A multicellular, neuro-mimetic model to study nanoparticle uptake in cells of the central nervous system

2014 ◽  
Vol 6 (9) ◽  
pp. 855-861 ◽  
Author(s):  
A. R. Fernandes ◽  
D. M. Chari
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Stem Cell ◽  
Gene Delivery ◽  
Neural Model ◽  
Cell Populations ◽  
Nanoparticle Uptake ◽  
System P ◽  
The Central Nervous System ◽  
In Cells

We describe a multicellular neural model to study nanoparticle uptake and gene delivery, using stem cell derived cell populations.

Stability of mRNA/Cationic Lipid Lipoplexes in Human and Rat Cerebrospinal Fluid: Methods and Evidence for Nonviral mRNA Gene Delivery to the Central Nervous System

2003 ◽  
Vol 14 (3) ◽  
pp. 191-202 ◽  
Author(s):  
Dua M. Anderson ◽  
Leon L. Hall ◽  
Anitha R. Ayyalapu ◽  
Van R. Irion ◽  
Michael H. Nantz ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Gene Delivery ◽  
Cationic Lipid ◽  
Mrna Gene ◽  
The Central Nervous System

Effects of an injectable functionalized self-assembling nanopeptide hydrogel on angiogenesis and neurogenesis for regeneration of the central nervous system

Nanoscale ◽  
2017 ◽  
Vol 9 (42) ◽  
pp. 16281-16292 ◽  
Author(s):  
Tzu-Wei Wang ◽  
Kai-Chieh Chang ◽  
Liang-Hsin Chen ◽  
Shih-Yung Liao ◽  
Chia-Wei Yeh ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Brain Tissue ◽  
Tissue Regeneration ◽  
Self Assembling ◽  
System P ◽  
Injured Brain ◽  
The Central Nervous System

Functionalised self-assembling nanopeptide hydrogel mediates angiogenesis and neurogenesis for injured brain tissue regeneration.

scholarly journals Multimodal Imaging of Stem Cell Implantation in the Central Nervous System of Mice

10.3791/3906 ◽  
2012 ◽  
Author(s):  
Nathalie De Vocht ◽  
Kristien Reekmans ◽  
Irene Bergwerf ◽  
Jelle Praet ◽  
Chloé Hoornaert ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Stem Cell ◽  
Multimodal Imaging ◽  
The Central Nervous System ◽  
Cell Implantation

A practical pH-compatible fluorescent sensor for hydrazine in soil, water and living cells

The Analyst ◽  
2020 ◽  
Vol 145 (22) ◽  
pp. 7380-7387 ◽  
Author(s):  
Huming Yan ◽  
Fangjun Huo ◽  
Yongkang Yue ◽  
Jianbin Chao ◽  
Caixia Yin
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Respiratory Tract ◽  
Human Body ◽  
Water Solubility ◽  
Fluorescent Sensor ◽  
Living Cells ◽  
Human Organs ◽  
System P ◽  
The Central Nervous System

The excellent water solubility of hydrazine (N2H4) allows it to easily invade the human body through the skin and respiratory tract, thereby damaging human organs and the central nervous system.

Demyelinating disorders of the central nervous system

2010 ◽  
pp. 4948-4963
Author(s):  
Siddharthan Chandran ◽  
Alastair Compston
Keyword(s):  
Multiple Sclerosis ◽  
Central Nervous System ◽  
Nervous System ◽  
Acute Disseminated Encephalomyelitis ◽  
Demyelinating Diseases ◽  
Demyelinating Disorder ◽  
System P ◽  
The Central Nervous System ◽  
Demyelinating Disorders ◽  
Brain And Spinal Cord

Clinicians suspect demyelination when episodes reflecting damage to white matter tracts within the central nervous system occur in young adults. The paucity of specific biological markers of discrete demyelinating syndromes places an emphasis on clinical phenotype—temporal and spatial patterns—when classifying demyelinating disorders. The diagnosis of multiple sclerosis, the most common demyelinating disorder, becomes probable when these symptoms and signs recur, involving different parts of the brain and spinal cord. Other important demyelinating diseases include post-infectious neurological disorders (acute disseminated encephalomyelitis), demyelination resulting from metabolic derangements (central pontine myelinosis), and inherited leucodystrophies that may present in children or in adults. Accepting differences in mechanism, presentation, and treatment, two observations can usefully be made when classifying demyelinating disorders. These are the presence or absence of inflammation, and the extent of focal vs. diffuse demyelination. Multiple sclerosis is prototypic for the former, whereas dysmyelinating disorders, such as leucodystrophies are representative of the latter....

Neurochemical Systems in the Central Nervous System

2013 ◽  
pp. 12-26
Author(s):  
Ariel Y. Deutch ◽  
Robert H. Roth
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Psychiatric Disorders ◽  
Neurotrophic Factors ◽  
Drugs Of Abuse ◽  
Large Majority ◽  
System P ◽  
Target Neuron ◽  
The Central Nervous System ◽  
The Brain

Chapter 2 describes the neurochemical organization of the brain. It summarizes the diverse types of molecules that neurons in the brain use as neurotransmitters and neurotrophic factors, and how these molecules are synthesized and metabolized. The chapter also presents the array of receptor proteins through which these molecules regulate target neuron functioning and the reuptake proteins that generally terminate the neurotransmitter signal. Today a large majority of all drugs used to treat psychiatric disorders, as well as most drugs of abuse, still have as their initial targets proteins involved directly in neurotransmitter function.

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