Down-regulation of MALAT1 inhibits cervical cancer cell invasion and metastasis by inhibition of epithelial–mesenchymal transition

2016 ◽  
Vol 12 (3) ◽  
pp. 952-962 ◽  
Author(s):  
Ruili Sun ◽  
Changfei Qin ◽  
Binyuan Jiang ◽  
Shujuan Fang ◽  
Xi Pan ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Prognostic Factor ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Epithelial Mesenchymal Transition ◽  
Cancer Cell Invasion ◽  
Invasion And Metastasis ◽  
Mesenchymal Transition ◽  
Non Coding Rna ◽  
Long Non Coding Rna

MALAT1, a member of the long non-coding RNA (lncRNA) family, has been reported to be highly enriched in many kinds of cancers and to be a metastasis marker and a prognostic factor.

scholarly journals Exo70 Isoform Switching upon Epithelial-Mesenchymal Transition Mediates Cancer Cell Invasion

2013 ◽  
Vol 27 (5) ◽  
pp. 560-573 ◽  
Author(s):  
Hezhe Lu ◽  
Jianglan Liu ◽  
Shujing Liu ◽  
Jingwen Zeng ◽  
Deqiang Ding ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Cell Invasion ◽  
Epithelial Mesenchymal Transition ◽  
Cancer Cell Invasion ◽  
Mesenchymal Transition ◽  
Isoform Switching

scholarly journals Markers of Cancer Cell Invasion: Are They Good Enough?

2019 ◽  
Vol 8 (8) ◽  
pp. 1092 ◽  
Author(s):  
Tatiana S. Gerashchenko ◽  
Nikita M. Novikov ◽  
Nadezhda V. Krakhmal ◽  
Sofia Y. Zolotaryova ◽  
Marina V. Zavyalova ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Epithelial Mesenchymal Transition ◽  
Migration And Invasion ◽  
Cancer Tissue ◽  
Cancer Cell Invasion ◽  
Mesenchymal Transition ◽  
Morphological Heterogeneity ◽  
Extracellular Matrix Components

Invasion, or directed migration of tumor cells into adjacent tissues, is one of the hallmarks of cancer and the first step towards metastasis. Penetrating to adjacent tissues, tumor cells form the so-called invasive front/edge. The cellular plasticity afforded by different kinds of phenotypic transitions (epithelial–mesenchymal, collective–amoeboid, mesenchymal–amoeboid, and vice versa) significantly contributes to the diversity of cancer cell invasion patterns and mechanisms. Nevertheless, despite the advances in the understanding of invasion, it is problematic to identify tumor cells with the motile phenotype in cancer tissue specimens due to the absence of reliable and acceptable molecular markers. In this review, we summarize the current information about molecules such as extracellular matrix components, factors of epithelial–mesenchymal transition, proteases, cell adhesion, and actin cytoskeleton proteins involved in cell migration and invasion that could be used as invasive markers and discuss their advantages and limitations. Based on the reviewed data, we conclude that future studies focused on the identification of specific invasive markers should use new models one of which may be the intratumor morphological heterogeneity in breast cancer reflecting different patterns of cancer cell invasion.

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