Reaction-based turn-on fluorescent probes with magnetic responses for Fe2+ detection in live cells

2015 ◽  
Vol 44 (19) ◽  
pp. 8942-8949 ◽  
Author(s):  
Siddhartha Maiti ◽  
Ziya Aydin ◽  
Yi Zhang ◽  
Maolin Guo
Keyword(s):  
Fluorescent Probes ◽  
Fluorescent Sensor ◽  
Live Cells ◽  
Turn On ◽  
Selective Reaction

A highly selective reaction-based “turn-on” fluorescent sensor is capable of detecting Fe2+ in mitochondria with distinct EPR responses.

Turn-on visible and ratiometric near-infrared fluorescent probes for distinction endogenous esterases and chymotrypsins in live cells

2020 ◽  
Vol 306 ◽  
pp. 127567 ◽  
Author(s):  
Jiemin Wang ◽  
Zhidong Teng ◽  
Ting Cao ◽  
Jing Qian ◽  
Lei Zheng ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Near Infrared ◽  
Live Cells ◽  
Turn On

scholarly journals Cancer-Specific hNQO1-Responsive Biocompatible Naphthalimides Providing a Rapid Fluorescent Turn-On with an Enhanced Enzyme Affinity

Sensors ◽  
2019 ◽  
Vol 20 (1) ◽  
pp. 53 ◽  
Author(s):  
Sun Young Park ◽  
Eugeine Jung ◽  
Jong Seung Kim ◽  
Sung-Gil Chi ◽  
Min Hee Lee
Keyword(s):  
Cancer Cells ◽  
Fluorescent Probes ◽  
Therapeutic Agent ◽  
Cell Imaging ◽  
Physiological Condition ◽  
Live Cells ◽  
Strong Fluorescence ◽  
Turn On ◽  
Efficient Detection ◽  
Agent Development

Human NAD(P)H:quinone oxidoreductase 1 (hNQO1) is overexpressed in cancer cells and associated with the drug resistance factor of cancer. The objective of this work is the development of fluorescent probes for the efficient detection of hNQO1 activity in cancer cells, which can be employed for the cancer diagnosis and therapeutic agent development. Herein, we report naphthalimide-based fluorescent probes 1 and 2 that can detect hNQO1. For hNQO1 activity, the probes showed a significant fluorescence increase at 540 nm. In addition, probe 1, the naphthalimide containing a triphenylphosphonium salt, showed an enhanced enzyme efficiency and rapid detection under a physiological condition. The detection ability of probe 1 was superior to that of other previously reported probes. Moreover, probe 1 was less cytotoxic during the cancer cell imaging and readily provided a strong fluorescence in hNQO1-overexpressed cancer cells (A549). We proposed that probe 1 can be used to detect hNQO1 expression in live cells and it will be applied to develop the diagnosis and customized treatment of hNQO1-related disease.

A new turn-on fluorescent sensor based on NBD for highly selective detection of Hg2+ in aqueous media and imaging in live cells

2014 ◽  
Vol 6 (13) ◽  
pp. 4797 ◽  
Author(s):  
Youming Shen ◽  
Youyu Zhang ◽  
Xiangyang Zhang ◽  
Chunxiang Zhang ◽  
Linli Zhang ◽  
...  
Keyword(s):  
Fluorescent Sensor ◽  
Aqueous Media ◽  
Live Cells ◽  
Selective Detection ◽  
Turn On

A two-photon “turn-on” fluorescent probe based on carbon nanodots for imaging and selective biosensing of hydrogen sulfide in live cells and tissues

The Analyst ◽  
2014 ◽  
Vol 139 (8) ◽  
pp. 1945-1952 ◽  
Author(s):  
Anwei Zhu ◽  
Zongqian Luo ◽  
Changqin Ding ◽  
Bo Li ◽  
Shuang Zhou ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Fluorescent Probe ◽  
Fluorescent Sensor ◽  
Live Cells ◽  
Carbon Nanodots ◽  
Specific Receptor ◽  
Two Photon ◽  
Turn On

A “turn-on” two-photon fluorescent sensor for H2S is developed, in which C-Dot is employed as a two-photon fluorophore and AE-TPEA–Cu2+complex is first designed as a specific receptor for H2S.

