A 18F-labeled dibenzocyclooctyne (DBCO) derivative for copper-free click labeling of biomolecules
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The new prosthetic group 18F-TEG-DBCO (dibenzocyclooctyne) can be prepared within a total reaction time of 60 min including purification with an overall yield (n.d.c.) of 34 ± 5%. Copper-free click cycloadditions with various biomolecule-azides resulted in very high RCYs under mild conditions.
2015 ◽
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1987 ◽
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1991 ◽
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