11 in thermosensitive chitosan-g-poly(N-isopropylacrylamide) (CPN) polymer solution, which offers a hydrogel depot for localized, sustained delivery of the therapeutics after the in situ formation of CPN@GO-CET/CPT11@shRNA hydrogel. An optimal drug formulation was achieved by considering both the loading efficiency and loading content of CPT-11 on GO-CET. A sustained and controlled release behavior was found for CPT-11 and shRNA from CPN hydrogel. Confocal microscopy analysis confirmed the intracellular trafficking for the targeted delivery of CPT-11 through interactions of CET with EGFR on the U87 cell surface. The efficient transfection of U87 using SLP2 shRNA was achieved using CPN as a delivery milieu, possibly by the formation of shRNA/CPN polyplex after hydrogel degradation. In vitro cell culture experiments confirmed cell apoptosis induced by CPT-11 released from acid organelles in the cytoplasm by flow cytometry, as well as reduced SLP2 protein expression and inhibited cell migration due to gene silencing. Finally, in vivo therapeutic efficacy was demonstrated using the xenograft of U87 tumor-bearing nude mice through non-invasive intratumoral delivery of CPN@GO-CET/CPT11@shRNA by injection. Overall, we have demonstrated the novelty of this thermosensitive hydrogel to be an excellent depot for the co-delivery of anticancer drugs and siRNA. The in situ forming hydrogel will not only provide extended drug release but also combine the advantages offered by the chitosan-based copolymer structure for siRNA delivery to broaden treatment modalities in cancer therapy.

scholarly journals Graphene oxide as a nanocarrier for controlled release and targeted delivery of an anticancer active agent, chlorogenic acid

2017 ◽  
Vol 74 ◽  
pp. 177-185 ◽  
Author(s):  
Farahnaz Barahuie ◽  
Bullo Saifullah ◽  
Dena Dorniani ◽  
Sharida Fakurazi ◽  
Govindarajan Karthivashan ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Controlled Release ◽  
Chlorogenic Acid ◽  
Targeted Delivery ◽  
Active Agent

Immobilization of gold nanoparticles on folate-conjugated dendritic mesoporous silica-coated reduced graphene oxide nanosheets: a new nanoplatform for curcumin pH-controlled and targeted delivery

Soft Matter ◽  
2018 ◽  
Vol 14 (12) ◽  
pp. 2400-2410 ◽  
Author(s):  
Samira Malekmohammadi ◽  
Hassan Hadadzadeh ◽  
Hossein Farrokhpour ◽  
Zahra Amirghofran
Keyword(s):  
Gold Nanoparticles ◽  
Graphene Oxide ◽  
Folic Acid ◽  
Mesoporous Silica ◽  
Reduced Graphene Oxide ◽  
Targeted Delivery ◽  
Cell Imaging ◽  
Graphene Oxide Nanosheets ◽  
Reduced Graphene ◽  
Gold Nps

A nanocarrier for curcumin targeted delivery and cell imaging was prepared by immobilization of gold NPs on the folic acid-modified dendritic mesoporous silica-coated reduced graphene oxide nanosheets.

Targeted delivery of SNX-2112 by polysaccharide-modified graphene oxide nanocomposites for treatment of lung cancer

2018 ◽  
Vol 185 ◽  
pp. 85-95 ◽  
Author(s):  
Xuan Liu ◽  
Xiaozhen Cheng ◽  
Fengzhe Wang ◽  
Longbao Feng ◽  
Yu Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Graphene Oxide ◽  
Targeted Delivery ◽  
Modified Graphene Oxide ◽  
Modified Graphene

Supramolecular fabrication of multilevel graphene-based gas sensors with high NO2 sensibility

Nanoscale ◽  
2015 ◽  
Vol 7 (22) ◽  
pp. 10259-10266 ◽  
Author(s):  
Zhuo Chen ◽  
Ahmad Umar ◽  
Shiwei Wang ◽  
Yao Wang ◽  
Tong Tian ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Gas Sensor ◽  
Silver Nanoparticle ◽  
Gas Sensors ◽  
Supramolecular Assembly ◽  
Sulphonic Acid ◽  
Reduced Graphene ◽  
Highly Sensitive

This work reports the supramolecular assembly of a silver nanoparticle-naphthalene-1-sulphonic acid-reduced graphene oxide (Ag-NA-rGO) composite and its utilization to fabricate a highly sensitive and selective gas sensor.

scholarly journals Porous silicon–graphene oxide core–shell nanoparticles for targeted delivery of siRNA to the injured brain

2016 ◽  
Vol 1 (5) ◽  
pp. 407-414 ◽  
Author(s):  
Jinmyoung Joo ◽  
Ester J. Kwon ◽  
Jinyoung Kang ◽  
Matthew Skalak ◽  
Emily J. Anglin ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Porous Silicon ◽  
Gene Silencing ◽  
Targeted Delivery ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Injured Brain ◽  
Core Shell Nanoparticles

A chemically targeted luminescent porous silicon–graphene oxide core–shell nanoparticle delivers siRNA for more effective gene silencing.

scholarly journals Magnetic Graphene Oxide for Dual Targeted Delivery of Doxorubicin and Photothermal Therapy

Nanomaterials ◽  
2018 ◽  
Vol 8 (4) ◽  
pp. 193 ◽  
Author(s):  
Yu-Jen Lu ◽  
Pin-Yi Lin ◽  
Pei-Han Huang ◽  
Chang-Yi Kuo ◽  
K.T. Shalumon ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Targeted Delivery ◽  
Photothermal Therapy ◽  
Magnetic Graphene Oxide ◽  
Magnetic Graphene
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