Bright, red emitting fluorescent sensor for intracellular imaging of Mg2+

2016 ◽  
Vol 14 (48) ◽  
pp. 11381-11388 ◽  
Author(s):  
Qitian Lin ◽  
Jessica J. Gruskos ◽  
Daniela Buccella
Keyword(s):  
Fluorescent Sensor ◽  
Low Energy ◽  
Live Cells ◽  
Energy Excitation ◽  
Intracellular Imaging ◽  
Turn On

A new fluorescent sensor with excellent turn-on ratio, low energy excitation and emission over 600 nm enables Mg2+detection in live cells.

A highly selective “turn-on” fluorescent sensor for zinc ion based on a cinnamyl pyrazoline derivative and its imaging in live cells

2018 ◽  
Vol 10 (16) ◽  
pp. 1833-1841 ◽  
Author(s):  
Yun-Shang Yang ◽  
Chun-Mei Ma ◽  
Ying-Peng Zhang ◽  
Qing-Hua Xue ◽  
Jia-Xi Ru ◽  
...  
Keyword(s):  
Fluorescence Probe ◽  
Fluorescent Sensor ◽  
Zinc Ion ◽  
Live Cells ◽  
Turn On ◽  
Pyrazoline Derivative

A fluorescence probe based on cinnamyl pyrazoline was developed and synthesized.

A highly sensitive fluorescent sensor for Al3+and Zn2+based on a diarylethene salicylhydrazide Schiff base derivative and its bioimaging in live cells

2016 ◽  
Vol 40 (10) ◽  
pp. 8579-8586 ◽  
Author(s):  
Yinglong Fu ◽  
Yayi Tu ◽  
Congbin Fan ◽  
Chunhong Zheng ◽  
Gang Liu ◽  
...  
Keyword(s):  
Schiff Base ◽  
Fluorescent Sensor ◽  
Live Cells ◽  
Dual Mode ◽  
Fluorescence Response ◽  
Color Changes ◽  
Turn On ◽  
Highly Sensitive ◽  
Base Derivative

A new photochromic diarylethene based sensor with a salicylhydrazide Schiff base displayed a dual-mode with a “turn on” fluorescence response and color changes upon addition of Al3+or Zn2+.

Turn-on fluorescent probe for dopamine detection in solutions and live cells based on in situ formation of aminosilane-functionalized carbon dots

2021 ◽  
Vol 1157 ◽  
pp. 338394
Author(s):  
Xiao-Yue Tang ◽  
Yi-Ming Liu ◽  
Xiao-Lin Bai ◽  
Hao Yuan ◽  
Yi-Kao Hu ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Carbon Dots ◽  
Live Cells ◽  
Turn On ◽  
Dopamine Detection ◽  
In Situ Formation

scholarly journals Fluorescent Probes for Live Cell Thiol Detection

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3575
Author(s):  
Shenggang Wang ◽  
Yue Huang ◽  
Xiangming Guan
Keyword(s):  
Fluorescent Probes ◽  
Biological System ◽  
High Sensitivity ◽  
Intracellular Distribution ◽  
Live Cell ◽  
Live Cells ◽  
High Demand ◽  
Non Invasive

Thiols play vital and irreplaceable roles in the biological system. Abnormality of thiol levels has been linked with various diseases and biological disorders. Thiols are known to distribute unevenly and change dynamically in the biological system. Methods that can determine thiols’ concentration and distribution in live cells are in high demand. In the last two decades, fluorescent probes have emerged as a powerful tool for achieving that goal for the simplicity, high sensitivity, and capability of visualizing the analytes in live cells in a non-invasive way. They also enable the determination of intracellular distribution and dynamitic movement of thiols in the intact native environments. This review focuses on some of the major strategies/mechanisms being used for detecting GSH, Cys/Hcy, and other thiols in live cells via fluorescent probes, and how they are applied at the cellular and subcellular levels. The sensing mechanisms (for GSH and Cys/Hcy) and bio-applications of the probes are illustrated followed by a summary of probes for selectively detecting cellular and subcellular thiols.

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