scholarly journals Graphene Oxide as a Nanocarrier for Controlled Loading and Targeted Delivery of Typhonium giganteum Drugs

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Xiaohua Gu ◽  
Rui Cao ◽  
Fu Li ◽  
Yan Li ◽  
Hongge Jia ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Graphene Oxide ◽  
Targeted Delivery ◽  
Drug Carrier ◽  
Dual Function ◽  
Natural Environments ◽  
Scanning Calorimetry ◽  
Environment Friendly ◽  
A549 Lung ◽  
Scanning Electron

In this study, Typhonium giganteum containing dual-function nanofibers composed of poly(butylene carbonate), polylactic acid, and graphene oxide (PBC/PLA/GO) were successfully fabricated by electrospinning. The results from thermogravimetric analysis (TG), differential scanning calorimetry (DSC), and Fourier-transform infrared spectroscopy (FTIR) indicate that no interactions occurred between PBC and PLA. The nanofiber microstructure upon which graphene oxide was evenly distributed was studied by scanning electron microscopy (SEM) and showed good silk properties. The nanofibers can be used as a drug carrier since loaded Typhonium giganteum fibers possess excellent biocompatibility. Such nanofibers are effective in inhibiting the proliferation of A549 lung cancer cells, and thus they have potential for replacing chemotherapy-based treatments of lung cancer. In addition, the PBC/PLA/GO nanofibers degrade in physiological and natural environments, which is an important feature when engineering tissues and environment-friendly materials.

Targeted delivery of doxorubicin to A549 lung cancer cells by CXCR4 antagonist conjugated PLGA nanoparticles

2014 ◽  
Vol 88 (2) ◽  
pp. 529-538 ◽  
Author(s):  
Chuda Chittasupho ◽  
Kriengsak Lirdprapamongkol ◽  
Prartana Kewsuwan ◽  
Narong Sarisuta
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Plga Nanoparticles ◽  
Lung Cancer Cells ◽  
Cxcr4 Antagonist ◽  
A549 Lung

A comparative study on the effect of higher acrylate on cross-linkable PMMA used as environment friendly latexes

2020 ◽  
Vol 32 (2) ◽  
pp. 135-141
Author(s):  
Sweta Shukla
Keyword(s):  
Thermal Analysis ◽  
Differential Scanning Calorimetry ◽  
Butyl Methacrylate ◽  
Cross Linking ◽  
Scanning Calorimetry ◽  
Environment Friendly ◽  
Glycol Diacrylate ◽  
Poly Propylene ◽  
Kinetics Of ◽  
Scanning Electron

The kinetics of emulsion polymerization of monomers methyl methacrylate (MMA)/ n-butyl methacrylate (BMA) was studied to investigate the effect of cross-linkable monomer poly(propylene glycol diacrylate) (PPGDA). The results showed that by the incorporation of PPGDA rate constant of reaction decreased. Fourier transform infrared spectroscopy and scanning electron microscope were used to characterize the synthesized polymers. The thermal analysis of samples was done by differential scanning calorimetry, and the results were compared by the previous studies with MMA/ n-butyl acrylate (BA) and MMA/2-ethylhexyl acrylate (EHA). The glass transition temperature ( T g) values show that the latexes prepared using BA and EHA as comonomer was suitable for binder purpose, but in the present study the T g is not suitable in case of BMA as higher acrylate comonomer. That may be due to more cross-linking in MMA-BMA-PPGDA. The results conclude that the BA and EHA can be used as the binder, but the use of BMA is limited for the binder in coating applications.

Targeted delivery of SNX-2112 by polysaccharide-modified graphene oxide nanocomposites for treatment of lung cancer

2018 ◽  
Vol 185 ◽  
pp. 85-95 ◽  
Author(s):  
Xuan Liu ◽  
Xiaozhen Cheng ◽  
Fengzhe Wang ◽  
Longbao Feng ◽  
Yu Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Graphene Oxide ◽  
Targeted Delivery ◽  
Modified Graphene Oxide ◽  
Modified Graphene

scholarly journals Synthesis and characterization of graphene oxide flakes for transparent thin films

2021 ◽  
Vol 22 (3) ◽  
pp. 595-601
Author(s):  
R.G. Abaszade ◽  
S.A. Mamedova ◽  
F.G. Agayev ◽  
S.I. Budzulyak ◽  
O.A. Kapush ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Graphene Oxide ◽  
Indium Tin Oxide ◽  
Electromagnetic Interference ◽  
Large Scale ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
X Ray ◽  
Scanning Electron

