Facile fabrication of reduction-responsive nanocarriers for controlled drug release

2014 ◽  
Vol 5 (17) ◽  
pp. 4879-4883 ◽  
Author(s):  
Rui Sun ◽  
Qiaojie Luo ◽  
Chen Gao ◽  
Ying Wang ◽  
Lilong Gao ◽  
...  
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
One Pot ◽  
Facile Fabrication ◽  
Crosslinked Micelles ◽  
Ether Ester

An amphiphilic multiblock poly(ether–ester) containing multiple thiols was facilely synthesized by “one-pot” polycondensation, and was used to prepare reduction-responsive core-crosslinked micelles for controlled drug release.

One-Pot Synthesis of Redox-Responsive Polymers-Coated Mesoporous Silica Nanoparticles and Their Controlled Drug Release

2013 ◽  
Vol 34 (17) ◽  
pp. 1387-1394 ◽  
Author(s):  
Jiao-Tong Sun ◽  
Ji-Gang Piao ◽  
Long-Hai Wang ◽  
Mohsin Javed ◽  
Chun-Yan Hong ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Release ◽  
One Pot ◽  
Responsive Polymers ◽  
One Pot Synthesis ◽  
Redox Responsive

Redox-responsive, core-crosslinked degradable micelles for controlled drug release

2016 ◽  
Vol 7 (41) ◽  
pp. 6330-6339 ◽  
Author(s):  
Yingchun Xia ◽  
Hua He ◽  
Xiangyu Liu ◽  
Ding Hu ◽  
Lichen Yin ◽  
...  
Keyword(s):  
Drug Release ◽  
Click Chemistry ◽  
Controlled Drug Release ◽  
Redox Responsive ◽  
One Step ◽  
Crosslinked Micelles

We developed novel redox-responsive, core-crosslinked micelles (CCLMs) via a simple, one-step click chemistry reaction.

One-pot synthesis of glutathione-responsive amphiphilic drug self-delivery micelles of doxorubicin–disulfide–methoxy polyethylene glycol for tumor therapy

2018 ◽  
Vol 6 (1) ◽  
pp. 39-43 ◽  
Author(s):  
Xiao Duan ◽  
Ting Bai ◽  
Junjie Du ◽  
Jie Kong
Keyword(s):  
Polyethylene Glycol ◽  
Drug Release ◽  
Tumor Therapy ◽  
Controlled Drug Release ◽  
One Pot ◽  
One Pot Synthesis ◽  
Amphiphilic Drug ◽  
Methoxy Polyethylene Glycol ◽  
Accumulated Toxicity

We present a novel glutathione-responsive amphiphilic drug self-delivery (DSD) micelle with one-pot synthesis to synergistically address the problems of controlled drug release, degradability, drug tracing and in vivo accumulated toxicity.

Gold embedded chitosan nanoparticles with cell membrane mimetic polymer coating for pH-sensitive controlled drug release and cellular fluorescence imaging

2020 ◽  
pp. 088532822095259
Author(s):  
Ke Ma ◽  
Yongbin Cheng ◽  
Xinran Wei ◽  
Daijun Chen ◽  
Xiaoli Zhao ◽  
...  
Keyword(s):  
Drug Release ◽  
Fluorescence Imaging ◽  
Colloidal Stability ◽  
Drug Loading ◽  
Tumor Therapy ◽  
Chitosan Nanoparticles ◽  
Fluorescence Emission ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
One Pot

In this work, gold embedded chitosan nanoparticles (Au@CS NPs) were fabricated by a one-pot method. The benzaldehyde-terminated poly[(2-methacryloyloxy) ethyl phosphorylcholine] (PMPC) was applied to modification of the gold doped chitosan nanoparticles. The obtained Au@CS-PMPC NPs had the diameter of 135 nm with a narrow distribution. The size of the Au@CS-PMPC NPs, as well as the size of the embedded gold NPs, might be well-controlled by adjusting the feeding ratio between chitosan and HAuCl4. Furthermore, the Au@CS-PMPC NPs showed increased colloidal stability, high drug loading content, pH-responsive drug release, excellent biocompatibility and bright fluorescence emission. The results demonstrated that Au@CS-PMPC NPs showed a great potential for tumor therapy via the combination advantages of pH-sensitive controlled drug release and cellular fluorescence imaging.

One-pot synthesis of pH-sensitive polymeric nanoparticles and controlled drug release study

2016 ◽  
Vol 12 (2) ◽  
pp. 469-470
Author(s):  
Xin Zhao ◽  
Ming Cao ◽  
Xiaoshuang Feng ◽  
Peng Chen ◽  
Ru Xia ◽  
...  
Keyword(s):  
Drug Release ◽  
Polymeric Nanoparticles ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
One Pot ◽  
Drug Release Study ◽  
One Pot Synthesis ◽  
Release Study

scholarly journals Synthesis and characterization of biodegradable poly(ether-ester) urethane acrylates for controlled drug release

2017 ◽  
Vol 74 ◽  
pp. 270-278 ◽  
Author(s):  
Xuepeng Feng ◽  
Guirong Wang ◽  
Kevin Neumann ◽  
Wei Yao ◽  
Lin Ding ◽  
...  
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Synthesis And Characterization ◽  
Biodegradable Poly ◽  
Ether Ester

Novel core–shell dextran–hemin crosslinked micelles: synthesis, photo-controlled drug release and excellent (synergetic) antitumor effect

2015 ◽  
Vol 3 (7) ◽  
pp. 1439-1445 ◽  
Author(s):  
Qingbo Yu ◽  
Anjian Xie ◽  
Yazhong Xiao ◽  
Shikuo Li ◽  
Fangzhi Huang ◽  
...  
Keyword(s):  
Drug Release ◽  
Antitumor Effect ◽  
Controlled Drug Release ◽  
Core Shell ◽  
Crosslinked Micelles

In this study, novel core–shell crosslinked dextran–hemin micelles were first successfully synthesized.

Amphiphilic poly(ethylene glycol)-b-poly(ethylene brassylate) copolymers: One-pot synthesis, self-assembly, and controlled drug release

2015 ◽  
Vol 26 (10) ◽  
pp. 1319-1321 ◽  
Author(s):  
Jiu-Cun Chen ◽  
Jun-Zhi Li ◽  
Jian-Hua Liu ◽  
Li-Qun Xu
Keyword(s):  
Drug Release ◽  
Ethylene Glycol ◽  
Self Assembly ◽  
Controlled Drug Release ◽  
Poly Ethylene Glycol ◽  
One Pot ◽  
One Pot Synthesis ◽  
Poly Ethylene

Reducing the Risk in Controlled Drug Release by Using Tannic Acid in Liposomal Formulations

2018 ◽  
Vol 68 (12) ◽  
pp. 2925-2918
Author(s):  
Gabriela Cioca ◽  
Maricel Agop ◽  
Marcel Popa ◽  
Simona Bungau ◽  
Irina Butuc
Keyword(s):  
Drug Release ◽  
Tannic Acid ◽  
Release Rate ◽  
Controlled Drug Release ◽  
Toxicity Threshold ◽  
Release System ◽  
Liposomal Formulations ◽  
Cross Linker ◽  
Natural Cross

One of the main challenges in designing a release system is the possibility to control the release rate in order to maintain it at a constant value below a defined limit, to avoid exceeding the toxicity threshold. We propose a method of overcoming this difficulty by introducing the drug into liposomes, prior to its inclusion in the hydrogel. Furthermore, a natural cross linker (as is tannic acid) is used, instead of the toxic cross linkers commonly used, thus reducing the toxicity of the release system as a whole.

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