We have synthesized large scale, thin, transparent graphene oxide (GO) flakes by Hummer’s method and investigated their suitability for fabrication of transparent nanocomposites. The GO flakes were comprehensively characterized by X-ray diffraction, Scanning Electron Microscopy (SEM), Energy Dispersive X-ray analysis (EDX), Raman spectroscopy and Differential Scanning Calorimetry (DSC). X-ray diffraction displayed the peak of graphene oxide at 9°degree, which is characteristic peak of GO in agreement with the literature results. Scanning Electron Microscopy images revealed that thin, transparent, flake form GO with 14,8 µm lateral size and 0,31µm thickness were synthesized. The comparison with literature results show that for the first time, our group could synthesize large scale, thin and more transparent GO flakes by simple Hummer’s method using simple dispersed graphite. EDX measurements indicate the formation of layered structure with oxygen containing functional groups. The intensity ratio between D and G peaks in the Raman spectra proves that less defective GO flakes have been synthesized. The solution ability of the synthesized material indicate that high quality GO flakes were synthesized, which make them effective soluble material due to oxygen containing groups formed on the graphene plane during synthesis process.DSC results shows that these flakes are thermally stable till 200°C.  Due to high solubility properties, large scale and transparency they can be very useful in fabrication of high optical transparent nanocompoties for replacement indium tin oxide transparent conductors in solar panels, biomedical applications and microwave absorbers for electromagnetic interference (EMI) environmental protection.

scholarly journals Two Novel Polysaccharides in Psoralea corylifolia L and anti-A549 Lung Cancer Cells Activity In Vitro

Molecules ◽  
2019 ◽  
Vol 24 (20) ◽  
pp. 3733 ◽  
Author(s):  
Zhenhua Yin ◽  
Wei Zhang ◽  
Juanjuan Zhang ◽  
Huili Liu ◽  
Qingfeng Guo ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Monosaccharide Composition ◽  
Water Soluble ◽  
Lung Cancer Cells ◽  
Psoralea Corylifolia ◽  
Scanning Calorimetry ◽  
Good Thermal Stability ◽  
A549 Lung

Two novel water soluble heteroglycan (PCp-I and PCp-II) with anti-A549 lung cancer cells activity were isolated from Psoralea corylifolia L. Their average molecular weights were 2.721 × 104 and 2.850 × 104. PCp-I and PCp-II had the same monosaccharide composition, but their molar ratios were different. Based on methylation and NMR spectroscopy, the part structure of PCp-I was identified. The results of scanning electron microscope (SEM) showed that PCp-I had an irregular porous structure and PCp-II was flaky and irregularly curved. The results of thermogravimetry-differential scanning calorimetry (TG-DSC) showed that PCp-I and PCp-II had good thermal stability. Furthermore, PCp-I and PCp-II exhibited significant anti-A549 lung cancer cells activity (IC50 = 64.84 and 126.30 μM) in vitro.

scholarly journals Functional Graphene Oxide Nanocarriers for Drug Delivery

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Yuanfeng Ye ◽  
Xincheng Mao ◽  
Jialing Xu ◽  
Jingyang Kong ◽  
Xiaohong Hu
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Targeted Delivery ◽  
Structural Information ◽  
Drug Carrier ◽  
Drug Loading ◽  
The Family ◽  
Before And After ◽  
Functional Graphene Oxide

The family of graphene has attracted increasing attention on account of their large specific surface area and good mechanical properties in the biomedical field. However, some characteristics like targeted delivery property and drug delivery capacity could not satisfy the need of a drug carrier. Herein, a graphene oxide (GO) nanocarrier was designed by modification of a folic acid (FA) derivative and a β-cyclodextrin (β-CD) derivative in order to improve two properties, respectively. In the first step, reactive or crosslinkable FA and aldehydic β-CD (β-CD-CHO) were designed and synthesized for further modification. In the second step, synthesized functional molecules were coupled onto GO sheets one by one to obtain the GO nanocarrier. IR spectra and XRD results were used to identify the chemical and structural information before and after modification for the GO nanocarrier. The final GO nanocarrier exhibited a typical thin wrinkled sheet morphology of the GO sheet without any influence by two functional molecules. Finally, in vitro evaluation was used to clarify the drug loading and controlling capacity of the nanocarrier as a drug delivery system. The results revealed that the GO nanocarrier had a better CPT loading capacity and showed better controllability for CPT release.

scholarly journals Apoptosis inducing ability of silver decorated highly reduced graphene oxide nanocomposites in A549 lung cancer

2016 ◽  
pp. 873 ◽  
Author(s):  
Syed Adil ◽  
Merajuddin Khan ◽  
Mujeeb Khan ◽  
Abdulhadi Al-Marri ◽  
Abdulrahman Al-Warthan ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Reduced Graphene ◽  
A549 Lung

β-Cyclodextrin modified graphene oxide–magnetic nanocomposite for targeted delivery and pH-sensitive release of stereoisomeric anti-cancer drugs

RSC Advances ◽  
2015 ◽  
Vol 5 (108) ◽  
pp. 89299-89308 ◽  
Author(s):  
Congli Wang ◽  
Bo Li ◽  
Weifen Niu ◽  
Shasha Hong ◽  
Bassam Saif ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Targeted Delivery ◽  
Drug Carrier ◽  
Layer By Layer ◽  
Innovative Drug ◽  
Assembly Method ◽  
Modified Graphene Oxide ◽  
Anti Cancer ◽  
Modified Graphene ◽  
Effective Layer

β-Cyclodextrin modified graphene oxide–magnetic (MGC) nanocomposite as an innovative drug carrier was the first to be developed via an effective layer-by-layer-assembly method.

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